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Behavioural Neurology

Yana Yunusova, Jamal Ansari, Joel Ramirez, Sanjana Shellikeri, Greg J Stanisz, Sandra E Black, Susan M Gillingham, Alex Kiss, Donald T Stuss, Lorne Zinman
The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS). 17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging. Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades...
2019: Behavioural Neurology
Weiyang Cheng, Sufang Xue, Fang Wu, Xiaowei Song, Qiang Huang, Haiqing Song, Jian Wu
Background and Purpose: Recently, several studies indicated the c.14576G>A variant on the ring finger protein 213 (RNF213), a founder variant of moyamoya diseases (MMD), was associated with non-MMD intracranial major artery stenosis/occlusion (non-MMD ICASO). We proposed that RNF213 variant-related ICASO including MMD might be a special entity with its own characteristics based on a genetic background. The aim of the study was to learn the clinical and vascular features of RNF213 variant-related ICASO...
2019: Behavioural Neurology
Harald Schrader, Thomas Bøhmer, Jan Aasly
Background: Systematic studies on factitious disorders and malingering in large populations are rare. To address this issue, we performed a nationwide epidemiological study in Norway on the incidence of these diagnoses in an unselected patient population. In particular, we tried to confirm the diagnoses and to estimate the contribution of Munchausen syndrome to the spectrum of factitious disorders. Methods: We analyzed data obtained from the Norwegian Patient Registry (NPR), which provided a deidentified list of all patients from 2008 to 2016 who had received the ICD-10 diagnosis of F68...
2019: Behavioural Neurology
Hajime Shishido, Masaki Ueno, Kana Sato, Masahisa Matsumura, Yasunori Toyota, Yutaka Kirino, Takashi Tamiya, Nobuyuki Kawai, Yasushi Kishimoto
There has been growing awareness of the correlation between an episode of traumatic brain injury (TBI) and the development of Alzheimer's disease (AD) later in life. It has been reported that TBI accelerated amyloid- β (A β ) pathology and cognitive decline in the several lines of AD model mice. However, the short-term and long-term effects of TBI by the weight-drop method on amyloid- β pathology and cognitive performance are unclear in wild-type (WT) mice. Hence, we examined AD-related histopathological changes and cognitive impairment after TBI in wild-type C57BL6J mice...
2019: Behavioural Neurology
Janet P Niemeier, Paul B Perrin, Bradley S Hurst, David M Foureau, Toan T Huynh, Susan L Evans, Jonathan E Silverman, M Elise McClannahan, Benjamin D Brusch, Mark Newman, Jean-Luc Mougeot, Amy K Wagner
Objective: To compare baseline and 72-hour hormone levels in women with traumatic brain injury (TBI) and controls. Setting: Hospital emergency department. Participants: 21 women ages 18-35 with TBI and 21 controls. Design: Repeated measures. Main Measures: Serum samples at baseline and 72 hours; immunoassays for estradiol (E2), progesterone (PRO), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cortisol (CORT); and health history...
2019: Behavioural Neurology
Veronica Guadagni, Marco Sarà, Massimiliano Conson, Antonio Carolei, Simona Sacco, Silvia Vadini, Caterina Pistarini, Arcangelo Barbonetti, Giuseppe Iaria, Francesca Pistoia
Background: Empathy has been conceptualized as comprising a cognitive and an emotional component, the latter being further divided into direct and indirect aspects, which refer, respectively, to the explicit evaluation of the observer's feelings while attending someone in an emotional situation and to the physiological response of the observer. Empathy has been previously investigated in several neurological disorders. Objective: This study is aimed at investigating empathy in patients with spinal cord injury (SCI)...
2019: Behavioural Neurology
Ebrahim M Yimer, Awol Surur, Dawit Zewdu Wondafrash, Abadi Kahsu Gebre
Background: Epilepsy is one of the common neurological illnesses which affects millions of individuals globally. Although the majority of epileptic patients have a good response for the currently available antiepileptic drugs (AEDs), about 30-40% of epileptic patients are developing resistance. In addition to low safety profiles of most of existing AEDs, there is no AED available for curative or disease-modifying actions for epilepsy so far. Objectives: This systematic review is intended to evaluate the effect of metformin in acute and chronic animal models of an epileptic seizure...
2019: Behavioural Neurology
Adam J Noble, Darlene Snape, Leone Ridsdale, Myfanwy Morgan, Sarah J Nevitt, Steve Goodacre, Anthony Marson
Purpose: To measure fidelity with which a group seizure first aid training intervention was delivered within a pilot randomized controlled trial underway in the UK for adults with epilepsy who visit emergency departments (ED) and informal carers. Estimates of its effects, including on ED use, will be produced by the trial. Whilst hardly ever reported for trials of epilepsy interventions-only one publication on this topic exists-this study provides the information on treatment fidelity necessary to allow the trial's estimates to be accurately interpreted...
2019: Behavioural Neurology
Márton Kovács, Attila Makkos, Dávid Pintér, Annamária Juhász, Gergely Darnai, Kázmér Karádi, József Janszky, Norbert Kovács
Background: Impulse control disorders in Parkinson's disease (PD) represent emerging problems with potentially devastating consequences. The standard screening methods for impulse control disorders are clinically imperfect. Although it is rarely reported, many patients utilize the Internet to fulfill their compulsive behaviors because of its easy accessibility. We designed a study to test the hypothesis that an active screening for excessive Internet use and Internet addiction might improve the sensitivity of identification of impulse control disorders...
2019: Behavioural Neurology
Erin L Foley, Marjorie L Nicholas, Carolyn M Baum, Lisa Tabor Connor
Objectives: For rehabilitation professionals to adequately address meaningful participation in social activities with their patients after a stroke, there must be a better understanding of neurobehavior, that is, how neurological impairment and its sequelae and environmental factors support or limit social participation. The current study examines how stroke severity (NIH Stroke Scale), its impact on perceived mobility (Stroke Impact Scale mobility domain), and the environment (MOS Social Support-Positive Social Interactions scale and Measure of Stroke Environment receptivity and built environment domains) influence social participation (Activity Card Sort: ACS)...
2019: Behavioural Neurology
Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R Hof, Goran Šimić
Two clinically distinct diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), have recently been classified as two extremes of the FTD/ALS spectrum. The neuropathological correlate of FTD is frontotemporal lobar degeneration (FTLD), characterized by tau-, TDP-43-, and FUS-immunoreactive neuronal inclusions. An earlier discovery that a hexanucleotide repeat expansion mutation in chromosome 9 open reading frame 72 ( C9orf72 ) gene causes ALS and FTD established a special subtype of ALS and FTLD with TDP-43 pathology (C9FTD/ALS)...
2019: Behavioural Neurology
Sara Bulgheroni, Matilde Taddei, Veronica Saletti, Silvia Esposito, Roberto Micheli, Daria Riva
Visual-spatial impairment has long been considered a hallmark feature of neurofibromatosis type 1 (NF1). No study investigating the cognitive and neuropsychological profile of NF1 used the Rey Complex Figure Test (RCFT) task as the primary measure of visual-perceptual abilities taking into consideration all functions involved including the strategic processing style. We compared 18 children with NF1, 17 siblings (S), and 18 typically developing children (TD) at intelligence scale and RCFT copy, recall, and recognition trials; we also evaluated the copy strategy as a measure of a visual-processing style...
2019: Behavioural Neurology
Antonella Bruni, Iolanda Martino, Maria Eugenia Caligiuri, Maria Grazia Vaccaro, Michele Trimboli, Cristina Segura Garcia, Pasquale De Fazio, Antonio Gambardella, Angelo Labate
Objectives: The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiatric comorbidity. Materials and Methods: Thirty-five patients with mTLE (22 males, mean age 40.7 ± 12.1) underwent awake and sleep EEG, 3T brain MRI, and an extensive standardized diagnostic neuropsychiatric battery: Temperament and Character Inventory-Revised (TCI-R), Beck Depression Inventory-2, and State-Trait Anxiety Inventory...
2019: Behavioural Neurology
Xiuyuan Zheng, Danfeng Chen, Tiebin Yan, Dongmei Jin, Zhiqiang Zhuang, Zhimei Tan, Wei Wu
Functional electrical stimulation can improve motor function after stroke. The mechanism may involve activity-dependent plasticity and brain remodeling. The aim of our study was to investigate the effectiveness of a patterned electrical stimulation FES mimic to gait in motor recovery among stroke survivors and to investigate possible mechanisms through brain fMRI. Forty-eight subjects were recruited and randomly assigned to a four-channel FES group ( n = 18), a placebo group ( n = 15), or a dual-channel FES group ( n = 15)...
2018: Behavioural Neurology
Xi Chen, Wen Liu
Objective: The Dental Activities Test (DAT) was developed to be used by dental, nursing, and other health professionals to assess the ability of persons with dementia to perform oral health-related activities and aid care planning. The instrument was designed as a unitary scale and has excellent internal consistency, test-retest reliability, interrater reliability, and construct validity. This study examines the underlying factor structure of the DAT among older adults in assisted living settings...
2018: Behavioural Neurology
Kai Zhang, Xiaofeng Chen, Fei Liu, Haili Tang, Jing Wang, Weina Wen
Neurological impairments such as stroke cause damage to the functional mobility of survivors and affect their ability to perform activities of daily living. Recently, robotic treatment for upper limb stroke rehabilitation has received significant attention because it can provide high-intensity and repetitive movement therapy. In this review, the current status of upper limb rehabilitation robots is explored. Firstly, an overview of mechanical design of robotics for upper-limb rehabilitation and clinical effects of part robots are provided...
2018: Behavioural Neurology
Sameh A Abd El Naby, Yahya M Naguib
Attention deficit hyperactivity disorder (ADHD) is among the most prevalent neurobehavioral disorders affecting children worldwide. The prevalence of ADHD is higher in children with epilepsy. Despite the plethora of conducted work, the precise cause of ADHD is not identified yet. We studied here the sociodemographic, clinical, electrophysiological, and biochemical profiles of children with ADHD, epilepsy, and ADHD with epilepsy. Subjects were divided into 4 groups (25 child/group): I-control, II-ADHD, III-epilepsy, and IV-ADHD with epilepsy...
2018: Behavioural Neurology
Abadi Kahsu Gebre, Amdemicheal Haylay
Background: Epilepsy is a chronic neurological disorder characterized by unprovoked recurrent seizure episodes. The disease has detrimental effects on social, cognitive, psychological, and physical components of life consequently quality of life of the patients. The level of the effect of the disease on quality life is influenced by different factors including the use of antiepileptic medications. Objectives: The study was aimed at assessing quality of life in patients with epilepsy and the variables affecting it in Mekelle city, northern Ethiopia...
2018: Behavioural Neurology
Peih-Ling Tsaih, Ming-Jang Chiu, Jer-Junn Luh, Yea-Ru Yang, Jiu-Jenq Lin, Ming-Hsia Hu
Objectives: To investigate the effects of practice variability combined with task-oriented electromyographic biofeedback (EMGBFB) on strength and balance in people with chronic stroke. Methods: Thirty-three participants were randomly assigned into the constant force EMGBFB tibialis anterior (TA) exercise (constant) group, the variable force EMGBFB tibialis anterior exercise (variable) group, or the upper extremity exercise without EMGBFB (control) group. Subjects in each group received 6 weekly sessions of exercise training (18 sessions, 40 minutes each)...
2018: Behavioural Neurology
Cerine C Hansen, Hanna Ljung, Eylert Brodtkorb, Arne Reimers
Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk factors, and the underlying mechanisms of AB induced by AEDs may help to facilitate management and reduce the risk of such side effects. The exact incidence of AB as an adverse effect of AEDs is difficult to estimate, but frequencies up to 16% have been reported. Primarily, levetiracetam (LEV), perampanel (PER), and topiramate (TPM), which have diverse mechanisms of action, have been associated with AB...
2018: Behavioural Neurology
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