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American Journal of Respiratory Cell and Molecular Biology

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https://read.qxmd.com/read/30995102/transcriptomic-responses-to-ivacaftor-and-prediction-of-ivacaftor-clinical-responsiveness
#1
Tao Sun, Zhe Sun, Yale Jiang, Annabel A Ferguson, Joseph M Pilewski, Jay K Kolls, Wei Chen, Kong Chen
Ivacaftor is a recently FDA-approved drug for the treatment of cystic fibrosis (CF) patients with at least one copy of the G511D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The transcriptomic effect of Ivacaftor in CF patients remains unclear. We aim to examine if and how the transcriptome of patients is influenced by Ivacaftor treatment and to determine if these data allow prediction of Ivacaftor responsiveness. Our data originate from the GOAL-G551D Observational Study...
April 17, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30995076/the-human-lung-cell-atlas-a-high-resolution-reference-map-of-the-human-lung-in-health-and-disease
#2
Herbert B Schiller, Daniel T Montoro, Lukas M Simon, Emma L Rawlins, Kerstin B Meyer, Maximilian Strunz, Felipe Vieira Braga, Wim Timens, Gerard H Koppelman, G R Scott Budinger, Janette K Burgess, Maarten van den Berge, Fabian J Theis, Aviv Regev, Naftali Kaminski, Jayaraj Rajagopal, Sarah A Teichmann, Alexander V Misharin, Martijn C Nawijn
Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease...
April 17, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30995072/preterm-lung-exhibits-distinct-spatiotemporal-proteome-expression-at-initiation-of-lung-injury
#3
Prue M Pereira-Fantini, Boyuan Pang, Sean G Byars, Regina B Oakley, Elizabeth J Perkins, Peter A Dargaville, Peter G Davis, Shuai Nie, Nicholas A Williamson, Vera Ignjatovic, David G Tingay
Objectives: To characterize time-dependent and regionally-specific injury patterns associated with early ventilation of the preterm lung using a mass-spectrometry based proteomic approach. Methods: Preterm lambs delivered at gestational age 124-127d were randomized to receive 15-min (n=7) or 90-min (n=10) of mechanical ventilation at standardized settings (positive end-expiratory pressure 8 cmH2 O, tidal volume 6-8 mL/kg) and were compared with unventilated control lambs (n=7). At study completion, lung tissue was taken from standardized gravity-dependent and non-dependent regions, and assessed for lung injury via histology, qPCR and by proteomic analysis via Orbitrap-mass spectrometry...
April 17, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30990760/cracking-the-beat-of-cilia-calcium-rocks
#4
Oliver H Wittekindt
No abstract text is available yet for this article.
April 16, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30986358/to-bet-or-not-to-bet-on-t-bet-as-a-therapeutic-target-in-emphysema
#5
Xiaoyun Wang, Joselyn Rojas-Quintero, Caroline A Owen
No abstract text is available yet for this article.
April 15, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30986092/cd44-and-xct-the-silver-bullet-for-endothelial-to-mesenchymal-transition-in-pulmonary-arterial-hypertension
#6
Vineet Agrawal, Anna R Hemnes
No abstract text is available yet for this article.
April 15, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30978296/beyond-fibroblast-heterogeneity-what-single-cell-rna-seq-tells-us
#7
Yong Zhou
No abstract text is available yet for this article.
April 12, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30978295/organophosphorus-pesticides-induce-cytokine-release-from-differentiated-human-thp1-cells
#8
Becky J Proskocil, Ana Cristina G Grodzki, David B Jacoby, Pamela J Lein, Allison D Fryer
Epidemiologic studies link organophosphorus pesticides (OPs) to increased incidence of asthma. In guinea pigs, OP-induced airway hyperreactivity requires macrophages and TNFα. Here, we determine whether OPs interact directly with macrophages to alter cytokine expression or release. Human THP1 cells differentiated into macrophages were exposed to parathion, chlorpyrifos, diazinon, or their oxon, phosphate or phosphorothioate metabolites for 24 h, in the absence or presence of reagents that block cholinergic receptors...
April 12, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30978114/smoking-impairs-the-immunomodulatory-capacity-of-lung-resident-mesenchymal-stem-cells-in-copd
#9
Tamara Cruz, Alejandra López-Giraldo, Guillaume Noell, Angela Guirao, Sandra Casas-Recasens, Tamara Garcia, Adela Saco, Jacobo Sellares, Alvar Agusti, Rosa Faner
Tobacco smoking is the main environmental risk factor of Chronic Obstructive Pulmonary Disease (COPD), but not all smokers develop the disease. A population of lung resident mesenchymal stem cells (LR-MSC) exist in healthy lungs, but how tobacco smoking affects them and their role in COPD have not been assessed yet. Using a sphere based culture technique, LR-MSC were isolated from lung tissue obtained from non-smokers, current and former smokers with and without COPD (n=53). Cells were characterized by flow cytometry and affymetrix arrays...
April 12, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30973786/cigarette-smoke-triggers-il-33-associated-inflammation-in-a-model-of-late-stage-copd
#10
Jasmine H Lee, Kendra L Hailey, Steven A Vitorino, Patricia A Jennings, Timothy D Bigby, Ellen C Breen
Chronic Obstructive Pulmonary Disease (COPD) is a worldwide threat. Cigarette smoke (CS) exposure causes cardiopulmonary disease, COPD and increases the risk for pulmonary tumors. In addition to poor lung function, those with COPD are susceptible to bouts of dangerous inflammation triggered by pollutants or infection. These severe inflammatory episodes can lead to additional exacerbations, hospitalization, further deterioration of lung function and reduced survival. Suitable models of the inflammatory conditions associated with CS, which potentiate the downward spiral in COPD patients, are lacking and the underlying mechanisms that trigger exacerbations are not well understood...
April 11, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30973760/ca-dreamin-carbonic-anhydrase-inhibitors-macrophages-and-pulmonary-hypertension
#11
Larissa A Shimoda
No abstract text is available yet for this article.
April 11, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30973753/glutamine-metabolism-is-required-for-collagen-protein-synthesis-in-lung-fibroblasts
#12
Robert B Hamanaka, Erin M O'Leary, Leah J Witt, Yufeng Tian, Gizem A Gökalp, Angelo Y Meliton, Nickolai O Dulin, Gökhan M Mutlu
Idiopathic pulmonary fibrosis is characterized by the TGF-β-dependent differentiation of lung fibroblasts into myofibroblasts, leading to excessive deposition of extracellular matrix proteins, which distort lung architecture and function. Metabolic reprogramming in myofibroblasts is emerging as an important mechanism in the pathogenesis IPF and recent evidence suggests that glutamine metabolism is required in myofibroblasts although the exact role of glutamine in myofibroblasts is unclear. Here we demonstrate that glutamine, and its conversion to glutamate by glutaminase is required for TGF-β-induced collagen protein production in lung fibroblasts...
April 11, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30965015/microbial-metabolites-in-cystic-fibrosis-a-target-for-future-therapy
#13
Stefanie Widder, Sylvia Knapp
No abstract text is available yet for this article.
April 9, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30965014/transcription-factor-t-bet-attenuates-the-development-of-elastase-induced-emphysema-in-mice
#14
Shigen Hayashi, Yosuke Matsuno, Yoshiya Tsunoda, Hirofumi Sakurai, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii, Keigyou Yoh, Satoru Takahashi, Nobuyuki Hizawa
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by peripheral airways inflammation and emphysema. Emerging evidence indicates a contribution of both innate and adaptive immune cells to the development of COPD. Transcription factor T-bet modulates the function of immune cells and therefore might be involved in the pathogenesis of COPD. To elucidate the role for T-bet in elastase-induced emphysema, pathological phenotypes were compared between wild-type and T-bet-/- mice...
April 9, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30965013/cellular-senescence-the-trojan-horse-in-chronic-lung-diseases
#15
Shruthi Hamsanathan, Jonathan K Alder, Jacobo Sellares, Mauricio Rojas, Aditi U Gurkar, Ana L Mora
Senescence is a cell-fate decision characterized by irreversible arrest of proliferation accompanied by senescence associated secretory phenotype (SASP). Traditionally, cellular senescence was recognized as a beneficial physiological mechanism during development, wound healing, and in tumor suppression. However, in recent years identification of negative consequences of cellular senescence has emerged, illuminating its role in several chronic pathologies. In this context, senescent cells persist or accumulate and have detrimental consequences...
April 9, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30958972/gamma-delta-t-cells-in-lung-cancer-malignant-pleural-effusion-friend-foe
#16
Edmund K Moon
No abstract text is available yet for this article.
April 8, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30958968/proline-glycine-proline-peptides-are-critical-in-the-development-of-smoke-induced-emphysema
#17
Mojtaba Abdul Roda, Xin Xu, Tarek H Abdalla, Mariam Sadik, Tomasz Szul, Preston E Bratcher, Liliana Viera, George M Solomon, J Michael Wells, Carmel M McNicholas, Frank A Redegeld, Gert Folkerts, J Edwin Blalock, Amit Gaggar
Chronic obstructive pulmonary disease (COPD) is a major cause of worldwide mortality and is characterized by an excessive airway neutrophilic response. The neutrophil chemoattractant proline-glycine-proline (PGP) and its more potent acetylated form (acPGP) have been found to be elevated in COPD patients and act via CXCR2. Here, we investigate the impact of neutralizing PGP peptides in a murine model for emphysema. The PGP neutralizing peptide L-arginine-threonine-arginine (RTR) was used first in a 6-week model of cigarette smoke exposure, where it attenuated lung inflammation...
April 8, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30958966/role-of-differential-estrogen-receptor-activation-on-airway-hyperreactivity-and-remodeling-in-a-murine-model-of-asthma
#18
Nilesh Sudhakar Ambhore, Rama Satyanarayana Raju Kalidhindi, Jagadish Loganathan, Sathish Venkatachalem
Evidence suggest that airway hyperresponsiveness (AHR) is a characteristic feature of asthma. Epidemiological studies confirm severity of asthma is greater in women, suggesting a critical role of female sex steroid hormones (especially estrogen). Also, very few in vivo studies report role of sex steroid hormones in asthma; however, sequence of events through differential activation of estrogen receptors (ERs) remain unanswered in asthmatic airways. Toward this goal, our recent in vitro findings indicate increased expression of ERβ in asthmatic airway smooth muscle (ASM) and that its activation by ERβ specific agonist downregulated airway remodeling...
April 8, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30958700/a-need-for-targeted-immunosuppression-following-lung-transplantation
#19
Ankit Bharat
No abstract text is available yet for this article.
April 8, 2019: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/30951642/carbonic-anhydrase-inhibition-ameliorates-inflammation-and-experimental-pulmonary-hypertension
#20
Hannes Hudalla, Zoe Michael, Nicolas Christodoulou, Gareth R Willis, Angeles Fernandez-Gonzalez, Evgenia J Filatava, Paul Dieffenbach, Laura E Fredenburgh, Robert S Stearman, Mark W Geraci, Stella Kourembanas, Helen Christou
RATIONALE: Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition (CAI) induces mild metabolic acidosis and exerts protective effects in hypoxic pulmonary hypertension (PH). Carbonic anhydrases and metabolic acidosis are further known to modulate immune cell activation. OBJECTIVE: To evaluate if CAI modulates macrophage activation, inflammation, and VSMC phenotypic switching in severe experimental PH...
April 5, 2019: American Journal of Respiratory Cell and Molecular Biology
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