Akitoshi Nakashima, Atsushi Furuta, Mihoko Yoshida-Kawaguchi, Kiyotaka Yamada, Haruka Nunomura, Keiko Morita, Ippei Yasuda, Satoshi Yoneda, Akemi Yamaki-Ushijima, Tomoko Shima, Sayaka Tsuda
Autophagy is a bulk degradation system that maintains cellular homeostasis by producing energy and/or recycling excess proteins. During early placentation, extravillous trophoblasts invade the decidua and uterine myometrium, facing maternal immune cells, which participate in the immune suppression of paternal and fetal antigens. Regulatory T cells will likely increase in response to a specific antigen before and during early pregnancy. Insufficient expansion of antigen-specific Treg cells, which possess the same T cell receptor, is associated with the pathophysiology of preeclampsia, suggesting sterile systemic inflammation...
March 2024: American Journal of Reproductive Immunology: AJRI