Journals Journal of Oral Pathology & Me...

Journal of Oral Pathology & Medicine
Xiangjian Wang, Shenjie Xu, Tao Fu, Yang Wu, Weilian Sun
BACKGROUND: Programmed cell death ligand 1 (PD-L1) and human leukocyte antigen/major histocompatibility complex (HLA/MHC) are two main kinds of immunophenotypes affecting the susceptibility to anti-PD therapy. Our previous study found that down-regulation of flap endonuclease-1 (FEN1) could not only inhibit PD-L1 expression, but also upregulate HLA expression in head and neck squamous cell carcinoma (HNSCC). We aimed to clarify whether downregulating FEN1 cloud enhance the response to PD-1 blockade, and possible mechanisms in HNSCC in vitro...
September 20, 2023: Journal of Oral Pathology & Medicine
Peter A Brennan
No abstract text is available yet for this article.
September 18, 2023: Journal of Oral Pathology & Medicine
Anna Luíza Damaceno Araújo, Viviane Mariano da Silva, Matheus Cardoso Moraes, Henrique Alves de Amorim, Felipe Paiva Fonseca, Maria Sissa Pereira Sant'Ana, Ricardo Alves Mesquita, Bruno Augusto Linhares Almeida Mariz, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Cristina Saldivia-Siracusa, Syed Ali Khurram, Alexander T Pearson, Manoela Domingues Martins, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Luiz Paulo Kowalski, Alan Roger Santos-Silva
BACKGROUND: Dysplasia grading systems for oral epithelial dysplasia are a source of disagreement among pathologists. Therefore, machine learning approaches are being developed to mitigate this issue. METHODS: This cross-sectional study included a cohort of 82 patients with oral potentially malignant disorders and correspondent 98 hematoxylin and eosin-stained whole slide images with biopsied-proven dysplasia. All whole-slide images were manually annotated based on the binary system for oral epithelial dysplasia...
September 15, 2023: Journal of Oral Pathology & Medicine
Daniela Giraldo-Roldan, Erin Crespo Cordeiro Ribeiro, Anna Luiza Damaceno Araújo, Paulo Victor Mendes Penafort, Viviane Mariano da Silva, Jeconias Câmara, Hélder Antônio Rebelo Pontes, Manoela Domingues Martins, Márcio Campos Oliveira, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Luiz Paulo Kowalski, Matheus Cardoso Moraes, Pablo Agustin Vargas
BACKGROUND: Odontogenic tumors (OT) are composed of heterogeneous lesions, which can be benign or malignant, with different behavior and histology. Within this classification, ameloblastoma and ameloblastic carcinoma (AC) represent a diagnostic challenge in daily histopathological practice due to their similar characteristics and the limitations that incisional biopsies represent. From these premises, we wanted to test the usefulness of models based on artificial intelligence (AI) in the field of oral and maxillofacial pathology for differential diagnosis...
September 15, 2023: Journal of Oral Pathology & Medicine
Jan-Michaél Hirsch, Ronak Sandy, Bengt Hasséus, Joakim Lindblad
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a widespread disease with only 50%-60% 5-year survival. Individuals with potentially malignant precursor lesions are at high risk. METHODS: Survival could be increased by effective, affordable, and simple screening methods, along with a shift from incisional tissue biopsies to non-invasive brush biopsies for cytology diagnosis, which are easy to perform in primary care. Along with the explainable, fast, and objective artificial intelligence characterisation of cells through deep learning, an easy-to-use, rapid, and cost-effective methodology for finding high-risk lesions is achievable...
September 14, 2023: Journal of Oral Pathology & Medicine
Jijun Chen, Liang Wang, Danhua Ma, He Zhang, Jiayan Fan, Hongyan Gao, Xinyu Xia, Wei Wu, Yuyuan Shi
BACKGROUND: In this study, we aimed to investigate the potential of miR-19a as a biomarker of OSCC and its underlying molecular mechanisms. METHODS: We collected serum and saliva samples from 66 OSCC patients and 66 healthy control subjects. Real-time PCR analysis, bioinformatic analysis and luciferase assays were performed to establish a potential signaling pathway of miR-19a/GRK6/GPCRs/PKC. Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and invasion...
September 14, 2023: Journal of Oral Pathology & Medicine
Ke Yang, Guixin Zhu, Yanan Sun, Yaying Hu, Yinan Lv, Yiwei Li, Juncheng Pan, Fu Chen, Yi Zhou, Jiali Zhang
BACKGROUND: We aimed to establish image recognition and survival prediction models using a novel scoring system of cyclin D1 expression pattern in patients with human papillomavirus-negative oral or oropharyngeal squamous cell carcinoma. METHODS: The clinicopathological data of 610 patients with human papillomavirus-negative oral/oropharyngeal squamous cell carcinoma were analyzed retrospectively. Cox univariate and multivariate risk regression analyses were performed to compare cyclin D1 expression pattern scoring with the traditional scoring method-cyclin D1 expression level scoring-in relation to patients' overall and progression-free survival...
September 13, 2023: Journal of Oral Pathology & Medicine
Yingchun Qie, Xia Sun, Yongqiang Yang, Tao Yan
Oral squamous cell carcinoma is the most common phenotype in pathology, which accounts for 80% of all oral cancers. The therapeutic methods of oral squamous cell carcinoma include surgical excision, chemotherapy, and radiotherapy. Whereas, the high recurrence rate and poor prognosis lead to a 5-year survival rate less than 50%. In order to explore more therapeutic strategies of oral squamous cell carcinoma, the relevant risk factors, mechanisms, and diagnostics are widely detected. The various exosome-mediated biological effects on the development of oral squamous cell carcinoma have drawn lots of attention...
September 13, 2023: Journal of Oral Pathology & Medicine
Dipti Sharma, Sagar N Pawar, Prasad Sulkshane, Rohit Waghole, Mohd Yasser, Sushil S Pawar, Sadhana Kannan, Nazia Chaudhary, Anjali Kalwar, Rahul Patil, Sudhir Nair, Sorab N Dalal, Tanuja Teni
BACKGROUND: Translationally controlled tumour protein (TCTP) is a multifunctional protein elevated in multiple cancers. However, studies on its role in oral carcinogenesis and prognosis are rare. We recently reported the role of its interacting partner, MCL1, in oral cancer progression and outcome. Hence, the present study aimed to assess TCTP expression in oral tumorigenesis and its association with patient outcomes alone and in combination with MCL1. METHODS: TCTP expression was assessed by immunohistochemistry and immunoblotting in oral tissues and cells, respectively...
August 13, 2023: Journal of Oral Pathology & Medicine
R Keerthika, Mala Kamboj, Akhil Girdhar, Anjali Narwal, Anju Devi, Rahul Anand, Manish Juneja
OBJECTIVE: Angiogenesis plays a vital role at the molecular level in various inflammatory lesions, that lead to their chronicity. Oral lichen planus is an immune-mediated chronic inflammatory disorder. The angiogenetic role and exact mechanisms in oral lichen planus are still unclear due to a dearth of studies. Its clinical significance with angiogenesis also requires further elucidation necessitating a thorough review of the studies that have been conducted so far. The present review was designed to identify the dependence of oral lichen planus progression on angiogenesis which could aid in devising metronomic treatments required to halt the progression of this disease...
August 8, 2023: Journal of Oral Pathology & Medicine
Shan Wang, Yingying Hong, Jiafei Qu, Jianyun Zhang, Yuhao Zhang, Jiemei Zhai, Tiejun Li
BACKGROUND: Odontogenic keratocysts (OKCs) are odontogenic jaw lesions that cause destruction and dysfunction of the jawbone. OKCs can be sporadic or associated with nevoid basic cell carcinoma syndrome (NBCCS). However, the factors that initiate OKCs and the mechanism of cyst formation remain unclear. Here, we investigated the impact of PTCH1 and SMO mutations on disease progression, as well as the effects of sonic hedgehog (SHH) signaling pathway inhibitors GDC-0449 and GANT61 on OKC fibroblasts...
August 8, 2023: Journal of Oral Pathology & Medicine
Fernando Galvão, Michele Patricia Rode, Paloma Santos de Campos, Gisele Eva Bruch, Virgínia Mendes Carregal, André Ricardo Massensini, Bibiana Franzen Matte, Marcelo Lazzaron Lamers, Tânia Beatriz Creczynski-Pasa, Ionara Rodrigues Siqueira
BACKGROUND: Considering that microRNAs (miRNAs), extracellular vesicles and particles (EVPs) and the amyloid precursor protein (APP) processing have been shown to be altered in oral squamous cells carcinoma (OSCC), it is possible that miRNAs that target APP processing pathways in EVPs are impacted in tumor cells. Our aim was to evaluate miRNAs that target APP itself or disintegrin and metalloproteinase domain 10 (ADAM10), which generate a trophic compound, sAPPα, in EVPs derived from OSCC cell lines, an aggressive and non-invasive, compared to normal keratinocytes...
August 7, 2023: Journal of Oral Pathology & Medicine
Michele Lodolo, Burinrutt Thanasuwat, Piri Veluppillai, Gus Bassani, Alessandro Villa
BACKGROUND: Mucolox™ is a mucosal drug delivery system that prolongs the contact time between the oral mucosa and topical corticosteroids, potentially reducing the need for multiple applications daily. This study aimed to assess the clinical efficacy and tolerability of dexamethasone 0.5 mg/5 mL solution in Mucolox™ for the management of oral inflammatory ulcerative diseases. METHODS: Participants were randomly assigned to receive dexamethasone 0...
August 7, 2023: Journal of Oral Pathology & Medicine
Xi-Qian Wang, Nian-Nian Zhong, Qi-Wen Man, Guang-Cai Xu, Si-Chen Yan, Li-Wei Peng, Yong-Gong Wang, Bing Liu, Lin-Lin Bu, Li Li
BACKGROUND: Salivary gland pleomorphic adenoma (SPA) is a common neoplasm of salivary glands that displays remarkable histological diversity. Previous studies have demonstrated the involvement of gene rearrangements and cytoskeleton-remodeling-related myoepithelial cells in SPA tumorigenesis. Cytoskeleton remodeling is necessary for epithelial-mesenchymal transition (EMT), a key process in tumor progression. However, the heterogeneity of tumor cells and cytoskeleton remodeling in SPA has not been extensively investigated...
August 7, 2023: Journal of Oral Pathology & Medicine
Khin Mya Tun, Nakarin Kitkumthorn, Dusit Bumalee, Tawepong Arayapisit, Puangwan Lapthanasupkul
BACKGROUND: PEA3 transcription factor has been identified as a downstream target of the MAPK and PI3K pathways, and PEA3 overexpression has been observed in a variety of tumor types. We aimed to evaluate PEA3 expression in odontogenic cysts and tumors and compare the expression among odontogenic lesions. In addition, the correlations between PEA3 expression and clinicopathological characteristics of conventional ameloblastoma and unicystic ameloblastoma were investigated. METHODS: This study was performed on 165 samples of odontogenic cysts and tumors including 20 dentigerous cysts, 20 odontogenic keratocysts, 16 adenomatoid odontogenic tumors, 5 ameloblastic fibromas, 45 unicystic ameloblastomas, and 59 conventional ameloblastomas...
August 7, 2023: Journal of Oral Pathology & Medicine
Giuseppe Perlangeli, Giovanni Lilloni, Giulia Salti, Andrea Ferri, Silvano Ferrari, Tito Poli
BACKGROUND: Oral squamous cell carcinoma (OSCC) treatment is based largely on the TNM stage. The eighth edition includes important new prognostic parameters (extranodal extension and depth of invasion), while it does not consider tumour molecular characteristics or minor invasion criteria (perineural and lymphovascular invasion, grading and resection margins). This study evaluated how well the TNM eighth edition predicts the biological behaviour of OSCC, considering survival and risk of locoregional recurrence...
August 1, 2023: Journal of Oral Pathology & Medicine
Martha Carnalla, Rosalba Rojas-Martínez, Tonatiuh Barrientos-Gutiérrez, Betania Allen-Leigh, Leith León-Maldonado, Lourdes Gutiérrez-Xicoténcatl, Alejandra J Portillo-Romero, Alan G Nyitray, Jorge Salmerón, Anna R Giuliano, Eduardo Lazcano-Ponce
BACKGROUND: Men who have sex with men (MSM) are at high risk for oral human papillomavirus (HPV infection). There are no specific screening guidelines to facilitate the identification of people at risk for oral HPV infection. We aimed to estimate the prevalence of oral high-risk HPV and create a risk score to identify MSM at higher risk for prevalent oral HPV. METHODS: We collected baseline data from a clinical trial from a subsample of 500 MSM attending sexually transmitted disease treatment clinics; they provided an oral gargle sample for high-risk HPV detection...
July 31, 2023: Journal of Oral Pathology & Medicine
Yixin Xu, Yixin Wang, Hui Xiao, Yongming Li
BACKGROUND: Oral breathing has an important impact on morphology and bone mineral density (BMD) in a mandible. This study aimed to investigate the hub genes and mechanism regulating the mandibular BMD decrease induced by nasal obstruction. METHODS: A unilateral nasal obstruction model was established in 1-week-old Wistar rats by electrocautery obstruction. BMD of the mandible was determined by micro-computed tomography. Transcriptome analysis was performed to identify differentially expressed genes (DEGs)...
July 25, 2023: Journal of Oral Pathology & Medicine
Mohammad S Alrashdan, Natheer H Al-Rawi, Yazan Hassona, Sausan Al Kawas, Nicola Cirillo
The predilection for women in systemic autoimmune diseases is well established. However, this sex bias in oral autoimmune diseases has been classically reported from an epidemiological perspective without any elaborate attempts to unveil the underlying mechanisms. The unique nature of the oral environment is likely to impose a combination of systemic and local factors that ultimately result in the sex bias in autoimmune diseases of the oral cavity. Variations of immune responses, target organ vulnerability, endocrine and genetic factors, sex chromosomes and modes of parental inheritance are potential systemic factors, while the oral microbiome, oral tolerance, saliva, and oral epithelial stem cells may account for local contributing factors...
July 14, 2023: Journal of Oral Pathology & Medicine
Rita R Roy, Takanaga Ochiai, Katsumitsu Shimada, Hiromasa Hasegawa
BACKGROUND: Odontogenic keratocysts constitute 10%-20% of odontogenic cysts and exhibit a distinctive corrugated parakeratinized lining epithelium. Considering that cornified envelope formation is an important phenomenon during keratinocyte differentiation, this study aimed to clarify the characteristics of cornified envelope formation in odontogenic keratocysts. METHODS: We investigated the cellular distribution of cornified envelope-related proteins (transglutaminases and their substrates), as well as the upstream regulatory protein c-Fos, by immunohistochemical analysis of the lining epithelium of 20 odontogenic keratocysts...
July 12, 2023: Journal of Oral Pathology & Medicine
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