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Journal of Oral Pathology & Medicine

A E Pilborough, D W Lambert, S A Khurram
Oral squamous cell carcinoma (OSCC) is a significant cause of morbidity and mortality worldwide, and accounts for the majority of head and neck cancers. Metastasis of primary tumours, primarily to cervical lymph nodes in the neck, is associated with worsening prognosis. Furthermore, the prognosis of patients with extranodal extension of metastatic tumour from the lymph nodes into the neck tissues is particularly poor. The factors affecting this process are poorly understood and detection is difficult pre-surgery...
May 14, 2019: Journal of Oral Pathology & Medicine
Zihang Ling, Xi Yang, Xiaobin Chen, Juan Xia, Bin Cheng, Xiaoan Tao
BACKGROUND: Although a few studies suggested that the chemokine CCL2 might be involved in the development of oral squamous cell carcinoma (OSCC), the exact mechanism remains unclear. In this study, we aimed to determine the resource of CCL2 in lesions and explored a potential mechanism that CCL2 promotes tumor progression. The study was an effort to provide new insights into the pathological role of CCL2 in OSCC. METHODS: Specimens of OSCC and normal oral mucosa were stained using immunohistochemistry (IHC) to assess the CCL2 expression...
May 11, 2019: Journal of Oral Pathology & Medicine
Sui-Wai Choi, Peter Thomson
BACKGROUND: Oral squamous cell carcinoma (SCC) is a lethal and deforming disease of rising incidence and global significance; 600,000 new cases are seen each year, including 40,000 in China. Despite advances in management, 50% of patients die within 5 years of diagnosis. Cancer is the leading cause of death in Hong Kong, with the Hong Kong Cancer Registry (HKCR) confirming a 2% increase in new cases each year, and oral SCC the tenth leading cause of cancer death in males. Strategies to improve clinical outcome require identification and early intervention in the 'high-risk' population...
May 9, 2019: Journal of Oral Pathology & Medicine
Vivian P Wagner, Roman Carlos, Mário J Romañach, Marcio A Lopes, Paul M Speight, Pablo A Vargas
The purpose of this study was to perform a systematic review of the literature concerning all documented cases of malignant transformation of craniomaxillofacial fibro-osseous lesions (FOLs). Three electronic databases were searched. Data were evaluated descriptively. Kaplan-Meier survival curves were constructed and compared using the log-rank test. A critical appraisal of included articles was performed through the Joanna Briggs Institute tool. A total 19 studies including 27 patients were selected for data extraction...
May 7, 2019: Journal of Oral Pathology & Medicine
Gargi S Sarode, Nilesh Kumar Sharma, Sachin C Sarode, Shankargouda Patil
We read with great interest an article by Oliva et al.1 Authors studied the clinicopathological and molecular characteristics of oral premalignant lesions (OPL) of non-smoker and smoker patients from which one or multiple oral squamous cell carcinomas (OSCC) have developed. Intriguingly, no molecular differences of OPL and OSCC were found between non-smoker and smoker patients, suggesting that genetic drivers of oral carcinogenesis can be common. This article is protected by copyright. All rights reserved.
May 6, 2019: Journal of Oral Pathology & Medicine
Jorge de la Oliva, Ana-Belen Larque, Carles Marti, Marta Bodalo-Torruella, Lara Nonell, Alfons Nadal, Paola Castillo, Ramón Sieira, Ada Ferrer, Eloy Garcia-Diez, Llucia Alos
BACKGROUND: Oral premalignant lesions (OPML) are frequently extensive and multifocal leading high morbidity for patients. Although oral squamous carcinoma (OSCC) in non-smoker patients is increasing, little is known about OPML and the carcinogenesis process in these patients. The aims of the study were to insight and compare the clinicopathological and molecular characteristics of OPML of non-smoker and smoker patients from which one or multiple OSCC have developed. METHODS: Eighty-one patients showing extensive and/or multifocal OPML were included in the survey...
April 21, 2019: Journal of Oral Pathology & Medicine
Xi Yang, Wei Liu
We read with interest the recent article (jop12683) by Foy et al. [1] entitled "Bibliometric analysis of a century of research on oral erythroplakia and leukoplakia". We congratulate the authors on conducting the first bibliometric analysis on oral erythroplakia and leukoplakia (OEL). The leading journals, authors and countries contributing to the research on OEL were analyzed. Yet, the interest was unfortunately not sustained through the reading for several concerned reasons. To begin with, we arguably provide specific comments on the article...
April 21, 2019: Journal of Oral Pathology & Medicine
Tianjiao Wang, Lin Wang, Huifang Yang, Han Lu, Jianyun Zhang, Nan Li, Chuan-Bin Guo
OBJECTIVES: Oral leukoplakia (OL) is the well-known disorder of oral mucosa, which has potential to be malignant and can lead to squamous cell carcinoma (OSCC). In the following study, we developed a comprehensive nomogram for predicting the malignant progression of OL, based on analysis of clinicopathological variables. MATERIALS AND METHODS: A retrospective analysis of patients diagnosed with OL was performed between 1998 and 2017 at the Peking University School and Hospital of Stomatology...
April 13, 2019: Journal of Oral Pathology & Medicine
Hung-Chih Chen, Yu-Kai Tseng, Chih-Wen Shu, Ta-Jung Weng, Huei-Han Liou, Liang-Ming Yen, I-Chien Hsieh, Cheng-Ching Wang, Pi-Chuan Wu, Yow-Ling Shiue, Ting-Ying Fu, Kuo-Wang Tsai, Luo-Ping Ger, Pei-Feng Liu
BACKGROUND: Type V collagen (COL5), in the functional heterotrimer [α1(V)2 α2(V)] isoform, participates in the malignancies of various cancers. However, its role in tongue squamous cell carcinoma (TSCC) remains unclear. MATERIALS AND METHODS: The expression levels of COL5A1 and COL5A2 polypeptide chains were examined using the tissue microarray from 245 TSCC patients with immunohistochemistry. Paired t-test and Wilcoxon signed-rank test were performed for comparisons among the groups...
April 10, 2019: Journal of Oral Pathology & Medicine
Eugene Ko
The aim of this systematic review was to address the clinicopathologic inconsistencies noted with primary oral leiomyosarcoma in the literature by amassing the available data published into a comprehensive analysis. Eligibility criteria included publications of cases with dedicated immunohistochemical work-up along with radiographs to evaluate location. Based on these criteria, the systematic review compiled 29 cases. Four primary location sites were identified in the reported cases: soft tissue presentation only, soft tissue with bony involvement, bony involvement only, and bony involvement with a soft tissue component...
April 8, 2019: Journal of Oral Pathology & Medicine
Mario Pérez-Sayáns, Andrés Blanco-Carrión, Monica G Oliveira Alves, Janete Dias De Almeida, A L Ambinder, Irene Lafuente-Ibáñez de Mendoza, José Manuel Aguirre-Urízar
BACKGROUND: Lipomas are benign neoplasms derived from adipose tissue that are unfrequently found in the oral cavity. The objective of this study is to identify the main clinicopathological characteristics of this tumour in a case series of oral lipomas (OL) in a population from Spain and Brazil. MATERIAL AND METHODS: A multicentre retrospective observational study was conducted in collaboration with the Oral Pathology Unit of the State University Universidade Estadual Paulista Filho de Mesquita (UNESP) in Brazil, and the Oral Medicine and Pathology Units of the University of Santiago de Compostela (USC) and the University of the Basque Country (UPV/EHU) in Spain...
April 8, 2019: Journal of Oral Pathology & Medicine
Jiameng Liu, Shan Chen, Yang Chen, Ningbo Geng, Chongjin Feng
BACKGROUND: The aim of this study was to ascertain the expression and role of FMNL3 in tongue squamous cell carcinoma (TSCC) tissues. MATERIALS AND METHODS: Immunohistochemistry, qRT-PCR and western blot were used to study the expression of FMNL3 in TSCC tissues and its adjacent normal tissues. The relationship between FMNL3 overexpression and various clinicopathological parameters and patients' survival were further assessed. Next, we applied SCC25 and UM1 cell lines to study the effect of FMNL3 on tumor cell proliferation, migration and invasion by silencing FMNL3...
April 7, 2019: Journal of Oral Pathology & Medicine
Nan Xie, Pei Yu, Haichao Liu, Xiqiang Liu, Jinsong Hou, Xiaohua Chen, Hongzhang Huang, Cheng Wang
BACKGROUND: Tumor budding is a valuable prognostic marker in oral tongue squamous cell carcinoma (OTSCC) but lacks a standardized scoring system. The aim of this study is to evaluate the prognostic value of tumor budding for OTSCC patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016. METHODS: Tumor budding was scored as ITBCC recommended in 255 patients with OTSCC. Then, associations between tumor budding and clinicopathologic parameters were examined...
March 30, 2019: Journal of Oral Pathology & Medicine
Ciro Dantas Soares, Thayná Melo de Lima Morais, Fernanda Viviane Mariano, Albina Altemani, Marcelo Brum Corrêa, Rodrigo Ribas Dias Dos Reis, Luciana Schultz Amorim, Sonia Maria Soares Ferreira, Oslei Paes de Almeida, Roman Carlos, Jacks Jorge
BACKGROUND: Head and neck mucosal melanomas (MMs) are rare tumors with adverse outcomes and poorer prognoses than their more common cutaneous counterparts (cutaneous melanomas-CMs). Few studies have compared the expression of mitochondrial dynamic markers in these tumors. This study aimed to access the correlations of mitochondrial markers with melanoma progression and their potential as predictors of lymph node involvement and distant metastasis. METHODS: Immunohistochemistry against anti-mitochondrial (AMT), dynamin-related protein 1 (DRP1), mitochondrial fission protein 1 (FIS1), mitofusin-1 (MFN1) and mitofusin-2 (MFN2) antibodies was performed in 112 cases of head and neck CM and MM...
March 27, 2019: Journal of Oral Pathology & Medicine
Shankargouda Patil, Kamran Habib Awan, Gururaj Arakeri, Chaminda Jayampath Seneviratne, Nagaraj Muddur, Shuaib Malik, Marco Ferrari, Peter A Brenann
BACKGROUND: Machine learning (ML) is powerful tool that can identify and classify patterns from large quantities of cancer genomic data that may lead to the discovery of new biomarkers, new drug targets, and a better understanding of important cancer genes. The aim of this systematic review was to evaluate the existing literature and assess the application of machine learning of genomic data in head and neck cancer (HNC). MATERIALS AND METHODS: The addressed focused question was "Does machine learning of genomic data play a role in prognostic prediction of HNC?" PubMed, EMBASE, Scopus, Web of Science, and grey literature from January 1990 up to and including May 2018 were searched...
March 25, 2019: Journal of Oral Pathology & Medicine
Rachel S Oeppen, Capt Mike Davidson, Duncan S Scrimgeour, Siavash Rahimi, Peter A Brennan
Multi-disciplinary team (MDT) meetings are widely used throughout medicine and dentistry, bringing together expertise and different opinions across many disciplines to benefit patient care. Depending on the cancer site and specialties involved, some MDTs can last for several hours, especially if there are many complex patients to discuss. However, concentration and attention can vary and distraction is almost inevitable with separate conversations between MDT members and the ever-increasing use of smartphones...
March 25, 2019: Journal of Oral Pathology & Medicine
Kyu-Young Oh, Sung-Dae Cho, Hye-Jung Yoon, Jae-Il Lee, Sun-Ha Ahn, Seong-Doo Hong
BACKGROUND: BRAF V600E mutations are activating mutations that have recently been detected in ameloblastoma. However, their prevalence has not been reported in East Asian patients with ameloblastoma and their clinicopathological significance remains unclear. In this study, we examined the prevalence and clinicopathological significance of BRAF V600E mutations in Korean patients with ameloblastoma. In addition, we investigated the relationship between BRAF V600E mutations and epithelial-mesenchymal transition, which has not been studied in ameloblastoma...
March 19, 2019: Journal of Oral Pathology & Medicine
Shankargouda Patil, Abdul Wahab H Alamir, Gururaj Arakeri, Kamran Habib Awan, Shilpa H Bhandi, Abdulsalam Aljabab, Nagaraj Maddur, Ricardo S Gomez, Peter A Brennan
INTRODUCTION: Shammah is a form of smokeless tobacco commonly used in the Arabian Peninsula. The data on the harmful effects of shammah on oral health, particularly oral malignancies is scarce. The aim of this review was to explore the association between shammah use and development of oral potentially malignant disorders (OPMD) and/or oral cancer. MATERIALS AND METHODS: PubMed, EMBASE, Scopus, Web of Science and grey literature from January 1990 up to and including April 2018 were searched...
March 18, 2019: Journal of Oral Pathology & Medicine
Jessica Maldonado-Mendoza, Velia Ramírez-Amador, Gabriela Anaya-Saavedra, Erika Ruíz-García, Héctor Maldonado-Martínez, Edith Fernández Figueroa, Abelardo Meneses-García
BACKGROUND: Mutations on KIT and downstream genes of MAPK pathway that overstimulate cellular proliferation has been associated with primary oral and sinonasal melanomas (POSNM); but there is limited information that allows the use of personalized therapy. Thus, the aim of the present study was to determine a possible association between the C-KIT immune histochemical expression with the presence of somatic driver mutations in NRAS, BRAF, KIT, MITF, and PTEN on POSNM. METHODS: A retrospective study that included 62 tumor samples of an oncological reference center in Mexico City (17-years period)...
March 15, 2019: Journal of Oral Pathology & Medicine
Paolo G Arduino, Roberto Broccoletti, Mario Carbone, Alessio Gambino, Veronica Sciannameo, Davide Conrotto, Marco Cabras, Savino Sciascia, Fulvio Ricceri, Simone Baldovino, Marco Carrozzo
BACKGROUND: Despite the frequency of oral involvement, there are unexpectedly few studies of either on the oral manifestations of pemphigus or their long-term management, and diagnostic delay in Dentistry is frequent. METHODS: We have examined outcome of patients presenting with predominantly oral pemphigus vulgaris (PV). Ninety-eight subjects were followed up for 85.12 months and treated with systemic steroids: 48 of them received adjunctive therapy with azathioprine, 16 with rituximab, 13 with mycophenolate mofetil, three with immunoglobulin and one with dapsone...
March 12, 2019: Journal of Oral Pathology & Medicine
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