Journals Journal of Oral Pathology & Me...

Journal of Oral Pathology & Medicine
Thomas George Kallarakkal, Zuraiza Mohamad Zaini, Wan Maria Nabillah Ghani, Lee Peng Karen-Ng, B S M S Siriwardena, Sok Ching Cheong, Wanninayake Mudiyanselage Tilakaratne
INTRODUCTION: A major pitfall of many of the established oral epithelial dysplasia (OED) grading criteria is their lack of reproducibility and accuracy to predict malignant transformation. The main objective of this study was to determine whether calibration of practicing oral pathologists on OED grading could improve the reproducibility of the WHO 2017 and the binary OED grading systems. METHODS: A nationwide online exercise was carried out to determine the influence of calibration on the reproducibility of the WHO 2017 and the binary OED grading systems...
December 11, 2023: Journal of Oral Pathology & Medicine
Jonathan Deng, Vaidehi Misra, Neehal Vilash, Wendi Wu, Cindy Hua, Kate Son, Federica Canfora, Fabian Y S Kong, Rita Paolini, Michael McCullough, Antonio Celentano
BACKGROUND: Coffee is one of the most consumed beverages in the world. Containing an abundance of bioactive molecules including polyphenols and flavonoids, the constituents of this beverage may exert antiproliferative, antioxidant and anti-inflammatory effects. METHODS: We conducted a systematic review to summarise the available evidence on the anticancer effects of coffee constituents and their potential therapeutic use for oral squamous cell carcinoma (OSCC). Studies were identified through a comprehensive search of OVID MEDLINE, OVID EMBASE and Web of Science, including articles from any year up to 15 May 2023...
November 13, 2023: Journal of Oral Pathology & Medicine
Lizeth Andrea Torres Torres, Gabriel Silva, Jovelina Samara Ferreira Alves, Tatiane Resende Ushida, Julia Potenza, Cristiana Bernadelli Garcia, Lucas Oliveira Sousa, Norberto Peporine Lopes, Luciana Oliveira Almeida, Andréia Machado Leopoldino
BACKGROUND: Oral squamous cell carcinoma has high recurrence and cisplatin resistance. As cancer stem cells, autophagy, and sphingolipids have been appointed as associated with chemotherapy resistance, we tested combined treatments targeting autophagy and/or sphingolipid metabolism with paclitaxel using cisplatin-resistant oral squamous cell carcinoma cells. METHODS: Cisplatin-resistant oral squamous cell carcinoma cells were maintained under exposition to FTY720 and chloroquine combined with paclitaxel and submitted to viability, clonogenicity, and spheres formation assays...
November 9, 2023: Journal of Oral Pathology & Medicine
Leonor Frey-Furtado, Inês Magalhães, Benedita Sampaio-Maia, Maria João Azevedo
BACKGROUND: Oral mucositis (OM) is a severe and common adverse effect of cancer treatment. The oral microbiome appears to play a role on the onset and severity of OM. Therefore, this systematic review aims to characterize the oral dysbiosis associated with OM. METHODS: The PRISMA checklist was followed and PubMed, Web of Science, and Scopus were screened for clinical studies characterizing the oral microbiome alterations in patients with OM. RESULTS: From a total of 2500 articles retrieved, we included nine articles in this systematic review...
November 2023: Journal of Oral Pathology & Medicine
Xiumei Zhuang, Xiaoxuan Lin, Ruogu Xu, Zhengchuan Zhang, Bin Zhou, Feilong Deng
BACKGROUND: Apoptosis resistance of myofibroblasts is critical in pathology of irradiation-induced fibrosis and osteoradionecrosis of the jaw (ORNJ). However, molecular mechanism of apoptosis resistance induced by irradiation in oral myofibroblasts remains largely obscure. METHODS: Matched ORNJ fibroblasts and normal fibroblasts pairs from gingival were primarily cultured, and myofibroblast markers of α-SMA and FAP were evaluated by qRT-PCR and western blot...
October 24, 2023: Journal of Oral Pathology & Medicine
Ashutosh Kumar Singh, Ragavi Alagarsamy, Rajib Chaulagain, Abanish Singh, Dipak Sapkota, Selvam Thavaraj, Rabindra P Singh
OBJECTIVES: This review aims to analyse the recurrence rate in BRAFv600e+ and BRAFv600e- ameloblastomas and explore its association with clinicopathological variables. METHODS: A comprehensive search was conducted using databases including PubMed, Embase, Cochrane Central Register of Controlled Trials,, Google Scholar and grey literature, without any limitation on start date or language up to 20 June 2023. A random effect meta-analysis was conducted and Metaregression analyses were performed based on available clinicopathological factors...
October 23, 2023: Journal of Oral Pathology & Medicine
Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Felipe da Mata Camargos, Ricardo Santiago Gomez, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Elismauro Francisco Mendonça, Sebastião Silvério Sousa-Neto, Ana Carolina Uchoa Vasconcelos, Sandra Beatriz Chaves Tarquínio, Patrícia Carlos Caldeira
BACKGROUND: This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics. METHODS: Nine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin-eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched...
October 18, 2023: Journal of Oral Pathology & Medicine
Shreya Chatterjee, Anju Devi, Mala Kamboj, Anjali Narwal
BACKGROUND: CTNNB1 gene encodes beta catenin, a transcriptional activator of Wnt pathway involved in the pathogenesis of odontogenic lesions. Though located intramembranously, its translocation into cytoplasm and nucleus could trigger cell proliferation, inhibition of apoptosis, invasion and migration of the tumour cell. MATERIALS AND METHODS: Five electronic databases including MEDLINE by PubMed, Google scholar, Scopus, Trip, Cochrane library and EMBASE until 1 January 2023 without period restriction were thoroughly searched...
October 15, 2023: Journal of Oral Pathology & Medicine
Dong Yuan, Xin-Qiang Li, Fang-Wen Qu, Yue Wang
BACKGROUND: Oral squamous cell carcinoma is an increasingly prevalent cancer type characterized by high incidence and mortality rates. Its early detection is challenging, primarily because of the absence of early molecular markers. Cuproptosis is a novel regulatory mechanism of cell death with implications in various cancers. In this study, we aimed to study cuproptosis-related genes in oral squamous cell carcinoma to identify their prognostic value. METHODS: By analyzing genomic, bulk RNA-seq, and single-cell RNA-seq data, we investigated 13 cuproptosis-related genes in The Cancer Genome Atlas-Oral Squamous Cell Carcinoma dataset and Gene Expression Omnibus repository (GSE172577)...
October 12, 2023: Journal of Oral Pathology & Medicine
Christian Seebauer, Eric Freund, Tobias Dieke, Sybille Hasse, Maria Segebarth, Christoph Rautenberg, Hans-Robert Metelmann, Sander Bekeschus
BACKGROUND: Oral leukoplakia (OL) is an unfavorable oral disease often resistant to therapy. To this end, cold physical plasma technology was explored as a novel therapeutic agent in an experimental setup. METHODS: Biopsies with a diameter of 3 mm were obtained from non-diseased and OL tissues. Subsequently, cold atmospheric pressure plasma (CAP) exposure was performed ex vivo in the laboratory. After 20 h of incubation, biopsies were cryo-conserved, and tissue sections were quantified for lymphocyte infiltrates, discriminating between naïve and memory cytotoxic and T-helper cells...
October 12, 2023: Journal of Oral Pathology & Medicine
Tao Ma, Silvia Montaner, Abraham Schneider
BACKGROUND: Compelling evidence implicates diabetes-associated hyperglycemia as a promoter of tumor progression in oral potentially malignant disorders (OPMD). Yet, information on hyperglycemia-induced cell signaling networks in oral oncology remains limited. Our group recently reported that glucose-rich conditions significantly enhance oral dysplastic keratinocyte viability and migration through epidermal growth factor receptor (EGFR) activation, a pathway strongly linked to oral carcinogenesis...
October 10, 2023: Journal of Oral Pathology & Medicine
Luiz Arthur Barbosa da Silva, Lucas Melo da Costa, Ana Camila Pereira Massetti, Laudenice de Lucena Pereira, Ericka Janine Dantas da Silveira, Tuula Anneli Salo, Ricardo Della Coletta, Márcia Cristina da Costa Miguel
BACKGROUND: Oral squamous cell carcinoma is characterized by high rates of morbidity and mortality. Evidence obtained for different types of cancer shows that tumor initiation, progression, and therapeutic resistance are regulated by heat shock factor 1. This research aimed to analyze the effects of heat shock factor 1 on the biological behavior of oral squamous cell carcinoma. METHODS: Clinicopathological and immunoexpression study of heat shock factor 1 in 70 cases of oral tongue SCC and functional assays by gene silencing of this factor in an oral tongue SCC cell line...
October 2, 2023: Journal of Oral Pathology & Medicine
Mubarak Ahmed Mashrah, Ying Fang, Wanxing Song, Sadeq Ali Al-Maweri, Yang Lan, Ge Linhu, Liping Wang
BACKGROUND: The present network meta-analysis aims to answer the question "what is the best topical intervention for the treatment of recurrent aphthous stomatitis that can provide an acceptable pain relief and promote wound healing?" METHODS: From inception to October 2022, PubMed, Embase, Scopus, Cochrane Library, and China National Knowledge Infrastructure were searched to identify all potentially eligible randomized controlled trials. The primary outcomes were pain scores and/or healing time, while the secondary outcomes were the associated side effects...
October 2023: Journal of Oral Pathology & Medicine
Santhosh Kumar J Urumarudappa, Vy Ngoc Thuy Tran, Hay Mar Oo, Monthira Suntiparpluacha, Somponnat Sampattavanich, Vinicius Rosa, Komkrit Ruangritchankul, Joao N Ferreira, Risa Chaisuparat
BACKGROUND: Mucoepidermoid carcinoma is a rare salivary gland malignant tumour. This study aimed to investigate inflammatory and immune signatures of mucoepidermoid carcinoma by identifying potential proteo-transcriptomic biomarkers towards the development of precision immuno-oncology treatment strategies. METHODS: A total of 30 biopsies obtained from patients diagnosed with mucoepidermoid carcinoma between 2013 and 2022 were analysed after H&E staining for scoring of histological inflammatory stroma subtypes and inflammatory hotspots with QuPath...
September 27, 2023: Journal of Oral Pathology & Medicine
Leon J Wils, Jos B Poell, Laura A N Peferoen, Ilkay Evren, Elisabeth R Brouns, Jan G A M de Visscher, Erik H van der Meij, Ruud H Brakenhoff, Elisabeth Bloemena
OBJECTIVE: Oral leukoplakia is the most common oral potentially malignant disorder. Malignant transformation of oral leukoplakia occurs at an annual rate of 1%-7%. WHO-defined classic epithelial dysplasia is an important predictor of malignant transformation of oral leukoplakia, but we have previously shown in a proof of concept study that prediction improves by incorporation of an architectural pattern of dysplasia, also coined as differentiated dysplasia. We aimed to analyze this finding in a larger cohort of patients...
September 25, 2023: Journal of Oral Pathology & Medicine
Xiangjian Wang, Shenjie Xu, Tao Fu, Yang Wu, Weilian Sun
BACKGROUND: Programmed cell death ligand 1 (PD-L1) and human leukocyte antigen/major histocompatibility complex (HLA/MHC) are two main kinds of immunophenotypes affecting the susceptibility to anti-PD therapy. Our previous study found that down-regulation of flap endonuclease-1 (FEN1) could not only inhibit PD-L1 expression, but also upregulate HLA expression in head and neck squamous cell carcinoma (HNSCC). We aimed to clarify whether downregulating FEN1 cloud enhance the response to PD-1 blockade, and possible mechanisms in HNSCC in vitro...
September 20, 2023: Journal of Oral Pathology & Medicine
Peter A Brennan
No abstract text is available yet for this article.
September 18, 2023: Journal of Oral Pathology & Medicine
Anna Luíza Damaceno Araújo, Viviane Mariano da Silva, Matheus Cardoso Moraes, Henrique Alves de Amorim, Felipe Paiva Fonseca, Maria Sissa Pereira Sant'Ana, Ricardo Alves Mesquita, Bruno Augusto Linhares Almeida Mariz, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Cristina Saldivia-Siracusa, Syed Ali Khurram, Alexander T Pearson, Manoela Domingues Martins, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Luiz Paulo Kowalski, Alan Roger Santos-Silva
BACKGROUND: Dysplasia grading systems for oral epithelial dysplasia are a source of disagreement among pathologists. Therefore, machine learning approaches are being developed to mitigate this issue. METHODS: This cross-sectional study included a cohort of 82 patients with oral potentially malignant disorders and correspondent 98 hematoxylin and eosin-stained whole slide images with biopsied-proven dysplasia. All whole-slide images were manually annotated based on the binary system for oral epithelial dysplasia...
September 15, 2023: Journal of Oral Pathology & Medicine
Daniela Giraldo-Roldan, Erin Crespo Cordeiro Ribeiro, Anna Luiza Damaceno Araújo, Paulo Victor Mendes Penafort, Viviane Mariano da Silva, Jeconias Câmara, Hélder Antônio Rebelo Pontes, Manoela Domingues Martins, Márcio Campos Oliveira, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Luiz Paulo Kowalski, Matheus Cardoso Moraes, Pablo Agustin Vargas
BACKGROUND: Odontogenic tumors (OT) are composed of heterogeneous lesions, which can be benign or malignant, with different behavior and histology. Within this classification, ameloblastoma and ameloblastic carcinoma (AC) represent a diagnostic challenge in daily histopathological practice due to their similar characteristics and the limitations that incisional biopsies represent. From these premises, we wanted to test the usefulness of models based on artificial intelligence (AI) in the field of oral and maxillofacial pathology for differential diagnosis...
September 15, 2023: Journal of Oral Pathology & Medicine
Jan-Michaél Hirsch, Ronak Sandy, Bengt Hasséus, Joakim Lindblad
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a widespread disease with only 50%-60% 5-year survival. Individuals with potentially malignant precursor lesions are at high risk. METHODS: Survival could be increased by effective, affordable, and simple screening methods, along with a shift from incisional tissue biopsies to non-invasive brush biopsies for cytology diagnosis, which are easy to perform in primary care. Along with the explainable, fast, and objective artificial intelligence characterisation of cells through deep learning, an easy-to-use, rapid, and cost-effective methodology for finding high-risk lesions is achievable...
September 14, 2023: Journal of Oral Pathology & Medicine
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