Kaiyan Liu, Jin Zhao, Han Yu, Jing Yang, Yi Ren
The objective of this study is to conduct a bibliometric analysis of research trends in hyperprolactinemia from 2011 to 2023. This analysis aims to provide researchers with insights into the current hotspots and frontiers related to hyperprolactinemia. It is worth noting that there are currently no existing reports on bibliometric analyses of hyperprolactinemia. The Social Science Citation Index (SSCI) and Science Citation Index Expanded (SCIE) databases of the Web of Science Core Collection were systematically searched for "articles" and "review articles" related to the topic of hyperprolactinemia from 2011 to 2023...
June 18, 2024: Journal of Neuroendocrinology
Adrian David Marais, Anne Hoffman, Diane Mary Blackhurst, Zephne Margeret van der Spuy
The polycystic ovary syndrome (PCOS) imparts health risks including dyslipidaemia, diabetes and cardiovascular disease that are amenable to lifestyle adjustment and/or medication. We describe dyslipidaemia in women referred to a gynaecological endocrine clinic. Clinical data and endocrine and lipoprotein investigations comprising fasting triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and calculated low density lipoprotein cholesterol (LDLC) were studied along with electrophoresis patterns of apolipoprotein B-containing lipoproteins...
June 10, 2024: Journal of Neuroendocrinology
Tarryn Radomsky, Ross C Anderson, Robert P Millar, Claire L Newton
G protein-coupled receptors (GPCRs) are central to the functioning of the hypothalamic-pituitary-gonadal axis (HPG axis) and include the rhodopsin-like GPCR family members, neurokinin 3 receptor, kappa-opioid receptor, kisspeptin 1 receptor, gonadotropin-releasing hormone receptor, and the gonadotropin receptors, luteinizing hormone/choriogonadotropin receptor and follicle-stimulating hormone receptor. Unsurprisingly, inactivating variants of these receptors have been implicated in a spectrum of reproductive phenotypes, including failure to undergo puberty, and infertility...
June 9, 2024: Journal of Neuroendocrinology
Hannes Leupe, Elin Pauwels, Timon Vandamme, Bliede Van den Broeck, Willem Lybaert, Jeroen Dekervel, Filip Van Herpe, Joris Jaekers, Frederik Cleeren, Johannes Hofland, Adrienne Brouwers, Michel Koole, Guy Bormans, Eric Van Cutsem, Karen Geboes, Annouschka Laenen, Chris Verslype, Sigrid Stroobants, Christophe M Deroose
[18 F]AlF-NOTA-octreotide ([18 F]AlF-OC) is a promising alternative for [68 Ga]Ga-DOTA-somatostatin analogs (SSAs) in positron emission tomography (PET) imaging of the somatostatin receptor (SSTR). Our aim is to assess changes in TNM staging and differences in patient management between [18 F]AlF-OC PET/CT and [68 Ga]Ga-DOTA-SSA PET/CT in the work-up of neuroendocrine tumor (NET) patients. Patients who underwent both [18 F]AlF-OC and [68 Ga]Ga-DOTA-TATE or [68 Ga]Ga-DOTA-NOC PET/CT in our multicenter study (Pauwels et al...
June 4, 2024: Journal of Neuroendocrinology
Elizabeth Vieyra, Roberto Calderón, Rosa Linares, Gabriela Rosas, Deyra A Ramírez, Julieta A Espinoza, Andrea Chaparro, Carlos-Camilo Silva, Roberto Domínguez, Leticia Morales-Ledesma
Reproduction in all mammalian species depends on the growth and maturation of ovarian follicles, that is, folliculogenesis. Follicular development can culminate with the rupture of mature follicles and the consequent expulsion of their oocytes (ovulation) or in atresia, characterized by the arrest of development and eventual degeneration. These processes are regulated by different neuroendocrine signals arising at different hypothalamic nuclei, including the suprachiasmatic nucleus (SCN). In the later, the activation of muscarinic receptors (mAChRs) and nicotinic receptors (nAChRs) by acetylcholine is essential for the regulation of the pre-ovulatory signals that stimulate the rupture of mature follicles...
June 3, 2024: Journal of Neuroendocrinology
Julietta A Sheng, Stuart A Tobet
Infections during pregnancy are associated with increased risk for adult neuropsychiatric disease, such as major depressive disorder, schizophrenia, and autism spectrum disorder. In mouse models of maternal immune activation (MIA), different toll-like receptors (TLRs) are stimulated to initiate inflammatory responses in mother and fetus. The goal of this study was to determine sex-dependent aspects of MIA using a TLR7/8 agonist, Resiquimod (RQ), on neurodevelopment. RQ was administered to timed-pregnant mice on embryonic day (E) 12...
June 1, 2024: Journal of Neuroendocrinology
Sebastien G Bouret, Hubert Vaudry, Vincent Prevot
No abstract text is available yet for this article.
May 31, 2024: Journal of Neuroendocrinology
Paul R Le Tissier, David R Grattan
No abstract text is available yet for this article.
May 29, 2024: Journal of Neuroendocrinology
Ximena Castillo, Georgina Ortiz, Edith Arnold, Zhijian Wu, Luis B Tovar Y Romo, Carmen Clapp, Gonzalo Martínez de la Escalera
Ischemic stroke is a significant global health issue, ranking fifth among all causes of death and a leading cause of serious long-term disability. Ischemic stroke leads to severe outcomes, including permanent brain damage and neuronal dysfunction. Therefore, decreasing and preventing neuronal injuries caused by stroke has been the focus of therapeutic research. In recent years, many studies have shown that fluctuations in hormonal levels influence the prognosis of ischemic stroke. Thus, it is relevant to understand the role of hormones in the pathophysiological mechanisms of ischemic stroke for preventing and treating this health issue...
May 29, 2024: Journal of Neuroendocrinology
Ashley Russo, Timothy DiPeri, Teodora Dumitra, Joshua Tseng, Eric Pletcher, Monica Justo, Courtney Chen, Nicholas Nissen, Farin Amersi, Jun Gong, Andrew Hendifar, Alexandra Gangi
Patients with gastroenteropancreatic (GEP) neuroendocrine tumors (NET) often present with advanced disease. Primary tumor resection (PTR) in the setting of unresectable metastatic disease is controversial. Most studies evaluating the impact of PTR on overall survival (OS) have been performed using large population-based databases, with limited treatment related data. This study aims to determine whether PTR improves OS and progression-free survival (PFS) in patients with metastatic well-differentiated GEP-NET...
May 17, 2024: Journal of Neuroendocrinology
Mohammad S Biswas, Erica M Gelman, Daniel J Alexopoulos, Kim L Keen, Ryan J Adam, Ei Terasawa
Neuroestrogens locally synthesized in the brain are known to play a role in sexual behaviors. However, the question of whether neuroestrogens are involved in the regulation of the gonadotropin-releasing hormone (GnRH) release is just emerging. Because previous studies in this lab indicate that neuroestradiol is also important for the pulsatile release as well as the surge release of GnRH in female rhesus monkeys, in the present study, we examined whether neuroestradiol plays a role in the estrogen-induced LH surge in orchidectomized (ORX) male rhesus monkeys...
May 17, 2024: Journal of Neuroendocrinology
Anna Koumarianou, Pier Luigi Filosso, Lisa Bodei, Justo P Castano, Lynnette Fernandez-Cuesta, Christophe M Deroose, Matthieu Foll, Clarisse Dromain, Nicholas Simon Reed, Martyn Caplin, Jaume Capdevila, Jenny Falkerby, Antongiulio Faggiano, Andrea Frilling, Enrique Grande, Rodney J Hicks, Atsuko Kasajima, Beata Kos-Kudla, B A Krishna, Eric Lim, Anja Rinke, Simron Singh, Chrissie Thirlwell, Marco Volante, Thomas Walter
Lung carcinoid tumours are neuroendocrine neoplasms originating from the bronchopulmonary tract's neuroendocrine cells, accounting for only 1%-3% of all lung cancers but 30% of all neuroendocrine tumours. The incidence of lung carcinoids, both typical and atypical, has been increasing over the years due to improved diagnostic methods and increased awareness among clinicians and pathologists. The most recent WHO classification includes a subgroup of lung carcinoids with atypical morphology and higher mitotic count and/or Ki67 labelling index...
May 16, 2024: Journal of Neuroendocrinology
Emma K McIlwraith, Neruja Loganathan, Kimberly W Y Mak, Wenyuan He, Denise D Belsham
Phoenixin (PNX) is a conserved secreted peptide that was identified 10 years ago with numerous studies published on its pleiotropic functions. PNX is associated with estrous cycle length, protection from a high-fat diet, and reduction of anxiety behavior. However, no study had yet evaluated the impact of deleting PNX in the whole animal. We sought to evaluate a mouse model lacking the PNX parent gene, small integral membrane protein 20 (Smim20), and the resulting effect on reproduction, energy homeostasis, and anxiety...
May 10, 2024: Journal of Neuroendocrinology
Håkan Ohlsson, Elisabeth Spaak, Anni Gålne, Anna Sundlöv, Martin Almquist
Somatostatin receptor positron emission tomography with computerised tomography imaging (SRI) has a high sensitivity for the detection of small intestinal neuroendocrine tumors (siNET), which makes it ideal for follow-up. The aim of the present study was to investigate whether follow-up with SRI in patients with siNET led to any change in the treatment of the patient and if patient and/or tumour factors were associated with such change. Adults with siNET who had undergone at least two SRI scans between 2013 and 2021 were identified...
April 28, 2024: Journal of Neuroendocrinology
Arthur Lefevre, Jazlynn Meza, Cory T Miller
The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work in rodents has produced much of our knowledge of OT, we lack basic information about its neurobiology in primates making it difficult to interpret the limited effects that OT manipulations have had in human patients. In fact, previous studies have revealed only limited OT fibers in primate brains...
April 24, 2024: Journal of Neuroendocrinology
Shin Urai, Seiji Tomofuji, Hironori Bando, Maki Kanzawa, Masaaki Yamamoto, Hidenori Fukuoka, Masahiro Tsuda, Genzo Iguchi, Wataru Ogawa
Anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis, a paraneoplastic syndrome resulting from an autoimmune response against PIT-1, typically manifests with undetectable levels of growth hormone (GH) and prolactin (PRL), and significantly low levels of serum thyroid-stimulating hormone (TSH) at diagnosis. These hormonal levels are highly specific to this disease and serve as key diagnostic indicators. Herein, we present a detailed clinical course of a 69-year-old male with a history of gastric cancer and lymph node metastases who developed anti-PIT-1 hypophysitis after the initiation of immune checkpoint inhibitor (ICI) therapy, specifically nivolumab, oxaliplatin, and capecitabine...
April 17, 2024: Journal of Neuroendocrinology
Martin J Kelly, Edward J Wagner
Recent molecular biological and electrophysiological studies have identified multiple transient receptor potential (TRP) channels in hypothalamic neurons as critical modulators of homeostatic functions. In particular, the canonical transient receptor potential channels (TRPCs) are expressed in hypothalamic neurons that are vital for the control of fertility and energy homeostasis. Classical neurotransmitters such as serotonin and glutamate and peptide neurotransmitters such as kisspeptin, neurokinin B and pituitary adenylyl cyclase-activating polypeptide signal through their cognate G protein-coupled receptors to activate TPRC 4, 5 channels, which are essentially ligand-gated calcium channels...
April 17, 2024: Journal of Neuroendocrinology
Pouya Saraei, Abbas Heshmati, Sare Hosseini
Small-cell neuroendocrine carcinomas (SCNECs) of the female genital tract are rare and aggressive tumors that are characterized by a high rate of recurrence and poor prognosis. They can arise from various sites within the female genital tract, including the cervix, endometrium, ovary, fallopian tube, vagina, and vulva. They are composed of cells with neuroendocrine features, such as the ability to produce and secrete hormones and peptides, and a high mitotic rate. Immunohistochemical staining for neuroendocrine markers, such as chromogranin A, synaptophysin, and CD56, can aid in the diagnosis of these tumors...
April 16, 2024: Journal of Neuroendocrinology
Nikolaos A Trikalinos, Hyun Kim, Anitha Vijayan, Maxwell Amurao, Vikas Prasad
Peptide receptor radionuclide therapy (PRRT) can be a very useful treatment for patients with neuroendocrine neoplasms and metastatic castration-resistant prostate cancer but it is routinely avoided in those with advanced kidney disease because it can adversely affect the renal function. Accordingly, no clear guidelines exist on the use of PRRT for patients on hemodialysis (HD). We performed a literature review to identify publications on HD patients who received PRRT with Lutetium-177 (Lu177 ) Dotatate and Y-90 and obtained information on Lu177 pharmacokinetics and early testing data from the manufacturer...
April 15, 2024: Journal of Neuroendocrinology
Suzanne M Moenter, J Rudolph Starrett
It has now been about a century since a flurry of discoveries identified first the pituitary, then more specifically the anterior pituitary and soon thereafter the central nervous system as components regulating gonadal and downstream reproductive functions. This was an era of ablation/replacement designs using at first rudimentary and then increasingly pure preparations of gonadal and pituitary "activities" or transplanting actual glands, whole or homogenized, among subjects. There was, of course, controversy as is typical of lively and productive scientific debates to this day...
April 12, 2024: Journal of Neuroendocrinology
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