journal
https://read.qxmd.com/read/38626924/inter-subject-correlation-of-electroencephalographic-and-behavioural-responses-reflects-time-varying-engagement-with-natural-music
#1
JOURNAL ARTICLE
Blair Kaneshiro, Duc T Nguyen, Anthony M Norcia, Jacek P Dmochowski, Jonathan Berger
Musical engagement can be conceptualized through various activities, modes of listening and listener states. Recent research has reported that a state of focused engagement can be indexed by the inter-subject correlation (ISC) of audience responses to a shared naturalistic stimulus. While statistically significant ISC has been reported during music listening, we lack insight into the temporal dynamics of engagement over the course of musical works-such as those composed in the Western classical style-which involve the formulation of expectations that are realized or derailed at subsequent points of arrival...
April 16, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38622053/temporal-mechanisms-in-frontoparallel-stereomotion-revealed-by-individual-differences-analysis
#2
JOURNAL ARTICLE
Ichasus Llamas-Cornejo, David H Peterzell, Ignacio Serrano-Pedraza
Masking experiments, using vertical and horizontal sinusoidal depth corrugations, have suggested the existence of more than two spatial-frequency disparity mechanisms. This result was confirmed through an individual differences approach. Here, using factor analytic techniques, we want to investigate the existence of independent temporal mechanisms in frontoparallel stereoscopic (cyclopean) motion. To construct stereomotion, we used sinusoidal depth corrugations obtained with dynamic random-dot stereograms. Thus, no luminance motion was present monocularly...
April 15, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38622050/lipid-nanoparticle-mediated-small-interfering-rna-delivery-as-a-potential-therapy-for-alzheimer-s-disease
#3
REVIEW
Tanvir Ahmed
Alzheimer's disease (AD) is a neurodegenerative condition that exhibits a gradual decline in cognitive function and is prevalent among a significant number of individuals globally. The use of small interfering RNA (siRNA) molecules in RNA interference (RNAi) presents a promising therapeutic strategy for AD. Lipid nanoparticles (LNPs) have been developed as a delivery vehicle for siRNA, which can selectively suppress target genes, by enhancing cellular uptake and safeguarding siRNA from degradation. Numerous research studies have exhibited the effectiveness of LNP-mediated siRNA delivery in reducing amyloid beta (Aβ) levels and enhancing cognitive function in animal models of AD...
April 15, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38616566/a-scalable-spiking-amygdala-model-that-explains-fear-conditioning-extinction-renewal-and-generalization
#4
JOURNAL ARTICLE
Peter Duggins, Chris Eliasmith
The amygdala (AMY) is widely implicated in fear learning and fear behaviour, but it remains unclear how the many biological components present within AMY interact to achieve these abilities. Building on previous work, we hypothesize that individual AMY nuclei represent different quantities and that fear conditioning arises from error-driven learning on the synapses between AMY nuclei. We present a computational model of AMY that (a) recreates the divisions and connections between AMY nuclei and their constituent pyramidal and inhibitory neurons; (b) accommodates scalable high-dimensional representations of external stimuli; (c) learns to associate complex stimuli with the presence (or absence) of an aversive stimulus; (d) preserves feature information when mapping inputs to salience estimates, such that these estimates generalize to similar stimuli; and (e) induces a diverse profile of neural responses within each nucleus...
April 14, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38602078/optogenetic-induction-of-chronic-glucocorticoid-exposure-in-early-life-leads-to-blunted-stress-response-in-larval-zebrafish
#5
JOURNAL ARTICLE
Jatin Nagpal, Helen Eachus, Olga Lityagina, Soojin Ryu
Early life stress (ELS) exposure alters stress susceptibility in later life and affects vulnerability to stress-related disorders, but how ELS changes the long-lasting responsiveness of the stress system is not well understood. Zebrafish provides an opportunity to study conserved mechanisms underlying the development and function of the stress response that is regulated largely by the neuroendocrine hypothalamus-pituitary-adrenal/interrenal (HPA/I) axis, with glucocorticoids (GC) as the final effector. In this study, we established a method to chronically elevate endogenous GC levels during early life in larval zebrafish...
April 11, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38578844/predicting-functional-impairments-with-lesion-derived-disconnectome-mapping-validation-in-stroke-patients-with-motor-deficits
#6
JOURNAL ARTICLE
Maedeh Khalilian, Martine Roussel, Olivier Godefroy, Ardalan Aarabi
Focal structural damage to white matter tracts can result in functional deficits in stroke patients. Traditional voxel-based lesion-symptom mapping is commonly used to localize brain structures linked to neurological deficits. Emerging evidence suggests that the impact of structural focal damage may extend beyond immediate lesion sites. In this study, we present a disconnectome mapping approach based on support vector regression (SVR) to identify brain structures and white matter pathways associated with functional deficits in stroke patients...
April 5, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38576223/cholinergic-interneurons-in-the-dorsal-striatum-play-an-important-role-in-the-acquisition-of-duration-memory
#7
JOURNAL ARTICLE
Masahiko Nishioka, Toshimichi Hata
The present study aimed to examine the effect of cholinergic interneuron lesions in the dorsal striatum on duration-memory formation. Cholinergic interneurons in the dorsal striatum may be involved in the formation of duration memory since they are among the main inputs to the dorsal striatal muscarinic acetylcholine-1 receptors, which play a role in the consolidation of duration memory. Rats were sufficiently trained using a peak-interval 20 s procedure and then infused with anti-choline acetyltransferase-saporin into the dorsal striatum to cause selective ablation of cholinergic interneurons...
April 4, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38576196/arched-a-residual-neural-network-for-prediction-of-cerebrospinal-fluid-amyloid-beta-from-amyloid-pet-images
#8
JOURNAL ARTICLE
Arina A Tagmazian, Claudia Schwarz, Catharina Lange, Esa Pitkänen, Eero Vuoksimaa
Detection and measurement of amyloid-beta (Aβ) in the brain is a key factor for early identification and diagnosis of Alzheimer's disease (AD). We aimed to develop a deep learning model to predict Aβ cerebrospinal fluid (CSF) concentration directly from amyloid PET images, independent of tracers, brain reference regions or preselected regions of interest. We used 1870 Aβ PET images and CSF measurements to train and validate a convolutional neural network ("ArcheD"). We evaluated the ArcheD performance in relation to episodic memory and the standardized uptake value ratio (SUVR) of cortical Aβ...
April 4, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38576168/functional-near-infrared-spectroscopy-evidence-of-cognitive-motor-interference-in-different-dual-tasks
#9
JOURNAL ARTICLE
Zi-Tong Ou, Qian Ding, Shan-Tong Yao, Lei Zhang, Ya-Wen Li, Yue Lan, Guang-Qing Xu
Dual tasks (DTs) combining walking with a cognitive task can cause various levels of cognitive-motor interference, depending on which brain resources are recruited in each case. However, the brain activation and functional connectivity underlying cognitive-motor interferences remain to be elucidated. Therefore, this study investigated the neural correlation during different DT conditions in 40 healthy young adults (mean age: 27.53 years, 28 women). The DTs included walking during subtraction or N-Back tasks...
April 4, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38576159/metabolic-disorders-exacerbate-the-formation-of-glial-scar-after-stroke
#10
JOURNAL ARTICLE
Julien Clain, David Couret, Matthieu Bringart, Arnaud Lecadieu, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Nicolas Diotel
Metabolic disorders are risk factors for stroke exacerbating subsequent complications. Rapidly after brain injury, a glial scar forms, preventing excessive inflammation and limiting axonal regeneration. Despite the growing interest in wound healing following brain injury, the formation of a glial scar in the context of metabolic disorders is poorly documented. In this study, we used db/db mice to investigate the impact of metabolic perturbations on brain repair mechanisms, with a focus on glial scarring. First, we confirmed the development of obesity, poor glucose regulation, hyperglycaemia and liver steatosis in these mice...
April 4, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38575329/choice-overload-interferes-with-early-processing-and-necessitates-late-compensation-evidence-from-electroencephalogram
#11
JOURNAL ARTICLE
Xinye Hu, Zong Meng, Qinghua He
Having a multitude of choices can be advantageous, yet an abundance of options can be detrimental to the decision-making process. Based on existing research, the present study combined electroencephalogram and self-reported methodologies to investigate the neural mechanisms underlying the phenomenon of choice overload. Behavioural data suggested that an increase in the number of options led to negative evaluations and avoidance of choice tendencies, even in the absence of time pressure. Event-related potential results indicated that the large choice set interfered with the early visual process, as evidenced by the small P1 amplitude, and failed to attract more attentional resources in the early stage, as evidenced by the small amplitude of P2 and N2...
April 4, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38575327/correction-to-mesial-temporal-dopamine-from-biology-to-behaviour
#12
(no author information available yet)
No abstract text is available yet for this article.
April 4, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38571321/alteration-of-synaptic-protein-composition-during-developmental-synapse-maturation
#13
REVIEW
Takeshi Kaizuka, Toru Takumi
The postsynaptic density (PSD) is a collection of specialized proteins assembled beneath the postsynaptic membrane of dendritic spines. The PSD proteome comprises ~1000 proteins, including neurotransmitter receptors, scaffolding proteins and signalling enzymes. Many of these proteins have essential roles in synaptic function and plasticity. During brain development, changes are observed in synapse density and in the stability and shape of spines, reflecting the underlying molecular maturation of synapses. Synaptic protein composition changes in terms of protein abundance and the assembly of protein complexes, supercomplexes and the physical organization of the PSD...
April 3, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38571281/a-critical-role-of-ca-2-calmodulin-dependent-protein-kinase-ii-in-coupling-between-evening-and-morning-circadian-oscillators-in-the-suprachiasmatic-nucleus
#14
JOURNAL ARTICLE
Tomoko Yoshikawa, Ken-Ichi Honma, Yasufumi Shigeyoshi, Yoko Yamagata, Sato Honma
Ca2+ /calmodulin-dependent protein kinase IIα (CaMKIIα) is widely expressed in the brain and is involved in various functions, including memory formation, mood and sleep. We previously reported that CaMKIIα is involved in the circadian molecular clock. Mice lacking functional CaMKIIα (K42R mice) exhibited a gradual increase in activity time (α decompression) of running-wheel (RW) activity due to a lengthened circadian period (τ) of activity offset under constant darkness (DD)...
April 3, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38570828/age-not-autism-influences-multisensory-integration-of-speech-stimuli-among-adults-in-a-mcgurk-macdonald-paradigm
#15
JOURNAL ARTICLE
Robert M Jertberg, Sander Begeer, Hilde M Geurts, Bhismadev Chakrabarti, Erik Van der Burg
Differences between autistic and non-autistic individuals in perception of the temporal relationships between sights and sounds are theorized to underlie difficulties in integrating relevant sensory information. These, in turn, are thought to contribute to problems with speech perception and higher level social behaviour. However, the literature establishing this connection often involves limited sample sizes and focuses almost entirely on children. To determine whether these differences persist into adulthood, we compared 496 autistic and 373 non-autistic adults (aged 17 to 75 years)...
April 3, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38566366/high-definition-turns-timing-dependent-different-behavioural-consequences-during-and-following-cathodal-high-definition-transcranial-direct-current-stimulation-hd-tdcs-in-a-magnitude-classification-task
#16
JOURNAL ARTICLE
Philipp A Schroeder, Hans-Christoph Nuerk, Jennifer Svaldi
Neuromodulation with transcranial direct current stimulation (tDCS) can transiently alter neural activity, but its spatial precision is low. High-definition (HD) tDCS was introduced to increase spatial precision by placing additional electrodes over the scalp. Initial evaluations of HD tDCS indicated polarity-specific neurophysiological effects-similar to conventional tDCS albeit with greater spatial precision. Here, we compared the effects of cathodal tDCS or HD tDCS in a 4 × 1 configuration over prefrontal cortex (PFC) regions on behavioural outcomes in a magnitude classification task...
April 2, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38558227/uncovering-the-determinants-of-brain-functioning-behavior-and-their-interplay-in-the-light-of-context
#17
JOURNAL ARTICLE
Igor Branchi
Notwithstanding the huge progress in molecular and cellular neuroscience, our ability to understand the brain and develop effective treatments promoting mental health is still limited. This can be partially ascribed to the reductionist, deterministic and mechanistic approaches in neuroscience that struggle with the complexity of the central nervous system. Here, I introduce the Context theory of constrained systems proposing a novel role of contextual factors and genetic, molecular and neural substrates in determining brain functioning and behavior...
April 1, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38558202/against-silent-retractions-in-neuroscience
#18
JOURNAL ARTICLE
Jaime A Teixeira da Silva, Timothy Daly
When an academic paper is published in a journal that assigns a digital object identifier (DOI) to papers, this is a de facto fait accompli. Corrections or retractions are supposed to follow a specific protocol, especially in journals that claim to follow the Committee on Publication Ethics (COPE) guidelines. In this paper, we highlight a case of a new, fully open access neuroscience journal that claims to be COPE-compliant, yet has silently retracted two papers since all records, bibliometrics, and PDF files related to their existence have been deleted from the journal's website...
April 1, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38558157/developmental-coordination-disorder-in-preterm-children-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Carolina Panceri, Graciele Sbruzzi, Larissa W Zanella, Andressa Wiltgen, Renato S Procianoy, Rita C Silveira, Nadia C Valentini
This study aimed to review the prevalence of developmental coordination disorder (DCD) in individuals born preterm and systematically explore this prevalence according to gestational age and different assessment cut-offs and compare it to full-term peers. The eligibility criteria were observational and experimental studies reporting the prevalence of DCD in preterm individuals. A systematic search was performed in databases from inception until March 2022. Two independent reviewers performed the selection. Study quality assessment was performed using the checklists from Joanna Briggs Institute (JBI)...
April 1, 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38556788/why-the-neural-ingredients-for-a-language-of-thought-are-not-like-spatial-cells-commentary-on-kazanina-poeppel-2023
#20
JOURNAL ARTICLE
Sander van Bree
No abstract text is available yet for this article.
March 31, 2024: European Journal of Neuroscience
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