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International Journal of Immunopathology and Pharmacology

Jiajing Luo, Yi Chen, Chengjia Ding, Jialing Qiu, Yulan Chen, Youping Lin, Lei Su, Dongxin Jiang
The purpose of this study was to focus on the underlying relationship between the hyperactivity for the peripheral monocytes and heat stroke by investigating the inflammatory oxidative activity of and the expression of superficial molecules. Peripheral blood samples were collected from 10 healthy adult volunteers. Human blood monocytes were isolated by density gradient centrifugation and sequent adherent culture. The objectives were divided into four groups: 43°C heat stress combined with lipopolysaccharide (LPS) group, 43°C heat stress group, LPS group, and control group...
January 2019: International Journal of Immunopathology and Pharmacology
Sufang Tian, Shu-Yuan Xiao, Qiongrong Chen, Huan Liu, Jie Ping
There is a significant overlap between intestinal lymphoproliferative disorders (LPDs) and inflammatory conditions of the intestine, including inflammatory bowel disease (IBD), in clinical, endoscopic, or histologic appearance, leading to diagnostic challenges. We report two cases of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) that were initially considered to be ulcerative colitis (UC) and lymphocytic colitis, respectively. Both patients presented with diarrhea and abdominal pain. Colonoscopy revealed hyperemia and scattered shallow ulcerations in the colon, without obvious mass...
January 2019: International Journal of Immunopathology and Pharmacology
Alessandro De Stefano, Liliana Mannucci, Federica Tamburi, Carmine Cardillo, Francesca Schinzari, Valentina Rovella, Steven Nisticò, Luigi Bennardo, Nicola Di Daniele, Manfredi Tesauro
Metabolic diseases are chronic disorders correlated to a greater risk of cardiovascular event and death. Recently, many data have sustained the biological link between microvascular dysfunction, oxidative stress, vascular inflammation, and metabolic diseases. The determination of new and specific blood biomarkers of vascular inflammation associated with obesity-related metabolic syndrome (MetS) and diabetes such as lipoprotein-associated phospholipase A2 (Lp-PLA2 ) could be useful to identify subject with high risk of cardiovascular events...
January 2019: International Journal of Immunopathology and Pharmacology
Marinella Tedesco
Folliculitis decalvans is a rare clinical disorder classified as primary neutrophilic scarring alopecia with a slight preference for the male gender. Here, we report the use of autologous fat transplantation as a source of stem cell therapy for hair re-growth assisted by inflammatory action of the fat itself in a female patient. The patient underwent adipose transplantation in April and September 2017. After treatments, the patient had no new pustules and no longer had pain or burning sensation in the affected area...
March 2018: International Journal of Immunopathology and Pharmacology
Naheed Akhtar, Muhammad Akram, Muhammad Daniyal, Saeed Ahmad
Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats...
March 2018: International Journal of Immunopathology and Pharmacology
Genglong Zhu, Xialei Liu, Haijing Li, Yang Yan, Xiaopeng Hong, Zhidong Lin
Liver cancer is one of the most common and lethal cancers in human digestive system, which kills more than half a million people every year worldwide. This study aimed to investigate the effects of kaempferol, a flavonoid compound isolated from vegetables and fruits, on hepatic cancer HepG2 cell proliferation, migration, invasion, and apoptosis, as well as microRNA-21 (miR-21) expression. Cell viability was detected using cell counting kit-8 (CCK-8) assay. Cell proliferation was measured using 5-bromo-2'-deoxyuridine (BrdU) incorporation assay...
March 2018: International Journal of Immunopathology and Pharmacology
Changlei Yao, Hongfa Li, Weitao Zhang
Benign prostatic hypertrophy (BPH) has become a troublesome disease for elder men. Triptolide (TPL) has been reported to be a potential anticancer agent. However, the potential effects of TPL on BPH have not been shown out. BPH-1 cells were treated with different concentrations of TPL and/or transfected with microRNA-218 (miR-218) inhibitor, pc-survivin, sh-survivin, or their corresponding controls (NC). Thereafter, cell viability was determined by CCK-8 assay. Cell migration was accessed by modified two-chamber migration assay...
March 2018: International Journal of Immunopathology and Pharmacology
Elena De Vecchi, Carlo Luca Romanò, Roberta De Grandi, Laura Cappelletti, Francesca Villa, Lorenzo Drago
Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified. Despite the important steps forward, identification of a gold standard has not yet been identified. In this study, usefulness of alpha defensin, leukocyte esterase, C-reactive protein (CRP), and white blood cells (WBCs) in synovial fluids alone and in combination for diagnosis of prosthetic joint infection was evaluated...
March 2018: International Journal of Immunopathology and Pharmacology
Andrea Ciorba, Virginia Corazzi, Chiara Bianchini, Claudia Aimoni, Stefano Pelucchi, Piotr Henryk Skarżyński, Stavros Hatzopoulos
Autoimmune inner ear disease (AIED) has been defined as a condition of bilateral sensorineural hearing loss (SNHL), caused by an 'uncontrolled' immune system response. The inner ear can be the direct target of the immune response, but it can be additionally damaged by a deposition of circulating immune complexes or by systemic immune-mediated diseases. The clinical expression of immune-mediated inner ear disease shows a progressive bilateral and asymmetric SNHL profile, which typically benefits from a steroid and immunosuppressive therapy...
March 2018: International Journal of Immunopathology and Pharmacology
Guohua Sun, Shuxian Qu, Siyi Wang, Ying Shao, Jingsong Sun
Acrylamide (ACR), formed during the Maillard reaction induced by high temperature in food processing, is one of the main causes of neurodegenerative diseases. Taurine, a free intracellular β-amino acid, is characterized by many functions, including antioxidation, anti-inflammatory, and neuroprotective properties. This promotes its application in the treatment of neurodegenerative diseases. In this study, the neuroprotective effects of taurine against ACR-induced neurotoxicity and the potential underlying mechanisms were explored...
January 2018: International Journal of Immunopathology and Pharmacology
Sara Torretta, Michele Gaffuri, Tullio Ibba, Pasquale Capaccio, Paola Marchisio, Antonella Maruca, Samantha Bosis, Lorenzo Pignataro
Non-tuberculous mycobacterial lymphadenitis (NTML) accounts for about 95% of the cases of head-and-neck mycobacterial lymphadenitis, and its prevalence has been increasing in the Western world. The diagnostic work-up can be challenging, and differential diagnoses such as tuberculous and suppurative lymphadenitis need to be considered. It may, therefore, not be diagnosed until the disease is in a late stage, by which time it becomes locally destructive and is characterized by a chronically discharging sinus...
January 2018: International Journal of Immunopathology and Pharmacology
Ling Li, Jun Qian, Ying Zhou, Yubao Cui
Allergies to various environmental factors, in particular mite species, represent a considerable healthcare burden with lost productivity resulting from symptoms including asthma, conjunctivitis, rhinitis, and atopic dermatitis. The complexity of mite species and the allergens that they produce complicates diagnosis and treatment; however, the advent of recombinant DNA technologies now allows clinicians to better pinpoint the specific sensitizing agents and creates new opportunities for avoidance or immunotherapy...
January 2018: International Journal of Immunopathology and Pharmacology
Roald Omdal, Inger Marie Skoie, Tore Grimstad
Chronic fatigue is a common phenomenon in inflammatory and autoimmune conditions, in cancer, and in neurodegenerative diseases. Although pain and psychological factors influence fatigue, there is an increasing understanding that there is a genetic basis, and that activation of the innate immune system is an essential generator of fatigue. Mast cells are important actors in innate immunity and serve specialized defense responses against parasites and other pathogens. They are also major effector cells in allergic reactions...
January 2018: International Journal of Immunopathology and Pharmacology
Manuele Casale, Antonio Moffa, Michele Cassano, Francesco Carinci, Michele Antonio Lopez, Eleonora Maria Consiglia Trecca, Sara Torretta, Vittorio Rinaldi, Lorenzo Pignataro
Saline nasal irrigations (SNIs) are often recommended as an additional non-pharmacological treatment for adults with chronic rhinosinusitis (CRS), for which it could even be considered a first-line treatment. However, there is a wide range of different SNI protocols. The aim of this article is to review the published literature regarding all of the potential therapeutic effects of SNIs in adult CRS patients who had not undergone sinus surgery and clarify the role of the various saline nasal solutions and protocols (particularly the volume, frequency and duration of treatment), and describe the nasal devices used...
January 2018: International Journal of Immunopathology and Pharmacology
Zhimin Hao, Sufen Yang
Rhabdomyosarcoma arising in abdomen and pelvis is an uncommon but important type of soft tissue sarcoma, posing a great challenge for clinicians. Sporadic cases of intra-abdominal rhabdomyosarcoma were reported, but mostly in pediatrics. We demonstrated a rare case of primary abdominopelvic rhabdomyosarcoma in an elderly woman who presented with a notable increase in abdominal circumference and constipation. Abdominal magnetic resonance imaging showed a huge mass throughout the abdomen and pelvis. Cytoreductive surgery was performed by gynecologists due to the suspicious diagnosis of disseminated leiomyosarcoma...
January 2018: International Journal of Immunopathology and Pharmacology
S Di Carlo, F De Angelis, E Brauner, D Rosella, P Papi, G Pompa, L Saptefrati, A M Cimpian, G Ciobanu
The purpose of the study was to perform an immunohistochemical and histological evaluation of samples taken from different bone regeneration procedures in atrophic human mandible. 30 patients (15 men and 15 women, age range of 35-60 years), non-smokers, with good general and oral health were recruited in this study and divided into three groups. The first group included patients who were treated with blood Concentration Growth Factors (bCGF), the second group included patients who were treated with a mixture of bCGF and autologous bone, while the third group of patients was treated with bCGF and tricalcium phosphate/hydroxyapatite (TCP-HA)...
January 2018: International Journal of Immunopathology and Pharmacology
Haijun Wang, Guobin Song, Haoyu Chuang, Chengdi Chiu, Ahmed Abdelmaksoud, Youfan Ye, Lei Zhao
Fibrosis is formed after injury in most of the organs as a common and complex response that profoundly affects regeneration of damaged tissue. In central nervous system (CNS), glial scar grows as a major physical and chemical barrier against regeneration of neurons as it forms dense isolation and creates an inhibitory environment, resulting in limitation of optimal neural function and permanent deficits of human body. In neurological damages, glial scar is mainly attributed to the activation of resident astrocytes which surrounds the lesion core and walls off intact neurons...
January 2018: International Journal of Immunopathology and Pharmacology
Mamdooh H Ghoneum, Takeshi Ogura, James K Gimzewski, Aya D Ghoneum, Michael C Henary, Sudhanshu Agrawal
Marina crystal minerals (MCM) are a mixture that contains crystallized minerals along with trace elements extracted from seawater. It is a nutritional supplement that is capable of enhancing natural killer (NK) cell activity and increasing T and B cell proliferation in humans post ingestion. However, its effect on dendritic cells (DCs), the cells that bridge innate and adaptive immunity, is not yet known. In this study, we examine the stimulatory effects of MCM on DCs' maturation and function in vitro. Human monocyte-derived DCs were treated with MCM at two different concentrations (10 and 20 µg/mL) for 24 h...
January 2018: International Journal of Immunopathology and Pharmacology
Natalia Ukleja-Sokołowska, Robert Zacniewski, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Kinga Lis, Łukasz Sokołowski, Rafał Adamczak, Zbigniew Bartuzi
Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumption of various kinds of foods - peach, pancakes with cottage cheese and fruit, a meal from a Chinese restaurant - all eaten on other occasions without symptoms. During diagnosis, skin prick tests were negative for all tested allergen extracts (both inhalatory and food) from Allergopharma...
January 2018: International Journal of Immunopathology and Pharmacology
Mohamed L Salem, Sabry A El-Naggar, Heba A Mahmoud, Rehab M Elgharabawy, Abeer M Bader
Although the majority of cancers respond to chemotherapy, most cancer types relapse, at least in part, due to the poor immunogenicity of most tumor. We have reported before that treatment of tumor bearing mice with a combination of the anti-cancer chemotherapy cyclophosphamide (CTX) and immunotherapy can result in complete tumor regression using T-cell receptor (TCR) transgenic CD8+ T cells specific to antigens. This study aimed to determine whether chemotherapy can cure immunogenic tumor which expresses non-self-tumor antigen and result in antitumor immunity...
January 2018: International Journal of Immunopathology and Pharmacology
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