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Journals International Journal of Immun...

International Journal of Immunopathology and Pharmacology

https://read.qxmd.com/read/38901876/exploring-the-relationship-between-oxidative-stress-status-and-inflammatory-markers-during-primary-sj%C3%A3-gren-s-syndrome-a-new-approach-for-patient-monitoring
#1
JOURNAL ARTICLE
Sarah Benchabane, Souad Sour, Sourour Zidi, Zohra Hadjimi, Lyazidi Nabila, Dahbia Acheli, Amel Bouzenad, Houda Belguendouz, Chafia Touil-Boukoffa
INTRODUCTION: Primary Sjögren's syndrome (pSS) is a chronic inflammatory disease primarily affects exocrine glands dysfunction. Oxidative stress (OS) is a phenomenon occurring as a result of an imbalance between the generation of free radicals and antioxidant defense system. Hence, we aimed to establish the status of OS and inflammatory response according to the pSS disease activity index. In this context, we investigated malondialdehyde (MDA), and antioxidant enzymes during pSS...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38898405/association-of-xrcc1-p-arg194trp-gene-polymorphism-with-the-risk-of-hepatocellular-carcinoma-in-hcv-egyptian-population-a-pilot-case-control-study
#2
JOURNAL ARTICLE
Rasha Ahmed Ghorab, Shaimaa H Fouad, Yara Elsaadawy, Marwa Hamdy, Sara I Taha
Background: Hepatocellular carcinoma (HCC) is the most common and fatal primary liver cancer. Genetic variants of DNA repair systems can reduce DNA repair capability and increase HCC risk. Objectives: This study aimed to examine, in Egyptian hepatitis C virus (HCV) patients, the relationship between the X-ray repair cross-complementing group 1 (XRCC1) rs1799782 single nucleotide polymorphism (SNP) and HCC susceptibility. Methods: We included 100 adult HCV-positive patients with HCC and 100 adult HCV-positive patients with liver cirrhosis as pathological controls...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38889772/is-preexisting-inflamed-jaw-marrow-a-hidden-co-morbidity-affecting-outcomes-of-covid-19-infections-clinical-comparative-study
#3
COMPARATIVE STUDY
Johann Lechner, Robert E McMahon, Jerry E Bouquot, Florian Notter, Fabian Schick
Introduction: Exceedingly high levels of the chemokine CCL5/RANTES have been found in fatty degenerated osteonecrotic alveolar bone cavities (FDOJ) and aseptic ischemic osteolysis of the jaw (AIOJ) from toothless regions. Because CCL5/RANTES seems to have a prominent role in creating the COVID-19 "cytokine storm", some researchers have used the monoclonal antibody Leronlimab to block the CCR5 on inflammatory cells. Objective: Is preexisting FDOJ/AIOJ jaw marrow pathology a "hidden" co-morbidity affecting some COVID-19 infections? To what extent does the chronic CCL5/RANTES expression from preexisting FDOJ/AIOJ areas contribute to the progression of the acute cytokine storm in COVID-19 patients? Methods: Authors report on reducing the COVID-19 "cytokine storm" by treating infected patients through targeting the chemokine receptor 5 (CCR5) with Leronlimab and interrupting the activation of CCR5 by high CCL5/RANTES signaling, thus dysregulating the inflammatory phase of the viremia...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38886178/non-neoplastic-b-cell-predominant-lymphoid-proliferations-at-the-organs-exposed-to-external-environment-mimicking-lymphoma-a-potential-diagnostic-pitfall
#4
JOURNAL ARTICLE
Yue Fan, Benjamin Ka Seng Thong, Ouyang Binshen, Xia Shen, Hongmei Yi, Chaofu Wang
Background: Typically, lymphatic tissue proliferative lesions include either benign lesions or lymphoma. However, not all lymphatic lesions can currently be accurately classified into one category, particularly in mucosal areas that are in contact with the external environment. Aims: To explore the morphology, immunophenotype, and molecular changes of Non-neoplastic B-cell predominant lymphoid proliferations (NBPLP) in pathological areas that are exposed to external surroundings which mimicked lymphoma. Methods and Results: 18 cases of Atypical lymphoid hyperplasia (AtLP)  were retrieved in this study...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38876119/deucravacitinib-and-shikonin-combination-therapy-ameliorates-imiquimod-induced-psoriasis-in-mice
#5
JOURNAL ARTICLE
Ling Xu, Ying Jiang, Fuping Xu, Jun Liu, Yuhong Jiang, Fang Fang, Lin Luo
INTRODUCTION: TYK2 inhibitors and traditional natural drugs as promising drugs for psoriasis therapy are receiving increasing attention. They both affect different molecules of JAK/STAT pathway, but it is currently unclear whether their combination will enhance the effect on psoriasis. In this study, we used imiquimod (IMQ)-induced psoriasis mouse model to investigate the therapeutic effects of the combined administration of deucravacitinib (TYK2 inhibitor) and shikonin. METHODS: Aldara cream containing 5% IMQ was used to topically treat the dorsal skin of each mouse for a total of six consecutive days to induce psoriasis...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38869980/corilagin-relieves-atherosclerosis-via-the-toll-like-receptor-4-signaling-pathway-in-vascular-smooth-muscle-cells
#6
JOURNAL ARTICLE
Yujie Wang, Yiqing Li, Yunfei Chen, Jinqian Mao, Jingyu Ji, Shaojun Zhang, Pan Liu, Khrystyna Pronyuk, David Fisher, Yiping Dang, Lei Zhao
INTRODUCTION: Corilagin possesses a diverse range of pharmacologic bioactivities. However, the specific protective effects and mechanisms of action of corilagin in the context of atherosclerosis remain unclear. In this study, we investigated the impact of corilagin on the toll-like receptor (TLR)4 signaling pathway in a mouse vascular smooth muscle cell line (MOVAS) stimulated by oxidized low-density lipoprotein (ox-LDL). Additionally, we examined the effects of corilagin in Sprague-Dawley rats experiencing atherosclerosis...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38836458/pre-pandemic-antibodies-screening-against-sars-cov-2-and-virus-detection-among-children-diagnosed-with-eruptive-fevers
#7
JOURNAL ARTICLE
Nouhaila Najimi, Latifa Tajount, Zakia Regragui, Chaimae Remz, Rokaya Ait-Lhaj-Mhand, Chaimae Kadi, Lamiae Belayachi, Fouad Seghrouchni, Nadia Dakka, Rabii Ameziane El Hassani, Elmir Elharti, Hicham Oumzil, Youssef Bakri
OBJECTIVES: This study aims to assess the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies against the spike (S) and nucleocapsid (NP) proteins, as well as neutralizing antibodies against the receptor-binding domain (RBD). Additionally, it aims to detect viral RNA of SARS-CoV-2 in pre-pandemic archival pediatric specimens collected before the announcement of the COVID-19 pandemic spread on March 20th , 2020, in Morocco. The objective is to investigate the existence of pre-pandemic immunity to SARS-CoV-2...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38831558/ondansetron-or-beta-sitosterol-antagonizes-inflammatory-responses-in-liver-kidney-lung-and-heart-tissues-of-irradiated-arthritic-rats-model
#8
JOURNAL ARTICLE
Rokaya E Maarouf, Mohamed K Abdel-Rafei, Noura M Thabet, Khaled S Azab, Laila Rashed, Nermeen M El Bakary
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder mainly affecting joints, yet the systemic inflammation can influence other organs and tissues. The objective of this study was to unravel the ameliorative capability of Ondansetron (O) or β-sitosterol (BS) against inflammatory reactions and oxidative stress that complicates Extra-articular manifestations (EAM) in liver, kidney, lung, and heart of arthritic and arthritic irradiated rats. METHODS: This was accomplished by exposing adjuvant-induced arthritis (AIA) rats to successive weekly fractions of total body γ-irradiation (2 Gray (Gy)/fraction once per week for four weeks, up to a total dose of 8 Gy)...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38764158/evaluation-of-the-protective-effect-of-coenzyme-q-10-on-hepatotoxicity-caused-by-acute-phosphine-poisoning
#9
JOURNAL ARTICLE
Mohammad Reza Hooshangi Shayesteh, Zahra Hami, Mohsen Chamanara, Mohammad Reza Parvizi, Alireza Golaghaei, Ehsan Nassireslami
Background : Aluminum phosphide (AlP) poisoning is prevalent in numerous countries, resulting in high mortality rates. Phosphine gas, the primary agent responsible for AlP poisoning, exerts detrimental effects on various organs, notably the heart, liver and kidneys. Numerous studies have documented the advantageous impact of Coenzyme Q10 (CoQ10 ) in mitigating hepatic injuries. The objective of this investigation is to explore the potential protective efficacy of CoQ10 against hepatic toxicity arising from AlP poisoning...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38760017/tyk2-ifitm3-ifnar2-and-oas3-single-nucleotide-polymorphisms-among-severe-covid-19-icu-patients-in-morocco
#10
JOURNAL ARTICLE
R Benmansour, M R Tagajdid, H El Hamzaoui, S Fjouji, N Doghmi, A Houba, I Belbacha, S Elkochri, R Aabi, H Elannaz, A Laraqui, B El Mchichi, T Chmitah, N Touil, K Ennibi, R Eljaoudi, E Elmir, I Amine Lahlou, H Oumzil
OBJECTIVES: This study aimed to explore the potential correlation between specific single nucleotide polymorphisms (TYK2, IFITM3, IFNAR2, and OAS3 variants) and the severity of COVID-19 in Moroccan patients. METHODS: A genetic analysis was conducted on 109 patients with PCR-confirmed SARS-CoV-2 infection in Morocco. Among these patients, 46% were hospitalized in the intensive care unit, while 59% were not hospitalized. Importantly, all patients lacked known risk factors associated with COVID-19 severity...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38721971/improved-gastric-residence-time-of-famotidine-by-raft-forming-drug-delivery-system-using-doe
#11
JOURNAL ARTICLE
Rajalakshmi Munusamy, Sangeetha Shanmugasundharam
OBJECTIVE: This study investigated the raft-forming suspension of famotidine as an anti-reflux formulation to improve the oral bioavailability of narrow absorption window drugs by enhancing gastric residence time (GRT) and preventing gastro-esophageal reflux disease (GERD). METHOD: Various combinations of raft-forming agents, such as Tragacanth gum (TG), guar gum (GG), and xanthan gum (XG), were evaluated alongside sodium alginate (SA) to develop an effective raft...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38712748/uncovering-novel-therapeutic-targets-in-glucose-nucleotides-and-lipids-metabolism-during-cancer-and-neurological-diseases
#12
REVIEW
Snežana M Jovičić
BACKGROUND: Cell metabolism functions without a stop in normal and pathological cells. Different metabolic changes occur in the disease. Cell metabolism influences biochemical and metabolic processes, signaling pathways, and gene regulation. Knowledge regarding disease metabolism is limited. OBJECTIVE: The review examines the cell metabolism of glucose, nucleotides, and lipids during homeostatic and pathological conditions of neurotoxicity, neuroimmunological disease, Parkinson's disease, thymoma in myasthenia gravis, and colorectal cancer...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38712735/revealing-the-potential-of-solute-carrier-family-31-copper-transporters-member-1-insights-into-its-role-in-bladder-cancer-progression-and-therapeutic-implications
#13
JOURNAL ARTICLE
Yun-Zhi Lin, Wei-Hui Liu, Yu-Peng Wu, Hai Cai, Qing-Shui Zheng, Yong Wei, Ning Xu, Xue-Yi Xue
Introduction: Bladder cancer represents a significant public health concern with diverse genetic alterations influencing disease onset, progression, and therapy response. In this study, we explore the multifaceted role of Solute Carrier Family 31 Member 1 (SLC31A1) in bladder cancer, a pivotal gene involved in copper homeostasis. Methods: Our research involved analyzing the SLC31A1 gene expression via RT-qPCR, promoter methylation via targeted bisulfite sequencing, and mutational status via Next Generation Sequencing (NGS) using the clinical samples sourced by the local bladder cancer patients...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38688472/resveratrol-promotes-the-differentiation-of-human-umbilical-cord-mesenchymal-stem-cells-into-esophageal-fibroblasts-via-akt-signaling-pathway
#14
JOURNAL ARTICLE
Xiujing Chen, Zihao Sun, Qian Wu, Lijuan Shao, Jiaxin Bei, Yiguang Lin, Hongjie Chen, Size Chen
Objectives: Resveratrol has been implicated in the differentiation and development of human umbilical cord mesenchymal stem cells. The differentiation of into esophageal fibroblasts is a promising strategy for esophageal tissue engineering. However, the pharmacological effect and underlying mechanism of resveratrol on human umbilical cord mesenchymal stem cells differentiation are unknown. Here, we investigated the effects and mechanism of resveratrol on the differentiation of human umbilical cord mesenchymal stem cells...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38687369/a-novel-immune-cell-signature-for-predicting-glioblastoma-after-radiotherapy-prognosis-and-guiding-therapy
#15
JOURNAL ARTICLE
Rong Huang, Xiaoxu Lu, Xueming Sun, Hui Wu
Background: Glioblastoma, a highly aggressive brain tumor, poses a significant clinical challenge, particularly in the context of radiotherapy. In this study, we aimed to explore infiltrating immune cells and identify immune-related genes associated with glioblastoma radiotherapy prognosis. Subsequently, we constructed a signature based on these genes to discern differences in molecular and tumor microenvironment immune characteristics, ultimately informing potential therapeutic strategies for patients with varying risk profiles...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38686946/clinical-role-of-ndrg2-based-methylation-status-on-survival-pattern-of-glioblastoma
#16
JOURNAL ARTICLE
Menha Swellam, Mohamed K Khalifa, Amira M Nageeb, Lobna Ezz El-Arab, Manal El-Mahdy, Khaled El-Bahy, Magda Sayed Mahmoud
OBJECTIVES: Gliobalstoma is the most common primary brain tumor in adults with an extensive genetic and transcriptional heterogeneity, still identification of the role of DNA methylation, as one of epigenetic alterations, is emerged. Authors aimed to study the clinical role of N-myc downstream-regulated gene 2 (NDRG2) -based methylation among GBM patients versus benign neurological diseases (BND), investigate its prognostic role and its relation with survival outcomes. METHODS: A total of 78 FFPE specimens were recruited as follows: GBM ( n = 58) and BND ( n = 20) then analyzed for NDRG2 methylation using Methyl II quantitative PCR system...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38679570/low-dose-metformin-suppresses-hepatocellular-carcinoma-metastasis-via-the-ampk-jnk-il-8-pathway
#17
JOURNAL ARTICLE
Chengwen Zhao, Lu Zheng, Yuting Ma, Yue Zhang, Chanjuan Yue, Feng Gu, Guoping Niu, Yongqiang Chen
BACKGROUND AND OBJECTIVES: Metformin, an oral hypoglycemic drug, has been suggested to possess antitumour activity in several types of cancers. Additionally, interleukin-8 (IL-8) has been reported to be involved in the development and metastasis of many cancers. However, the effect of metformin on IL-8 expression in hepatocellular carcinoma (HCC) remains unclear. Therefore, this study aimed to investigate whether metformin could inhibit IL-8 expression to exert an inhibitory effect on HCC progression...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38652556/macrophage-derived-exosomal-mirna-141-triggers-endothelial-cell-pyroptosis-by-targeting-nlrp3-to-accelerate-sepsis-progression
#18
JOURNAL ARTICLE
Feng Zhan, Jun Zhang, Ping He, Wenteng Chen, Yanhong Ouyang
Sepsis, critical condition marked by severe organ dysfunction from uncontrolled infection, involves the endothelium significantly. Macrophages, through paracrine actions, play a vital role in sepsis, but their mechanisms in sepsis pathogenesis remain elusive. Objective: We aimed to explore how macrophage-derived exosomes with low miR-141 expression promote pyroptosis in endothelial cells (ECs). Exosomes from THP-1 cell supernatant were isolated and characterized. The effects of miR-141 mimic/inhibitor on apoptosis, proliferation, and invasion of Human Umbilical Vein Endothelial Cells (HUVECs) were assessed using flow cytometry, CCK-8, and transwell assays...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38649141/effect-of-overweight-obesity-on-relationship-between-fractional-exhaled-nitric-oxide-and-airway-hyperresponsiveness-in-chinese-elderly-patients-with-asthma
#19
JOURNAL ARTICLE
Fengjia Chen, Yangli Liu, Long-Hua Sun, Zhimin Zeng, Xinyan Huang
Purpose: This retrospective study investigates the influence of overweight and obesity status on pulmonary function, airway inflammatory markers, and airway responsiveness in elderly asthma patients. Methods: Patients with asthma older than 65 years old who completed a bronchial provocation test (BPT) or bronchial dilation test (BDT) and a fractional exhaled nitric oxide (FeNO) test between December 2015 and June 2020 were identified retrospectively for this study. All of the patients were categorized into overweight/obesity and non-obesity groups based on their BMI...
2024: International Journal of Immunopathology and Pharmacology
https://read.qxmd.com/read/38520313/impact-of-il-10-gene-promoter-polymorphisms-on-treatment-response-in-hcv-patients-a-systematic-review-a-meta-analysis-and-a-meta-regression
#20
JOURNAL ARTICLE
Tarak Dhaouadi, Awatef Riahi, Taïeb Ben Abdallah, Yousr Gorgi, Imen Sfar
The impact of interleukin-10 (IL-10) gene promoter polymorphisms (SNPs) on treatment response in HCV patients was dissimilarly estimated. Hence, the aim of this meta-analysis was to robustly assess the effect of IL-10 SNPs on treatment response in HCV patients. An electronic literature search was carried out through PubMed, EMBASE, Web of science, and Scopus databases. Studies assessing the association between IL-10 polymorphisms and treatment response in HCV patients were included. Studies were excluded if genotype frequencies are not consistent with the Hardy-Weinberg Equilibrium (HWE) or in case of including patients with hepatitis B virus coinfection...
2024: International Journal of Immunopathology and Pharmacology
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