Meghan J Chenoweth
No abstract text is available yet for this article.
June 11, 2024: Neuropsychopharmacology
Hayley H A Thorpe, Pierre Fontanillas, Benjamin K Pham, John J Meredith, Mariela V Jennings, Natasia S Courchesne-Krak, Laura Vilar-Ribó, Sevim B Bianchi, Julian Mutz, Sarah L Elson, Jibran Y Khokhar, Abdel Abdellaoui, Lea K Davis, Abraham A Palmer, Sandra Sanchez-Roige
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then compared our results to the largest available GWAS of coffee intake from the UK Biobank (UKB; N = 334,659)...
June 11, 2024: Neuropsychopharmacology
Megan Ulmer Carnes, Bryan C Quach, Linran Zhou, Shizhong Han, Ran Tao, Meisha Mandal, Amy Deep-Soboslay, Jesse A Marks, Grier P Page, Brion S Maher, Andrew E Jaffe, Hyejung Won, Laura J Bierut, Thomas M Hyde, Joel E Kleinman, Eric O Johnson, Dana B Hancock
Smoking is a leading cause of preventable morbidity and mortality. Smoking is heritable, and genome-wide association studies (GWASs) of smoking behaviors have identified hundreds of significant loci. Most GWAS-identified variants are noncoding with unknown neurobiological effects. We used genome-wide genotype, DNA methylation, and RNA sequencing data in postmortem human nucleus accumbens (NAc) to identify cis-methylation/expression quantitative trait loci (meQTLs/eQTLs), investigate variant-by-cigarette smoking interactions across the genome, and overlay QTL evidence at smoking GWAS-identified loci to evaluate their regulatory potential...
June 4, 2024: Neuropsychopharmacology
Simon Wein, Marco Riebel, Philipp Seidel, Lisa-Marie Brunner, Viola Wagner, Caroline Nothdurfter, Rainer Rupprecht, Jens V Schwarzbach
TSPO ligands are promising alternatives to benzodiazepines in the treatment of anxiety, as they display less pronounced side effects such as sedation, cognitive impairment, tolerance development and abuse potential. In a randomized double-blind repeated-measures study we compare a benzodiazepine (alprazolam) to a TSPO ligand (etifoxine) by assessing side effects and acquiring resting-state fMRI data from 34 healthy participants after 5 days of taking alprazolam, etifoxine or a placebo. To study the effects of the pharmacological interventions in fMRI in detail and across different scales, we combine in our study complementary analysis strategies related to whole-brain functional network connectivity, local connectivity analysis expressed in regional homogeneity, fluctuations in low-frequency BOLD amplitudes and coherency of independent resting-state networks...
May 31, 2024: Neuropsychopharmacology
Natalie Ertl, Tom P Freeman, Claire Mokrysz, Shelan Ofori, Anna Borissova, Kat Petrilli, H Valerie Curran, Will Lawn, Matthew B Wall
Adolescence is a time of rapid neurodevelopment and the endocannabinoid system is particularly prone to change during this time. Cannabis is a commonly used drug with a particularly high prevalence of use among adolescents. The two predominant phytocannabinoids are Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which affect the endocannabinoid system. It is unknown whether this period of rapid development makes adolescents more or less vulnerable to the effects of cannabis on brain-network connectivity, and whether CBD may attenuate the effects of THC...
May 28, 2024: Neuropsychopharmacology
Jobe L Ritchie, Shuyi Qi, David A Soto, Sydney E Swatzell, Hope I Grenz, Avery Y Pruitt, Lilia M Artimenia, Spencer K Cooke, Craig W Berridge, Rita A Fuchs
Environmental stimuli elicit drug craving and relapse in cocaine users by triggering the retrieval of strong cocaine-related contextual memories. Retrieval can also destabilize drug memories, requiring reconsolidation, a protein synthesis-dependent storage process, to maintain memory strength. Corticotropin-releasing factor (CRF) signaling in the basolateral amygdala (BLA) is necessary for cocaine-memory reconsolidation. We have hypothesized that a critical source of CRF in the BLA is the dorsal raphe nucleus (DR) based on its neurochemistry, anatomical connectivity, and requisite involvement in cocaine-memory reconsolidation...
May 27, 2024: Neuropsychopharmacology
Cara C Young, Santiago Papini, Haruka Minami, Hitoshi Morikawa, Michael W Otto, John D Roache, Jasper A J Smits
Preclinical research with rodents suggests that the L-type calcium channel blocker isradipine can enhance long-term extinction of conditioned place preference for addictive substances when it is administered in conjunction with extinction training. Although isradipine alone, which is FDA-approved for hypertension, has not shown a direct effect on craving in human drug users, its potential to augment behavioral treatments designed to reduce craving remains unknown. We conducted a triple-blind, randomized placebo-controlled pilot clinical trial of isradipine combined with a novel virtual reality cue exposure therapy (VR-CET) approach with multimodal cues that targeted craving...
May 24, 2024: Neuropsychopharmacology
Jared Butts, Patrick Sweeney
No abstract text is available yet for this article.
May 24, 2024: Neuropsychopharmacology
Emilio Merlo Pich
No abstract text is available yet for this article.
May 23, 2024: Neuropsychopharmacology
Lucina Q Uddin, F Xavier Castellanos, Vinod Menon
Approaching the 30th anniversary of the discovery of resting state functional magnetic resonance imaging (rsfMRI) functional connectivity, we reflect on the impact of this neuroimaging breakthrough on the field of child and adolescent psychiatry. The study of intrinsic functional brain architecture that rsfMRI affords across a wide range of ages and abilities has yielded numerous key insights. For example, we now know that many neurodevelopmental conditions are associated with more widespread circuit alterations across multiple large-scale brain networks than previously suspected...
May 22, 2024: Neuropsychopharmacology
Sara L Kroll, Philip Meier, Leah M Mayo, Jürg Gertsch, Boris B Quednow
Opioid-related overdose deaths are still on the rise in North America, emphasizing the need to better understand the underlying neurobiological mechanisms regarding the development of opioid use disorder (OUD). Recent evidence from preclinical and clinical studies indicate that the endocannabinoid system (ECS) may play a crucial role in stress and reward, both involved in the development and maintenance of substance use disorders. Animal models demonstrate a specific crosstalk between the ECS and the endogenous opioid system...
May 21, 2024: Neuropsychopharmacology
Charles B Nemeroff
No abstract text is available yet for this article.
May 21, 2024: Neuropsychopharmacology
Carly B Fabian, Nilah D Jordan, Rebecca H Cole, Lily G Carley, Shannon M Thompson, Marianne L Seney, Max E Joffe
Despite established sex differences in the prevalence and presentation of psychiatric disorders, little is known about the cellular and synaptic mechanisms that guide these differences under basal conditions. The proper function of the prefrontal cortex (PFC) is essential for the top-down regulation of motivated behaviors. The activity of the PFC is tightly controlled by parvalbumin-expressing interneurons (PV-INs), a key subpopulation of fast-spiking GABAergic cells that regulate cortical excitability through direct innervations onto the perisomatic regions of nearby pyramidal cells...
May 21, 2024: Neuropsychopharmacology
Leon D Lotter, Susanne Nehls, Elena Losse, Juergen Dukart, Natalya Chechko
The maternal brain undergoes significant reorganization during birth and the postpartum period. However, the temporal dynamics of these changes remain unclear. Using resting-state functional magnetic resonance imaging, we report on local and global brain function alterations in 75 mothers in their first postpartum week, compared to 23 nulliparous women. In a subsample followed longitudinally for the next six months, we observed a temporal and spatial dissociation between changes observed at baseline (cluster mass permutation: pFWE < 0...
May 20, 2024: Neuropsychopharmacology
Mia I Allen, Marissa B Costa, Bernard N Johnson, Robert W Gould, Michael A Nader
Considerable research has suggested that certain cognitive domains may contribute to cocaine misuse. However, there are gaps in the literature regarding whether cognitive performance before drug exposure predicts susceptibility to cocaine self-administration and how cognitive performance relates to future cocaine intake. Thus, the present study aimed to examine cognitive performance, as measured using automated CANTAB cognitive battery, prior to and following acquisition of cocaine self-administration under a concurrent drug vs...
May 17, 2024: Neuropsychopharmacology
Ana Domi, Davide Cadeddu, Erika Lucente, Francesco Gobbo, Christian Edvardsson, Michele Petrella, Elisabet Jerlhag, Mia Ericson, Bo Söderpalm, Louise Adermark
The transition to alcohol use disorder (AUD) involves persistent neuroadaptations in executive control functions primarily regulated by the medial prefrontal cortex. However, the neurophysiological correlates to behavioral manifestations of AUD are not fully defined. The association between cortical neuroadaptations and behavioral manifestations of addiction was studied using a multi-symptomatic operant model based on the DSM-5 diagnostic criteria for AUD. This model aimed to characterize an AUD-vulnerable and AUD-resistant subpopulation of outbred male Wistar rats and was combined with electrophysiological measurements in the prelimbic cortex (PL)...
May 16, 2024: Neuropsychopharmacology
Marta Teferi, Hannah Gura, Milan Patel, Abigail Casalvera, Kevin G Lynch, Walid Makhoul, Zhi-De Deng, Desmond J Oathes, Yvette I Sheline, Nicholas L Balderston
Repetitive transcranial magnetic stimulation (rTMS) treatment protocols targeting the right dlPFC have been effective in reducing anxiety symptoms comorbid with depression. However, the mechanism behind these effects is unclear. Further, it is unclear whether these results generalize to non-depressed individuals. We conducted a series of studies aimed at understanding the link between anxiety potentiated startle and the right dlPFC, following a previous study suggesting that continuous theta burst stimulation (cTBS) to the right dlPFC can make people more anxious...
May 13, 2024: Neuropsychopharmacology
Dylan E Kirsch, Erica N Grodin, Steven J Nieto, Annabel Kady, Lara A Ray
Early life stress (ELS) increases risk for psychiatric illness, including alcohol use disorder (AUD). Researchers have hypothesized that individuals with and without a history of ELS who have the same primary DSM-5 diagnosis are clinically and biologically distinct. While there is strong support for this hypothesis in the context of mood disorders, the hypothesis remains largely untested in the context of AUD. This study investigated the impact of ELS on the neuroclinical phenomenology and inflammatory profile of individuals with AUD...
May 13, 2024: Neuropsychopharmacology
Conor H Murray
No abstract text is available yet for this article.
May 13, 2024: Neuropsychopharmacology
Xue-Fen Zhang, Yi-Dan Li, Yue Li, Ying Li, Dan Xu, Lin-Lin Bi, Hai-Bo Xu
The ventral subiculum (vSUB), the major output structure of the hippocampal formation, regulates motivation, stress integration, and anxiety-like behaviors that rely on heightened arousal. However, the roles and underlying neural circuits of the vSUB in wakefulness are poorly known. Using in vivo fiber photometry and multichannel electrophysiological recordings in mice, we found that the vSUB glutamatergic neurons exhibited high activities during wakefulness. Moreover, activation of vSUB glutamatergic neurons caused an increase in wakefulness and anxiety-like behaviors and induced a rapid transition from sleep to wakefulness...
May 11, 2024: Neuropsychopharmacology
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