Dandara Andrade de Santana, Poliana Ramos Braga, Cláudia Malheiros Camillo-Coutinho, Valéria Souza Freitas, Patrícia Ramos Cury, Daniel Araki Ribeiro, Iguaracyra Barreto de Araújo, Flávia Caló de Aquino Xavier, Jean Nunes Dos Santos
BACKGROUND: Transcription factors are important in the epithelial-mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype. Thus, the objective of this study was to analyze the expression and identify the localization of cellular markers related to the epithelial-mesenchymal transition process in salivary gland tumors. STUDY DESIGN: The expression and localization of E-CADERIN, N-CADERIN, SLUG, SNAIL, and TWIST were evaluated, using immunohistochemistry, in 48 salivary gland tumors, being 17 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 17 mucoepidermoid carcinomas (MEC)...
February 13, 2024: Journal of Oral Pathology & Medicine