journal
https://read.qxmd.com/read/38305333/tlr9-knockdown-alleviates-sepsis-via-disruption-of-myd88-nf-%C3%AE%C2%BAb-pathway-activation
#21
JOURNAL ARTICLE
Lili Li, Lili Jiang, Shuzhu Mao, Jiajian Ye
Sepsis is a life-threatening organ dysfunction due to dysregulated host response to infection, accompanied by a high rate of mortality worldwide. During sepsis progression, toll-like receptors (TLRs) play essential roles in the aberrant inflammatory response that contributes to sepsis-related mortality. Here, we demonstrated a critical role of TLR9 in the progression of sepsis. A septic mouse model was established by cecal ligation and puncture (CLP), then administered with lentivirus encoding si-TLR9/LY294002...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38305332/integrated-bioinformatics-analysis-to-identify-a-novel-four-gene-prognostic-model-of-breast-cancer-and-reveal-its-association-with-immune-infiltration
#22
JOURNAL ARTICLE
Yunhua Zhu, Junjie Luo, Yifei Yang
Liquid-liquid phase separation (LLPS) impact immune signaling in cancer and related genes have shown prognostic value in breast cancer (BRCA). However, the crosstalk between LLPS and immune infiltration in BRCA remain unclear. Therefore, we aimed to develop a novel prognostic model of BRCA related to LLPS and immune infiltration. BRCA-related, liquid-liquid phase separation (LLPS)-related genes, and differentially expressed genes (DEGs) were identified using public databases. Mutation and drug sensitivity analyses were performed using Gene Set Cancer Analysis database...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37947073/mechanism-study-of-polydatin-in-treating-spinal-cord-injury-by-modulating-mitochondrial-membrane-potential-based-on-network-pharmacology-and-molecular-docking
#23
JOURNAL ARTICLE
Bo Dong, Xijing He
Spinal cord injury (SCI) is one of the most devastating central lesions, and mitochondrial function plays an important role in secondary injury after SCI. Polydatin (PD) is a natural glycosylated precursor of resveratrol, showing mitochondrial preservation effects in the central nervous system. This study aimed to identify the hub target genes of PD on mitochondrial membrane potential (MMP) in SCI. A comprehensive analysis was performed on SCI-related genes, MMP-related genes, and PD targets screening from public databases...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37947072/novel-pi-3-k-p85%C3%AE-p110%C3%AE-itk-lat-plc-%C3%AE-2-and-fyn-adap-carma1-tak1-pathways-define-reverse-signaling-via-fasl
#24
JOURNAL ARTICLE
Pawan Kumar, Kamalakannan Rajasekaran, Subramaniam Malarkannan
The role of FasL in initiating death signals through Fas is well characterized. However, the reverse signaling pathway downstream of FasL in effector lymphocytes is poorly understood. Here, we identify that FasL functions as an independent activation receptor in NK cells. Activation via FasL results in the production of LFN-γ, GM-CSF, RANTES, MIP-1α, and MIP1-β. Proximal signaling of FasL requires Lck and Fyn. Upon activation, FasL facilitates the phosphorylation of PI(3)K-p85α/p55α subunits...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37947071/phage-pef771-for-the-treatment-of-periapical-periodontitis-induced-by-enterococcus-faecalis-yn771
#25
JOURNAL ARTICLE
Yingying Xiang, Rongyu Yang, Xuelin Li, Hao Huang, Kaiwen Duan, Fei Song
Enterococcus faecalis was the main causative bacteria of refractory periapical periodontitis (PP), there is a pressing need to explore effective methods for eradicating E. faecalis in patients with refractory PP. This study aimed to assess the anti-infective effectiveness of phage PEf771 in treating periapical inflammation in rats. We developed a rat model of PP through E. faecalis YN771 induction. Micro-computed tomography and hematoxylin-eosin staining were utilized to evaluate bone destruction and inflammation in experimental teeth for seven consecutive weeks...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37947070/plausible-influence-of-hla-class-i-and-class-ii-diversity-on-sars-cov-2-vulnerability
#26
REVIEW
Neha Sharma, Gaurav Sharma, Devinder Toor
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the global coronavirus disease 2019 (COVID-19) pandemic, which adversely affected almost all aspects of human life and resulted in the loss of millions of lives, while affecting nearly 0.67 billion people worldwide. SARS-CoV-2 still poses a challenge to the healthcare system as there are more than 200,000 active cases of COVID-19 around the globe. Epidemiological data suggests that the magnitude of morbidity and mortality due to COVID-19 was low in a few geographical regions and was unpredictably higher in a few regions...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37947069/hsa_circ_0037722-drives-keloid-formation-by-interacting-with-mir-140-3p-and-nr2f2
#27
JOURNAL ARTICLE
Xixi Wu, Hu Gao, Fan Li
Keloids can invade normal skin tissues to lead to itching, pain, hemorrhaging and suppuration, thereby affecting the mental health of patients. circRNAs can participate in keloids formation, but the role of hsa_circ_0037722 in keloids is still unknown. The goal of our study was to reveal the role of hsa_circ_0037722 in keloids. The levels of hsa_circ_0037722, miR-140-3p and NR2F2 in keloids was confirmed by qRT-PCR. Cell experiments were applied to assess the effect of hsa_circ_0037722/miR-140-3p/NR2F2 axis on keloids formation...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37947068/the-potential-mechanisms-of-qufeng-zhitong-capsule-against-rheumatoid-arthritis-based-on-network-pharmacology-and-in-vitro-experiments
#28
JOURNAL ARTICLE
Haili Lin, Xiaokang Du, Yilu Wang, Chengsong Cai, Jin Gao, Haiyan Xiang, Feng Pan
Qufeng Zhitong capsule (QFZTC) is a traditional Chinese herbal formula with potential therapeutic efficacy in rheumatoid arthritis (RA). This study seeks to clarify the potential effects and mechanisms of QFZTC against RA. Active compounds and targets of QFZTC were retrieved from the Herbal Ingredients' Targets (HIT), Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and Traditional Chinese Medicine Integrated Database (TCMID) databases. RA-related targets were searched on GeneCards and DisGeNET databases...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/37943151/interleukin-34-in-disease-progressions-a-comprehensive-review
#29
JOURNAL ARTICLE
Prerona Boruah, Nikhita Deka
IL-34, a cytokine, discovered a decade before and is known to be a colony stimulating factor CSF-1 receptor (CSF-1R) ligand. Along with CSF-1R, it also interacts with syndecan-1 receptors and protein-tyrosine phosphatase (PTP-ζ). Hence, IL-34 takes part in a number of biological activities owing to its involvement in different signaling pathways. This review was done to analyze the recent studies on the functions of IL-34 in progression of diseases. The role of IL-34 under the physiological and pathological settings is studied by reviewing current data...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37943150/the-role-of-t-cells-in-alzheimer-s-disease-pathogenesis
#30
JOURNAL ARTICLE
Jin Zhao, Xiaofang Wang, Yusheng He, Pingyi Xu, Laijun Lai, Younggie Chung, Xinghua Pan
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with memory decline and cognitive impairment, which is related to hallmark protein aggregates, amyloid-β (Аβ) plaques and neurofibrillary tangles; the latter are accumulated with hyperphosphorylated Tau protein. Immune cells play an important role in AD pathogenesis. Although the role of T cells in AD remains controversial, studies have shown that T cell deficiency is associated with increased AD pathology. In contrast, transplantation of T cells reduces AD pathology...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37943149/zc3h13-enhances-the-malignancy-of-cervical-cancer-by-regulating-m6a-modification-of-ckap2
#31
JOURNAL ARTICLE
Yuan Zhang, Xiaoqing Chen, Huiqun Chen, Ying Zhang
Sustained expression of zinc finger CCCH-type containing 13 (ZC3H13) in tumors is essential for cancer cell malignancy; however, our understanding of its clinical effects and mechanisms in cervical cancer (CC) is limited. In this study, we aimed to reveal the effect on CC progression of ZC3H13-mediated N6-methyladenosine (m6A) modification to stabilize cytoskeleton-associated protein 2 (CKAP2) expression. CC tissues and paired adjacent normal tissues were collected from 50 patients. qRT-PCR was used to clarify ZC3H13 and CKAP2 expression levels in the CC tissues...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37938194/identification-of-autophagy-related-targets-of-berberine-against-non-small-cell-lung-cancer-and-their-correlation-with-immune-cell-infiltration-by-combining-network-pharmacology-molecular-docking-and-experimental-verification
#32
JOURNAL ARTICLE
Liang Xu
OBJECTIVE: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and identify novel therapeutic targets. METHODS: Berberine-related targets were acquired from SuperPred, SwissTargetPrediction, and GeneCards. NSCLC-re-lated targets were collected from GeneCards and DisGeNET. Differentially expressed genes (DEGs) were identified GEO database, UCSC Xena, and limma...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37938193/supercharged-nk-cell-based-immuotherapy-in-humanized-bone-marrow-liver-and-thymus-hu-blt-mice-model-of-oral-pancreatic-glioblastoma-hepatic-melanoma-and-ovarian-cancers
#33
JOURNAL ARTICLE
Kawaljit Kaur, Anahid Jewett
In this paper, we review a number of in vitro and in vivo studies regarding the efficacy of supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have performed studies using six different types of cancer models of oral, pancreatic, glioblastoma, melanoma, hepatic and ovarian cancers using hu-BLT mice. Our in vitro studies demonstrated that primary NK cells preferentially target cancer stem-like cells (CSCs)/poorly differentiated tumors whereas sNK cells target both CSCs/poorly-differentiated and well-differentiated tumors significantly higher than primary activated NK cells...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37938192/personalized-precision-immunotherapy-for-amyotrophic-lateral-sclerosis-als
#34
JOURNAL ARTICLE
Dipnarine Maharaj, Kawaljit Kaur, Adrian Saltese, Jacqueline Gouvea
Neurological syndrome amyotrophic lateral sclerosis (ALS) affects motor neurons and is characterized by progressive motor neuron loss in the brain and spinal cord. ALS starts with mainly focal onset but when the disease progresses, it spreads to different parts of the body, with survival limits of 2-5 years after disease initiation. To date, only supportive care is provided for ALS patients, and no effective treatment or cure has been discovered. This review is focused on clinical and immunological aspects of ALS patients, based on our case studies, and we discuss the treatment we have provided to those patients based on a detailed evaluation of their peripheral blood immune cells and blood-derived serum secreted factors, cytokines, chemokines and growth factors...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37831521/th17-cells-orchestrators-of-mucosal-inflammation-and-potential-therapeutic-targets
#35
JOURNAL ARTICLE
Dorsa Iraji, Bergithe E Oftedal, Anette S B Wolff
T helper 17 (Th17) cells represent a specialized subgroup of effector CD4+ T cells known for their role in provoking neutrophil-driven tissue inflammation, particularly within mucosal tissues. Although they are pivotal for defending the host against extracellular bacteria and fungi, they have also been associated with development of various T cell-mediated inflammatory conditions, autoimmune diseases, and even cancer. Notably, Th17 cells exhibit a dual nature, with different Th17 cell subtypes showcasing distinct effector functions and varying capacities to incite autoimmune tissue inflammation...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37831520/network-pharmacology-to-reveal-the-molecular-mechanisms-of-rutaceous-plant-derived-limonin-ameliorating-non-alcoholic-steatohepatitis
#36
JOURNAL ARTICLE
Wei Wang, Li Yang, Minjie Hu, Yonglin Yang, Qiang Ma, Jiayu Chen
BACKGROUND: Limonin shows promise in alleviating non-alcoholic fatty liver disease. We investigated the mechanisms of limonin against non-alcoholic steatohepatitis (NASH) using network pharmacology and molecular docking. METHODS: Public databases provided NASH- and limonin-associated targets. VennDiagram identified potential limonin targets for NASH. Enrichment analysis explored the limonin-NASH relationship. PPI network analysis, CytoHubba models, and bioinformatics identified hub genes for NASH treatment...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37831519/physical-activity-increases-immunity-to-covid-19-infection
#37
JOURNAL ARTICLE
Kiran Dudhat
Coronavirus are truly one of the maximum critical fantastic-stranded non-segmented RNA viruses, named after the approximately 126-nm-diameter envelope around the nucleic acid-protein complicated. The virus causes significant harm to human fitness, including direct injury to the respiratory system, immune system compromise, worsening of the underlying clinical conditions, and eventually systemic failure and death. Exercise affects the immune system's antiviral mechanisms. Modest exercise, done before or after infection, improves morbidity and mortality to the contamination, according to animal investigations using influenza and simplex virus in the respiratory tract...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37830192/recent-advancement-and-novel-application-of-natural-polyphenols-for-the-treatment-of-allergy-asthma-from-phytochemistry-to-biological-implications
#38
REVIEW
Meera Kumari, Mohd Aftab Siddiqui, Amresh Gupta
Allergic diseases, primarily IgE-mediated, exert a substantial global health burden. A pivotal role in allergic reactions is played by mast cells, with histamine serving as a central mediator. Within this context, plant-based polyphenols, abundantly present in vegetables and fruits, show promising potential for allergy prevention. These natural compounds, particularly flavonoids, possess anti-inflammatory and anti-allergic properties, influencing dendritic cells, modulating macrophages, and fostering the proliferation of B cells and T cells...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37830191/kiaa1429-promotes-nasopharyngeal-carcinoma-progression-by-mediating-m6a-modification-of-ptgs2
#39
JOURNAL ARTICLE
Lingling Wu, Yuanhong Zhou, Jun Fu
Emerging evidence suggests that dysregulation of a N6-methyladenosine (m6A) methyltransferase KIAA1429 participates in the pathogenesis of multiple cancers except for nasopharyngeal carcinoma (NPC). This study is aimed to explore the function of KIAA1429 in NPC progression. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used to confirm the mRNA expression in NPC by bioinformatic analysis. The levels of KIAA1429 and PTGS2 was detected by quantitative reverse transcription polymerase chain reaction and Western blotting...
2023: Critical Reviews in Immunology
https://read.qxmd.com/read/37830190/losartan-induced-angioedema-with-acute-hypoxemic-respiratory-failure-anaphylaxis-a-case-report
#40
JOURNAL ARTICLE
Yusuf Kagzi, David Bradley Money, Asa Zoe Oxner, Alifiya Kagzi
Angioedema is a condition characterized by swelling of the skin or mucosa resulting from loss of vascular integrity that leads to swelling of mucosal tissues and can lead to life-threatening respiratory compromise. Drug-induced angioedema is not a frequent side effect seen with angiotensin receptor blockers (ARBs), particularly when there are no other contributing risk factors like a prior episode. Few studies reported subsequent angioedema episodes after ARB use in patients who had a prior episode with angiotensin converting enzyme inhibitors; however, there are very few cases that documented non-fatal angioedema after ARB as the only therapy...
2023: Critical Reviews in Immunology
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