journal
https://read.qxmd.com/read/36958514/evaluation-of-feos-score-and-super-responder-criteria-in-a-real-life-cohort-treated-with-anti-il5-il5r
#1
JOURNAL ARTICLE
Daniel Laorden, Ester Zamarrón, David Romero, Javier Domínguez-Ortega, Elena Villamañán, Itsaso Losantos, Francisco Gayá, Santiago Quirce, Rodolfo Álvarez-Sala
No abstract text is available yet for this article.
March 21, 2023: Respiratory Medicine
https://read.qxmd.com/read/36934856/establishing-a-balloon-pulmonary-angioplasty-program-for-chronic-thromboembolic-pulmonary-hypertension-a-united-states-single-center-experience
#2
JOURNAL ARTICLE
Lauren N Carlozzi, Josh Lee, Lia M Barros, Yonatan Buber, Delphine L Chen, Michael Mulligan, Karen Ordovas, David D Ralph, Samuel G Rayner, Peter J Leary, Zachary L Steinberg
INTRODUCTION: Balloon pulmonary angioplasty (BPA) is a less invasive treatment alternative for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are unable to move forward with pulmonary thromboendarterectomy. This report describes a single-center experience with a nascent BPA program in the United States (US). METHODS: All patients who underwent BPA between August 2018-2021 were included in this retrospective, single-center observational cohort...
March 17, 2023: Respiratory Medicine
https://read.qxmd.com/read/36933674/association-between-abdominal-and-general-obesity-and-respiratory-symptoms-asthma-and-copd-results-from-the-rhine-study
#3
JOURNAL ARTICLE
Marta A Kisiel, Oscar Arnfelt, Eva Lindberg, Oscar Jogi, Andrei Malinovschi, Ane Johannessen, Bryndis Benediktsdottir, Karl Franklin, Mathias Holm, Francisco Gomez Real, Torben Sigsgaard, Thorarinn Gislason, Lars Modig, Christer Janson
INTRODUCTION: Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. AIMS AND OBJECTIVES: We aimed to explore the associations of abdominal obesity with respiratory symptoms, asthma, and chronic obstructive pulmonary disease independently from general obesity in women and men. METHODS: This cross-sectional study was based on the Respiratory Health in Northern Europe (RHINE) III questionnaire (n = 12 290) conducted in 2010-2012...
March 16, 2023: Respiratory Medicine
https://read.qxmd.com/read/36931576/efficacy-of-oral-amantadine-among-patients-hospitalised-with-covid-19-a-randomised-double-blind-placebo-controlled-multicentre-study
#4
JOURNAL ARTICLE
Adam Barczyk, Małgorzata Czajkowska-Malinowska, Małgorzata Farnik, Marek Barczyk, Łukasz Boda, Szczepan Cofta, Jan Duława, Maciej Dyrbuś, Rafał Harat, Maciej Huk, Sylwia Kotecka, Artur Nahorecki, Jacek Nasiłowski, Wojciech Naumnik, Grzegorz Przybylski, Monika Słaboń-Willand, Szymon Skoczyński, Krystian Wita, Grzegorz Zioło, Piotr Kuna
BACKGROUND: Amantadine has been proposed as a treatment for COVID-19 because it shows anti-SARS-CoV-2 activity in vitro. However, to date, no controlled study has assessed the safety and efficacy of amantadine in COVID-19. RESEARCH QUESTION: Whether amantadine is effective and safe among patients with different COVID-19 severity classifications. STUDY DESIGN: and Methods: This was multi-centre, randomised, placebo-controlled study.Patients with oxygen saturation ≤94% and no need for high-flow oxygen or ventilatory support were randomly allocated to receive oral amantadine or placebo (1:1) for 10 days in addition to standard care...
March 15, 2023: Respiratory Medicine
https://read.qxmd.com/read/36931575/towards-development-of-evidence-to-inform-recommendations-for-the-evaluation-and-management-of-bronchiectasis
#5
REVIEW
Patrick A Flume, Ashwin Basavaraj, Bryan Garcia, Kevin Winthrop, Emily Di Mango, Charles L Daley, Julie V Philley, Emily Henkle, Anne E O'Donnell, Mark Metersky
Bronchiectasis (BE) is a chronic condition characterized by airway dilation as a consequence of a variety of pathogenic processes. It is often associated with persistent airway infection and an inflammatory response resulting in cough productive of purulent sputum, which has an adverse impact on quality of life. The prevalence of BE is increasing worldwide. Treatment guidelines exist for managing BE, but they are generally informed by a paucity of high-quality evidence. This review presents the findings of a scientific advisory board of experts held in the United States in November 2020...
March 15, 2023: Respiratory Medicine
https://read.qxmd.com/read/36931574/interventional-pulmonology-techniques-in-lung-transplantation
#6
REVIEW
Michele Mondoni, Rocco Francesco Rinaldo, Paolo Solidoro, Fabiano Di Marco, Filippo Patrucco, Stefano Pavesi, Andrea Baccelli, Paolo Carlucci, Dejan Radovanovic, Pierachille Santus, Federico Raimondi, Sergio Vedovati, Letizia Corinna Morlacchi, Francesco Blasi, Giovanni Sotgiu, Stefano Centanni
Lung transplantation is a key therapeutic option for several end-stage lung diseases. Interventional pulmonology techniques, mostly bronchoscopy, play a key role throughout the whole path of lung transplantation, from donor evaluation to diagnosis and management of post-transplant complications. We carried out a non-systematic, narrative literature review aimed at describing the main indications, contraindications, performance characteristics and safety profile of interventional pulmonology techniques in the context of lung transplantation...
March 15, 2023: Respiratory Medicine
https://read.qxmd.com/read/36924849/obstructive-sleep-apnea-modulates-clinical-outcomes-post-acute-myocardial-infarction-a-large-longitudinal-veterans-dataset-report
#7
JOURNAL ARTICLE
Ritwick Agrawal, Amir Sharafkhaneh, Vijay Nambi, Ahmed BaHammam, Javad Razjouyan
BACKGROUND: While the longer-term Obstructive Sleep apnea (OSA)-related intermittent hypoxia (IH) leads to various comorbidities, it has become increasingly evident that OSA confers protective advantages during and after acute myocardial infarction (AMI). We hypothesized in patients who were admitted with acute MI, the presence of OSA is associated with lower in-hospital mortality compared to those without a prior diagnosis of OSA. METHODS: In this nationwide retrospective study utilizing Veterans Health Administration records, we included patients hospitalized for MI with a history of sleep disorders from 1999-2020...
March 14, 2023: Respiratory Medicine
https://read.qxmd.com/read/36924848/is-asthma-s-heterogeneity-too-vast-to-use-traditional-phenotyping-for-modern-biologic-therapies
#8
JOURNAL ARTICLE
Nicole van der Burg, Ellen Tufvesson
No abstract text is available yet for this article.
March 14, 2023: Respiratory Medicine
https://read.qxmd.com/read/36907367/a-path-forward-in-the-development-of-new-aerosol-drug-delivery-devices-for-pediatrics
#9
REVIEW
Jennifer A O'Neil, Larry Villasmil-Urdaneta
Inhaled medications are widely accepted as being the optimal route for treating pediatric respiratory diseases, a leading cause of hospitalization and death. Despite jet nebulizers being the preferred inhalation device for neonates and infants, current devices face performance issues with most of the drug never reaching the target lung location. Previous work has aimed to improve pulmonary drug deposition, yet nebulizer efficiency remains low. The development of an inhalant therapy that is efficacious and safe for pediatrics depends on a well-designed delivery system and formulation...
March 10, 2023: Respiratory Medicine
https://read.qxmd.com/read/36906187/efficacy-of-once-daily-single-inhaler-fixed-dose-combination-of-mometasone-indacaterol-glycopyrronium-in-patients-with-asthma-with-or-without-persistent-airflow-limitation-post-hoc-analysis-from-the-iridium-study
#10
JOURNAL ARTICLE
Richard N Van Zyl-Smit, Huib Am Kerstjens, Jorge F Maspero, Konstantinos Kostikas, Motoi Hosoe, Ana-Maria Tanase, Peter D'Andrea, Karen Mezzi, Dominic Brittain, David Lawrence, Kenneth R Chapman
BACKGROUND: A novel, once-daily, fixed-dose combination of mometasone furoate/indacaterol acetate/glycopyrronium bromide (MF/IND/GLY) delivered via Breezhaler® is the first inhaled corticosteroid/long-acting ꞵ2 -agonist/long-acting muscarinic antagonist (ICS/LABA/LAMA) therapy approved for the maintenance treatment of asthma in adults inadequately controlled on ICS/LABA combination. In patients with asthma and persistent airflow limitation (PAL), maximal treatment, especially with combination is suggested...
March 9, 2023: Respiratory Medicine
https://read.qxmd.com/read/36906186/coping-styles-with-stress-and-its-relations-to-psychiatric-and-clinical-symptoms-in-patients-with-sarcoidosis-a-latent-profile-analysis
#11
JOURNAL ARTICLE
Pawel Holas, Estelle Figueira-Putresza, Joanna Domagala-Kulawik
OBJECTIVE: Although stress and styles of coping with it can have a major impact on one's health and can determine the course and management of chronic diseases, no previous studies have evaluated coping strategies and their relation to emotional distress and clinical symptoms in sarcoidosis. METHODS: In two consecutive studies, we investigated differences in coping styles of sarcoidosis patients in comparison to healthy control subjects and the association of identified profiles to an objective measurement of disease (Forced Vital Capacity) and symptoms such as dyspnoea, pain, anxiety and depressive symptoms in 36 patients with sarcoidosis (study 1) and 93 patients with sarcoidosis (study 2)...
March 9, 2023: Respiratory Medicine
https://read.qxmd.com/read/36906185/interaction-of-smoking-and-social-status-on-the-risk-of-respiratory-outcomes-in-a-swedish-adult-population-a-nordic-epilung-study
#12
JOURNAL ARTICLE
Muwada Bashir Awad Bashir, Rani Basna, Linnea Hedman, Helena Backman, Linda Ekerljung, Heidi Andersén, Göran Wennergren, Laxmi Bhatta, Anne Lindberg, Bo Lundbäck, Hannu Kankaanranta, Eva Rönmark, Bright I Nwaru
BACKGROUND: Evidence abounds on the independent roles of social class and smoking in relation to obstructive airway diseases, but data are sparse on the impact of their interaction. We evaluated whether and to what extent social class and smoking interact in relation to risk of respiratory diseases in adults. METHODS: Data from the population-based studies, West Sweden Asthma Study (WSAS, n = 23,753) and Obstructive Lung Disease in Northern Sweden studies (OLIN, n = 6519), were used, constituting randomly selected adults aged 20-75 years...
March 9, 2023: Respiratory Medicine
https://read.qxmd.com/read/36889522/non-pharmacological-and-non-invasive-interventions-for-chronic-pain-in-people-with-chronic-obstructive-pulmonary-disease-a-systematic-review-without-meta-analysis
#13
REVIEW
Jeanette R Morris, Samantha L Harrison, Jonathan Robinson, Denis Martin, Leah Avery
OBJECTIVES: Chronic Obstructive Pulmonary Disease (COPD) is complicated by chronic pain. People with COPD report higher pain prevalence than the general population. Despite this, chronic pain management is not reflected in current COPD clinical guidelines and pharmacological treatments are often ineffective. We conducted a systematic review that aimed to establish the efficacy of existing non-pharmacological and non-invasive interventions on pain and identify behaviour change techniques (BCTs) associated with effective pain management...
March 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/36889521/the-role-of-riociguat-in-combination-therapies-for-pulmonary-arterial-hypertension
#14
REVIEW
Franck F Rahaghi, Maria Giovanna Trivieri, Sandeep Sahay
Effective clinical decision-making in initial treatment selection and switching or escalations of therapy for pulmonary arterial hypertension (PAH) depends on multiple factors including the patient's risk profile. Data from clinical trials suggest that switching from a phosphodiesterase-5 inhibitor (PDE5i) to the soluble guanylate cyclase stimulator riociguat may provide clinical benefit in patients not reaching treatment goals. In this review, we cover the clinical evidence for riociguat combination regimens for patients with PAH and discuss their evolving role in upfront combination therapy and switching from a PDE5i as an alternative to escalating therapy...
March 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/36889520/idiopathic-pulmonary-fibrosis-is-more-strongly-associated-with-coronary-artery-disease-than-chronic-obstructive-pulmonary-disease
#15
JOURNAL ARTICLE
Kevin Bray, Sandeep Bodduluri, Young-Il Kim, Vivek Sthanam, Hrudaya Nath, Surya P Bhatt
INTRODUCTION: Previous studies have shown that the population attributable risk of low forced expiratory volume in one second (FEV1 ) for coronary artery disease (CAD) is substantial. FEV1 can be low either because of airflow obstruction or ventilatory restriction. It is not known if low FEV1 arising from spirometric obstruction or restriction are differently associated with CAD. METHODS: We analyzed high resolution computed tomography (CT) scans acquired at full inspiration in lifetime non-smoker adults with no lung disease (controls) and those with chronic obstructive pulmonary disease enrolled in the Genetic Epidemiology of COPD (COPDGene) study...
March 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/36889519/the-creatinine-to-cystatin-c-ratio-a-surrogate-marker-of-muscle-mass-as-a-predictor-of-lung-function-decline-in-older-adults-a-nationwide-longitudinal-study-in-china
#16
JOURNAL ARTICLE
Ke Wang, Shuli Jia, Wanyu Zhao, Meiling Ge, Birong Dong
BACKGROUND: Lung function decline is associated with sarcopenia, known as loss of skeletal muscle mass. The serum creatinine to cystatin C ratio (CCR) has been proposed as a biomarker of muscle mass. The associations between CCR and lung function decline are unknown. METHODS: The study used two waves of data from China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Serum creatinine and cystatin C were collected at baseline survey (2011). Lung function was assessed by peak expiratory flow (PEF) at 2011 and 2015...
March 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/36889518/pneumothorax-in-hospitalized-covid-19-patients-with-severe-respiratory-failure-risk-factors-and-outcome
#17
JOURNAL ARTICLE
B Ragnoli, T Cena, A Radaeli, P Pochetti, L Conti, A Calareso, J Morjaria, Mario Malerba
PNX was described as an uncommon complication in COVID-19 patients but clinical risk predictors and the potential role in patient's outcome are still unclear. We assessed prevalence, risk predictors and mortality of PNX in hospitalized COVID- 19 with severe respiratory failure performing a retrospective observational analysis of 184 patients admitted to our COVID-19 Respiratory Unit in Vercelli from October 2020 to March 2021. We compared patients with and without PNX reporting prevalence, clinical and radiological features, comorbidities, and outcomes...
March 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/36889517/a-scoping-review-of-co-creation-practice-in-the-development-of-non-pharmacological-interventions-for-people-with-chronic-obstructive-pulmonary-disease-a-health-cascade-study
#18
REVIEW
Qingfan An, Marlene Sandlund, Danielle Agnello, Lauren McCaffrey, Sebastien Chastin, Ragnberth Helleday, Karin Wadell
BACKGROUND: Incorporating co-creation processes may improve the quality of outcome interventions. However, there is a lack of synthesis of co-creation practices in the development of Non-Pharmacological Interventions (NPIs) for people with Chronic Obstructive Pulmonary Disease (COPD), that could inform future co-creation practice and research for rigorously improving the quality of care. OBJECTIVE: This scoping review aimed to examine the co-creation practice used when developing NPIs for people with COPD...
March 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/36871867/living-with-sarcoidosis-virtual-roundtable-dialogue-with-patients-and-healthcare-professionals
#19
JOURNAL ARTICLE
Marc A Judson, Paolo Spagnolo, Rebecca Stanfel, Garrie Farrow, Ana-Maria Tanase, Flavia Perna, Robert P Baughman
BACKGROUND: Sarcoidosis is a multisystem disease, characterised by the infiltration of various organs by non-necrotising granulomas. The disease's heterogeneity complicates the study of patients' experiences. OBJECTIVE: To gather insight into life experiences, unmet needs and views on hypothetically emerging treatment options among patients living with sarcoidosis. METHODS: Multinational, virtual, interactive, moderated discussion of specific questions between people with sarcoidosis, with experienced clinicians participating...
March 3, 2023: Respiratory Medicine
https://read.qxmd.com/read/36871866/lung-ultrasound-as-a-tool-for-monitoring-the-interstitial-changes-in-recently-hospitalised-patients-with-covid-19-pneumonia-the-covidlus-study
#20
JOURNAL ARTICLE
Tuck-Kay Loke, Naomi Earl, Austin C H Begbey, Naveen Sharma, Niklas R Wakeham, Hyon-Mok Sohn, Sarah J Greenslade, Emma Ince, Miriam Davey, Karina Cox
Background Long-term respiratory effects can occur after COVID-19 pneumonia (CP). The COVID Lung Ultrasound Study (COVIDLUS) aimed to investigate the utility of serial lung ultrasound (LUS) to track functional and physiological recovery after hospitalisation in patients with CP. Methods Between April 2021 and April 2022, 21 patients were recruited at discharge (D0). LUS was performed on D0, day 41 (D41) and day 83 (D83). CT Thorax was performed on D83. Lymphocyte count, Ferritin, Lactate Dehydrogenase, Troponin, CRP, and D-dimers were measured at D0, D41 and D83...
March 3, 2023: Respiratory Medicine
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