Shuangshuang Zhao, Chenglin Miao, Xuedi Gao, Zhifang Li, John E Eriksson, Yaming Jiu
Vimentin, a type III intermediate filament, reorganizes into what is termed the 'vimentin cage' in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in most observed cases...
January 2, 2024: Current Opinion in Cell Biology