Journals Journal of Oral Pathology & Me...

Journal of Oral Pathology & Medicine
Aria Sun, Dileep Sharma, Siu-Wai Choi, Poornima Ramamurthy, Peter Thomson
BACKGROUND: Oral cancer, predominantly squamous cell carcinoma (SCC), is a lethal and deforming disease of rising incidence. Although largely preventable by eliminating harmful tobacco and alcohol risk factor behaviour, five-year survival rates remain around 50%, primarily due to late presentation of advanced stage disease. Whilst low socio-economic status, regional and remote location and Indigenous status are associated with head and neck cancer in general, detailed incidence and demographic data for oral SCC in Australia are limited...
February 28, 2023: Journal of Oral Pathology & Medicine
Eder da Silva Dolens, Everton Freitas de Morais, Lívia Máris Ribeiro Paranaíba, Ana Lúcia Carrinho Ayroza Rangel, Alhadi Almangush, Tuula Salo, Peter A Brennan, Ricardo D Coletta
BACKGROUND: Although nerve involvement can predict recurrence and prognosis in oral squamous cell carcinomas (OSCC), there still have controversies and limitations regarding the standardization for its detection. In this study we explore the impact of neural invasion in OSCC prognosis, comparing intraneural invasion (INI, tumor cells inside nerve structure) and perineural invasion (PNI, cells involving the nerve, but not invading its sheath). METHODS: Surgical slides stained with hematoxylin and eosin from 235 patients with OSCC were carefully verified for the presence of INI and PNI...
February 27, 2023: Journal of Oral Pathology & Medicine
Elisabetta Caprini, Giampaolo D'Agnese, Peter A Brennan, Siavash Rahimi
The increase of the incidence of Human Papilloma Virus (HPV) dependent oropharyngeal squamous cell carcinoma (OPSCC) is alarming, although we have greatly progressed in the classification and staging of this disease. We now know that OPSCC-HPV+ is a sub-type of head and neck squamous cell carcinoma with favourable prognosis and good response to therapy that needs a proper system of classification and staging. Thus, in routine practice it is essential to test patients for the presence of HPV. The most popular technique to assess HPV status is immunohistochemistry on biopsy samples with p16, which is an excellent surrogate for high-risk HPV infection...
February 27, 2023: Journal of Oral Pathology & Medicine
Shuning Zhang, Yuqing Dong, Shuangyuan Zhao, Fei Bi, Ming Xuan, Guiquan Zhu, Weihua Guo, Zhuang Zhang
BACKGROUND: Oral tongue squamous cell carcinoma tends to metastasize to cervical lymphatic nodes early which leads to a 50% drop of survival rate. CXCL1 could be secreted by LNMTca8113 cell induced lymphatic endothelial cells (LECs) and promoted LNMTca8113 cell migration. The current study aimed to further explore the effect of CXCL1 on the proliferation and migration abilities of tongue cancer cells and the prognostic value of serum CXCL1 in OTSCC. METHODS: Cell proliferation and migration ability were analyzed by CCK8 assays and transwell migration assays...
February 24, 2023: Journal of Oral Pathology & Medicine
Michael P Hughes, Fatima H Labeed, Kai F Hoettges, Stephen Porter, Valeria Mercadante, Nicholas Kalavrezos, Colin Liew, James A McCaul, Raghav Kulkarni, James Cymerman, Cyrus Kerawala, Julie Barber, Mark P Lewis, Stefano Fedele
BACKGROUND: Delays in the identification and referral of oral cancer remain frequent. An accurate and non-invasive diagnostic test to be performed in primary care may help identifying oral cancer at an early stage and reduce mortality. PANDORA was a proof-of-concept prospective diagnostic accuracy study aimed at advancing the development of a dielectrophoresis-based diagnostic platform for oral squamous cell carcinoma (OSCC) and epithelial dysplasia (OED) using a novel automated DEPtech 3DEP analyser...
February 21, 2023: Journal of Oral Pathology & Medicine
Liming Zhang, Yuchen Shen, Zhenfeng Wang, Xiao Li, Weiya Xia, Xindong Fan, Lixin Su, Deming Wang
BACKGROUND: Venous malformation (VM) is a kind of congenital vascular anomaly with high incidence of recurrence, detailed pathogenesis and standard treatment of VM still lack now. Increasing evidence showed exosomal RNA plays a pivotal role in various diseases. However, the underlying mechanism of VM basing on the potential differentially exosomal RNAs remains unclear. METHODS: Comparative high-throughput sequencing with serum exosomes from three VM patients and three healthy donors was used to explore differentially expressed (DE) circRNAs, DE lncRNAs and DE mRNAs involving the formation of VM...
February 19, 2023: Journal of Oral Pathology & Medicine
Agnieszka M Frydrych, Bede van Schaijik, Richard Parsons, Omar Kujan
BACKGROUND: Oral leukoplakia (OL) is one of the most prevalent oral potentially malignant disorders (OPMD). Although there is emerging evidence that quality of life (QoL) is impaired in subjects with OL; studies to date are based on single and heterogenous point-in-time assessments. The aim of this study was to ascertain if QoL scores change over time in individuals diagnosed with OL. METHODS: Forty-one individuals with OL were administered the Short Generic Health Questionnaire (SF-12) and the discipline-specific Oral Potentially Malignant Disorder Questionnaire (OPMDQ) at four points in time: at the time of clinical diagnosis, at the post-biopsy review (confirmed diagnosis), and at 3- and 6-month follow-up appointments...
February 17, 2023: Journal of Oral Pathology & Medicine
Lianmei Ye, Mubarak Ahmed Mashrah, Linhu Ge, Ying Fang, Xueqi Guo, Qing Ge, Liping Wang
OBJECTIVES: To evaluate the effect of platelet-rich fibrin alone or in combination with different biomaterials for the treatment of periodontal intra-bony defect. METHODS: Up to April 2022, Cochrane library, Medline, EMBASE, and Web of Science databases were searched for randomized clinical trials. The outcomes of interest were probing pocket depth reduction, clinical attachment level gain, bone gain, and bone defect depth reduction. Bayesian network meta-analysis with 95% credible intervals was calculated...
February 15, 2023: Journal of Oral Pathology & Medicine
Lucas Lacerda de Souza, Felipe Paiva Fonseca, Anna Luiza Damaceno Araújo, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Syed Ali Khurram, Luiz Paulo Kowalski, Harim Tavares Dos Santos, Saman Warnakulasuriya, James Dolezal, Alexander T Pearson, Alan Roger Santos-Silva
Oral potentially malignant disorders (OPMDs) represent precursor lesions that may undergo malignant transformation to oral cancer. There are many known risk factors associated with the development of OPMDs, and contribute to the risk of malignant transformation. Although many advances have been reported to understand the biological behaviour of OPMDs, their clinical features that indicate the characteristics of malignant transformation are not well established. Early diagnosis of malignancy is the most important factor to improve patients' prognosis...
February 15, 2023: Journal of Oral Pathology & Medicine
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February 2023: Journal of Oral Pathology & Medicine
Susana Ríos, Simón Álvarez, Patricio C Smith, Claudia G Sáez, Catherine Andrade, Nelson Pinto, Constanza E Martínez
BACKGROUND AND OBJECTIVE: Leucocyte- and platelet-rich fibrin has been developed to stimulate wound healing response. However, it is currently unknown whether smoking affects the biological responses elicited by leucocyte- and platelet-rich fibrin on periodontal ligament-derived mesenchymal stromal cells. This study analyzes the kinetics of biomolecule release from leucocyte- and platelet-rich fibrin derived from smokers and nonsmokers and their effect on periodontal ligament cell proliferation and migration as essential biological activities during wound healing...
February 2023: Journal of Oral Pathology & Medicine
Mariana Mota Nunes, Adriana Aparecida Silva da Costa, Thalita Soares Tavares, Maria Cássia Ferreira Aguiar, Carolina Castro Martins, Patrícia Carlos Caldeira
BACKGROUND: The aim of this study was to collect, synthesize, and analyze the clinic-demographic data of rhabdomyosarcoma affecting the oral cavity of young children. METHODS: The clinical question was "What are the clinical characteristics of oral rhabdomyosarcoma in children aged zero to two years?" Two independent reviewers selected the studies, extracted data, and assessed the methodological quality through the Joanna Briggs Institute Checklist. Descriptive statistics were performed in SPSS...
January 30, 2023: Journal of Oral Pathology & Medicine
W Awotoye, J Whitt, B Yoo, M S Farooqi, E Farrow, V Allareddy, B A Amendt, S Rengasamy Venugopalan
OBJECTIVE: Ameloblastomas are a group of common odontogenic tumors that originate from the dental epithelium. These tumors are aggressive in nature and present as slow growing painless cortical expansion of the jaw. Histologically, the follicular and plexiform subtypes constitute two-thirds of solid/multicystic ameloblastomas. The objective of this study was to understand the genetic architecture of follicular and plexiform ameloblastomas using deep whole-exome sequencing (dWES). METHODS: Archived formalin-fixed paraffin-embedded (FFPE) tissue blocks of follicular (n=4) and plexiform (n=6) ameloblastomas were retrieved and genomic DNAs were isolated from the tumor tissue dissected from the FFPE block...
January 30, 2023: Journal of Oral Pathology & Medicine
Rogerio M Castilho, Matthew S Castilho, Zoë Simmons, Cristiane H Squarize
The United States is facing a dramatic shortage of clinician-scientists within the domains of medicine and dentistry. In this perspective article, we stressed the problem involving the continuous shortage of specialized professionals capable of addressing complex basic sciences questions, while maintaining clinical relevance. Here we present a different perspective regarding the early engagement of young students to clinical sciences by teaming up with high schools across the US, and to energize the debate on our current shortage of clinician-scientists...
January 24, 2023: Journal of Oral Pathology & Medicine
Maria Gabriella Apolinário Xavier, Maria de Lourdes Neves de Moura, Lucas Nascimento Ribeiro, Marianne de Vasconcelos Carvalho, Stefânia Jeronimo Ferreira
BACKGROUND: The effects of laser therapy on normal cells are well known and accepted, but the impact of this therapy on malignant cells are not yet fully understood. This review aims to map and outline what the scientific literature addresses on the effects of laser therapy on malignant cells. METHODS: This review article followed the guidelines of the PRISMA-ScR protocol, being all the search, analysis, and selection of articles based on it. RESULTS: After all application of the predetermined criteria, five studies were included, dated between the years 2013 and 2021...
January 24, 2023: Journal of Oral Pathology & Medicine
Baojun Li, Yuanjing Lv, Cui Zhang, Cheng Xiang
OBJECTIVE: Oral squamous cell carcinoma (OSCC) is the most prevailing oral malignancy. LncRNA HOXA11-AS shows prominent roles in OSCC. This study explored the effects of lncRNA HOXA11-AS on regulating OSCC stem cell stemness and radiosensitivity by targeting miR-518a-3p/PDK1. METHODS: Human OSCC cell lines SCC9 and SCC15 were selected. CD133+ cancer stem cells (CSCs) were sorted by immunomagnetic beads. CD133 expression in cells and HOXA11-AS expression in SCC9, SCC15 and CD133+ SCC9, CD133+ SCC15 cells were assessed by flow cytometry and RT-qPCR...
January 20, 2023: Journal of Oral Pathology & Medicine
Lilianny Querino Rocha de Oliveira, Alhadi Almangush, Ahmed Al-Samadi, Tuula Salo, Ricardo D Coletta
In the last decades, the search for biomarkers for response to therapy and prognosis, with potential of providing information about the likely course and outcome of disease, has been intense in oral squamous cell carcinomas (OSCC). Although several biomarkers, ranging from genetic and molecular alterations to clinical and histopathological features, have been described, only a few of them are used in routine practice. The aim of this review is to outline the recent advances in OSCC biomarkers, exploring those related to clinical and histopathological features, cancer cells and components of the tumor microenvironment...
January 19, 2023: Journal of Oral Pathology & Medicine
Peter A Brennan, John Hardie, Rachel S Oeppen
Human error is an inevitable and therefore can be considered as a 'normal' part of everyday life. Unfortunately, error can never be eliminated completely. However, learning from our mistakes can help reduce problems in future. 50 years ago, most clinicians paid little or no attention to the Human Factors (HF) that can affect individual and team performance. It has only been in the last 20-25 years that colleagues in healthcare have truly begun recognizing the importance of HF and non-technical skills in medicine and dentistry and how their application can significantly improve patient safety and aid better team working and staff morale in the clinical setting and laboratory...
January 11, 2023: Journal of Oral Pathology & Medicine
Isadora Pereira Gomes, Victor Coutinho Bastos, Letícia Martins Guimarães, Carolina Cavaliéri Gomes
The advances in molecular technologies have allowed a better understanding of the molecular basis of odontogenic cysts and tumours. PTCH1 mutations have been reported in a high proportion of odontogenic keratocyst. BRAF p.V600E are recurrent in ameloblastoma and KRAS p.G12V/R in adenomatoid odontogenic tumour, dysregulating the MAPK/ERK pathway. Notably, BRAF p.V600E is also detected in ameloblastic carcinoma, but at a lower frequency than in its benign counterpart ameloblastoma. Recently, adenoid ameloblastoma has been shown to be BRAF wild-type and to harbour CTNNB1 (β-catenin gene) mutations, further suggesting that it is not an ameloblastoma subtype...
January 11, 2023: Journal of Oral Pathology & Medicine
Julia Yu Fong Chang, Pei Hsuan Lu, Chih-Huang Tseng, Yi-Ping Wang, Jang-Jaer Lee, Chun-Pin Chiang
BACKGROUND: There are still some controversies about the results of anti-BRAF V600E-specific antibody immunohistochemistry in ameloblastomas. This study aimed to examine the accuracy of V600E-specific antibody immunohistochemistry in detection of BRAF V600E mutation in ameloblastoma tissue sections of different ages. METHODS: The BRAF V600E status of 64 ameloblastoma specimens was assessed using both Sanger sequencing and V600E-specific antibody immunohistochemistry, and the sensitivity, specificity, positive predictive value, and negative predictive value were calculated...
January 10, 2023: Journal of Oral Pathology & Medicine
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