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Journals Pharmacological Research : the...

Pharmacological Research : the Official Journal of the Italian Pharmacological Society

https://read.qxmd.com/read/39025169/the-role-of-amino-acid-metabolism-alterations-in-acute-ischemic-stroke-from-mechanism-to-application
#1
REVIEW
Xiang-Ping Wang, Dan Yan, Xia-Ping Jin, Wen-Yan Zhang, Tao Shi, Xiang Wang, Wenjuan Song, Xing Xiong, Duancheng Guo, Sheng Chen
Acute ischemic stroke (AIS) is the most prevalent type of stroke, and due to its high incidence, disability rate, and mortality rate, it imposes a significant burden on the health care system. Amino acids constitute one of the most crucial metabolic products within the human body, and alterations in their metabolic pathways have been identified in the microenvironment of AIS, thereby influencing the pathogenesis, severity, and prognosis of AIS. The amino acid metabolism characteristics in AIS are complex. On one hand, the dynamic progression of AIS continuously reshapes the amino acid metabolism pattern...
July 16, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39019336/brain-gliomas-diagnostic-and-therapeutic-issues-and-the-prospects-of-drug-targeted-nano-delivery-technology
#2
REVIEW
Baoqin Song, Xiu Wang, Lijing Qin, Shehbaz Hussain, Wanjun Liang
Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment and a low patient survival rate. Due to the heterogeneity and invasiveness of tumors, lack of personalized clinical treatment design, and physiological barriers, it is often difficult to accurately distinguish gliomas, which dramatically affects the subsequent diagnosis, imaging treatment, and prognosis. Fortunately, nano-delivery systems have demonstrated unprecedented capabilities in diagnosing and treating gliomas in recent years...
July 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39009292/insight-into-endothelial-cell-derived-extracellular-vesicles-in-cardiovascular-disease-molecular-mechanisms-and-clinical-implications
#3
REVIEW
Xia Wang, Ben He
The endothelium is crucial in regulating vascular function. Extracellular vesicles (EVs) serve as membranous structures released by cells to facilitate intercellular communication through the delivery of nucleic acids, lipids, and proteins to recipient cells in an paracrine or endocrine manner. Endothelial cell-derived EVs (EndoEVs) have been identified as both biomarkers and significant contributors to the occurrence and progression of cardiovascular disease (CVD). The impact of EndoEVs on CVD is complex and contingent upon the condition of donor cells, the molecular cargo within EVs, and the characteristics of recipient cells...
July 13, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39009291/natural-polysaccharides-as-promising-reno-protective-agents-for-the-treatment-of-various-kidney-injury
#4
REVIEW
Yufei Ye, Maoting Li, Wei Chen, Hongrui Wang, Xuhui He, Nanmei Liu, Zhiyong Guo, Chengjian Zheng
Renal injury, a prevalent clinical outcome with multifactorial etiology, imposes a substantial burden on society. Currently, there remains a lack of effective management and treatments. Extensive research has emphasized the diverse biological effects of natural polysaccharides, which exhibit promising potential for mitigating renal damage. This review commences with the pathogenesis of four common renal diseases and the shared mechanisms underlying renal injury. The renoprotective roles of polysaccharides in vivo and in vitro are summarized in the following five aspects: antioxidative stress effects, antiapoptotic effects, antiinflammatory effects, antifibrotic effects, and gut modulatory effects...
July 13, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39004243/extracellular-vesicles-meet-mitochondria-potential-roles-in-regenerative-medicine
#5
REVIEW
Shujie Wu, Tao Yang, Meirui Ma, Le Fan, Lin Ren, Gen Liu, Yiqiao Wang, Bin Cheng, Juan Xia, Zhichao Hao
Extracellular vesicles (EVs), secreted by most cells, act as natural cell-derived carriers for delivering proteins, nucleic acids, and organelles between cells. Mitochondria are highly dynamic organelles responsible for energy production and cellular physiological processes. Recent evidence has highlighted the pivotal role of EVs in intercellular mitochondrial content transfer, including mitochondrial DNA (mtDNA), proteins, and intact mitochondria. Intriguingly, mitochondria are crucial mediators of EVs release, suggesting an interplay between EVs and mitochondria and their potential implications in physiology and pathology...
July 12, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39004242/relationship-between-clonal-evolution-and-drug-resistance-in-bladder-cancer-a-genomic-research-review
#6
REVIEW
Zhouting Tuo, Ying Zhang, Dengxiong Li, Yetong Wang, Ruicheng Wu, Jie Wang, Qingxin Yu, Luxia Ye, Fanglin Shao, Dilinaer Wusiman, Yubo Yang, Koo Han Yoo, Mang Ke, Uzoamaka Adaobi Okoli, William C Cho, Susan Heavey, Wuran Wei, Dechao Feng
Bladder cancer stands as a prevalent global malignancy, exhibiting notable sex-based variations in both incidence and prognosis. Despite substantial strides in therapeutic approaches, the formidable challenge of drug resistance persists. The genomic landscape of bladder cancer, characterized by intricate clonal heterogeneity, emerges as a pivotal determinant in fostering this resistance. Clonal evolution, encapsulating the dynamic transformations within subpopulations of tumor cells over time, is implicated in the emergence of drug-resistant traits...
July 12, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39002871/apabetalone-a-bet-protein-inhibitor-inhibits-kidney-damage-in-diabetes-by-preventing-pyroptosis-via-modulating-the-p300-h3k27ac-plk1-axis
#7
JOURNAL ARTICLE
Min Wang, Zhaohui Huang, Xin Li, Ping He, He Sun, Yali Peng, QiuLing Fan
Many inflammatory disorders, including diabetic kidney disease (DKD), are associated with pyroptosis, a type of inflammation-regulated cell death. The purpose of this work was to ascertain the effects of apabetalone, which targets BRD4, a specific inhibitor of the bromodomain (BRD) and extra-terminal (BET) proteins that target bromodomain 2, on kidney injury in DKD. This study utilized pharmacological and genetic approaches to investigate the effects of apabetalone on pyroptosis in db/db mice and human tubular epithelial cells (HK-2)...
July 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39002870/cancer-associated-fibroblasts-mediate-resistance-to-anti-egfr-therapies-in-cancer
#8
REVIEW
Shuang Dai, Yingtong Liu, Zheran Liu, Ruidan Li, Feng Luo, Yan Li, Lei Dai, Xingchen Peng
Over the last decade, epidermal growth factor receptor (EGFR)-targeted therapies have transformed the treatment landscape for patients with advanced solid tumors. Despite these advances, resistance to anti-EGFR therapies is still a significant clinical challenge. While cell-autonomous mechanisms of resistance are well-documented, they do not fully elucidate the complexity of drug resistance. Cancer-associated fibroblasts (CAFs), key mediators within the tumor microenvironment (TME), have emerged as pivotal players in cancer progression and chemoresistance...
July 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39002869/toll-like-receptor-4-mutation-mitigates-gut-microbiota-mediated-hypertensive-kidney-injury
#9
JOURNAL ARTICLE
Suravi Majumder, Sathnur B Pushpakumar, Hebah Almarshood, Rosemary Ouseph, Dibson D Gondim, Venkatakrishna R Jala, Utpal Sen
Hypertension-associated dysbiosis is linked to several clinical complications, including inflammation and possible kidney dysfunction. Inflammation and TLR4 activation during hypertension result from gut dysbiosis-related impairment of intestinal integrity. However, the contribution of TLR4 in kidney dysfunction during hypertension-induced gut dysbiosis is unclear. We designed this study to address this knowledge gap by utilizing TLR4 normal (TLR4N) and TLR4 mutant (TLR4M) mice. These mice were infused with high doses of Angiotensin-II for four weeks to induce hypertension...
July 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39002868/unravelling-the-impact-of-rna-methylation-genetic-and-epigenetic-machinery-in-the-treatment-of-cardiomyopathy
#10
REVIEW
Li Liu, Linxing Yu, Yubo Wang, Liufang Zhou, Yan Liu, Xingshou Pan, Jianjun Huang
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and epigenetic dysregulation playing a pivotal role in its pathogenesis. Emerging evidence from the burgeoning field of epitranscriptomics has brought to light the significant impact of various RNA modifications, notably N6-methyladenosine (m6A), 5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), 2'-O-methylation (Nm), and 6,2'-O-dimethyladenosine (m6Am), on cardiomyocyte function and the broader processes of cardiac and vascular remodelling...
July 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/39002867/asparagine-a-key-metabolic-junction-in-targeted-tumor-therapy
#11
REVIEW
Xuan Wang, Weijian Gong, Xueyou Xiong, Xuemei Jia, Juan Xu
Nutrient bioavailability in the tumor microenvironment plays a pivotal role in tumor proliferation and metastasis. Among these nutrients, glutamine is a key substance that promotes tumor growth and proliferation, and its downstream metabolite asparagine is also crucial in tumors. Studies have shown that when glutamine is exhausted, tumor cells can rely on asparagine to sustain their growth. Given the reliance of tumor cell proliferation on asparagine, restricting its bioavailability has emerged as promising strategy in cancer treatment...
July 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38992851/amplifying-hepatic-l-aspartate-levels-suppresses-ccl-4-induced-liver-fibrosis-by-reversing-glucocorticoid-receptor-%C3%AE-mediated-mitochondrial-malfunction
#12
JOURNAL ARTICLE
Rui Su, Hui-Ling Fu, Qian-Xue Zhang, Chen-Yan Wu, Guan-Yu Yang, Jun-Jie Wu, Wen-Jie Cao, Jin Liu, Zhong-Ping Jiang, Cong-Jun Xu, Yong Rao, Ling Huang
Liver fibrosis is a determinant-stage process of many chronic liver diseases and affected over 7.9 billion populations worldwide with increasing demands of ideal therapeutic agents. Discovery of active molecules with anti-hepatic fibrosis efficacies presents the most attacking filed. Here, we revealed that hepatic L-aspartate levels were decreased in CCl4 -induced fibrotic mice. Instead, supplementation of L-aspartate orally alleviated typical manifestations of liver injury and fibrosis. These therapeutic efficacies were alongside improvements of mitochondrial adaptive oxidation...
July 9, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38992850/pi3k-akt-signaling-pathway-molecular-mechanisms-and-therapeutic-potential-in-depression
#13
REVIEW
Ningning Guo, Xin Wang, Muran Xu, Jie Bai, Hao Yu, Le Zhang
Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of depression is complex and involves multiple signal transduction pathways and molecular changes. The PI3K/AKT pathway is an essential signaling pathways in nerve cells, which is widely expressed in emotion-related regions of the brain. Therefore, the PI3K/AKT pathway may play a moderating role in mood disorders...
July 9, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38977208/carnosic-acid-an-effective-phenolic-diterpenoid-for-prevention-and-management-of-cancers-via-targeting-multiple-signaling-pathways
#14
REVIEW
Xufei Chen, Cuntao Wei, Juanjuan Zhao, Dandan Zhou, Yue Wang, Shengxiang Zhang, Haiyue Zuo, Jianhui Dong, Zeyuan Zhao, Man Hao, Xirui He, Yangyang Bian
Cancer is a serious global public health issue, and a great deal of research has been made to treat cancer. Of these, discovery of promising compounds that effectively fight cancer always has been the main point of interest in pharmaceutical research. Carnosic acid (CA) is a phenolic diterpenoid compound widely present in Lamiaceae plants such as Rosemary (Rosmarinus officinalis L.). In recent years, there has been increasing evidence that CA has significant anti-cancer activity, such as leukaemia, colorectal cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, stomach cancer, lymphoma, prostate cancer, oral cancer, etc...
July 6, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38977207/fragile-treg-cells-traitors-in-immune-homeostasis
#15
REVIEW
Xiyu Song, Ruo Chen, Jiaxin Li, Yumeng Zhu, Jianhua Jiao, Hongjiao Liu, Zhinan Chen, Jiejie Geng
Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss of immunosuppression. Fragile Treg cells are formatively, phenotypically and functionally diverse in various diseases, further complicating the role of Treg cells in the immunotherapeutic response and offering novel targets for disease treatment by modulating specific Treg subsets...
July 6, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38972495/advancing-cancer-therapy-the-role-of-microrna-in-clinical-applications
#16
LETTER
Jianing Li, Yongsheng Zhang, Tong Fu, Guoli Xing, Ying Tong
No abstract text is available yet for this article.
July 5, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38971271/high-expression-of-runx1-in-colorectal-cancer-subtype-accelerates-malignancy-by-inhibiting-hmgcr
#17
JOURNAL ARTICLE
Zhilin Chang, Bing Liu, Han He, Xiaoyan Li, Hui Shi
Colorectal cancer (CRC) presents a complex landscape, characterized by both inter-tumor and intra-tumor heterogeneity. RUNX1, a gene implicated in modulating tumor cell growth, survival, and differentiation, remains incompletely understood regarding its impact on CRC prognosis. In our investigation, we discerned a positive correlation between elevated RUNX1 expression and aggressive phenotypes across various CRC subtypes. Notably, knockdown of RUNX1 demonstrated efficacy in restraining CRC proliferation both in vitro and in vivo, primarily through inducing apoptosis and impeding cell proliferation...
July 4, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38971270/assessment-of-sodium-glucose-cotransporter-2-inhibitors-sglt2i-and-other-antidiabetic-agents-in-alzheimer-s-disease-a-population-based-study
#18
JOURNAL ARTICLE
Mar Garcia Zamora, Gemma García-Lluch, Lucrecia Moreno, Juan Pardo, Consuelo Cháfer Pericas
The lack of effective treatments for dementia has led to explore the potential of antidiabetic agents as a possible approach. This cross-sectional and population-based study aimed to investigate the relationship between each antidiabetic drug and their defined daily doses (DDDs) and the use of anti-Alzheimer's disease (AD) drugs in order to establish new possible hypotheses about the role of antidiabetic drugs in AD. For that purpose, a database containing information on medications prescribed to 233183 patients aged 50 years or older between 2018 and 2020 was used...
July 4, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38971269/discovery-and-characterization-of-a-new-class-of-nad-independent-sirt1-activators
#19
JOURNAL ARTICLE
S Della Torre, G Dell'Omo, J Dellavedova, L Palazzolo, E Scanziani, Eberini, A Pinto, N Mitro, P Conti, A Villa, P Ciana
The activity of sirtuin 1 (SIRT1, a member of the NAD+ -dependent deacetylases family) decreases during aging as NAD+ levels naturally decline, thus increasing the risk of several age-associated diseases. Several sirtuin-activating compounds (STACs) have been developed to counteract the age-associated reduction in SIRT1 activity, and some of them are currently under development in clinical trials. STACs induce SIRT1 activation, either through allosteric activation of the enzyme in the presence of NAD+ , or by increasing NAD+ levels by inhibiting its degradation or by supplying a key precursor in biosynthesis...
July 4, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38969274/discovery-of-novel-fgf-trap-small-molecules-endowed-with-anti-myeloma-activity
#20
JOURNAL ARTICLE
Sara Taranto, Riccardo Castelli, Giuseppe Marseglia, Laura Scalvini, Federica Vacondio, Alessandra Gianoncelli, Giovanni Ribaudo, Jessica Faletti, Giorgia Gazzaroli, Edoardo Rocca, Roberto Ronca, Marco Rusnati, Antonio Sacco, Aldo Maria Roccaro, Marco Presta, Marco Mor, Arianna Giacomini, Silvia Rivara
Fibroblast growth factors (FGFs) act as proangiogenic and mitogenic cytokines in several cancers, including multiple myeloma (MM). Indeed, corrupted FGF autocrine and paracrine secretion induces an aberrant activation of the FGF receptor (FGFR) signaling sustaining cancer cell spreading and resistance to pharmacological treatments. Thus, FGF traps may represent a promising anti-cancer strategy to hamper the ligand-dependent activation of the FGF/FGFR system. We previously identified NSC12 as the first orally available small molecule FGF trap able to inhibit the growth and progression of several FGF-dependent tumor models...
July 3, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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