journal
https://read.qxmd.com/read/38044059/splenectomy-reappraised-bridging-the-gap-in-immune-cytopenia-treatment-paradigms
#21
EDITORIAL
Christina Waldron, George Goshua
No abstract text is available yet for this article.
December 3, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/38037246/endocrine-disrupting-chemicals-mainstream-recognition-of-health-effects-and-implications-for-the-practicing-internist
#22
JOURNAL ARTICLE
Leonardo Trasande, Robert M Sargis
Rapidly advancing evidence documents that a broad array of synthetic chemicals found ubiquitously in the environment contribute to disease and disability across the lifespan. Although the early literature focused on early life exposures, endocrine-disrupting chemicals (EDCs) are now understood to contribute substantially to chronic disease in adulthood, especially metabolic, cardiovascular, and reproductive consequences as well as endocrine cancers. The contribution to mortality is substantial, with over 90,000 deaths annually and at least $39 billion/year in lost economic productivity in the United States (US) due to exposure to certain phthalates that are used as plasticizers in food packaging...
November 30, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/38018736/vagus-nerve-sars-cov-2-infection-and-inflammatory-reflex-dysfunction-is-there-a-causal-relationship
#23
JOURNAL ARTICLE
Ulf Andersson, Kevin J Tracey
Autonomic dysfunction is a clinical hallmark of infection caused by SARS-CoV-2, but the underlying mechanisms are unknown. The vagus nerve inflammatory reflex is an important, well-characterized mechanism for the reflexive suppression of cytokine storm, and its experimental or clinical impairment facilitates the onset and progression of hyperinflammation. Recent pathological evidence from COVID-19 victims reveals viral infection and inflammation in the vagus nerve and associated nuclei in the medulla oblongata...
November 29, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/38013625/clinical-presentation-course-and-prognosis-of-patients-with-mixed-connective-tissue-disease-a-multicenter-retrospective-cohort
#24
JOURNAL ARTICLE
Kevin Chevalier, Benjamin Thoreau, Marc Michel, Bertrand Godeau, Christian Agard, Thomas Papo, Karim Sacre, Raphaèle Seror, Xavier Mariette, Patrice Cacoub, Ygal Benhamou, Hervé Levesque, Cécile Goujard, Olivier Lambotte, Bernard Bonnotte, Maxime Samson, Félix Ackermann, Jean Schmidt, Pierre Duhaut, Jean-Emmanuel Kahn, Thomas Hanslik, Nathalie Costedoat-Chalumeau, Benjamin Terrier, Alexis Regent, Bertrand Dunogue, Pascal Cohen, Véronique Le Guern, Eric Hachulla, Benjamin Chaigne, Luc Mouthon
OBJECTIVES: The objective of this study is to better characterize the features and outcomes of a large population of patients with mixed connective tissue disease (MCTD). METHODS: We performed an observational retrospective multicenter cohort study in France. Patients who fulfilled at least one diagnostic criterion set for MCTD and none of the criteria for other differentiated CTD (dCTD) were included. RESULTS: Three hundred and thirty patients (88% females, median [interquartile range] age of 35 years [26-45]) were included...
November 27, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/38013596/temporal-trends-in-guideline-recommended-cardiometabolic-testing-completeness-before-initiating-immune-checkpoint-inhibitors-a-cohort-study
#25
LETTER
Jeffrey Shi Kai Chan, Oscar Hou In Chou, Teddy Tai Loy Lee, Yan Hiu Athena Lee, Raymond Ngai Chiu Chan, Edward Christopher Dee, Kenrick Ng, Tong Liu, Gary Tse
No abstract text is available yet for this article.
November 27, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/38013593/transfusions-in-autoimmune-hemolytic-anemias-frequency-and-clinical-significance-of-alloimmunization
#26
JOURNAL ARTICLE
Francesco Versino, Nicoletta Revelli, Stefania Villa, Loredana Pettine, Anna Zaninoni, Daniele Prati, Francesco Passamonti, Wilma Barcellini, Bruno Fattizzo
BACKGROUND: Autoimmune hemolytic anemia (AIHA) may be associated with transfusion reactions and risk of alloimmunization. OBJECTIVES: To evaluate the transfusion policy and rate of alloimmunization and its clinical significance in AIHA. METHODS: Data from 305 AIHA patients followed at a reference hematologic Center in Milan, Italy from 1997 to 2022 were retrospectively/prospectively collected (NCT05931718). RESULTS: Overall, 33% patients required transfusions with a response rate of 83% and eight transfusion reactions (7%), none hemolytic...
November 27, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/38011942/circulating-extracellular-choline-acetyltransferase-regulates-inflammation
#27
JOURNAL ARTICLE
Arielle H Gabalski, Aisling Tynan, Tea Tsaava, Jian Hua Li, Diana Lee, Tyler D Hepler, Daniel Hide, Sam George, Carlos E Bravo Iñiguez, Dane A Thompson, Cassie Zhu, Haichao Wang, Michael Brines, Kevin J Tracey, Sangeeta S Chavan
BACKGROUND: Choline acetyltransferase (ChAT) is required for the biosynthesis of acetylcholine, the molecular mediator that inhibits cytokine production in the cholinergic anti-inflammatory pathway of the vagus nerve inflammatory reflex. Abundant work has established the biology of cytoplasmic ChAT in neurons, but much less is known about the potential presence and function of ChAT in the extracellular milieu. OBJECTIVES: We evaluated the hypothesis that extracellular ChAT activity responds to inflammation and serves to inhibit cytokine release and attenuate inflammation...
November 27, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37994187/lower-risks-of-cirrhosis-and-hepatocellular-carcinoma-with-glp-1ras-in-type-2-diabetes-a-nationwide-cohort-study-using-target-trial-emulation-framework
#28
JOURNAL ARTICLE
Chun-Ting Yang, Wen-Yu Yao, Chen-Yi Yang, Zi-Yang Peng, Huang-Tz Ou, Shihchen Kuo
BACKGROUND: To assess the association of cirrhosis and hepatocellular carcinoma (HCC) with the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) versus long-acting insulins (LAIs), which are the two commonly prescribed injectable glucose-lowering agents (GLAs) for patients with type 2 diabetes (T2D) after the failure of multiple oral GLAs. METHODS: We emulated a target trial using the nationwide data of a Taiwanese cohort with T2D. Incident new users of GLP-1RAs and LAIs during 2013-2018 were identified, and propensity score (PS) matching was applied to ensure between-group comparability in baseline patient characteristics...
November 22, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37990795/disease-modifying-antirheumatic-drugs-and-risk-of-thyroxine-treated-autoimmune-thyroid-disease-in-patients-with-rheumatoid-arthritis
#29
JOURNAL ARTICLE
Kristin Waldenlind, Bénédicte Delcoigne, Saedis Saevarsdottir, Johan Askling
BACKGROUND: Autoimmune thyroid disease (AITD) and rheumatoid arthritis (RA) share a genetic background, and the prevalence of AITD in RA patients is increased. Whereas immunomodulatory treatments are used in RA, they are rarely used in AITD. OBJECTIVES: We hypothesized that disease-modifying antirheumatic drugs (DMARDs) as used in RA might lower the risk of incident AITD. METHODS: A nationwide cohort study including 13,731 patients with new-onset RA from the Swedish Rheumatology Quality Register 2006-2018 and 63,201 matched general population comparators linked to national registers to identify AITD...
November 22, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37983848/high-incidence-of-immune-mediated-inflammatory-diseases-in-sepsis-survivors-a-nationwide-exposed-nonexposed-epidemiological-study
#30
JOURNAL ARTICLE
Arthur Mageau, Aloïs Helary, Stephane Ruckly, Andrey Strukov, Thomas Papo, Jean-François Timsit, Karim Sacre
OBJECTIVE: Sepsis is characterized by an excessive release of inflammatory cytokines. Cytokine dysregulation is pivotal to the pathophysiology of immune-mediated inflammatory diseases (IMIDs). We aimed to analyze the incidence of IMIDs in patients who survived sepsis. METHODS: We performed a matched-cohort study using the National Medico-Administrative Hospital database in order to analyze the association between sepsis and incident IMIDs in 2020 in France. Sepsis was defined by the combination of at least one infection diagnosis code and one organ failure code...
November 20, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37983845/minimal-hepatic-encephalopathy-is-associated-with-a-higher-risk-of-overt-hepatic-encephalopathy-and-poorer-survival
#31
JOURNAL ARTICLE
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
BACKGROUND AND AIMS: Minimal hepatic encephalopathy (MHE) is a frequent complication in patients with liver cirrhosis. Its impact on predicting the development of overt hepatic encephalopathy (OHE) and survival has not been studied in large multicenter studies. METHODS: Data from patients recruited at eight centers across Europe and the United States were analyzed. MHE was detected using the psychometric hepatic encephalopathy score (PHES). A subset was also tested with the simplified animal naming test (S-ANT1)...
November 20, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37964404/optoelectronic-control-of-cardiac-rhythm-toward-shock-free-ambulatory-cardioversion-of-atrial-fibrillation
#32
REVIEW
Vincent Portero, Shanliang Deng, Gerard J J Boink, Guo Qi Zhang, Antoine de Vries, Daniël A Pijnappels
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, progressive in nature, and known to have a negative impact on mortality, morbidity, and quality of life. Patients requiring acute termination of AF to restore sinus rhythm are subjected to electrical cardioversion, which requires sedation and therefore hospitalization due to pain resulting from the electrical shocks. However, considering the progressive nature of AF and its detrimental effects, there is a clear need for acute out-of-hospital (i...
November 14, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37941149/genetics-of-human-longevity-from-variants-to-genes-to-pathways
#33
JOURNAL ARTICLE
Larissa Smulders, Joris Deelen
The current increase in lifespan without an equivalent increase in healthspan poses a grave challenge to the healthcare system and a severe burden on society. However, some individuals seem to be able to live a long and healthy life without the occurrence of major debilitating chronic diseases, and part of this trait seems to be hidden in their genome. In this review, we discuss the findings from studies on the genetic component of human longevity and the main challenges accompanying these studies. We subsequently focus on results from genetic studies in model organisms and comparative genomic approaches to highlight the most important conserved longevity-associated pathways...
November 8, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37941106/11%C3%AE-hydroxysteroid-dehydrogenase-and-the-brain-not-yet-lost-in-translation
#34
REVIEW
Jonathan Seckl
11-beta-hydroxysteroid dehydrogenases (11β-HSDs) catalyse the conversion of active 11-hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11-keto forms (cortisone, 11-dehydrocorticosterone). They were first reported in the body and brain 70 years ago, but only recently have they become of interest. 11β-HSD2 is a dehydrogenase, potently inactivating glucocorticoids. In the kidney, 11β-HSD2 generates the aldosterone-specificity of intrinsically non-selective mineralocorticoid receptors...
November 8, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37926862/long-term-glucocorticoids-in-relation-to-the-metabolic-syndrome-and-cardiovascular-disease-a-systematic-review-and-meta-analysis
#35
REVIEW
Susanne Kuckuck, Robin Lengton, Mariëtte R Boon, Eric Boersma, Brenda W J H Penninx, Maryam Kavousi, Elisabeth F C van Rossum
The striking link of Cushing's syndrome with the metabolic syndrome (MetS) and cardiovascular disease (CVD) suggests that long-term exposure to extremely high cortisol levels catalyzes cardiometabolic deterioration. However, it remained unclear whether the findings from the extreme glucocorticoid overabundance observed in Cushing's syndrome could be translated into more subtle variations in long-term glucocorticoid levels among the general population, for example, due to chronic stress. Here, we performed a systematic review (PROSPERO: CRD42023425541) of evidence regarding the role of subtle variations in long-term biological stress, measured as levels of scalp hair cortisol (HairF) and cortisone (HairE), in the context of MetS and CVD in adults...
November 5, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37925625/hba1c-dependent-projection-of-long-term-renal-outcomes
#36
JOURNAL ARTICLE
Frederic Arnold, Julia Kappes, Felix A Rottmann, Lukas Westermann, Thomas Welte
BACKGROUND: Diabetes mellitus is a major risk factor for the development of chronic kidney disease (CKD). There is limited data addressing the value of glycated hemoglobin (HbA1c) to predict renal outcomes independent of diabetes status. METHODS: This single-center retrospective observational study presents data of 19,285 subjects, irrespective of initial CKD or diabetes status. The primary endpoint was defined as the time to manifestation of moderate CKD (estimated glomerular filtration rate [eGFR] <60 mL/min/1...
November 5, 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37766515/cognitive-dysfunction-in-post-covid-19-condition-mechanisms-management-and-rehabilitation
#37
REVIEW
Marika Möller, Kristian Borg, Christer Janson, Maria Lerm, Johan Normark, Katarina Niward
The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed...
November 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37538023/the-2021-kdigo-blood-pressure-target-and-the-progression-of-chronic-kidney-disease-findings-from-know-ckd
#38
JOURNAL ARTICLE
Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Sue Kyung Park, Yaeni Kim, Ji Yong Jung, Jong Cheol Jeong, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline for the management of blood pressure (BP) in chronic kidney disease (CKD) recommends a target systolic BP of <120 mmHg as this target can provide cardiovascular benefits. However, it remains unclear whether implementing the new BP target could improve kidney outcomes. METHODS: The association between the 2021 KDIGO BP target and CKD progression was examined and compared with the 2012 KDIGO BP target among 1724 participants included in the KoreaN Cohort Study for Outcomes in Patients With CKD...
November 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37254886/elevated-low-density-lipoprotein-cholesterol-an-inverse-marker-of-morbidity-and-mortality-in-patients-with-myocardial-infarction
#39
JOURNAL ARTICLE
Jessica Schubert, Bertil Lindahl, Håkan Melhus, Henrik Renlund, Margrét Leosdottir, Ali Yari, Peter Ueda, Tomas Jernberg, Emil Hagström
BACKGROUND: The incidence of atherosclerotic cardiovascular disease increases with levels of low-density lipoprotein cholesterol (LDL-C). Yet, a paradox may exist where lower LDL-C levels at myocardial infarction (MI) are associated with poorer prognoses. OBJECTIVE: To assess the association between LDL-C levels at MI with risk factor burden and cause-specific outcomes. METHODS: Statin-naive patients hospitalized for a first MI and registered in SWEDEHEART were included...
November 2023: Journal of Internal Medicine
https://read.qxmd.com/read/37183186/cardiorespiratory-dysautonomia-in-post-covid-19-condition-manifestations-mechanisms-and-management
#40
REVIEW
Artur Fedorowski, Monika Fagevik Olsén, Frida Nikesjö, Christer Janson, Judith Bruchfeld, Maria Lerm, Kristofer Hedman
A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately 1 out of 10 COVID-19 convalescents reports persistent health issues more than 3 months after initial recovery. This 'post-COVID-19 condition' may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults - particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome or airway disorders - and explore the evidence for chronic autonomic dysfunction as a potential underlying mechanism...
November 2023: Journal of Internal Medicine
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