Journals Journal of Oral Pathology & Me...

Journal of Oral Pathology & Medicine
Bo Zhang, Lulu Wang, Chang Liu
BACKGROUND: The objective of this study was to evaluate and compare the expression levels of TNF-α, omentin-1, and IL-6 in periodontitis patients before and after treatment with biological antimicrobial peptide (AMP) periodontal gel. METHODS: There involved 86 periodontitis patients admitted to our hospital from January 2020 to March 2021. They were equally and randomly distributed into the study group and the control group. The efficacy and adverse reactions were compared between the two groups after treatment, Additionally, the sulcus bleeding index (SBI), plaque index (PLI), gingival index (GI), periodontal probing depth (PD), and levels of TNF-α, omentin-1, and IL-6 were measured before and after treatment...
March 2024: Journal of Oral Pathology & Medicine
Saman Warnakulasuriya, Lakshman Samaranayake, W M Tillakaratne
No abstract text is available yet for this article.
February 2024: Journal of Oral Pathology & Medicine
Luiz Cláudio Pires Duarte, Karlayle Teixeira, Barbara Magalhães Figueiredo Dias, Felipe Paiva Fonseca, Denise Vieira Travassos, Chané Smit, Maurício Augusto Aquino de Castro, Aline Araujo Sampaio
BACKGROUND: Tongue cancer is associated with debilitating diseases and poor prognostic outcomes. The use of imaging techniques like ultrasonography to assist in the clinical management of affected patients is desirable, but its reliability remains debatable. Therefore, the aim of this study is to investigate the importance of ultrasound use for the clinicopathological management of tongue cancer. METHODS: A scoping review was carried out using specific search strategies in the following electronic databases: PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar...
February 2024: Journal of Oral Pathology & Medicine
Shi-Zhou Deng, Xuechen Wu, Lingshu Kong, Bo Cheng, Lin Dai
BACKGROUND: Ubiquitination, small ubiquitin-related modifiers, and NEDDylation are now found to function in cancer biology; however, its role in the oral cancer patients remains unclear. METHODS: A set of bioinformatic tools was integrated to analyze the expression and prognostic significance of ubiquitin and ubiquitin-like (UB/UBL) genes. A UB/UBL-related risk score was developed via correlation analyses, univariate Cox regression, and multivariate Cox regression...
January 17, 2024: Journal of Oral Pathology & Medicine
Chané Smit, Liam Robinson, Jason Ker-Fox, Felipe Paiva Fonseca, Willie F P van Heerden, André Uys
BACKGROUND: The purpose of the current study was to report on the clinical presentation and radiologic features of 155 cases of ameloblastoma (AB), representing a detailed, large, single-centre radiologic study. METHODS: Histologically confirmed cases were reviewed over 11 years. Demographic and clinical data were retrieved from the patient's records. Radiologic information was analysed from available radiographs. The radiologic features of ABs were assessed according to the mean age of presentation and the mean duration of the lesion...
January 11, 2024: Journal of Oral Pathology & Medicine
Arularasan Anbinselvam, Abdul-Warith O Akinshipo, Akinyele O Adisa, Olajumoke A Effiom, Xinhe Zhu, Kehinde E Adebiyi, Godwin T Arotiba, Sunday O Akintoye
BACKGROUND: Ameloblastoma is an aggressively growing, highly recurrent odontogenic jaw tumor. Its association with BRAFV600E mutation is an indication for BRAFV00E-inhibitor therapy The study objective was to identify a sensitive low-cost test for BRAFV600E-positive ameloblastoma. We hypothesized that immunohistochemical staining of formalin-fixed paraffin-embedded tissues for BRAFV600E mutation is a low-cost surrogate for BRAFV600E gene sequencing when laboratory resources are inadequate for molecular testing...
January 7, 2024: Journal of Oral Pathology & Medicine
Mai Seki, Takaaki Sano, Emi Saito, Masaru Ogawa, Satoshi Yokoo, Tetsunari Oyama
BACKGROUND: Tertiary lymphoid structures (TLSs) are observed in cancer-invasive sites of various organs, and show evidence of tumor-specific B and/or T cells, suggesting an active humoral antitumor response. The aim of this study was to evaluate the relationship between TLSs and prognosis in patients with tongue squamous cell carcinoma (TSCC) after preoperative S-1 chemotherapy. METHODS: Among 196 TSCC cases, 111 patients who received preoperative S-1 chemotherapy were compared to 85 patients who did not receive chemotherapy...
January 6, 2024: Journal of Oral Pathology & Medicine
Karoline Gomes da Silveira, Luiza de Almeida Souto Montenegro, Diana Santana de Albuquerque, Carlos Augusto Pereira do Lago, José Rodrigues Laureano Filho, Ricardo José Holanda de Vasconcellos
BACKGROUND: The aim of the present systematic review was to summarize evidence on odontogenic carcinosarcoma, analyzing clinical, epidemiological, imaging, histopathological, immunohistochemical, therapeutic, and prognostic features of this tumor. MATERIALS AND METHODS: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches were performed in the Ovid MEDLINE (Wolters Kluwer), PubMed (National Library of Medicine), Web of Science (Thomson Reuters), Scopus (Elsevier), and LILACS (Latin American and Caribbean Center on Health Sciences Information) databases, without publication date or language restrictions...
January 1, 2024: Journal of Oral Pathology & Medicine
Paulo Victor Mendes Penafort, André Caroli Rocha, Fernanda Viviane Mariano, Jean Nunes Dos Santos, Márcio Campos Oliveira, Pablo Agustin Vargas, Marcelo Sperandio
BACKGROUND: Ameloblastoma and ameloblastic carcinoma are epithelial odontogenic tumors that can be morphologically similar. In the present study, we evaluated the DNA content and Ki-67 index in the two tumors. METHODS: The paraffin blocks of the tumors were selected to obtain sections for the immunohistochemical reactions and preparation of the cell suspension for acquisition in a flow cytometer. The Random Forest package of the R software was used to verify the contribution of each variable to classify lesions into ameloblastoma or ameloblastic carcinoma...
January 1, 2024: Journal of Oral Pathology & Medicine
Martín Pérez-Leal, Federico Lanciano, Nicla Flacco, Cristina Estornut, María Carmen Carceller
INTRODUCTION: Oral submucous fibrosis (OSMF) is a well-known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high-risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF...
January 2024: Journal of Oral Pathology & Medicine
Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Anna Luíza Damaceno Araújo, Lucas Lacerda de Souza, Maria Inês Mantuani Pascoaloti, Vanessa Fátima Bernardes, Maria Cássia Ferreira Aguiar, Pablo Agustin Vargas, Felipe Paiva Fonseca, Hélder Antônio Rebelo Pontes, Marcio Ajudarte Lopes, Alan Roger Santos-Silva, Tarcília Aparecida da Silva, Patrícia Carlos Caldeira
BACKGROUND: Amyloidosis exhibits a variable spectrum of systemic signs and oral manifestations that can be difficult to diagnose. This study aimed to characterize the clinical, demographic, and microscopic features of amyloidosis in the oral cavity. METHODS: This collaborative study involved three Brazilian oral pathology centers and described cases with a confirmed diagnosis of amyloidosis on available oral tissue biopsies. Clinical data were obtained from medical records...
January 2024: Journal of Oral Pathology & Medicine
Hui Yao, Yiwen Deng, Guanhuan Du, Yufeng Wang, Guoyao Tang
OBJECTIVES: To test the hypothesis that cardiovascular diseases and risk factors are associated with ulcer relapse in after-retirement patients with recurrent aphthous stomatitis. SUBJECTS AND METHODS: This retrospective cohort study analyzed the data of 40 minor recurrent aphthous stomatitis patients aged 55-75 years, admitted to Oral Medicine Clinic at one university hospital in China between 2016 and 2018. The diagnosis of minor recurrent aphthous stomatitis was made based on the history and manifestation of oral ulcers...
January 2024: Journal of Oral Pathology & Medicine
Antonio Celentano
No abstract text is available yet for this article.
December 28, 2023: Journal of Oral Pathology & Medicine
Thomas George Kallarakkal, Zuraiza Mohamad Zaini, Wan Maria Nabillah Ghani, Lee Peng Karen-Ng, B S M S Siriwardena, Sok Ching Cheong, Wanninayake Mudiyanselage Tilakaratne
INTRODUCTION: A major pitfall of many of the established oral epithelial dysplasia (OED) grading criteria is their lack of reproducibility and accuracy to predict malignant transformation. The main objective of this study was to determine whether calibration of practicing oral pathologists on OED grading could improve the reproducibility of the WHO 2017 and the binary OED grading systems. METHODS: A nationwide online exercise was carried out to determine the influence of calibration on the reproducibility of the WHO 2017 and the binary OED grading systems...
December 11, 2023: Journal of Oral Pathology & Medicine
Jonathan Deng, Vaidehi Misra, Neehal Vilash, Wendi Wu, Cindy Hua, Kate Son, Federica Canfora, Fabian Y S Kong, Rita Paolini, Michael McCullough, Antonio Celentano
BACKGROUND: Coffee is one of the most consumed beverages in the world. Containing an abundance of bioactive molecules including polyphenols and flavonoids, the constituents of this beverage may exert antiproliferative, antioxidant and anti-inflammatory effects. METHODS: We conducted a systematic review to summarise the available evidence on the anticancer effects of coffee constituents and their potential therapeutic use for oral squamous cell carcinoma (OSCC). Studies were identified through a comprehensive search of OVID MEDLINE, OVID EMBASE and Web of Science, including articles from any year up to 15 May 2023...
November 13, 2023: Journal of Oral Pathology & Medicine
Lizeth Andrea Torres Torres, Gabriel Silva, Jovelina Samara Ferreira Alves, Tatiane Resende Ushida, Julia Potenza, Cristiana Bernadelli Garcia, Lucas Oliveira Sousa, Norberto Peporine Lopes, Luciana Oliveira Almeida, Andréia Machado Leopoldino
BACKGROUND: Oral squamous cell carcinoma has high recurrence and cisplatin resistance. As cancer stem cells, autophagy, and sphingolipids have been appointed as associated with chemotherapy resistance, we tested combined treatments targeting autophagy and/or sphingolipid metabolism with paclitaxel using cisplatin-resistant oral squamous cell carcinoma cells. METHODS: Cisplatin-resistant oral squamous cell carcinoma cells were maintained under exposition to FTY720 and chloroquine combined with paclitaxel and submitted to viability, clonogenicity, and spheres formation assays...
November 9, 2023: Journal of Oral Pathology & Medicine
Leonor Frey-Furtado, Inês Magalhães, Benedita Sampaio-Maia, Maria João Azevedo
BACKGROUND: Oral mucositis (OM) is a severe and common adverse effect of cancer treatment. The oral microbiome appears to play a role on the onset and severity of OM. Therefore, this systematic review aims to characterize the oral dysbiosis associated with OM. METHODS: The PRISMA checklist was followed and PubMed, Web of Science, and Scopus were screened for clinical studies characterizing the oral microbiome alterations in patients with OM. RESULTS: From a total of 2500 articles retrieved, we included nine articles in this systematic review...
November 2023: Journal of Oral Pathology & Medicine
Xiumei Zhuang, Xiaoxuan Lin, Ruogu Xu, Zhengchuan Zhang, Bin Zhou, Feilong Deng
BACKGROUND: Apoptosis resistance of myofibroblasts is critical in pathology of irradiation-induced fibrosis and osteoradionecrosis of the jaw (ORNJ). However, molecular mechanism of apoptosis resistance induced by irradiation in oral myofibroblasts remains largely obscure. METHODS: Matched ORNJ fibroblasts and normal fibroblasts pairs from gingival were primarily cultured, and myofibroblast markers of α-SMA and FAP were evaluated by qRT-PCR and western blot...
October 24, 2023: Journal of Oral Pathology & Medicine
Ashutosh Kumar Singh, Ragavi Alagarsamy, Rajib Chaulagain, Abanish Singh, Dipak Sapkota, Selvam Thavaraj, Rabindra P Singh
OBJECTIVES: This review aims to analyse the recurrence rate in BRAFv600e+ and BRAFv600e- ameloblastomas and explore its association with clinicopathological variables. METHODS: A comprehensive search was conducted using databases including PubMed, Embase, Cochrane Central Register of Controlled Trials,, Google Scholar and grey literature, without any limitation on start date or language up to 20 June 2023. A random effect meta-analysis was conducted and Metaregression analyses were performed based on available clinicopathological factors...
October 23, 2023: Journal of Oral Pathology & Medicine
Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Felipe da Mata Camargos, Ricardo Santiago Gomez, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Elismauro Francisco Mendonça, Sebastião Silvério Sousa-Neto, Ana Carolina Uchoa Vasconcelos, Sandra Beatriz Chaves Tarquínio, Patrícia Carlos Caldeira
BACKGROUND: This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics. METHODS: Nine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin-eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched...
October 18, 2023: Journal of Oral Pathology & Medicine
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