Arielle H Gabalski, Aisling Tynan, Tea Tsaava, Jian Hua Li, Diana Lee, Tyler D Hepler, Daniel Hide, Sam George, Carlos E Bravo Iñiguez, Dane A Thompson, Cassie Zhu, Haichao Wang, Michael Brines, Kevin J Tracey, Sangeeta S Chavan
BACKGROUND: Choline acetyltransferase (ChAT) is required for the biosynthesis of acetylcholine, the molecular mediator that inhibits cytokine production in the cholinergic anti-inflammatory pathway of the vagus nerve inflammatory reflex. Abundant work has established the biology of cytoplasmic ChAT in neurons, but much less is known about the potential presence and function of ChAT in the extracellular milieu. OBJECTIVES: We evaluated the hypothesis that extracellular ChAT activity responds to inflammation and serves to inhibit cytokine release and attenuate inflammation...
November 27, 2023: Journal of Internal Medicine