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Zeitschrift Für Naturforschung. C, A Journal of Biosciences

Uwe T Bornscheuer
No abstract text is available yet for this article.
February 11, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Naglaa S Ashmawy, Haidy A Gad, Nawal Al-Musayeib, Sherweit H El-Ahmady, Mohamed L Ashour, Abdel Nasser B Singab
Phytochemical investigation of Polyscias guilfoylei leaves extract (PGE) led to the isolation of nine compounds, that is, ent-labda-8(17),13-diene-15,18-diol (1), stigmasterol (2), spinasterol (3), N-(1,3-dihydroxyoctadecan-2-yl) palmitamide (4), panaxydiol (5), 3-O-β-d-glucopyranosylstigmasta-5,22-diene-3-β-ol (6), (8Z)-2-(2 hydroxypentacosanoylamino) octadeca-8-ene-1,3,4-triol (7), 4-hydroxybenzoic acid (8), and tamarixetin 3,7-di-O-α-L-rhamnopyranoside (9). Compound 4 is reported in this study for the first time in nature whereas compound 9 is reported for the second time...
February 6, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Ashraf M El-Sayed, Andrew Sporle, César Gemeno, Júlia K Jósvai, Gregory S Simmons, David M Suckling
We recently identified unique caterpillar-induced plant volatile compounds emitted from apple leaves infested with the larvae of various leafroller species. In subsequent field tests, binary blends of phenylacetonitrile+acetic acid and 2-phenylethanol+acetic acid were found to be attractive to a range of tortricid leafroller species (Tortricidae: Tortricinae) in both the Southern and Northern Hemispheres. In this work, the caterpillar-induced plant volatiles from the apple-leafroller system were tested in two vineyards in Spain and Hungary for their attractiveness to the grape frugivore Lobesia botrana (Tortricidae: Olethreutinae)...
February 5, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Angela Viviana Ruales-Salcedo, Juan Carlos Higuita, Javier Fontalvo, John M Woodley
While the application of enzymes to synthetic and industrial problems continues to grow, the major development today is focused on multi-enzymatic cascades. Such systems are particularly attractive, because many commercially available enzymes operate under relatively similar operating conditions. This opens the possibility of one-pot operation with multiple enzymes in a single reactor. In this paper the concept of modules is introduced whereby groups of enzymes are combined in modules, each operating in a single reactor, but with the option of various operating strategies to avoid any complications of nonproductive interactions between the enzymes, substrates or products in a given reactor...
February 2, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Vishnu S T Srinivasamurthy, Dominique Böttcher, Uwe T Bornscheuer
Multi-enzyme cascade reactions capture the essence of nature's efficiency by increasing the productivity of a process. Here we describe one such three-enzyme cascade for the synthesis of 6-hydroxyhexanoic acid. Whole cells of Escherichia coli co-expressing an alcohol dehydrogenase and a Baeyer-Villiger monooxygenase (CHMO) for internal cofactor regeneration were used without the supply of external NADPH or NADP+. The product inhibition caused by the ε-caprolactone formed by the CHMO was overcome by the use of lipase CAL-B for in situ conversion into 6-hydroxyhexanoic acid...
January 26, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Desislava Teneva, Rositsa Denkova-Kostova, Bogdan Goranov, Yana Hristova-Ivanova, Aleksandar Slavchev, Zapryana Denkova, Georgi Kostov
This study aims to investigate the chemical composition, antioxidant, and antimicrobial activity of Citrus aurantium L zest essential oil. The identification of the chemical compounds was done using chromatography analysis. The antioxidant activity was studied by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Results showed that the main components of the essential oil were limonene (85.22%), β-myrcene (4.3%), and α-pinene (1.29%). Regarding the DPPH radical scavenging ability, the zest essential oil showed higher activity than limonene...
January 26, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Feng Zhu, Yanping Che, Fei Xu, Yangkai Zhou, Kun Qian, Yonghui Liao, Zhaolin Ji
Virus-induced gene silencing (VIGS) is an effective strategy for rapid gene function analysis. It is well established that the NAC transcription factor and salicylic acid (SA) signal pathway play essential roles in response to biotic stresses. However, simultaneous silencing of two target genes using VIGS in plants has been rarely reported. Therefore, in this report, we performed VIGS to silence simultaneously the SA-binding protein 2 (NbSABP2) and NbNAC1 in Nicotiana benthamiana to investigate the gene silencing efficiency of simultaneous silencing of two genes...
January 22, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Rong-Rui Wei, Qin-Ge Ma, Guo-Yue Zhong, Ming Yang, Zhi-Pei Sang
Three new benzisoquinolinones (1-3), together with seven known benzisoquinolinone derivatives (4-10), were isolated from Portulaca oleracea for the first time. The structures of the isolated compounds (1-10) had been elucidated on the basis of extensive spectroscopic methods including ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance techniques and by comparison with data reported in the references. All isolated compounds were assayed for cytotoxicities against selected human lines in vitro by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay...
January 11, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Christin Peters, Rebecca Buller
Biocatalysis has developed enormously in the last decade and now offers solutions for the sustainable production of chiral and highly functionalised asset molecules. Products generated by enzymatic transformations are already being used in the food, feed, chemical, pharmaceutical and cosmetic industry, and the accessible compound panoply is expected to expand even further. In particular, the combination of stereo-selective enzymes in linear cascade reactions is an elegant strategy toward enantiomeric pure compounds, as it reduces the number of isolation and purification steps and avoids accumulation of potentially unstable intermediates...
January 11, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Abdelaaty Hamed, Mohamed Ismail, Mohammad M El-Metwally, Marcel Frese, Tarek M A Ibrahim, Atef F El-Haddad, Norbert Sewald, Mohamed Shaaban
As a continuation of our earlier research concerning the investigation of microbial bioactive secondary metabolites from the terrestrial Penicillium sp.KH Link 1809 isolate KHMM, the fungus was re-cultivated on a large scale to explore its bioactive compounds intensively. Fifteen compounds, including seven alkaloids (1-7), one sesquiterpene (8), an acetylenic system (9), two sterols, and sphengolipid, were identified. Their structures were established on the bases of extensive one- and two-dimensional nuclear magnetic resonance and mass measurements, and by comparison with literature data...
January 11, 2019: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Zahid Iqbal, Muhammad Ishaq, Adnan Aslam, Wei Gao
Previous studies show that certain physical and chemical properties of chemical compounds are closely related with their molecular structure. As a theoretical basis, it provides a new way of thinking by analyzing the molecular structure of the compounds to understand their physical and chemical properties. The molecular topological indices are numerical invariants of a molecular graph and are useful to predict their bioactivity. Among these topological indices, the eccentric-connectivity index has a prominent place, because of its high degree of predictability of pharmaceutical properties...
December 13, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Jan Muschiol, Anne S Meyer
The ability of an engineered β-N-acetylhexosaminidase to utilize a reactive oxazoline as donor molecule for transglycosylation reaction to synthesize human milk oligosaccharide backbone structures was studied. The human milk oligosaccharide precursor lacto-N-triose II and three regioisomers could be synthesized using the oxazoline, which was either in situ-generated resulting in a chemo-enzymatic sequential cascade or was used as a purified compound. The highest observed concentration of overall transglycosylation products in a cascade reaction was 13...
December 11, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Wei Gao, Muhammad Kamran Siddiqui, Najma Abdul Rehman, Mehwish Hussain Muhammad
Dendrimers are large and complex molecules with very well defined chemical structures. More importantly, dendrimers are highly branched organic macromolecules with successive layers or generations of branch units surrounding a central core. Topological indices are numbers associated with molecular graphs for the purpose of allowing quantitative structure-activity relationships. These topological indices correlate certain physico-chemical properties such as the boiling point, stability, strain energy, and others, of chemical compounds...
December 8, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Dasha Mihaylova, Radka Vrancheva, Ivelina Desseva, Ivan Ivanov, Ivayla Dincheva, Mariya Popova, Aneta Popova
The study's objective was to investigate the volatile compounds, assess the total phenolic content and phenolic acids profile, determine the antioxidant capacity and evaluate the anthocyanin and flavonoid contents in stinging nettle (Urtica dioica L.), tansy (Tanacetum vulgare L.), bladder campion (Silene vulgaris (Moench) Garcke) and rosehip fruit (Rosa canina L. cv. Plovdiv 1). The total phenolic content ranged from 0.55±0.00 to 47.39±0.41 mg GAE/g dw, total flavonoids ranged from 0.45±0.02 to 17.27±0...
December 8, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Noor Ul Huda, Shamsul Islam, Muhammad Zia, Kainaat William, Fakhar I Abbas, Muhammad Ihtisham Umar, Muhammad Adnan Iqbal, Abdul Mannan
The current study was conducted to evaluate the antimicrobial, antioxidant, antileishmanial and cytotoxic potential of designed derivatives of 1,1'-(1,3-phenylenebis(methylene))bis(3-alkyl/aryl-1H-benzimidazol-3-ium) salts. The antibacterial potential of the test compounds was investigated against Staphylococcus aureus, Pseudomonas aeruginosa and two methicillin-resistant S. aureus (MRSA) strains (MRSA10, MRSA11), where compound 6 showed the best results. For brine shrimp lethality bioassay (BSLB), compound 6 again showed up to 100% mortality at 200 μg/mL and 56...
November 30, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Abdur Rauf, Saud Bawazeer, Ghias Uddin, Bina S Siddiqui, Haroon Khan, Taibi Ben Hadda, Yahia Nasser Mabkhot, Usama Shaheen, Mohamed Fawzy Ramadan
The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from Pistacia integerrima in various animal paradigms. In a rotarod test, PA caused a significant (p<0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused promising activity (p<0.05) after treatment for 30, 60 and 90 min. The muscle relaxant potential of PA was strongly complimented by the traction and chimney tests, showing a dominant effect after 60 min of treatment...
November 27, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Asmaa A Magd-El-Din, Hanan A Mousa, Ammar A Labib, Ashraf S Hassan, Amira S Abd El-All, Mamdouh M Ali, Ahmed A El-Rashedy, Ahmed H El-Desoky
A new series of Schiff bases containing benzіmidazole moiety 11-17 were synthesized by the reaction of 4-(1H-benzо[d]іmіdazоl-2-yl)anіline (1) with different aromatic aldehydes (4-10) via conventional heating and microwave irradiation methods. The structures of the novel Schiff bases were characterized by using different spectral data. Also, metal complexes 18-21 of compound 13 were synthesized, and their structure was confirmed by spectral measurements (IR, NMR, UV), molar conductivity, magnetic susceptibility and thermo-gravimetric analysis...
November 27, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Jinfeng Yang, Yong Soo Kwon, Myong Jo Kim
The Rhus verniciflua Stokes (RVS) extract is used as a traditional herbal medicine in Southeast Asian countries such as Korea and China. In the present study, one phenolic acid and six flavonoids were isolated from an 80% ethanol RVS extract to examine their antimicrobial activities. These compounds were identified as 3',4',7-trihydroxyflavone (1), methyl gallate (2), gallic acid (3), fusti (4), fisetin (5), butin (6), and sulfuretin (7) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nuclear magnetic resonance spectroscopy...
November 27, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Djalma M de Oliveira, Cristiane B Pereira, Graziele Mendes, Jochen Junker, Markus Kolloff, Luiz H Rosa, Carlos A Rosa, Tânia M A Alves, Carlos L Zani, Susana Johann, Betania B Cota
The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250...
November 27, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Dasha Mihaylova, Radka Vrancheva, Nadezhda Petkova, Manol Ognyanov, Ivelina Desseva, Ivan Ivanov, Mariya Popova, Aneta Popova
Nettle (Urtica dioica L.), tansy (Tanacetum vulgare L.), bladder campion (Silene vulgaris (Moench) Garcke, waterpepper (Polygonum hydropiper L.), common centaury (Centaurium erythraea Pers.) and rose hip fruit (Rosa canina L. cv. Plovdiv 1) were used for preparation of different water extracts (infusion, decoction and microwave extract) and ethanol (tincture) extracts. Carotenoids (lutein, lycopene and β-carotene), tocopherols (α-, γ- and δ-), organic acids (ascorbic, malic, fumaric and citric), five macro- and three microelements, sugars and uronic acids content in the obtained extracts were analyzed...
November 27, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
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