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Journals International Journal of Devel...

International Journal of Developmental Biology

https://read.qxmd.com/read/35980192/exploring-the-sister-cells-of-embryo-sac-developmental-and-functional-attributes
#21
JOURNAL ARTICLE
Inderdeep Kaur, Monika Koul
Synergids are metabolically dynamic cells of the egg apparatus and represent an important component of the female gametophyte. Besides directing the growth of the pollen tube towards the micropylar end of the embryo sac, these ephemeral structures make room for the pollen tube cytoplasm. Nature of chemotrophic substances that direct the growth of the pollen tube, the mechanism of degeneration of one of the synergids before fertilization and the molecular aspects of synergid morphogenesis have been studied in detail...
August 1, 2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35833524/the-mesenchymal-potential-of-trunk-neural-crest-cells
#22
JOURNAL ARTICLE
Monica Alves Rodrigues-Da-Silva, Guilherme de Espindola da Silveira, Clarissa Reginato Taufer, Giordano Wosgrau Calloni
It has long been held that the main difference between cranial and trunk neural crest (CNC and TNC, respectively) was the potential of CNC to originate mesenchymal cell types, especially skeletogenic. This is an age-old question that continues to challenge researchers, even today. Unfortunately, to date, no consensus has concluded the extent of TNC mesenchymal potential, nor has a systematic review been conducted to organize current knowledge about this fascinating question. However, the number of studies related to this question have expanded and deepened considerably in the last few years thanks to several new different species of vertebrates employed, the generation of transgenic animal strains, the combination of cell markers, and also the improvement of cell culture conditions through the use of different substrates and signaling molecules...
July 8, 2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35238394/epithelial-endothelial-transition-and-endothelial-mesenchymal-transition
#23
JOURNAL ARTICLE
Domenico Ribatti
The movement of continuous sheets of epithelial cells occurs during embryonic development, tissue repair, and cancer. Common to cellular and molecular principles of collective cell migration, invading cancers seem to reactivate embryonic pathways and patterns of cell movement. Epithelial cells possess the capability to become mesenchymal cells in a process called epithelial mesenchymal transition (EMT), which has been extensively studied and described. The aim of this article is to summarizes the most recent literature data concerning less known epithelial-endothelial transition and endothelial-mesenchymal transition...
February 21, 2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35238392/heterogeneity-of-quiescent-and-active-neural-stem-cells-in-the-postnatal-brain
#24
JOURNAL ARTICLE
Dimitrios Dimitrakopoulos, Dimitrios Kakogiannis, Ilias Kazanis
In the postnatal mammalian brain, neurogenic activity is retained in anatomically restricted areas, driven by pools of Neural Stem Cells (NSCs). These cells and their progeny have been studied intensively as potential targets for regenerative treatments, aiming either to their in situ manipulation, or to their use as sources of cells for transplantation-based strategies. Although their full identity, heterogeneity and differentiation potential remain elusive, due to the absence of specific cell-type markers, our knowledge on their properties is constantly expanding...
February 21, 2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35238393/pleiotrophin-nitric-oxide-and-glutamate-ampa-receptors-in-chick-cerebellum-morphogenesis
#25
JOURNAL ARTICLE
Vasiliki Kommata, Evaggelia Alexopoulou, Elentina K Argyrousi, Catherine R Dermon
Avian cerebellum, a highly conserved, laminated and foliated structure, provides an excellent model for developmental studies. During the intermediate embryonic stages, granule cell progenitor proliferation and the inwards migration of post-mitotic granule cells have been implicated in the morphogenesis of cerebellar cortex cytoarchitecture and foliation. The present study questioned the spatio-temporal expression pattern of pleiotrophin, an extracellular matrix growth factor, during the morphogenesis of embryonic cerebellum and the roles of ionotropic AMPA glutamate receptors and the diffusible neuromodulator nitric oxide (NO) in the proliferation pattern of EGL granule cell progenitors...
February 9, 2022: International Journal of Developmental Biology
https://read.qxmd.com/read/36942693/single-cell-transcriptomics-defines-dot1l-interacting-partners-and-downstream-target-genes-in-the-mouse-molar-dental-pulp
#26
JOURNAL ARTICLE
Rosa Guzzo, Badam Enkhmandakh, Timothy Becker, Pujan Joshi, Paul Robson, Anushree Vijaykumar, Mina Mina, Dong-Guk Shin, Dashzeveg Bayarsaihan
Although histone methyltransferases are implicated in many key developmental processes, the contribution of individual chromatin modifiers in dental tissues is not well understood. Using single-cell RNA sequencing, we examined the expression profiles of the disruptor of telomeric silencing 1-like ( Dot1L) gene in the postnatal day 5 mouse molar dental pulp. Dot1L is the only known enzyme that methylates histone 3 on lysine 79, a modification associated with gene expression. Our research revealed 15 distinct clusters representing different populations of mesenchymal stromal cells (MSCs), immune cells, pericytes, ameloblasts and endothelial cells...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35980193/intraflagellar-transport-20-cilia-dependent-and-cilia-independent-signaling-pathways-in-cell-development-and-tissue-homeostasis
#27
REVIEW
Fu-Chang Jin, Ming-Hui Zhou, Jing-Jing Chen, Yi Lin, Qi-Wei Zhang, Qiu-Xian Xu, Chang-Chun Zhang, Zhen-Gang Zhang
Intraflagellar transport (IFT) is an essential condition for ciliogenesis. The primary cilia protrude like antennae and act as chemical or mechanical sensory organelles that coordinate specific receptor localization and signal transduction. IFT20 is the smallest molecule in IFT complex B, which is located in both the cilia and the Golgi complex. Recent studies have shown that IFT20 is a key molecule in multiple signaling pathways. Importantly, in the function of IFT20, signal transduction is not restricted to cilia, but is also involved in non-ciliary functions...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35770734/correlation-between-cdk1-protein-and-cdk1-mrna-during-oocyte-maturation-in-mouse
#28
JOURNAL ARTICLE
Ya-Ting Sun, Ai-Zhen Zhu
The aim of this study was to investigate the correlation between CDK1 protein and CDK1 mRNA during oocyte maturation in vivo in mouse. GV, GVBD, MI and MII oocytes were obtained from mice, respectively. Western blot validated that the CDK1 protein expression increased continuously and significantly with oocyte maturation in vivo (P<0.05). Real-time qRT-PCR showed that CDK1 mRNA expression was down-regulated significantly during transformation from GV to MI stages (P<0.05), and up-regulated significantly during transformation from MI to MII stages (P<0...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35583074/aristotle-384-322-bc-the-beginnings-of-embryology
#29
JOURNAL ARTICLE
Nikolas Zagris
Aristotle made important contributions to many fields-biology, physics, metaphysics, logic, ethics, rhetoric, psychology, aesthetics, poetry- that are now cultivated by specialized experts, but he never lost sight of the aim of unifying knowledge, of understanding the world as an organized whole. Aristotle was the first to combine wet, field biology with daring cosmological thinking. He is the father of natural history and the first embryologist known to history. Aristotle's classic treatises History of Animals/Περί ζῴων ἱστορίαι , and On the Generation of Animals/ Περί ζῴων γενέσεως "enjoyed for more than fifteen hundred years an authority altogether without parallel"...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35583073/developmental-biology-in-greece
#30
JOURNAL ARTICLE
Nikolas Zagris
No abstract text is available yet for this article.
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/35238395/hyaluronan-receptor-cd44-developmentally-regulated-expression-and-role-in-the-early-chick-embryo
#31
JOURNAL ARTICLE
Konstantinos Konstantopoulos, Alexandros Dimiropoulos, Nikolas Zagris
CD44 is a membrane glycoprotein and is the main receptor for hyaluronan. We studied CD44 expression and spatio-temporal distribution by RT-PCR and immunofluorescence, and used an anti-CD44 blocking antibody to perturb CD44-depended signalling programs in the early chick embryo. The intense CD44 levels we detected in the morula embryo (XI) were of particular interest, suggestive of a maternally stored transcript. Intriguingly, the early presence of CD44 seemed to be essential for the rapid synthesis of hyaluronan...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/34881788/keratinocyte-differentiation-and-proteolytic-pathways-in-skin-patho-physiology
#32
JOURNAL ARTICLE
Eleni Zingkou, Georgios Pampalakis, Georgia Sotiropoulou
The epidermis is a stratified epithelium that forms the barrier between the organism and its environment. It is mainly composed of keratinocytes at various stages of differentiation. The stratum corneum is the outermost layer of the epidermis and is formed of multiple layers of anucleated keratinocytes called corneocytes. We aim to highlight the roles of epidermal differentiation and proteolysis in skin diseases. Skin biopsies isolated from Spink5-/- mice, the established model of Netherton syndrome (NS), and from patients with NS, seborrheic dermatitis (SD) and psoriasis, as well as healthy controls, were analyzed by histology and immunohistochemistry...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/34549793/on-the-role-of-pleiotrophin-and-its-receptors-in-development-and-angiogenesis
#33
REVIEW
Evangelia Papadimitriou, Eleni Mourkogianni, Despoina Ntenekou, Magdalini Christopoulou, Marina Koutsioumpa, Margarita Lamprou
The secreted growth factor pleiotrophin (PTN) is expressed in all species and is evolutionarily highly conserved, suggesting that it plays a significant role in the regulation of important processes. The observation that it is highly expressed at early stages during development and in embryonic progenitor cells highlights a potentially important contribution to development. There is ample evidence of the role of PTN in the development of the nervous system and hematopoiesis, some, albeit inconclusive, evidence of its role in the skeletomuscular system, and limited evidence of its role in the development of other organs...
2022: International Journal of Developmental Biology
https://read.qxmd.com/read/34881801/prenatal-alcohol-exposure-affects-developmental-differentiation-of-interictal-discharges-in-septal-and-temporal-hippocampus
#34
JOURNAL ARTICLE
Maria-Eleni Evangelaki, Caterina Psarropoulou
Prenatal alcohol exposure (PAE) provokes lifelong CNS dysfunction, including an increased susceptibility to seizure disorders. We investigated hippocampal excitability in vitro in the offspring of dams exposed to a mild ethanol concentration throughout pregnancy (ethanol 15%v/v in drinking water). Hippocampal slices were prepared from the offspring at a Young (Y, 21-30 Postnatal Days, PND) or Adult (A, 60 PND) age, with controls from same age Normal rats (N). Synchronous spontaneous interictal-type epileptiform discharges (IEDs) were induced by bathing the slices in Mg2+ -free ACSF or in 4-Aminopyridine (4-AP, 50µM) and were recorded from CA1 pyramidal layer of Temporal (T) and Septal slices (S)...
November 22, 2021: International Journal of Developmental Biology
https://read.qxmd.com/read/34881800/evidence-of-swim-secretion-and-association-with-extracellular-matrix-in-the-drosophila-embryo
#35
JOURNAL ARTICLE
Valeria Kaltezioti, Katerina M Vakaloglou, Aristidis S Charonis, Christos G Zervas
Secreted wingless-interacting protein (Swim) is the Drosophila ortholog gene of the mammalian Tubulointerstitial Nephritis Antigen Like 1 (TINAGL1), known also as lipocalin-7 (LCN7), or adrenocortical zonation factor 1 (AZ-1). Swim and TINAGL1 proteins share a significant homology, including the somatomedin B and the predictive inactive C1 cysteine peptidase domains. In mammals, both TINAGL1 and its closely related homolog TINAG have been identified in basement membranes, where they may function as modulators of integrin-mediated adhesion...
November 22, 2021: International Journal of Developmental Biology
https://read.qxmd.com/read/34881799/vascular-cell-matrix-adhesion-in-development-and-cancer
#36
JOURNAL ARTICLE
Christina Arapatzi, Georgia Rouni, Vassiliki Kostourou
The development and homeostasis of vertebrate organisms depend on the "tree of life", that is the intricate network of vascular tubes composed by endothelial cells attached to the basement membrane and surrounded by perivascular cells. Although many studies have revealed the fundamental role of cytokines, growth factors and Notch signalling in vascular morphogenesis, we still lack sufficient understanding of the molecular mechanisms controlling the various steps of the angiogenic processes. Emerging data highlight that cell adhesions are key players in vascular morphogenesis...
November 22, 2021: International Journal of Developmental Biology
https://read.qxmd.com/read/34881798/expression-of-hey-marks-a-subset-of-enteroendocrine-cells-in-the-drosophila-embryonic-and-larval-midgut
#37
JOURNAL ARTICLE
Emilia Skafida, Christos Delidakis, Maria Monastirioti
Hey is a conserved transcription factor of the bHLH-Orange family and it participates in the response to Notch signaling in certain tissues. Whereas three Hey paralogues exist in mammalian genomes, Drosophila possesses a single Hey gene. Fly Hey is expressed in the subset of newborn neurons that receive a Notch signal to differentiate them from their sibling cells after the asymmetric division of precursors called ganglion-mother-cells. We used a polyclonal anti-Hey serum and a GFP-tagged transgenic duplication of the Hey locus to examine its expression in tissues outside the nervous system in embryos and larvae...
November 22, 2021: International Journal of Developmental Biology
https://read.qxmd.com/read/34881797/lipid-rafts-integrity-is-essential-for-the-prolactin-induced-mitogenesis-in-mouse-embryonic-stem-cells
#38
JOURNAL ARTICLE
Sophia Karouzaki, Charoula Peta, Emmanouella Tsirimonaki, George Leondaritis, Kostas Vougas, George T Tsangaris, Dimitra Mangoura
Embryonic stem cells, ESCs, retain the capacity to self-renew, yet, the protein machinery essential in maintaining this undifferentiated status remains largely undefined. Signalling interactions are initiated and enhanced at the plasma membrane lipid rafts, within constrains and regulation applied by the actin and tubulin cytoskeleton systems. First, we undertook a comprehensive approach using twodimensional gel electrophoresis and mass spectrometry analysis combined with Western blotting and immunofluorescence analyses at the single cell level to compile the proteome profile of detergentfree preparations of lipid rafts of E14 mouse embryonic stem cells...
November 22, 2021: International Journal of Developmental Biology
https://read.qxmd.com/read/34881796/age-dependent-modulation-of-short-term-neuronal-dynamics-in-the-dorsal-and-ventral-rat-hippocampus
#39
JOURNAL ARTICLE
George Trompoukis, Giota Tsotsokou, Andriana Koutsoumpa, Maria Tsolaki, Georgia Vryoni, Costas Papatheodoropoulos
Brain aging is associated with alterations in the behavioral effectiveness to process information, due to mechanisms that are still largely unclear. Short-term neuronal activity dynamics are basic properties of local brain networks profoundly involved in neural information processing. In this study, we investigated the properties of short-term changes of excitatory synaptic transmission and neuronal excitation in the CA1 field of dorsal and ventral hippocampal slices from young adult and aged rats. We found that short-term synaptic plasticity (i...
November 22, 2021: International Journal of Developmental Biology
https://read.qxmd.com/read/34881795/rna-silencing-pathways-in-plant-development-and-defense
#40
JOURNAL ARTICLE
Nikoleta Kryovrysanaki, Anthony James, Martha Tselika, Eirini Bardani, Kriton Kalantidis
RNA silencing refers to a conserved eukaryotic process and is regarded as one of the most important processes in plants, with the ability to regulate gene expression both transcriptionally and post-transcriptionally. Different classes of non-coding RNAs (ncRNAs) constitute key components of the RNA silencing pathways and play pivotal roles in modulating various biological processes as well as host-pathogen interactions. One of the most extensively studied classes of ncRNAs are the 20-24 nucleotide (nt) long microRNAs (miRNAs), which are core components of the endogenous gene silencing pathway...
November 22, 2021: International Journal of Developmental Biology
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