Amitay Cohen, Alon Mass, Joel Reiter, David Haim Zangen, Malena Cohen-Cymberknoh
BACKGROUND: Impaired glycemic control and the subsequent development of Cystic fibrosis Related Diabetes (CFRD) are prevalent complications, affecting up to 50% of adults with cystic fibrosis (CF). CFTR modulator (CFTRm) therapies improve pulmonary functions, reduce exacerbation rates, increase survival in people with CF (pwCF) and appear to have a positive effect on extrapulmonary manifestations, such as nutritional state, improvements in upper respiratory symptoms, and quality of life...
May 16, 2024: Respiratory Medicine
A Younes, S Mandigout, L Robin, B Borel
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) is usually associated with sedentary behavior (SB). Literature reports a harmful impact of SB on the physical, mental, and social health of individuals with COPD. However, Pulmonary Rehabilitation (PR) programs seem to have no clear effect on changing SB. Therefore, our study aimed to identify the strategies used in the literature to reduce SB among individuals with COPD. METHOD: A scoping review was conducted to summarize the current literature regarding the proposed strategies to reduce SB in individuals with COPD...
May 15, 2024: Respiratory Medicine
Malena Cohen-Cymberknoh, Maya Ariel Dabby, Bar Gindi Reiss, Joel Melo Tanner, Gema Pérez, Noah Lechtzin, Eva Polverino, Javier Pérez Miranda, Andrea Gramegna, Stefano Aliberti, Hagit Levine, Huda Mussaffi, Hanna Blau, Dario Prais, Meir Mei-Zahav, Michal Shteinberg, Galit Livnat, Michal Gur, Lea Bentur, Damian G Downey, Adi Dagan, Inbal Golan-Tripto, Micha Aviram, Pedro Mondejar-Lopez, Elie Picard, Carsten Schwarz, Petr Jakubec, Traci M Kazmerski, Hagai Amsalem, Drorit Hochner Celnikier, Eitan Kerem, Joel Reiter
BACKGROUND: Quality of life and survival in Cystic Fibrosis (CF) have improved dramatically, making family planning a feasible option. Maternal and perinatal outcomes in women with CF (wwCF) are similar to those seen in the general population. However, the effect of undergoing multiple pregnancies is unknown. METHODS: A multinational-multicenter retrospective cohort study. Data was obtained from 18 centers worldwide, anonymously, on wwCF 18-45 years old, including isease severity and outcome, as well as obstetric and newborn complications...
May 10, 2024: Respiratory Medicine
Timothy R Aksamit, Nicole C Lapinel, Radmila Choate, Joseph Feliciano, Kevin L Winthrop, Andreas Schmid, Jasmanda Wu, Sebastian Fucile, Mark L Metersky
BACKGROUND: This study aimed to evaluate the association between the number of non-cystic fibrosis bronchiectasis (bronchiectasis) exacerbations during baseline and follow-up (objective 1) and to identify longitudinal changes in FEV1 associated with exacerbation frequency (objective 2). METHODS: This was a retrospective cohort study of adult patients enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria Research Registry September 2008 to March 2020...
May 9, 2024: Respiratory Medicine
Nazrul Islam, David Reid
Antibiotic-resistant bacteria associated with LRTIs are frequently associated with inefficient treatment outcomes. Antibiotic-resistant Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, and Staphylococcus aureus, infections are strongly associated with pulmonary exacerbations and require frequent hospital admissions, usually following failed management in the community. These bacteria are difficult to treat as they demonstrate multiple adaptational mechanisms including biofilm formation to resist antibiotic threats...
May 8, 2024: Respiratory Medicine
Matthew Wells, Sam Harding, Giles Dixon, Kirsten Buckley, Anne-Marie Russell, Shaney L Barratt
Pulmonary Fibrosis (PF) describes a group of lung diseases characterised by progressive scarring (fibrosis). Symptoms worsen over time and include breathlessness, tiredness, and cough, giving rise to psychological distress. Significant morbidity accompanies PF, so ensuring patients' care needs are well defined and provided for, represents an important treatment strategy. The purpose of this systematic review was to synthesise what is currently known about the psychosocial morbidity, illness experience and needs of people with pulmonary fibrosis and their informal caregivers...
May 8, 2024: Respiratory Medicine
Lee-Yuan Lin, Yu-Chih Wu, Jie-Syuan Wu, Hsiu-Yu Tai, Tsai-Wei Huang, Wun-Hao Cheng
BACKGROUND: Fibrotic interstitial lung disease (fILD) is characterised primarily by impaired lung function and quality of life. The present study investigated whether oxygen therapy could improve exercise capacity among patients with fILD. METHODS: Previously published randomised controlled trials (RCTs) were surveyed. A systematic review and meta-analysis was conducted to evaluate the effectiveness of oxygen therapy in improving the exertional capacity of patients with fILD...
May 6, 2024: Respiratory Medicine
Javad Razjouyan, Nicola A Hanania, Sara Nowakowski, Ritwick Agrawal, Amir Sharafkhaneh
BACKGROUND: Disturbed sleep in patients with COPD impact quality of life and predict adverse outcomes. RESEARCH QUESTION: To identify distinct phenotypic clusters of patients with COPD using objective sleep parameters and evaluate the associations between clusters and all-cause mortality to inform risk stratification. STUDY DESIGN AND METHODS: A longitudinal observational cohort study using nationwide Veterans Health Administration data of patients with COPD investigated for sleep disorders...
May 4, 2024: Respiratory Medicine
Priyanka Choudhury, Sanjukta Dasgupta, Abhik Kar, Sagartirtha Sarkar, Pratip Chakraborty, Parthasarathi Bhattacharyya, Sushmita Roychowdhury, Koel Chaudhury
Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is associated with worse clinical outcomes and decreased survival rates. In absence of disease specific diagnostic/therapeutic targets and unclear pathophysiology, there is an urgent need for the identification of potential genetic/molecular markers and disease associated pathways. The present study aims to use a bioinformatics approach to identify and validate hypoxia-associated gene signatures in COPD-PH patients. Additionally, hypoxia-related inflammatory profile is also explored in these patients...
May 2, 2024: Respiratory Medicine
Toshiro Goto, Christian Gomez Hernandez, Yasushi Tsujimoto, Takashi Kitagawa
No abstract text is available yet for this article.
April 30, 2024: Respiratory Medicine
Maeve G Macmurdo, Xinge Ji, Pratik Pimple, Amy L Olson, Alex Milinovich, Blaine Martyn-Dow, Aman Pande, Alex Zajichek, Janine Bauman, Shaun Bender, Craig Conoscenti, David Sugano, Michael W Kattan, Daniel A Culver
RATIONALE: The proportion of patients who develop progressive pulmonary fibrosis (PPF), along with risk factors for progression remain poorly understood. OBJECTIVES: To examine factors associated with an increased risk of developing PPF among patients at a referral center. METHODS: We identified patients with a diagnosis of interstitial lung disease (ILD) seen within the Cleveland Clinic Health System. Utilizing a retrospective observational approach we estimated the risk of developing progression by diagnosis group and identified key clinical predictors using the FVC component of both the original progressive fibrotic interstitial lung disease (PFILD) and the proposed PPF (ATS) criteria...
April 30, 2024: Respiratory Medicine
Mario Cazzola, Mauro Maniscalco
No abstract text is available yet for this article.
April 26, 2024: Respiratory Medicine
HyeIn Ji, Laren D Tan, George W Hafzalla, Nolan Nguyen, Abdullah Alismail
The prevalence of asthma among the elderly population has witnessed a notable rise, presenting unique challenges in diagnosis and management. Biologic therapies, such as omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab, and tezepelumab, have demonstrated efficacy in targeting specific pathways associated with severe asthma in elderly individuals. However, a significant research gap exists in the application of these therapies in elderly asthma patients. Despite the considerable size of the elderly asthma population and the social and economic burden that this specific demographic imposes on society, the available body of research catering to this group is limited...
April 26, 2024: Respiratory Medicine
Rashmi Shankar, Charaka M Hadinnapola, Allan B Clark, Huzaifa Adamali, Nazia Chaudhuri, Lisa G Spencer, Andrew M Wilson
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive condition associated with a variable prognosis. The relationship between socioeconomic status or distance travelled to respiratory clinics and prognosis is unclear. RESEARCH QUESTION: To determine whether socioeconomic status, distance to hospital and time to referral affects survival in patients with IPF. STUDY DESIGN AND METHODS: In this retrospective cohort study, we used data collected from the British Thoracic Society Interstitial Lung Diseases Registry, between 2013 and 2021 (n = 2359) and calculated the quintile of Index of Multiple Deprivation 2019 score, time from initial symptoms to hospital attendance and distance as the linear distance between hospital and home post codes...
April 25, 2024: Respiratory Medicine
Andreas Rydell, Christer Janson, Karin Lisspers, Yi-Ting Lin, Johan Ärnlöv
INTRODUCTION: Data is limited on influence of forced expiratory volume in 1 s (FEV1 ) and forced vital capacity (FVC) in a large adult population, including individuals with normal spirometry at baseline. METHODS: Using the UK Biobank cohort, a multivariable Cox regression analysis was conducted on 406,424 individuals to examine the association between FEV1 and FVC, categorized into three groups based on their percentage of predicted values (%pred) (≥80, 60-80 and < 60), and overall mortality, cardiovascular mortality, myocardial infarction, stroke, and heart failure over approximately 12...
April 25, 2024: Respiratory Medicine
Alessandra Sorano, Carlo Fumagalli, Elenia Cinelli, Surinder S Birring, Giovanni A Fontana, Federico Lavorini
OBJECTIVE: To implement subjective methods for measuring the impact of chronic cough on patients' daily life, including an Italian version of the symptom-specific, health status measure for patients with chronic cough, i.e. the Leicester Cough Questionnaire (LCQ). METHODS: Sixty-five chronic cough patients attended a tertiary cough clinic on two separate occasions 8 weeks apart. The visual analogue scale for cough severity (VAS), the LCQ and the cough disturbance score (CDS) were administered on both occasions...
April 24, 2024: Respiratory Medicine
Sicheng Zhang, Luyang Gao, Zhihui Zhao, Qing Zhao, Tao Yang, Qixian Zeng, Yi Zhang, Xin Li, Zhihua Huang, Anqi Duan, Qin Luo, Zhihong Liu
BACKGROUND: Emerging evidence has shown that the blood urea nitrogen to serum albumin ratio (BAR) is associated with the severity and prognosis of heart failure. However, its role in idiopathic pulmonary arterial hypertension (IPAH) remains unclear. This study investigated the associations between BAR and functional status, echocardiographic findings, hemodynamics, and long-term outcomes among patients with IPAH. METHODS: This study included consecutive patients who underwent right heart catheterization (RHC) and were diagnosed with IPAH between January 2013 and January 2018 at Fuwai Hospital...
April 22, 2024: Respiratory Medicine
Hannah Smith, Robert Easterling, Jianing Ma, Meghana Moodabagil, Alexa Meara, Dwight H Owen, Elliot Crouser, Arindam Singha, Kevin Ho
INTRODUCTION: Sarcoid-like reactions (SLRs) to immune checkpoint inhibitors (ICIs) are a rare but increasingly recognized immune-related adverse event of which the clinical significance is unclear. METHODS: We conducted a retrospective cohort study at a tertiary academic center of consecutive patients who received at least one dose of ICI from 2013-2020. Patient characteristics, risk factors, and outcomes were compared between patients with and without SLR following ICI treatment...
April 20, 2024: Respiratory Medicine
Mila Fradkin, Maya Elyashiv, Amasha Camel, Nirit Agay, Michael Brik, Pierre Singer, Rachel Dankner
BACKGROUND: We followed prolonged mechanically ventilated (PMV) patients for weaning attempts and explored factors associated with successful weaning and long-term survival. METHODS: This historical cohort study included all adult PMV patients admitted to a single rehabilitation hospital during 2015-2018 and followed for survival according to weaning success up to 3 years or the end of 2021. RESULTS: The study included 223 PMV patients. Of them, 124(55...
April 18, 2024: Respiratory Medicine
T David Koster, Pallav L Shah, Arschang Valipour, Gerard J Criner, Felix J F Herth, Richard Sue, Douglas K Hogarth, Ralitza T Martin, Amit K Mahajan, Raed Alalawi, Lisa Kopas, Avi Cohen, Douglas E Wood, Jonathan Kurman, Narinder S Shargill, Mark Dransfield, Dirk-Jan Slebos, Michael Perch
Bronchoscopic lung volume reduction treatment with Zephyr one-way valves is an effective guideline-based treatment option for patients with severe emphysema and hyperinflation. However, in some cases the treatment response is less than anticipated or there might be a loss of initial treatment effect. Reasons for the lack of response can include incorrect assessment of collateral ventilation, improper valve placement, or patient related factors. Loss of initial benefit can be due to granulation tissue formation and subsequent valve dysfunction, or there may be side effects such as excessive coughing or infectious problems...
April 18, 2024: Respiratory Medicine
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