journal
https://read.qxmd.com/read/37729955/cell-free-ace2-rna-a-potential-biomarker-of-covid-19-severity
#1
JOURNAL ARTICLE
Nour Jalaleddine, Mellissa Gaudet, Andrea Mogas, Mahmood Hachim, Abiola Senok, Narjes Saheb Sharif-Askari, Bassam Mahboub, Rabih Halwani, Qutayba Hamid, Saba Al Heialy
Despite the downward trend of COVID-19 pandemic and increased immunity of the general population, COVID-19 is still an elusive disease with risks due to emerging variants. Fast and reliable diagnosis of COVID-19 disease would allow better therapeutic interventions for patients at risk to develop more severe outcomes. Cell-free RNAs (cfRNAs) have been proven to be an effective biomarker in cancer and infectious diseases. It has been reported that cfRNAs are amplified in the bloodstream of these patients and at earlier stages of the disease, reflecting tissue damage...
September 18, 2023: Respiratory Medicine
https://read.qxmd.com/read/37729954/burden-of-pulmonary-hypertension-due-to-chronic-obstructive-pulmonary-disease-analysis-of-exacerbations-and-healthcare-resource-utilization-in-the-united-states
#2
JOURNAL ARTICLE
James R Klinger, Benjamin Wu, Kellie Morland, Peter Classi, Ryan Fiano, Shannon Grabich
BACKGROUND: The burden of pulmonary hypertension (PH) among patients with chronic obstructive pulmonary disease (COPD) is not well understood. The present retrospective cohort study aimed to quantify the clinical and economic burden of PH in patients with COPD. METHODS: Adults with COPD were retrospectively identified in the Optum® Clinformatics® Data Mart between July 1, 2016 and June 30, 2021. Those diagnosed with PH were assigned to the PH-COPD cohort and those without a diagnosis of PH were assigned to the COPD cohort...
September 18, 2023: Respiratory Medicine
https://read.qxmd.com/read/37717791/palliative-care-interventions-in-chronic-respiratory-diseases-a-systematic-review
#3
REVIEW
Marta Fé Santos, Paulo Reis-Pina
INTRODUCTION: Chronic respiratory diseases represent a significant burden of disease globally, with high morbidity and mortality. Individuals living with these conditions, as well as their families, face considerable physical, emotional and social challenges. Palliative care might be a valuable approach to address their complex needs, but evidence to prove this is still scarce. OBJECTIVES: This systematic review aimed to study the effectiveness of palliative care interventions in health-related outcomes (quality of life, symptom control, symptom burden, psychological well-being, advance care planning, use of health services, and survival) in chronic respiratory patients...
September 15, 2023: Respiratory Medicine
https://read.qxmd.com/read/37696313/the-spectrum-of-pulmonary-amyloidosis
#4
REVIEW
Anas Riehani, Ayman O Soubani
Amyloidosis is a disease caused by misfolded proteins that deposit in the extracellular matrix as fibrils, resulting in the dysfunction of the involved organ. The lung is a common target of Amyloidosis, but pulmonary amyloidosis is uncommonly diagnosed since it is rarely symptomatic. Diagnosis of pulmonary amyloidosis is usually made in the setting of systemic amyloidosis, however in cases of localized pulmonary disease, surgical or transbronchial tissue biopsy might be indicated. Pulmonary amyloidosis can be present in a variety of discrete entities...
September 9, 2023: Respiratory Medicine
https://read.qxmd.com/read/37696312/efficacy-of-inhaled-tiotropium-add-on-to-budesonide-formoterol-in-patients-with-bronchiolitis-obliterans-developing-after-hematopoietic-stem-cell-transplantation
#5
JOURNAL ARTICLE
Jeong Uk Lim, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chin Kook Rhee
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is the lung manifestation of chronic graft-versus-host disease after hematopoietic stem cell transplantation (HSCT). We assessed whether inhaled tiotropium add-on to the combination regimen including budesonide/formoterol improve pulmonary function and the chronic obstructive pulmonary disease assessment test (CAT) scores in patients with BOS. METHODS: Post-HSCT patients diagnosed as BOS in Seoul St. Mary's Hospital were reviewed retrospectively...
September 9, 2023: Respiratory Medicine
https://read.qxmd.com/read/37690570/long-term-clinical-outcomes-of-elexacaftor-tezacaftor-ivacaftor-therapy-in-adults-with-cystic-fibrosis-and-advanced-pulmonary-disease
#6
JOURNAL ARTICLE
Daniela Savi, Francesca Lucca, Gloria Tridello, Ilaria Meneghelli, Isabella Comello, Sara Tomezzoli, Monica Signorini, Elena Proietti, Giulia Cucchetto, Sonia Volpi, Marco Cipolli
BACKGROUND: The combination of cystic fibrosis transmembrane conductance regulator (CFTR) modulators elexacaftor, tezacaftor and ivacaftor (ELX/TEZ/IVA) has been approved for treatment of cystic fibrosis (CF) patients (pwCF) homozygous and heterozygous for Phe508del. We aim to assess the long-term effects of ELX/TEZ/IVA therapy on clinical outcomes in severe pwCF. METHODS: Lung function, pulmonary exacerbation (PEx), sweat chloride concentration, body mass index (BMI) and the respiratory domain of the cystic fibrosis questionnaire-revised (CFQ-R RD) were prospectively evaluated in a cohort of pwCF who were candidates for inclusion in a compassionate program of ELX/TEZ/IVA therapy...
September 8, 2023: Respiratory Medicine
https://read.qxmd.com/read/37683776/respiratory-syncytial-virus-burden-and-risk-factors-for-severe-disease-in-patients-presenting-to-the-emergency-department-with-flu-like-symptoms-or-acute-respiratory-failure
#7
JOURNAL ARTICLE
Pierachille Santus, Dejan Radovanovic, Maria Rita Gismondo, Sara Giordana Rimoldi, Alessandra Lombardi, Fiammetta Danzo, Andrea Gori, Spinello Antinori, Giuliano Rizzardini
BACKGROUND: Predictors of Respiratory Syncytial Virus (RSV) infection and determinants of RSV unfavorable outcomes are still unclear. We assessed RSV burden and investigated the risk factors associated with RSV positive swab and RSV severe disease. METHODS: A retrospective, single center, cohort study included all consecutive patients referred to the emergency department of L. Sacco University Hospital (Milan) with flu-like symptoms or acute respiratory failure (aRF) tested per protocol for SARS-CoV-2, RSV, Influenza A (InvA) during the 2022-2023 autumn/winter season...
September 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/37683775/guest-editor-s-bio-dr-nicola-a-hanania
#8
EDITORIAL
Nicola A Hanania
No abstract text is available yet for this article.
September 6, 2023: Respiratory Medicine
https://read.qxmd.com/read/37673413/endobronchial-lung-volume-reduction-with-valves-reduces-exacerbations-in-severe-emphysema-patients
#9
JOURNAL ARTICLE
Judith Maria Brock, Felix Böhmker, Paul Ulrich Schuster, Ralf Eberhardt, Daniela Gompelmann, Konstantina Kontogianni, Susanne Dittrich, Nicola Benjamin, Felix Herth
BACKGROUND AND OBJECTIVE: Exacerbations drive the progression of chronic obstructive pulmonary disease (COPD). Endoscopic lung volume reduction (ELVR) with valves is an established treatment option for patients with severe emphysema. Post-interventional exacerbations are observed in 8-17% of cases. Whether the exacerbation rate changes in the medium term after ELVR, is not known. METHODS: This is a single-center retrospective analysis of severe emphysema patients with endobronchial valve implantation...
September 4, 2023: Respiratory Medicine
https://read.qxmd.com/read/37660900/guest-editor-s-bio-dr-zuzana-diamant
#10
EDITORIAL
Zuzanna Diamant
No abstract text is available yet for this article.
September 1, 2023: Respiratory Medicine
https://read.qxmd.com/read/37660899/guest-editor-s-bio-dr-sven-seys
#11
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2023: Respiratory Medicine
https://read.qxmd.com/read/37659437/clinical-significance-of-normalized-airflow-obstruction-in-patients-with-chronic-obstructive-pulmonary-disease
#12
JOURNAL ARTICLE
Yun Seok Kim, Yong Il Hwang, Jae Ha Lee, Yong Bum Park, Cheon Woong Choi, Ki-Suck Jung, Kwang Ha Yoo, Seong Yong Lim, Ju Sang Kim, Joon Young Choi
BACKGROUND: There is ongoing debate regarding the diagnostic criteria for chronic obstructive pulmonary disease (COPD); recent studies have focused on the early COPD detection and management. Here, we compared clinical features and prognosis in patients with FEV1/FVC<0.70 at baseline, according to normalized airflow obstruction status during follow-up. METHODS: We used the Korea COPD Subgroup Study (KOCOSS) cohort database, a prospective nationwide observational COPD study...
August 31, 2023: Respiratory Medicine
https://read.qxmd.com/read/37659436/clinical-features-and-outcomes-of-children-s-interstitial-lung-disease-accompanied-with-connective-tissue-disease-a-prospective-cohort-study
#13
JOURNAL ARTICLE
Gaoli Jiang, Jingyi Xia, Quanli Shen, Weiming Chen, Jianfeng Huang, Libo Wang, Li Sun, Liling Qian
BACKGROUND: Medical complexity of childhood interstitial lung disease (chILD) with connective tissue disease (CTD) poses a considerable challenge to pediatricians. METHODS: Clinical characteristics, laboratory findings, pulmonary function tests (PFTs), treatments and outcomes obtained for patients with CTD-chILD were analyzed in a prospective study. RESULTS: Patients' median age at diagnosis was 7 years old. About 29.4% (15/51) suffered rapidly progressive childhood ILD (RP-chILD) with a high mortality rate (33...
August 31, 2023: Respiratory Medicine
https://read.qxmd.com/read/37659435/dupilumab-efficacy-in-high-sleep-disturbance-management-among-patients-with-type-2-asthma
#14
JOURNAL ARTICLE
Jorge F Maspero, Shirin Shafazand, Jeremy Cole, Ian D Pavord, William W Busse, Jérôme Msihid, Rebecca Gall, Xavier Soler, Amr Radwan, Asif H Khan, Lucia de Prado Gómez, Juby A Jacob-Nara
BACKGROUND: Patients with asthma often experience sleep disturbances. We assessed the 5-item Asthma Control Questionnaire (ACQ-5) score ≥2.5 as a useful threshold to identify patients with moderate-to-severe type 2 asthma and high sleep disturbance (HSD) and investigated dupilumab efficacy on clinical and sleep-related outcomes among patients with HSD. METHODS: QUEST (NCT02414854) data were used in this post hoc analysis. A composite endpoint from validated patient-reported outcomes was developed to identify patients with HSD using sleep-related items from the ACQ-5, Asthma-Related Quality-of-Life Questionnaire, Rhino-Conjunctivitis Quality-of-Life Questionnaire, and Sino-Nasal Outcome Test-22...
August 31, 2023: Respiratory Medicine
https://read.qxmd.com/read/37657534/association-between-severe-bronchiolitis-in-infancy-and-age-6-year-lung-function
#15
JOURNAL ARTICLE
Geneva D Mehta, Anna Chen Arroyo, Zhaozhong Zhu, Janice A Espinola, Jonathan M Mansbach, Kohei Hasegawa, Carlos A Camargo
BACKGROUND AND OBJECTIVES: Understanding early life risk factors for decreased lung function could guide prevention efforts and improve lung health throughout the lifespan. Our objective was to investigate the association between history of severe (hospitalized) bronchiolitis in infancy and age 6-year lung function. METHODS: We analyzed data from two prospective cohort studies: infants hospitalized with bronchiolitis and a parallel cohort of healthy infants. Children were followed longitudinally, and spirometry was performed at age 6 years...
August 30, 2023: Respiratory Medicine
https://read.qxmd.com/read/37657533/predictors-of-treatment-response-to-pregabalin-in-unexplained-or-refractory-chronic-cough
#16
JOURNAL ARTICLE
Mathieu D Saint-Pierre
BACKGROUND: Patients with chronic cough (>8 weeks) often remain symptomatic after appropriate investigations and therapeutic trials. Prior research has shown a benefit in certain individuals from pregabalin, but clinical improvement is quite unpredictable and variable. OBJECTIVE: The main objective of this study was to identify the demographic and clinical characteristics associated with a higher likelihood of cough improvement with a trial of pregabalin therapy...
August 30, 2023: Respiratory Medicine
https://read.qxmd.com/read/37640274/a-remote-monitoring-enabled-home-exercise-prescription-for-patients-with-interstitial-lung-disease-at-risk-for-exercise-induced-desaturation
#17
JOURNAL ARTICLE
Claire E Child, Morgan L Kelly, Haley Sizelove, Marissa Garvin, Julia Guilliams, Paul Kim, Haotian D Cai, SiWei Luo, Kevin J McQuade, Erik R Swenson, Amanda T Wise, Ylinne T Lynch, Lawrence A Ho, Mary Beth Brown
RATIONALE: Alternatives to center-based pulmonary rehabilitation are needed to improve patient access to this important therapy. A critical challenge to overcome is how to maximize safety of unsupervised exercise for at-risk patients. We investigated if a novel remote monitoring-enabled mobile health (mHealth) program is safe, feasible, and effective for patients who experience exercise-induced hemoglobin desaturation. METHODS: An interstitial lung disease (ILD) commonly associated with pronounced exercise desaturation was investigated - the rare, female-predominant ILD lymphangioleiomyomatosis (LAM)...
August 26, 2023: Respiratory Medicine
https://read.qxmd.com/read/37640273/efficacy-and-safety-of-aclidinium-formoterol-versus-monotherapies-and-aclidinium-versus-placebo-in-chinese-and-other-asian-patients-with-moderate-to-severe-copd-the-avant-phase-3-study
#18
JOURNAL ARTICLE
Yongchang Sun, Eduard Molins, Sami Z Daoud, Roopa Trivedi, Catherine Stewart, Rosa Lamarca, Pranob Bharali, Esther Garcia-Gil
AVANT was a Phase 3, 24-week, randomized, parallel-group, double-blind, double-dummy, placebo-controlled study to assess the efficacy and safety of aclidinium/formoterol 400 μg/12 μg combination vs monotherapies and placebo (1:1:1:1) in Asian patients (∼70% of whom were Chinese) with moderate-to-severe stable chronic obstructive pulmonary disease (COPD). Endpoints were analyzed hierarchically to incorporate type I error control. At Week 24, aclidinium/formoterol demonstrated improvements from baseline in 1-h morning post-dose forced expiratory volume in 1 s (FEV1 ) vs aclidinium (least squares [LS] mean 92 mL; 95% confidence interval [CI] 60, 124; p < 0...
August 26, 2023: Respiratory Medicine
https://read.qxmd.com/read/37633422/views-and-experiences-of-healthcare-practitioners-supporting-people-with-copd-who-have-used-activity-monitors-more-than-just-steps
#19
JOURNAL ARTICLE
L J Wilde, C Percy, C Clark, G Ward, P A Wark, L Sewell
INTRODUCTION: Activity monitors (apps and wearables) are increasingly used by the general population, including people with Chronic Obstructive Pulmonary Disease (COPD). There is potential for activity monitors to support increases in physical activity for people with COPD and healthcare practitioners (HCPs) are likely to be key in supporting their use, but little is currently known about HCPs' views or experiences. This qualitative research aimed to explore HCPs' views and experiences of supporting people with COPD who have used activity monitors...
August 24, 2023: Respiratory Medicine
https://read.qxmd.com/read/37633421/utility-of-the-enhanced-liver-fibrosis-score-as-a-blood-biomarker-of-pulmonary-fibrosis-secondary-to-sars-cov-2-pneumonia
#20
JOURNAL ARTICLE
Alexa Núñez, Cristina Aljama, Cristina Esquinas, Gerard Orriols, Pablo Gabriel-Medina, Georgina Farago, Galo Granados, Francisco Rodriguez-Frias, Mònica Pons, Marc Miravitlles, Miriam Barrecheguren
INTRODUCTION: SARS-CoV-2 pneumonia can lead to several sequelae, among them, pulmonary fibrosis. The Enhanced Liver Fibrosis (ELF) score is a panel of serum markers of liver fibrosis. We aimed to describe the utility of the ELF score as a biomarker of pulmonary fibrosis secondary to COVID-19 pneumonia. METHODS: Chest computed tomography (CT) scan, lung function tests (LFT) and blood analysis were obtained at three months after discharge. Data were analysed according to ELF scores and posteriorly divided into ELF tertiles...
August 24, 2023: Respiratory Medicine
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