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Journals Pharmacological Research : the...

Pharmacological Research : the Official Journal of the Italian Pharmacological Society

https://read.qxmd.com/read/38417775/bioenergetic-dysfunction-in-the-pathogenesis-of-intervertebral-disc-degeneration
#1
REVIEW
Chao Song, Peixuan Hu, Renpeng Peng, Feng Li, Zhong Fang, Yong Xu
Intervertebral disc (IVD) degeneration is a frequent cause of low back pain and is the most common cause of disability. Treatments for symptomatic IVD degeneration, including conservative treatments such as analgesics, physical therapy, anti-inflammatories and surgeries, are aimed at alleviating neurological symptoms. However, there are no effective treatments to prevent or delay IVD degeneration. Previous studies have identified risk factors for IVD degeneration such as aging, inflammation, genetic factors, mechanical overload, nutrient deprivation and smoking, but metabolic dysfunction has not been highlighted...
February 26, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38417774/functional-significance-of-o-linked-n-acetylglucosamine-protein-modification-in-regulating-autophagy
#2
REVIEW
Zhuang Zhu, Wenhao Ren, Shaoming Li, Ling Gao, Keqian Zhi
Autophagy is a core molecular pathway that preserves cellular and organismal homeostasis. Being susceptible to nutrient availability and stress, eukaryotic cells recycle or degrade internal components via membrane transport pathways to provide sustainable biological molecules and energy sources. The dysregulation of this highly conserved physiological process has been strongly linked to human disease. Post-translational modification, a mechanism that regulates protein function, plays a crucial role in autophagy regulation...
February 26, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38413347/corrigendum-to-new-therapies-towards-a-better-glycemic-control-in-youths-with-type-1-diabetes-pharmacol-res-2023-aug-3-195-106882
#3
Roque Cardona-Hernandez, Klemen Dôvc, Torben Biester, Laya Ekhlaspour, Maddalena Macedoni, Martin Tauschmann, Chiara Mameli
No abstract text is available yet for this article.
February 26, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38403257/selection-strategy-of-second-line-biologic-therapies-in-adult-patients-with-ulcerative-colitis-following-prior-biologic-treatment-failure-systematic-review-and-meta-analysis
#4
REVIEW
Hu Zhang, Chenlu Mu, Yu Gu, Fanyi Meng, Xiali Qin, Hailong Cao
BACKGROUND: Optimizing second-line biologic therapies for adult ulcerative colitis (UC) post first-line failure is essential. OBJECTIVE: Compare second-line biologic therapy efficacy in adult UC patients with prior treatment failure. METHODS: A comprehensive search of electronic databases up to May 2023 was conducted to assess second-line biologic therapy efficacy using a random effects model. Parameters analyzed included clinical remission rate, clinical response rate, mucosal healing rate, annual discontinuation rate, and colectomy rates...
February 23, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38403256/targeting-autophagy-to-counteract-neuroinflammation-a-novel-antidepressant-strategy
#5
REVIEW
Hua Gan, Qingyu Ma, Wenzhi Hao, Nating Yang, Zhe-Sheng Chen, Lijuan Deng, Jiaxu Chen
Depression is a common disease that affects physical and mental health and imposes a considerable burden on afflicted individuals and their families worldwide. Depression is associated with a high rate of disability and suicide. It causes a severe decline in productivity and quality of life. Unfortunately, the pathophysiological mechanisms underlying depression have not been fully elucidated, and the risk of its treatment is still presented. Studies have shown that the expression of autophagic markers in the brain and peripheral inflammatory mediators are dysregulated in depression...
February 23, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38395207/unveiling-the-role-of-ipla-2-%C3%AE-in-neurodegeneration-from-molecular-mechanisms-to-advanced-therapies
#6
REVIEW
Jiabin Liu, Jieqiong Tan, Beisha Tang, Jifeng Guo
Calcium-independent phospholipase A2 β (iPLA2 β), a member of the phospholipase A2 (PLA2s) superfamily, is encoded by the PLA2G6 gene. Mutations in the PLA2G6 gene have been identified as the primary cause of infantile neuroaxonal dystrophy (INAD) and, less commonly, as a contributor to Parkinson's disease (PD). Recent studies have revealed that iPLA2 β deficiency leads to neuroinflammation, iron accumulation, mitochondrial dysfunction, lipid dysregulation, and other pathological changes, forming a complex pathogenic network...
February 21, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38387744/maresins-as-novel-anti-inflammatory-actors-and-putative-therapeutic-targets-in-sepsis
#7
REVIEW
Yan Sun, Shujun Sun, Pu Chen, Yan Dai, Dong Yang, Yun Lin, Lisha Yi
Sepsis, a complex clinical syndrome characterized by an exaggerated host response to infection, often necessitates hospitalization and intensive care unit admission. Delayed or inaccurate diagnosis of sepsis, coupled with suboptimal treatment strategies, can result in unfavorable outcomes, including mortality. Maresins, a newly discovered family of lipid mediators synthesized from docosahexaenoic acid by macrophages, have emerged as key players in promoting inflammation resolution and the termination of inflammatory processes...
February 20, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38382648/in-vitro-models-for-neuropathic-pain-phenotypic-screening-in-brain-therapeutics
#8
JOURNAL ARTICLE
A L Martínez, J Brea, D López, N Cosme, M Barro, X Monroy, J Burgueño, M Merlos, M I Loza
The discovery of brain therapeutics faces a significant challenge due to the low translatability of preclinical results into clinical success. To address this gap, several efforts have been made to obtain more translatable neuronal models for phenotypic screening. These models allow the selection of active compounds without predetermined knowledge of drug targets. In this review, we present an overview of various existing models within the field, examining their strengths and limitations, particularly in the context of neuropathic pain research...
February 19, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38368184/corrigendum-to-palmitoylethanolamide-and-polydatin-combination-reduces-inflammation-and-oxidative-stress-in-vascular-injury-pharmacol-res-123-2017-83-92
#9
Enrico Gugliandolo, Roberta Fusco, Flavia Biundo, Ramona D'Amico, Filippo Benedetto, Rosanna Di Paola, Salvatore Cuzzocrea
No abstract text is available yet for this article.
February 16, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38367917/acox1-deficiency-induced-lipid-metabolic-disorder-facilitates-chronic-interstitial-fibrosis-development-in-renal-allografts
#10
JOURNAL ARTICLE
Yang-He Zhang, Bin Liu, Qingfei Meng, Dan Zhang, Hongxia Yang, Guangtao Li, Yuxiong Wang, Mingdi Liu, Nian Liu, Jinyu Yu, Si Liu, Honglan Zhou, Zhi-Xiang Xu, Yishu Wang
Chronic interstitial fibrosis presents a significant challenge to the long-term survival of transplanted kidneys. Our research has shown that reduced expression of acyl-coenzyme A oxidase 1 (ACOX1), which is the rate-limiting enzyme in the peroxisomal fatty acid β-oxidation pathway, contributes to the development of fibrosis in renal allografts. ACOX1 deficiency leads to lipid accumulation and excessive oxidation of polyunsaturated fatty acids (PUFAs), which mediate epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) reorganization respectively, thus causing fibrosis in renal allografts...
February 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38364957/an-account-on-the-history-of-pharmacology-in-spain
#11
EDITORIAL
Ana María Aldea-Perona, Jesús Flórez Beledo, Jesús Frías Iniesta, Antonio G García, Juan Tamargo, Francisco Zaragozá
Here we present an account on the history of pharmacology in Spain. Pharmacology as an independent science in Europe began with the creation of university chairs. Of particular relevance was the appointment in 1872 of Osswald Shmiedeberg as chairman of an Institute of Pharmacology at the University of Strassbourg, Germany. Teófilo Hernando pioneered in Spain the new emerging pharmacology at the beginning of the XX Century. He made a posdoctoral stay in the laboratory of Schmiedeberg, working on digitalis...
February 14, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38354870/cdk12-inhibition-upregulates-atg7-triggering-autophagy-via-akt-foxo3-pathway-and-enhances-anti-pd-1-efficacy-in-colorectal-cancer
#12
JOURNAL ARTICLE
Zimei Wu, Wenxin Zhang, Lu Chen, Tianxiao Wang, Xinhai Wang, Huanying Shi, Liudi Zhang, Mingkang Zhong, Xiaojin Shi, Xiang Mao, Haifei Chen, Qunyi Li
As the world's fourth most deadly cancer, colorectal cancer (CRC) still needed the novel therapeutic drugs and target urgently. Although cyclin-dependent kinase 12 (CDK12) has been shown to be implicated in the malignancy of several types of cancer, its functional role and mechanism in CRC remain largely unknown. Here, we found that suppression of CDK12 inhibited tumor growth in CRC by inducing apoptosis. And CDK12 inhibition triggered autophagy by upregulating autophagy related gene 7 (ATG7) expression. Inhibition of autophagy by ATG7 knockdown and chloroquine (CQ) further decreased cell viability induced by CDK12 inhibition...
February 13, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38354869/isothiocyanates-in-medicine-a-comprehensive-review-on-phenylethyl-allyl-and-benzyl-isothiocyanates
#13
REVIEW
Cosima C Hoch, Maria Shoykhet, Tobias Weiser, Lena Griesbaum, Julie Petry, Khouloud Hachani, Gabriele Multhoff, Ali Bashiri Dezfouli, Barbara Wollenberg
In recent years, isothiocyanates (ITCs), bioactive compounds primarily derived from Brassicaceae vegetables and herbs, have gained significant attention within the biomedical field due to their versatile biological effects. This comprehensive review provides an in-depth exploration of the therapeutic potential and individual biological mechanisms of the three specific ITCs phenylethyl isothiocyanate (PEITC), allyl isothiocyanate (AITC), and benzyl isothiocyanate (BITC), as well as their collective impact within the formulation of ANGOCIN® Anti-Infekt N (Angocin)...
February 12, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38342327/natural-products-for-combating-multidrug-resistance-in-cancer
#14
REVIEW
Ting Chen, Zhicheng Xiao, Xiaoyan Liu, Tingfang Wang, Yun Wang, Fei Ye, Juan Su, Xuan Yao, Liyan Xiong, Dong-Hua Yang
Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted drugs, which has been a significant challenge in cancer management. With the growing advances in technologies in isolation and identification of natural products, the potential of natural products in combating cancer multidrug resistance has received substantial attention. Importantly, natural products can impact multiple targets, which can be valuable in overcoming drug resistance from different perspectives. In the current review, we will describe the well-established mechanisms underlying multidrug resistance, and introduce natural products that could target these multidrug resistant mechanisms...
February 9, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38341056/alternative-splicing-in-cardiomyopathy-insights
#15
LETTER
Concetta Schiano, Claudio Napoli
No abstract text is available yet for this article.
February 8, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38341055/novel-nano-drug-delivery-system-for-natural-products-and-their-application
#16
REVIEW
Li Huang, Xue-Hua Huang, Xi Yang, Jia-Qin Hu, Yi-Zhun Zhu, Pei-Yu Yan, Ying Xie
The development of natural products for potential new drugs faces obstacles such as unknown mechanisms, poor solubility, and limited bioavailability, which limit the broadened applicability of natural products. Therefore, there is a need for advanced pharmaceutical formulations of active compounds or natural products. In recent years, novel nano-drug delivery systems (NDDS) for natural products, including nanosuspensions, nanoliposomes, micelle, microemulsions/self-microemulsions, nanocapsules, and solid lipid nanoparticles, have been developed to improve solubility, bioavailability, and tissue distribution as well as for prolonged retention and enhanced permeation...
February 8, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38336311/the-vegfs-vegfrs-system-in-alzheimer-s-and-parkinson-s-diseases-pathophysiological-roles-and-therapeutic-implications
#17
REVIEW
Claudia Ceci, Pedro Miguel Lacal, Maria Luisa Barbaccia, Nicola Biagio Mercuri, Grazia Graziani, Ada Ledonne
The vascular endothelial growth factors (VEGFs) and their cognate receptors (VEGFRs), besides their well-known involvement in physiological angiogenesis/lymphangiogenesis and in diseases associated to pathological vessel formation, play multifaceted functions in the central nervous system (CNS). In addition to shaping brain development, by controlling cerebral vasculogenesis and regulating neurogenesis as well as astrocyte differentiation, the VEGFs/VEGFRs axis exerts essential functions in the adult brain both in physiological and pathological contexts...
February 7, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38336310/combining-choline-bitartrate-and-vitamin-b12-ameliorates-cognitive-impairment-in-hypertensive-elders-with-cognitive-frailty
#18
LETTER
Pasquale Mone, Valentina Trimarco, Urna Kansakar, Raffaele Izzo, Gaetano Santulli, Bruno Trimarco
No abstract text is available yet for this article.
February 7, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38331236/nanoparticles-and-sirna-a-new-era-in-therapeutics
#19
JOURNAL ARTICLE
María Dolores Pérez-Carrión, Inmaculada Posadas, Valentín Ceña
Since its discovery in 1998, the use of small interfering RNA (siRNA) has been increasing in biomedical studies because of its ability to very selectively inhibit the expression of any target gene. Thus, siRNAs can be used to generate therapeutic compounds for different diseases, including those that are currently 'undruggable'. This has led siRNA-based therapeutic compounds to break into clinical settings, with them holding the promise to potentially revolutionise therapeutic approaches. To date, the United States Food and Drug Administration (FDA) have approved 5 compounds for treating different diseases including hypercholesterolemia, transthyretin-mediated amyloidosis (which leads to polyneuropathy), hepatic porphyria, and hyperoxaluria...
February 6, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38325728/single-cell-and-spatial-transcriptomics-reveals-that-ptprg-activates-the-m-6-a-methyltransferase-virma-to-block-mitophagy-mediated-neuronal-death-in-alzheimer-s-disease
#20
JOURNAL ARTICLE
Donghua Zou, Xiaohua Huang, Yating Lan, Mika Pan, Jieqiong Xie, Qi Huang, Jingyi Zeng, Chun Zou, Zifei Pei, Cuihua Zou, Yingwei Mao, Jiefeng Luo
Neuronal death is one of the key pathologies in Alzheimer's disease (AD). How neuronal death begins in AD is far from clear, so clarifying this process may help develop effective therapies. This study collected single-cell RNA sequencing data of 85 AD samples and 83 control samples, covering the prefrontal cortex, internal olfactory cortex, superior parietal lobe, superior frontal gyrus, caudal internal olfactory cortex, somatosensory cortex, hippocampus, superior frontal cortex and peripheral blood mononuclear cells...
February 5, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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