Ana Carolina Laus, Izabela Natalia Faria Gomes, Aline Larissa Virginio da Silva, Luciane Sussuchi da Silva, Mirella Baroni Milan, Silvia AparecidaTeixeira, Ana Carolina Baptista Moreno Martin, Letícia do Nascimento Braga Pereira, Carlos Eduardo Barbosa de Carvalho, Camila Souza Crovador, Flávia Escremin de Paula, Flávia Caroline Nascimento, Helder Teixeira de Freitas, Vinicius de Lima Vazquez, Rui Manuel Reis, Renato José da Silva-Oliveira
Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer that can result in significant morbidity, although it is usually well-managed and rarely metastasizes. However, the lack of commercially available cSCC cell lines hinders our understanding of this disease. This study aims to establish and characterize a new metastatic cSCC cell line derived from a Brazilian patient. A tumor biopsy was taken from a metastatic cSCC patient, immortalized, and named HCB-541 after several passages. The cytokeratin expression profile, karyotypic alterations, mutational analysis, mRNA and protein differential expression, tumorigenic capacity in xenograft models, and drug sensitivity were analyzed...
April 3, 2024: Human Cell