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Respiratory Medicine

Alicia K Gerke
No abstract text is available yet for this article.
February 6, 2019: Respiratory Medicine
Michelle Terwiel, Coline H M van Moorsel
INTRODUCTION: Although the presence of familial sarcoidosis has been confirmed, clinical and epidemiological data on its characteristics are scattered and sometimes paradoxical. The objective of this review is to assess what is known on the clinical epidemiology of familial sarcoidosis, by combining data from early case reports with recent population based data; aiming to support in clinical decision making and providing information to patients. METHOD: A systematic review of the literature in PubMed was done and 27 studies with clinical or epidemiological data on familial sarcoidosis, published between 1947 and 2017, were included...
December 13, 2018: Respiratory Medicine
P Heukels, C C Moor, J H von der Thüsen, M S Wijsenbeek, M Kool
Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar epithelial injury triggers the early development of fibrosis. These injuries, in combination with dysregulated wound repair and fibroblast dysfunction, lead to ongoing tissue remodelling and fibrosis seen in end-stage pulmonary fibrosis. Although the exact etiology in IPF is unknown and probably diverse, all stages of fibrosis are accompanied by innate and adaptive immune responses...
February 2019: Respiratory Medicine
Saara Taponen, Jukka Uitti, Kirsi Karvala, Ritva Luukkonen, Lauri Lehtimäki
BACKGROUND: Age at asthma onset is associated with severity and outcomes of the disease. OBJECTIVE: We studied if age at asthma diagnosis is related to employment and outcomes in working career. PATIENTS AND METHODS: A questionnaire was sent to 2613 adults with asthma in Tampere, Finland, and a follow-up questionnaire was sent after six years. Asthmatics were divided into groups based on their employment status: working full-time or work disability...
February 2019: Respiratory Medicine
O Bonhomme, B Duysinx, V Heinen, N Detrembleur, J-L Corhay, R Louis
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies"). To the best of our knowledge, this article is the first to present pCLE images during medical thoracoscopy. We present here 3 different patients referred for various health problems. A precise description of pleural cavity pCLE images after intravenous fluorescein injection (a fluorophore) together with corresponding macroscopical and histological studies is performed...
February 2019: Respiratory Medicine
Janusz Ciółkowski, Andrzej Emeryk, Paweł Hydzik, Justyna Emeryk-Maksymiuk, Elwira Kosmala, Barbara Stasiowska
BACKGROUND: Stability of asthma is a clinical phenotype of the disease based on long-term evaluation of control of asthma symptoms and its exacerbations. A relationship between airway inflammation and clinical classification of asthma based on stability criterion has not been well studied. OBJECTIVES: The purpose of our study was to analyze the inflammation profile of stable and unstable asthma in adolescents treated with moderate and high doses of inhaled corticosteroids...
February 2019: Respiratory Medicine
Jobst F Roehmel, Tilmann Kallinich, Doris Staab, Carsten Schwarz
BACKGROUND: Recurrent joint pain is frequently observed in patients with CF and can lead to reduced activity and quality of life. We conducted this observational study to assess the clinical manifestations, frequency, and risk factors of CF associated arthropathy. METHODS: Clinical data were collected using a digital quality management system, medical records, and by conducting structured interviews. Univariate and multivariate statistical analysis were performed for statistical interpretation...
February 2019: Respiratory Medicine
Nawar Diar Bakerly, Ashley Woodcock, Susan Collier, David A Leather, John P New, Jodie Crawford, Catherine Harvey, Jørgen Vestbo, Isabelle Boucot
BACKGROUND: SLS COPD was the first open-label randomised controlled trial demonstrating a reduction in moderate/severe COPD exacerbations with once-daily inhaled fluticasone furoate/vilanterol (FF/VI) in everyday clinical practice. Here we report FF/VI effectiveness and safety in predefined patient subgroups. METHODS: Patients with COPD, exacerbation history, and receiving maintenance inhaler therapy, were randomised to initiate FF/VI 100/25 μg or continue usual care (UC) with 12 months' follow-up...
February 2019: Respiratory Medicine
Marcello Bosi, Giulia Milioli, Liborio Parrino, Francesco Fanfulla, Sara Tomassetti, Andrea Melpignano, Irene Trippi, Anna Elisabetta Vaudano, Claudia Ravaglia, Susanna Mascetti, Venerino Poletti
PURPOSE: the study aims at describing the role of sleep disordered breathing (SDB) on daytime symptoms, quality of sleep and quality of life (QoL) in patients with moderate-severe IPF. METHODS: we enrolled 34 consecutive room air breathing IPF outpatients who received a full-night polysomnography. The following questionnaires were administered: Epworth Sleepiness Score (ESS), Pittsburg Sleep Quality Index (PSQI), StGeorge's Questionnaire (StGQ). RESULTS: patients were classified in 3 groups:Group A (NO-SDB, 9 patients), Group B(OSAS without sleep-related hypoxemia, 17 patients), Group C(OSAS with sleep-related hypoxemia, 8 patients)...
February 2019: Respiratory Medicine
Ga-Young Ban, Yoon-Jeong Jeong, So-Hee Lee, Seung-Soo Shin, Yoo-Seob Shin, Hae-Sim Park, Seung-Hyun Kim, Young-Min Ye
BACKGROUND: Delayed drug hypersensitivity to first-line anti-tuberculosis medication is a major challenge in tuberculosis treatment. OBJECTIVE: This study was performed to investigate the efficacy/tolerability of desensitization therapy in treatment of first-line anti-tuberculosis medication hypersensitivity and the usefulness of immunologic evaluation therein. METHODS: This study was conducted as a prospective, observational cohort study...
February 2019: Respiratory Medicine
Alberto Papi, Jinping Zheng, Gerard J Criner, Leonardo M Fabbri, Peter M A Calverley
BACKGROUND: N-acetylcysteine (NAC) 600 mg twice daily is a well-tolerated oral antioxidant mucolytic that reduces the risk of moderate to severe chronic obstructive pulmonary disease (COPD) exacerbations. PANTHEON was one of the largest studies to evaluate NAC in COPD. It recruited current, ex- and never-smokers, concomitantly treated with other medications, and used a symptom-based definition of COPD exacerbations rather than the conventional healthcare resource utilisation (HCU) criteria...
February 2019: Respiratory Medicine
David Bennett, Maria Antonietta Mazzei, Bridget Collins, Elena Bargagli, Sudhakar Pipavath, Donatella Spina, Maria Lucia Valentini, Cesare Rinaldi, Gloria Bettini, Alessandro Ginori, Rosa Metella Refini, Paola Rottoli, Ganesh Raghu
BACKGROUND: The diagnostic algorithm for idiopathic pulmonary fibrosis (IPF) guidelines has some shortcomings. The aim of the present study was to develop a novel software, "IPFdatabase", that could readily apply the diagnostic criteria per IPF guidelines and make a 'virtual' diagnosis of IPF. METHODS: Software was developed as a step-by-step compilation of necessary information according to guidelines to enable a diagnosis of IPF. Software accuracy was validated primarily by comparing software diagnoses to those previously made at a Center for Interstitial Lung Diseases...
February 2019: Respiratory Medicine
Eileen M Harder, Wassim H Fares
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease that causes widespread abnormal vasculature development, resulting in multiple complications including pulmonary hypertension (PH). Despite the potential severity of PH, there is a lack of data on hospitalization characteristics and outcomes in the HHT-PH population. The purpose of this analysis was to describe trends and outcomes of HHT-PH hospitalizations within the National (Nationwide) Inpatient Sample (NIS)...
February 2019: Respiratory Medicine
L Bjermer, G Eriksson, F Radner, Stefan Peterson, J O Warner
BACKGROUND: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA; Airsonett® ) has been shown to provide significant reduction of exposure to allergens in the breathing zone, leading to long-term reduction in airway inflammation and improvement in quality of life. Allergic asthma patients uncontrolled on GINA step 4 were found to benefit the most. A frequently asked question from clinicians and funders is related to time to onset (TTO) of improvements for patients using TLA...
February 2019: Respiratory Medicine
Magno F Formiga, Isabel Vital, Gisel Urdaneta, Michael A Campos, Lawrence P Cahalin
BACKGROUND: Inspiratory muscle function in COPD has been traditionally described in terms of maximal inspiratory pressure (MIP). Arguably, however, is the day-to-day relevance of MIP, given that individuals rarely need maximal inspiratory forces to perform general tasks, but rather repeated breathing muscle contractions which demand endurance. The sustained maximal inspiratory pressure (SMIP) reflects the ability of the respiratory muscles to maintain force over time (i.e. single-breath work capacity)...
February 2019: Respiratory Medicine
Karsten Keller, Lukas Hobohm, Thomas Münzel, Mir Abolfazl Ostad, Christine Espinola-Klein
BACKGROUND: Peripheral artery disease (PAD) and chronic obstructive pulmonary disease (COPD) are both related with high in-hospital mortality. We aimed to investigate the impact of COPD on the in-hospital outcomes in PAD. METHODS: PAD patients were selected based on ICD-code I70.2 of the German nationwide database, stratified for COPD and compared regarding adverse in-hospital outcomes. RESULTS: Between 01/2005-12/2015, 5,611,827 inpatients (64...
February 2019: Respiratory Medicine
Susana Conde Diez, Ana Viejo Casas, Juan Luis Garcia Rivero, Juan Carlos Lopez Caro, Felix Ortiz Portal, Gualberto Diaz Saez
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder in which airflow is obstructed. Viral or bacterial upper respiratory tract infections (URTIs) may lead to exacerbations. Homeopathic medication administration to COPD patients during the influenza-exposure period may help to reduce the frequency of common URTIs. METHODS: This prospective, observational, multicenter study was carried out in Cantabria, Spain. Patients with COPD were divided into two groups: group 1 received conventional treatment + homeopathic medication (diluted and dynamized extract of duck liver and heart; Boiron) (OG); group 2 received conventional treatment only (CG)...
January 2019: Respiratory Medicine
Thomas Reijnders, Michael Schuler, Michael Wittmann, Danijel Jelusic, Thierry Troosters, Wim Janssens, Nikola M Stenzel, Konrad Schultz, Andreas von Leupoldt
Anxiety is a highly prevalent psychological comorbidity in patients with chronic obstructive pulmonary disease (COPD) and has detrimental effects on pulmonary rehabilitation (PR) outcomes. It has been suggested that disease-specific fears could play an even more important role in COPD patients' disease progression. However, little is known about how different disease-specific fears impact COPD. This study examined how different disease-specific fears relate to different PR outcome measures in COPD patients and how these relationships evolve over the course of PR...
January 2019: Respiratory Medicine
Sujit Vijay Sakpal, Steven Donahue, Hector Saucedo Crespo, Christopher Auvenshine, Suresh Kumar Agarwal, Jawad Nazir, Robert N Santella, Jeffery Steers
Pulmonary infections are frequent complications in abdominal solid-organ transplantation (aSOT) which may threaten patient and allograft survival. Accurate diagnosis and treatment of pulmonary infections in this population can be challenging. Immunosuppressive therapy not only increases the risk of acquiring opportunistic and non-opportunistic infections, but it also impairs the inflammatory responses associated with microbial invasion which in an otherwise normal host produce clinical and radiologic responses that allow for early identification of the offending pathogen...
January 2019: Respiratory Medicine
Hideki Yasui, Naoki Inui, Masato Karayama, Kazutaka Mori, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda
BACKGROUND: Dyspnea is a common symptom in chronic obstructive pulmonary disease (COPD). The modified Medical Research Council (mMRC) dyspnea scale is a widely used questionnaire to assess dyspnea. However, the relationship of the mMRC dyspnea scale with morphological airway structures in COPD remains unclear. We evaluated the correlation between the mMRC dyspnea scale and imaging-based airway structures in patients with COPD. METHODS: The wall area (WA) and airway inner luminal area (Ai) of third-to sixth-generation bronchi and the percentage of low attenuation area with less than -950 HU (%LAA) of the lungs were measured using three-dimensional computed tomography in patients with COPD...
January 2019: Respiratory Medicine
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