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Journal of Internal Medicine | Page 2

Hye Jung Park, Jae Hwa Cho, Hyung Jung Kim, Ju-Young Park, Hye Sun Lee, Min Kwang Byun
BACKGROUND: Sarcopenia may worsen disease progression and lead to poor outcomes in chronic obstructive pulmonary disease (COPD). OBJECTIVES: We aimed to determine the effect of BMI on the development of COPD and mortality. METHODS: We enrolled 437,584 participants with COPD registered in the physical health check-up cohort database of the Korean National Health Interview Survey from 2002 to 2003, based on the ICD-10 code and prescribed medication...
June 18, 2019: Journal of Internal Medicine
Miguel Carracedo, Anna Witasp, Abdul Rashid Qureshi, Andres Laguna-Fernandez, Torkel Brismar, Peter Stenvinkel, Magnus Bäck
BACKGROUND: Chemerin is an adipokine that signals through the G-protein coupled receptor ChemR23 and is associated with inflammation, glucose homeostasis, lipid metabolism, and renal function, all of which strongly influence cardiovascular risk. However, elevated chemerin provides a survival advantage in patients with chronic kidney disease (CKD), but how this relates to the cardiovascular phenotype is unknown. OBJECTIVES: The aim of the present study was to establish the association of chemerin with coronary calcification and to determine the effects of chemerin signaling, through ChemR23, in vascular smooth muscle cell (VSMC) calcification...
June 13, 2019: Journal of Internal Medicine
Juha Rannikko, Dafne Jacome Sanz, Zsuzsanna Ortutay, Tapio Seiskari, Janne Aittoniemi, Reetta Huttunen, Jaana Syrjänen, Marko Pesu
BACKGROUND: The proprotein convertase subtilisin/kexin type 9 (PCSK9) enzyme controls blood cholesterol levels by downregulating the expression of the low-density lipoprotein receptor (LDLR). Pathogenic lipids (e.g. lipopolysaccharide) are removed from the circulation by an LDLR/PCSK9-dependent mechanism, thus it has been suggested that PCSK9 inhibitors may be beneficial in the treatment of infections. We measured plasma PCSK9 levels in patients with culture-positive bacteraemia and explored pathogen-dependent and infection site-dependent effects as well as correlations between patient characteristics and outcome...
June 5, 2019: Journal of Internal Medicine
Y Shang, A Marseglia, L Fratiglioni, A-K Welmer, R Wang, H-X Wang, W Xu
BACKGROUND: The natural history of prediabetes in older adults remains unknown. OBJECTIVES: To assess the rate at which prediabetes progresses to diabetes, leads to death or reverts to normoglycaemia in older adults and to identify prognostic factors related to different outcomes of prediabetes. METHODS: In the Swedish National Study on Aging and Care-Kungsholmen, 2575 diabetes-free participants aged ≥60 years were examined at baseline and followed for up to 12 years...
June 4, 2019: Journal of Internal Medicine
C Zhong, W Cozen, R Bolanos, J Song, S S Wang
Epidemiologic and laboratory evidence has consistently supported a strong inflammatory and immune component for lymphoma aetiology. These studies have consistently implicated variation in the immune gene, human leucocyte antigen (HLA), to be associated with lymphoma risk. In this review, we summarize the historical and recent evidence of HLA in both lymphoma aetiology and survival. The recent momentum in uncovering HLA associations has been propelled by the conduct of genome-wide association studies (GWAS), which has permitted the evaluation of imputed HLA alleles in much larger sample sizes than historically feasible with allelotyping studies...
June 3, 2019: Journal of Internal Medicine
David de Gonzalo-Calvo, David Vilades, Pablo Martínez-Camblor, Àngela Vea, Laura Nasarre, Jesus Sanchez Vega, Rubén Leta, Francesc Carreras, Vicenta Llorente-Cortés
OBJECTIVES: To explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD). METHODS: Plasma samples were collected from 237 consecutive patients referred for coronary computed tomography angiography (CCTA). Presence, extension and severity of coronary stenosis were evaluated using the indexes: presence of diameter stenosis ≥ 50%, segment involvement score (SIS), segment stenosis score (SSS) and 3-vessel plaque score...
May 29, 2019: Journal of Internal Medicine
Anthony W Segal
The fruitless search for the cause of Crohn's disease has been conducted for more than a century. Various theories, including autoimmunity, Mycobacterial infection and aberrant response to food and other ingested materials, have been abandoned for lack of robust proof. This review will provide the evidence, obtained from patients with this condition, that the common predisposition to Crohn's is a failure of the acute inflammatory response to tissue damage. This acute inflammation normally attracts large numbers of neutrophil leukocytes which engulf and clear bacteria and autologous debris from the inflamed site...
May 28, 2019: Journal of Internal Medicine
Daniel Reichart, Christina Magnussen, Tanja Zeller, Stefan Blankenberg
Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and, consecutively, contractile dysfunction. The causes of DCM are heterogeneous. DCM often results from myocarditis, exposure to alcohol, drugs or other toxins and metabolic or endocrine disturbances. In about 35% of patients, genetic mutations can be identified that usually involve genes responsible for cytoskeletal, sarcomere, and nuclear envelope proteins. Due to its heterogeneity, a detailed diagnostic work-up is necessary to identify the specific underlying cause and exclude other conditions with phenotype overlap...
May 27, 2019: Journal of Internal Medicine
Johannes Mofors, Marie Holmqvist, Linnea Westermark, Albin Björk, Marika Kvarnström, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Per Eriksson, Elke Theander, Thomas Mandl, Marie Wahren-Herlenius, Gunnel Nordmark
OBJECTIVES: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status. METHODS: A cohort of patients with primary Sjögren's syndrome in Sweden (n=960) and matched controls from the general population (n=9,035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction, and venous thromboembolism...
May 25, 2019: Journal of Internal Medicine
C Mazzaro, L Dal Maso, M Visentini, S Gitto, P Andreone, F Toffolutti, V Gattei
Cryoglobulinemic vasculitis (CV) can develop in 1.2-4% of hepatitis B virus (HBV)-infected patients. HBV infection affects about 350 million people worldwide. It can progress from acute or fulminant hepatitis to chronic hepatitis, cirrhosis or hepatocellular carcinoma. Twenty per cent of HBV patients may develop extra-hepatic manifestations, such as polyarteritis nodosa, glomerulonephritis, dermatitis, polyarthralgias and arthritis, lung disease, aplastic anaemia. Our review focuses on the role of antiviral agent nucleot(s)ide analogues (NAs) in treatment of HBV-related CV...
May 24, 2019: Journal of Internal Medicine
T Zeller, S Appelbaum, K Kuulasmaa, T Palosaari, S Blankenberg, P Jousilahti, V Salomaa, M Karakas
INTRODUCTION: The relevance of low testosterone concentrations for incident coronary heart disease (CHD) and mortality has been discussed in various studies. Here, we evaluate the predictive value of low baseline testosterone levels in a large population-based cohort. METHODS: We measured the serum levels of testosterone in 7671 subjects (3710 male, 3961 female) of the population-based FINRISK97 study. RESULTS: The median follow-up (FU) was 13...
May 23, 2019: Journal of Internal Medicine
Y Peng, J Q Li, P P Zhang, X Zhang, L Y Peng, H Chen, J X Zhou, S Z Zhang, H X Yang, J J Liu, H F Guo, J Li, X Zhang, Y Zhao, X F Zeng, F C Zhang, Y Y Fei, W Zhang
OBJECTIVES: The aim of this study was to investigate the predictive factors for relapse of IgG4-related disease (IgG4-RD) and observe the long-term clinical outcomes in patients with IgG4-RD. METHODS: We included in the present analysis 122 patients who were newly diagnosed with IgG4-RD, treated with glucocorticoid (GC) monotherapy or GC and immunosuppressant combination therapy, and followed for at least 3 years. Clinical relapse, response and side effects were recorded...
May 23, 2019: Journal of Internal Medicine
I R Reid, A M Horne, B Mihov, A Stewart, E Garratt, K R Wiessing, M J Bolland, S Bastin, G D Gamble
BACKGROUND: We recently reported that the administration of zoledronate every 18 months to osteopenic older women reduces the incidence of fractures. OBJECTIVE: Here, we present a more detailed analysis of that trial to determine whether baseline clinical characteristics impact on the anti-fracture efficacy of this intervention. METHODS: This is a prospective, randomized, placebo-controlled, double-blind trial in osteopenic postmenopausal women aged ≥ 65 years, to determine the anti-fracture efficacy of zoledronate...
August 2019: Journal of Internal Medicine
G Barbany, C Arthur, A Liedén, M Nordenskjöld, R Rosenquist, B Tesi, K Wallander, E Tham
In recent years, detection of cell-free tumour DNA (ctDNA) or liquid biopsy has emerged as an attractive noninvasive methodology to detect cancer-specific genetic aberrations in plasma, and numerous studies have reported on the feasibility of ctDNA in advanced cancer. In particular, ctDNA assays can capture a more 'global' portrait of tumour heterogeneity, monitor therapy response, and lead to early detection of resistance mutations. More recently, ctDNA analysis has also been proposed as a promising future tool for detection of early cancer and/or cancer screening...
August 2019: Journal of Internal Medicine
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No abstract text is available yet for this article.
July 2019: Journal of Internal Medicine
L Rydén, A Zettergren, N M Seidu, X Guo, S Kern, K Blennow, H Zetterberg, S Sacuiu, I Skoog
BACKGROUND: Atrial fibrillation increases risk of stroke, and thus risk of cognitive impairment and dementia. Emerging evidence suggests an association also in the absence of stroke. We aimed to examine the association between atrial fibrillation and incident dementia, with and without exclusion of individuals with stroke, and if sex and genetic factors modify the possible association. METHODS: In 2000-2001, a population-based sample of 70-year-olds (N = 561) underwent comprehensive somatic and neuropsychiatric examinations, as part of the Gothenburg H70 Birth Cohort Studies...
July 2019: Journal of Internal Medicine
M Tobiasson, A O Kittang
Next-generation sequencing (NGS) is rapidly changing the clinical care of patients with myelodysplastic syndrome (MDS). NGS can be used for various applications: (i) in the diagnostic process to discriminate between MDS and other diseases such as aplastic anaemia, myeloproliferative disorders and idiopathic cytopenias; (ii) for classification, for example, where the presence of SF3B1 mutation is one criterion for the ring sideroblast anaemia subgroups in the World Health Organization 2016 classification; (iii) for identification of patients suitable for targeted therapy (e...
July 2019: Journal of Internal Medicine
N Marklund, B-M Bellander, A K Godbolt, H Levin, P McCrory, E P Thelin
Traumatic brain injury (TBI) is a major cause of acquired disability globally, and effective treatment methods are scarce. Lately, there has been increasing recognition of the devastating impact of TBI resulting from sports and other recreational activities, ranging from primarily sport-related concussions (SRC) but also more severe brain injuries requiring hospitalization. There are currently no established treatments for the underlying pathophysiology in TBI and while neuro-rehabilitation efforts are promising, there are currently is a lack of consensus regarding rehabilitation following TBI of any severity...
June 2019: Journal of Internal Medicine
C Feldman, S Normark, B Henriques-Normark, R Anderson
It is now well recognized that cardiovascular events (CVE) occur quite commonly, both in the acute phase and in the long-term, in patients with community-acquired pneumonia (CAP). CVE have been noted in up to 30% of patients hospitalized with all-cause CAP. One systematic review and meta-analysis of hospitalized patients with all-cause CAP noted that the incidence rates for overall cardiac events were 17.7%, for incident heart failure were 14.1%, for acute coronary syndromes were 5.3% and for incident cardiac arrhythmias were 4...
June 2019: Journal of Internal Medicine
H Zetterberg, B Winblad, C Bernick, K Yaffe, M Majdan, G Johansson, V Newcombe, L Nyberg, D Sharp, O Tenovuo, K Blennow
Traumatic brain injury (TBI) is clinically divided into a spectrum of severities, with mild TBI being the least severe form and a frequent occurrence in contact sports, such as ice hockey, American football, rugby, horse riding and boxing. Mild TBI is caused by blunt nonpenetrating head trauma that causes movement of the brain and stretching and tearing of axons, with diffuse axonal injury being a central pathogenic mechanism. Mild TBI is in principle synonymous with concussion; both have similar criteria in which the most important elements are acute alteration or loss of consciousness and/or post-traumatic amnesia following head trauma and no apparent brain changes on standard neuroimaging...
June 2019: Journal of Internal Medicine
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