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American Journal of Reproductive Immunology: AJRI

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https://read.qxmd.com/read/30817041/meconium-stained-amniotic-fluid-exposure-is-associated-with-a-lower-incidence-of-offspring-long-term-infectious-morbidity
#1
Dorit Paz Levy, Asnat Walfisch, Tamar Wainstock, Ruslan Sergienko, Dvora Kluwgant, Daniella Landau, Eyal Sheiner
OBJECTIVE: Meconium stained amniotic fluid (MSAF) is a well-established risk factor for immediate adverse neonatal outcomes, and was recently suggested to be associated with microbial invasion of the amniotic cavity. We aimed to determine whether MSAF exposure during labor carries a longer lasting impact on pediatric infectious morbidity. STUDY DESIGN: A population-based cohort analysis was performed including all singleton deliveries occurring between 1991-2014 at a single tertiary medical center...
February 28, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30811743/bi-directional-regulation-between-1st-trimester-htr8-svneo-trophoblast-cells-and-in-vitro-differentiated-th17-treg-cells-suggest-a-fetal-maternal-regulatory-loop-in-human-pregnancy
#2
Songcun Wang, Jinfeng Qian, Fengrun Sun, Mengdie Li, Jiangfeng Ye, Mingqing Li, Meirong Du, Dajin Li
PROBLEM: During normal pregnancy, delicate crosstalk is established between fetus-derived trophoblasts and maternal immune cells to ensure maternal-fetal tolerance and successful placentation. Dysfunction in these interactions,has been highly linked to certain pregnancy complications. METHOD OF STUDY: Naïve CD4+ T cells were cultivated with or without 1st trimester derived trophoblast cell line HTR8/SVneo cells in the absence or presence of T helper 17 (Th17) or regulatory (Treg)cell-inducing differentiation conditions...
February 27, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30811719/lipoxin-a4-interferes-with-embryo-implantation-via-suppression-of-epithelial-mesenchymal-transition
#3
Zhangye Xu, Shenzhi Zhao, Tong Zhou, Tingting Liao, Xianping Huang, Huiqiu Xiang, Qiong Zhang, Yanjun Huang, Feng Lin, Duyun Ye, Yinping Huang
PROBLEM: To assess whether lipoxin A4 (LXA4) interferes with embryo implantation via epithelial-mesenchymal transition (EMT) suppression. METHOD OF STUDY: We developed a mouse model of LXA4 blocked embryo implantation, and detected EMT indicators to confirm that LXA4 associated EMT suppression might be a mechanism of interfering with embryo implantation. ILK, FPR2, VEGF, MMPs, Akt, GSK3β, NF-ĸB, Twist, vimentin, fibronectin and β-catenin mRNA levels were determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time RT-PCR; while protein localization and amounts were assessed by immunohistochemistry and Western blot, respectively; MMP activity was assessed by the gelatin zymography, The status of implantation in pregnant animals was assessed by the Pontamine blue reaction test...
February 27, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30811718/glutathione-s-transferase-m1-polymorphism-and-proinflammatory-cytokines-tumor-necrosis-factor-%C3%AE-and-interleukin-1%C3%AE-are-associated-with-preeclampsia-in-serbian-women
#4
Tamara Sljivancanin Jakovljevic, Olivera Kontic-Vucinic, Nadja Nikolic, Jelena Carkic, Ivan Soldatovic, Jelena Milasin
PROBLEM: Preeclampsia has a multifactorial origin with genetic, immunological and environmental factors described as main contributors to its onset. This study aimed to investigate glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) gene polymorphisms, the expression of proinflammatory cytokines (TNF-α, IL-1β, IL-6), and the potential relationship between GSTs polymorphisms and cytokine expression levels in preeclampsia and uncomplicated pregnancy. METHOD OF STUDY: This prospective case-control study included 50 women with preeclampsia and 50 healthy pregnant women...
February 27, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30803068/the-involvement-of-the-progesterone-receptor-in-pibf-and-gal-1-expression-in-the-mouse-endometrium
#5
Biserka Mulac-Jeričević, Sandra Šućurović, Tamara Gulic, Julia Szekeres-Bartho
PROBLEM: The progesterone regulated genes; PIBF and Gal-1 are key players in the feto-maternal immunological interaction. This study aims to investigate the expression of PIBF and Gal-1 in WT and progesterone receptor KO models as well as subsequent effects of PIBF on decidualization of stromal cells. METHOD OF THE STUDY: PRAKO, PRBKO and PRKO BALB/c mice were used for assessing the role of PR isoforms in PIBF induction. PIBF- and Gal-1 mRNA expression in the uterus was tested by real-time PCR...
February 25, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30784128/anti-chlamydia-igg-and-iga-are-insufficient-to-prevent-endometrial-chlamydia-infection-in-women-and-increased-anti-chlamydia-igg-is-associated-with-enhanced-risk-for-incident-infection
#6
Toni Darville, Hannah L Albritton, Wujuan Zhong, Li Dong, Catherine M O'Connell, Taylor B Poston, Alison J Quayle, Nilu Goonetilleke, Harold C Wiesenfeld, Sharon L Hillier, Xiaojing Zheng
PROBLEM: Chlamydia infections in women can ascend to the upper genital tract, and repeated infections are common, placing women at risk for sequelae. The protective role of anti-chlamydia antibodies to surface exposed antigens in ascending and incident infection is unclear. METHOD OF STUDY: A whole-bacterial ELISA was used to quantify chlamydia-specific IgG and IgA in serum and cervical secretions of 151 high-risk women followed longitudinally. Correlations were determined between antibody and cervical burden and causal mediation analysis investigated the effect of antibody on ascension...
February 19, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30768818/are-b-cells-altered-in-the-decidua-of-women-with-preterm-or-term-labor
#7
Yaozhu Leng, Roberto Romero, Yi Xu, Jose Galaz, Rebecca Slutsky, Marcia Arenas-Hernandez, Valeria Garcia-Flores, Kenichiro Motomura, Sonia S Hassan, Andrea Reboldi, Nardhy Gomez-Lopez
PROBLEM: The immunophenotype of B cells at the maternal-fetal interface (decidua) in labor at term and preterm labor is poorly understood. METHOD OF STUDY: Decidual tissues were obtained from women with preterm or term labor and from non-labor gestational age-matched controls. Immunophenotyping of decidual B cells was performed using multi-color flow cytometry. RESULTS: 1) In the absence of acute or chronic chorioamnionitis, total B cells were more abundant in the decidua parietalis of women who delivered preterm than those who delivered at term, regardless of the presence of labor; 2) decidual transitional and naïve B cells were the most abundant B-cell subsets; 3) decidual B1 B cells were increased in women with labor at term or preterm labor and chronic chorioamnionitis compared to those without this placental lesion; 4) decidual transitional B cells were reduced in women with preterm labor compared to those without labor; 5) naïve, class-switched, and non-class-switched B cells in the decidual tissues underwent mild alterations with the process of preterm labor and/or placental inflammation; 6) decidual plasmablasts seemed to increase in women with labor at term or preterm labor with chronic chorioamnionitis; and 7) decidual B cells expressed high levels of interleukin (IL)-12, IL-6 and/or IL-35...
February 15, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30758898/toll-like-receptor-9-maternal-cell-free-dna-and-myometrial-cell-response-to-cpg-oligodeoxynucleotide-stimulation
#8
Stacy Beck, Irina A Buhimschi, Taryn L Summerfield, William E Ackerman, Ozlem Guzeloglu-Kayisli, Umit A Kayisli, Guomao Zhao, Frederick Schatz, Charles J Lockwood, Catalin S Buhimschi
PROBLEM: Among mechanisms triggering onset of parturition, it has been recently postulated that Toll-Like Receptor (TLR)9 engagement by cell-free DNA (cfDNA) triggers inflammation, myometrial contractions and labor in absence of infection. The current study evaluated whether direct (myometrial) or indirect (decidual) TLR9 engagement enhances human myometrial contractility. METHOD OF STUDY: TLR9 expression and cellular localization were surveyed by immunohistochemistry of placenta, fetal membranes, and myometrium in term (gestational age [GA]:>37 weeks) labor (TL, n=7) or term non-labor (TNL, n=7) tissues...
February 13, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30756436/cd49a-regulates-the-function-of-human-decidual-natural-killer-cells
#9
Huirong Li, Yuanyuan Hou, Shitong Zhang, Yuanqin Zhou, Dezheng Wang, Siyue Tao, Fang Ni
PROBLEM: The function of CD49a on human decidual natural killer (dNK) cells is unknown. METHOD OF STUDY: The expression of CD49a on dNK cells from human patients with recurrent spontaneous abortions or age-matched healthy controls was analyzed by flow cytomertry. DNK cells were treated with CD49a neutralizing antibody and analyzed for function (cytokines production and cytotoxic activity). Long noncoding RNA (lncRNA) microarray analysis was used to identify a potential regulator of CD49a...
February 13, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30737988/myeloid-derived-suppressor-cells-depletion-may-cause-pregnancy-loss-via-upregulating-the-cytotoxicity-of-decidual-natural-killer-cells
#10
Jiabin Ren, Weihong Zeng, Fuju Tian, Siming Zhang, Fan Wu, Xiaoli Qin, Yan Zhang, Yi Lin
PROBLEM: Maternal immune system tolerance to the semiallogeneic fetus is critical for a successful pregnancy. Studies have shown that myeloid-derived suppressor cells (MDSCs) play an important role in maintaining feto-maternal tolerance. However, the mechanisms remain poorly understood. METHODS: Flow cytometry was used to evaluate the percentage of MDSCs in an allogeneic-normal-pregnant mouse model during different periods of gestation. We further assessed the percentage of MDSCs and their subtypes (granulocytic MDSCs [GR-MDSCs] and monocytic MDSCs [MO-MDSCs]) in a spontaneous abortion mouse model...
February 9, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30734977/the-immunophenotype-of-decidual-macrophages-in-acute-atherosis
#11
Navleen Gill, Yaozhu Leng, Roberto Romero, Yi Xu, Bogdan Panaitescu, Derek Miller, Afrah Arif, Salma Mumuni, Faisal Qureshi, Chaur-Dong Hsu, Sonia S Hassan, Anne Cathrine Staff, Nardhy Gomez-Lopez
PROBLEM: Acute atherosis is a uteroplacental arterial lesion that is associated with pregnancy complications such as preeclampsia and preterm birth, the leading cause of perinatal morbidity and mortality worldwide. However, the immunobiology of acute atherosis is poorly understood. METHOD OF STUDY: Placental basal plate samples were collected from women who delivered with (n = 11) and without (n = 31) decidua basalis lesions of acute atherosis. Multi-color flow cytometry was used to quantify M1- and M2-like macrophage subsets and the expression of iNOS and IL-12 by decidual macrophages...
February 8, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30689264/the-role-of-monocytic-myeloid-derived-suppressor-cells-in-the-pathogenesis-of-endometriosis
#12
LETTER
Fabio Barra, Simone Ferrero
Letter to the editor in response to the article "CD33+ CD14+ CD11b+ HLA-DR- monocytic myeloid-derived suppressor cells recruited and activated by CCR9/CCL25 are crucial for the pathogenic progression of endometriosis" by Sun et al. This article is protected by copyright. All rights reserved.
January 28, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30689243/tacrolimus-treatment-for-infertility-related-to-maternal-fetal-immune-interactions
#13
Koushi Yamaguchi
Many approaches have been used to achieve successful pregnancies in patients with infertility, though existing treatments remain unsatisfactory in patients with infertility caused by abnormal maternal-fetal immunity. However, our understanding of the immunological aspects of infertility has steadily progressed, aided by recent research into organ transplantation and cancer. The results of these recent analyses have led to the development and evaluation of several candidate immunological treatments, but the use of immunological treatments remains a novel approach...
January 28, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30682223/evidence-for-an-association-between-endometriosis-fibromyalgia-and-autoimmune-diseases
#14
Hila Greenbaum, Clara Weil, Gabriel Chodick, Varda Shalev, Vered H Eisenberg
PROBLEM: The aim of this study was to investigate the prevalence of and the association between endometriosis, fibromyalgia and autoimmune disease (AID) in a large population database and to describe healthcare resource utilization (HCRU) in affected women. METHODS: A retrospective cross-sectional study was performed using the computerized databases of Maccabi Healthcare Services (MHS), a 2.1-million-member healthcare plan in Israel. Age-sex-specific point prevalence rates of endometriosis and fibromyalgia were calculated for end of 2015...
January 25, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30681748/nisin-reduces-uterine-inflammation-in-rats-by-modulating-the-concentrations-of-the-pro-and-anti-inflammatory-cytokines
#15
Zhifeng Jia, Meiling He, Chunjie Wang, Aorigele Chen, Xin Zhang, Jin Xu, Fu He, Liu Bo
PROBLEM: The Staphylococcus aureus has been found to be associated with clinical endometritis of cow. The result of oral antibiotic remains poor. Therefore, this study investigates the role of nisin in endometritis. METHOD OF STUDY: The effect of nisin on the growth curve and cell wall of S. aureus were determined in vitro. Besides the blank control group, animals with established postpartum were inoculated with 0.1 mL S. aureus intravaginally. Two days post-inoculation, the animals were administered nisin (25 mg/kg), kanamycin (30 mg/kg) and water (model group) for 7 days...
January 25, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30672642/alteration-of-the-immune-cell-profiles-in-the-pathophysiology-of-tubal-ectopic-pregnancy
#16
Xia Wang, Cheuk-Lun Lee, Hang Wun Raymond Li, Madhavi Vijayan, Yonggang Duan, William S B Yeung, Yuanzhen Zhang, Philip C N Chiu
Tubal ectopic pregnancy (TEP) refers to implantation of conceptus in the fallopian tube. It makes up over 98% of ectopic pregnancy (EP), which is the leading cause of maternal morbidity and mortality in the first trimester of pregnancy. Immune cells at the maternal-fetal interface play important roles in the process of embryo implantation, stroma decidualization, and early placental development. Alterations in the composition, phenotype, and activity of the immune cells in the fallopian tubes contribute towards the onset of TEP...
January 23, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30672631/lectin-pathway-proteins-of-the-complement-system-in-normotensive-pregnancy-and-preeclampsia
#17
Julie Brogaard Larsen, Anita Sylvest Andersen, Christine Lodberg Hvas, Steffen Thiel, Michael Rud Lassen, Anne-Mette Hvas, Anette Tarp Hansen
PROBLEM: The lectin pathway of the complement system may be involved in the pathogenesis of preeclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with preeclampsia, placental infarctions and intrauterine growth restriction (IUGR). METHOD OF STUDY: We included 51 women with normotensive pregnancies and 54 women with pregnancies complicated by preeclampsia. Blood samples were obtained at gestational weeks 16, 33, 37, and after delivery for the normotensive pregnant women and before and after delivery for women with preeclampsia...
January 23, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30629310/combining-individual-chlamydia-trachomatis-igg-antibodies-momp-tarp-cpaf-omp2-and-hsp60-for-tubal-factor-infertility-prediction
#18
Eleanne F van Ess, Anat Eck, Jolande A Land, Servaas A Morré, Sander Ouburg
PROBLEM: Tubal factor infertility (TFI) is a severe complication of genital C. trachomatis infections. In fertility work-up chlamydia antibody test (CAT) is used to predict TFI. The predictive value for TFI of most commonly used CAT is moderate. METHOD OF STUDY: 183 infertile Dutch Caucasian women were included in this study. All underwent tubal patency testing (HSG or laparoscopy). Cases had TFI, controls had no TFI (i.e. normal findings during HSG or laparoscopy)...
January 10, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30624814/serum-markers-of-b-cell-activation-in-pregnancy-during-late-gestation-delivery-and-the-postpartum-period
#19
Jorge Lima, Geraldine Cambridge, Andreia Vilas-Boas, Catarina Martins, Luís-Miguel Borrego, Maria Leandro
PROBLEM: B cells are vital for the normal evolution of pregnancy due to their humoral and possible regulatory activities. Our group and others have documented that circulating B cell subsets undergo changes from normal late pregnancy to the postpartum period. However, the underlying mechanisms are poorly understood. Therefore, this study examined the degree of B cell activation in normal pregnancy by analyzing the levels of serum markers in healthy pregnant women during the third trimester of pregnancy, the day of delivery, and the postpartum period...
January 9, 2019: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/30614120/metabolic-syndrome-mediates-pro-inflammatory-responses-of-inflammatory-cells-in-preeclampsia
#20
Gisoo Jabalie, Majid Ahmadi, Ladan Koushaeian, Shadi Eghbal-Fard, Amir Mehdizadeh, Amin Kamrani, Sedigheh Abdollahi-Fard, Laya Farzadi, Mohammad Hojjat-Farsangi, Mohammad Nouri, Mehdi Yousefi
PROBLEM: To investigate whether metabolic syndrome (MetS) is associated with exacerbation of inflammatory responses in preeclamptic (PE) patients, the dynamic changes of Th17 and Treg cells, monocytes, cytokines and transcription pattern of inflammasome related genes were analyzed in 35 women with PE suffering from MetS in comparison to 38 PE women without MetS and healthy pregnant women. METHOD OF STUDY: Expression of inflammasome related genes, cytokines and also TLR4 were measured using Real-Time PCR...
January 5, 2019: American Journal of Reproductive Immunology: AJRI
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