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JOURNAL ARTICLE
Hannah Smith, Robert Easterling, Jianing Ma, Meghana Moodabagil, Alexa Meara, Dwight H Owen, Elliot Crouser, Arindam Singha, Kevin Ho
INTRODUCTION: Sarcoid-like reactions (SLRs) to immune checkpoint inhibitors (ICIs) are a rare but increasingly recognized immune-related adverse event of which the clinical significance is unclear. METHODS: We conducted a retrospective cohort study at a tertiary academic center of consecutive patients who received at least one dose of ICI from 2013-2020. Patient characteristics, risk factors, and outcomes were compared between patients with and without SLR following ICI treatment...
April 20, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Mila Fradkin, Maya Elyashiv, Amasha Camel, Nirit Agay, Michael Brik, Pierre Singer, Rachel Dankner
BACKGROUND: We followed prolonged mechanically ventilated (PMV) patients for weaning attempts and explored factors associated with successful weaning and long-term survival. METHODS: This historical cohort study included all adult PMV patients admitted to a single rehabilitation hospital during 2015-2018 and followed for survival according to weaning success up to 3 years or the end of 2021. RESULTS: The study included 223 PMV patients. Of them, 124(55...
April 18, 2024: Respiratory Medicine
#3
REVIEW
T David Koster, Pallav L Shah, Arschang Valipour, Gerard J Criner, Felix J F Herth, Richard Sue, Douglas K Hogarth, Ralitza T Martin, Amit K Mahajan, Raed Alalawi, Lisa Kopas, Avi Cohen, Douglas E Wood, Jonathan Kurman, Narinder S Shargill, Mark Dransfield, Dirk-Jan Slebos, Michael Perch
Bronchoscopic lung volume reduction treatment with Zephyr one-way valves is an effective guideline-based treatment option for patients with severe emphysema and hyperinflation. However, in some cases the treatment response is less than anticipated or there might be a loss of initial treatment effect. Reasons for the lack of response can include incorrect assessment of collateral ventilation, improper valve placement, or patient related factors. Loss of initial benefit can be due to granulation tissue formation and subsequent valve dysfunction, or there may be side effects such as excessive coughing or infectious problems...
April 18, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Virginia Mara Reis Gomes, Magda Carvalho Pires, Polianna Delfino Pereira, Alexandre Vargas Schwarzbold, Angélica Gomides Dos Reis Gomes, Bruno Porto Pessoa, Christiane Correa Rodrigues Cimini, Danyelle Romana Alves Rios, Fernando Anschau, Francine Janaína Magalhães Nascimento, Genna Maira Santos Grizende, Giovanna Grunewald Vietta, Joanna d'Arc Lyra Batista, Karen Brasil Ruschel, Marcelo Carneiro, Marco Aurélio Reis, Maria Aparecida Camargos Bicalho, Paula Fonseca Porto, Priscilla Pereira Dos Reis, Silvia Ferreira Araújo, Vandack Nobre, Milena Soriano Marcolino
PURPOSE: To develop a mortality risk score for COVID-19 patients admitted to intensive care units (ICU), and to compare it with other existing scores. MATERIALS AND METHODS: It is a retrospective observational study, including consecutive adult patients with laboratory-confirmed COVID-19 admitted to ICUs of 18 hospitals from nine Brazilian cities, from 09/2021 to 07/2022. Potential predictors were selected based on the literature review. Generalized Additive Models were used to examine outcomes and predictors...
April 17, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Lauren M Zell-Baran, Silpa Krefft, Matthew Strand, Cecile S Rose
RATIONALE: Exposure to burn pit smoke, desert and combat dust, and diesel exhaust during military deployment to Southwest Asia and Afghanistan (SWA) can cause deployment-related respiratory diseases (DRRDs) and may confer risk for worsening lung function after return. METHODS: Study subjects were SWA-deployed veterans who underwent occupational lung disease evaluation (n=219). We assessed differences in lung function by deployment exposures and DRRD diagnoses. We used linear mixed models to assess changes in lung function over time...
April 17, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Giorgio Walter Canonica, Christian Domingo, Kim L Lavoie, Amrit Kaliasethi, Shireen Quli Khan, Anurita Majumdar, Sourabh Fulmali
INTRODUCTION: Patient adherence to maintenance medication is critical for improving clinical outcomes in asthma and is a recommended guiding factor for treatment strategy. Previously, the APPaRENT studies assessed patient and physician perspectives on asthma care; here, a post-hoc analysis aimed to identify patient factors associated with good adherence and treatment prescription patterns. METHODS: APPaRENT 1 and 2 were cross-sectional online surveys of 2866 adults with asthma and 1883 physicians across Argentina, Australia, Brazil, Canada, China, France, Italy, Mexico, and the Philippines in 2020-2021...
April 16, 2024: Respiratory Medicine
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JOURNAL ARTICLE
A M Yohannes, R Casaburi, S Dryden, N A Hanania
BACKGROUND: Anxiety is common in patients with chronic obstructive pulmonary disease (COPD). However, there is little evidence available regarding gender differences, and severity of dyspnea in relation to anxiety in patients with COPD. AIMS: We examined gender differences and the association of dyspnea with anxiety in a cohort of patients with COPD prior to entering a pulmonary rehabilitation (PR) program. METHOD: We analyzed data from a prospective cohort of COPD patients who attended PR from 2013 to 2019 in Lytham, Lancashire, UK...
April 15, 2024: Respiratory Medicine
#8
REVIEW
Emerging therapies: Potential roles of SGLT2 inhibitors in the management of pulmonary hypertension.
Taimin Luo, Hui Wu, Wanlong Zhu, Liaoyun Zhang, Yilan Huang, Xuping Yang
Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases. Pulmonary hypertension due to left heart disease (PH-LHD) currently lacks targeted therapies, while Pulmonary arterial hypertension (PAH), despite approved treatments, carries considerable residual risk. Metabolic dysfunction has been linked to the pathogenesis and prognosis of PH through various studies, with emerging metabolic agents offering a potential avenue for improving patient outcomes...
April 15, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Yuan Zhou, Shujing Duan, Lei Zhang, Fangchen Peng
OBJECTIVE: A study has analyzed the long-term cost-effectiveness of fluticasone furoate/umeclidinium bromide/vilanterol combination therapy (FF/UMEC/VI) versus umeclidinium bromide/vilanterol dual therapy (UMEC/VI) in the treatment of moderate or severe chronic obstructive pulmonary disease (COPD), providing evidence for decision-making in COPD treatment. METHODS: From the perspective of the whole society, a Markov model based on the severity of COPD was established, consisting of four states: moderate, severe, very severe, and death ...
April 13, 2024: Respiratory Medicine
#10
JOURNAL ARTICLE
Francesco Lapi, Ettore Marconi, Francesco Paolo Lombardo, Iacopo Cricelli, Elena Ansaldo, Marco Gorini, Claudio Micheletto, Fabiano Di Marco, Claudio Cricelli
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the fourth most important cause of death in high-income countries. Inappropriate use of COPD inhaled therapy, including the low adherence (only 10% to 40% of patients reporting an adequate compliance) may shrink or even nullify the proven benefits of these medications. As such, an accurate prediction algorithm to assess at national level the risk of COPD exacerbation might be relevant for general practictioners (GPs) to improve patient's therapy...
April 13, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Andrea Portacci, Monica Amendolara, Vitaliano Nicola Quaranta, Ilaria Iorillo, Enrico Buonamico, Fabrizio Diaferia, Sara Quaranta, Cristian Locorotondo, Annalisa Schirinzi, Esterina Boniello, Silvano Dragonieri, Giovanna Elisiana Carpagnano
BACKGROUND AND OBJECTIVES: Reliable biomarkers able to predict post-COVID syndrome development are still lacking. The aim of the study was to evaluate the relationship between Galectin-3 blood concentrations and the development of post-COVID syndrome. METHODS: We performed a single-center, prospective, observational study, enrolling 437 consecutive patients attending our outpatient clinic for the post-COVID assessment. For each patient, we recorded the main clinical, functional and radiological findings...
April 12, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Keiji Fujiwara, Fumiya Watanabe, Fumiko Uesugi, Koji Furuuchi, Masashi Ito, Tatsuya Kodama, Yoshiaki Tanaka, Takashi Yoshiyama, Satoshi Mitarai, Atsuyuki Kurashima, Ken Ohta, Kozo Morimoto
BACKGROUND: Although international nontuberculous mycobacterial pulmonary disease (NTM-PD) guidelines highlight symptom presence at diagnosis, the clinical characteristics of asymptomatic Mycobacterium avium complex pulmonary infection (MAC-PI) patients remain understudied. We clarified the clinical characteristics and course of asymptomatic MAC-PI patients. METHODS: We retrospectively analyzed 200 consecutive patients with MAC-PIs and adequate available data who newly met the microbiological and radiological criteria for NTM-PD at Fukujuji Hospital from January 2018 to June 2020...
April 9, 2024: Respiratory Medicine
#13
JOURNAL ARTICLE
Melissa H Roberts, Mei Sheng Duh, Kieran J Rothnie, Shiyuan Zhang, Alexandrosz Czira, David Slade, Wendy Y Cheng, Philippe Thompson-Leduc, Alexandra Greatsinger, Adina Zhang, Douglas Mapel
INTRODUCTION: Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed. METHODS: A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescription claim for inhaled corticosteroid/long-acting β2 -agonist, and ≥1 medical claim with a diagnosis code for asthma was conducted...
April 7, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Mei Sheng Duh, Melissa H Roberts, Kieran J Rothnie, Wendy Y Cheng, Philippe Thompson-Leduc, Shiyuan Zhang, Alexandrosz Czira, David Slade, Alexandra Greatsinger, Adina Zhang, Douglas Mapel
INTRODUCTION: Despite adherence to inhaled corticosteroid/long-acting β2 -agonist (ICS/LABA) therapy, many patients with asthma experience moderate exacerbations. Data on the impact of moderate exacerbations on the healthcare system are limited. This study assessed the frequency and economic burden of moderate exacerbations in patients receiving ICS/LABA. METHODS: Retrospective, longitudinal study analyzed data from Optum's de-identified Clinformatics® Data Mart Database recorded between October 1, 2015, and December 31, 2019...
April 7, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Diana Betancor, Blanca Barroso, Marcela Valverde-Monge, Alicia Gomez-Lopez, Joaquin Sastre
No abstract text is available yet for this article.
April 5, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Lisa De Rose, John Sorge, Brianna Blackwell, Mark Benjamin, Ayman Mohamed, Theodoor Roverts, Susan Szpunar, Louis D Saravolatz
BACKGROUND: The Prognostic Nutritional Index (PNI) uses albumin levels and total lymphocyte count to predict the relationship between immune-nutritional state and prognosis in a variety of diseases, however it has not been studied in community acquired bacterial pneumonia (CABP). We conducted a historical cohort study to determine if there was an association between PNI and clinical outcomes in patients with CABP. METHODS: We reviewed 204 adult patients with confirmed CABP, and calculated admission PNI and Neutrophil-to-Lymphocyte Ratio (NLR)...
April 5, 2024: Respiratory Medicine
#17
JOURNAL ARTICLE
Julie Van Woensel, Bart Koopman, Mart Schiefer, Coen van Kan, Marlou Janssen, Sofia Ramiro, César Magro-Checa, Robert Bm Landewé, Martijn D de Kruif, Paul Bresser, Rémy Lm Mostard
BACKGROUND: Clinical presentation and prevalence of organ involvement is highly variable in sarcoidosis and depends on ethnic, genetic and geographical factors. These data are not extensively studied in a Dutch population. AIM: To determine the prevalence of organ involvement and the indication for systemic immunosuppressive therapy in newly diagnosed sarcoidosis patients in the Netherlands. METHODS: Two large Dutch teaching hospitals participated in this prospective cohort study...
April 4, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Kefang Lai, Dejun Sun, Ranran Dai, Ronnie Samoro, Hae-Sim Park, Annika Åstrand, David Cohen, Maria Jison, Vivian H Shih, Viktoria Werkström, Yuhui Yao, Yajuan Zhang, Wenying Zheng, Nanshan Zhong, Albay Albert, Bo Jianping, Chen Bi, Chen Lijun, Chen Mei, Chen Min, Chen Ping, Chen Zhimin, Chian Chih-Feng, Cho You Sook, Fu Xiuhua, Gao Xiwen, Gu Wei, Han Wei, Han Zhihai, Hu Xi Wei, Huang Kewu, Huang Mao, Isidro Marie Grace Dawn, Jeong Inbeom, Jiang Luning, Jiang Mingyan, Jiang Shanping, Jin Meiling, Kang Jian, Kim Jin Woo, Kim Sang-Ha, Kuang Jiulong, Kuo Ping-Hung, Li Jie, Li Manxiang, Li Minjing, Li Ruoran, Li Wen, Li Xianhua, Li Yanming, Lim Seong Yong, Liu Chuanhe, Liu Chuntao, Liu Jing, Liu Xiaoxia, Lu Huiyu, Luo Zhuang, Ma Shengxi, Mao Liangping, Min Kyung Hoon, Mu Lin, Park Choon-Sik, Park Hae Sim, Park Hye-Kyung, Park Jung-Won, Perng Diahn-Warng, Samoro Ronnie, Shi Guochao, Sun Debin, Sun Dejun, Wang Chun-Hua, Wang Guangfa, Wang Limin, Wang Xuefen, Wang Yan, Wei Liping, Wu Haihong, Xiao Yi, Xiao Zuke, Xie Canmao, Xu Jin-Fu, Xu Xingxiang, Xu Xiyuan, Yan Jianping, Yang Hongzhong, Yoon Ho Joo, Yu Wencheng, Zhang Jin, Zhang Longju, Zhang Min, Zhang Wei, Zhao Jianping, Zhao Ziwen, Zhu Xiaoli, Zhu Yingqun
BACKGROUND: Benralizumab is indicated as add-on therapy in patients with uncontrolled, severe eosinophilic asthma; it has not yet been evaluated in a large Asian population with asthma in a clinical trial. OBJECTIVE: To evaluate the efficacy and safety of benralizumab in patients with severe asthma in Asia. METHODS: MIRACLE (NCT03186209) was a randomized, Phase 3 study in China, South Korea, and the Philippines. Patients aged 12-75 years with severe asthma receiving medium-to-high-dose inhaled corticosteroid/long-acting β2 -agonists, stratified (2:1) by baseline blood eosinophil count (bEOS) (≥300/μL; <300/μL), were randomized (1:1) to benralizumab 30 mg or placebo...
April 1, 2024: Respiratory Medicine
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JOURNAL ARTICLE
Anna L Stoustrup, Daisy J A Janssen, Nienke Nakken, Emiel F M Wouters, Alda Marques, Ulla Møller Weinreich, Martijn A Spruit
INTRODUCTION: In patients with chronic obstructive pulmonary disease (COPD), loneliness and social isolation are associated with increased morbidity and decreased mobility, self-reliance, and health-related quality of life. Social support has been shown to improve these outcomes. AIMS: This cross-sectional study aimed to investigate the level of experienced social support and the clinical outcomes associated with inadequate social support among patients with COPD with a resident loved one...
April 1, 2024: Respiratory Medicine
#20
JOURNAL ARTICLE
Sara Lundell, Ulf Isaksson, Anna-Britt Coe, Samantha L Harrison, Senada Hajdarevic
Assessment of self-conscious emotions is important to develop tailored interventions for people with chronic obstructive pulmonary disease (COPD). Previous instruments have largely been developed for mental health populations. The Self-Conscious Emotions in COPD Questionnaire was the first instrument to assess self-conscious emotions in people with COPD, but it was only available in English. The aim was to translate the Self-Conscious Emotions in COPD Questionnaire into Swedish and to evaluate its psychometric properties and internal structure in a Swedish context...
April 1, 2024: Respiratory Medicine
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