journal
https://read.qxmd.com/read/38845164/colonoscopy-findings-after-increasing-two-stool-faecal-immunochemical-test-fit-cut-off-cross-sectional-analysis-of-the-screesco-randomized-trial
#1
JOURNAL ARTICLE
Marcus Westerberg, Julia Eriksson, Chris Metcalfe, Christian Löwbeer, Anders Ekbom, Robert Steele, Lars Holmberg, Anna Forsberg
BACKGROUND: We determined the impact of an increased two-stool faecal immunochemical test (FIT) cut-off on colonoscopy positivity and relative sensitivity and specificity in the randomized controlled screening trial screening of Swedish colons conducted in Sweden. METHODS: We performed a cross-sectional analysis of participants in the FIT arm that performed FIT between March 2014 and 2020 within the study registered with ClinicalTrials.gov, NCT02078804, who had a faecal haemoglobin concentration of at least 10 µg/g in at least one of two stool samples and who underwent a colonoscopy (n = 3841)...
June 6, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38829151/has-mortality-in-the-united-states-returned-to-pre-pandemic-levels-an-analysis-of-provisional-2023-data
#2
JOURNAL ARTICLE
Abdul Mannan Khan Minhas, Marat Fudim, Erin D Michos, Dmitry Abramov
BACKGROUND: The COVID-19 pandemic, which started in 2020, resulted in greater all-cause mortality in 2020 and in subsequent years. Whether all-cause mortality remains elevated in 2023 compared to pre-pandemic numbers is unknown. METHODS AND RESULTS: The United States (US) Center for Disease Control Wide-Ranging, Online Data for Epidemiologic Research database was used to compare mortality rates between 2019 and provisional data for 2022 and 2023. Age-adjusted mortality rates (AAMRs) for all-cause as well as top causes of mortality were collected...
June 3, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38825772/circadian-and-ultradian-rhythms-clinical-implications
#3
REVIEW
Stafford L Lightman, Becky L Conway-Campbell
The hypothalamic-pituitary-adrenal axis is an extremely dynamic system with a combination of both circadian and ultradian oscillations. This state of 'continuous dynamic equilibration' provides a platform that is able to anticipate events, is sensitive in its response to stressors, remains robust during perturbations of both the internal and external environments and shows plasticity to adapt to a changed environment. In this review, we describe these oscillations of glucocorticoid (GC) hormones and why they are so important for GC-dependent gene activation in the brain and liver, and their consequent effects on the regulation of synaptic and memory function as well as appetite control and metabolic regulation...
June 2, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38805484/il-1%C3%AE-dna-complex-elevation-distinguishes-autoinflammatory-disorders-from-autoimmune-and-infectious-diseases
#4
LETTER
Anastasia-Maria Natsi, Efstratios Gavriilidis, Christina Antoniadou, Evangelos Papadimitriou, Vasileios Papadopoulos, Victoria Tsironidou, Dimitris Anastasios Palamidas, Loukas Chatzis, Eleni Sertaridou, Dimitrios Tsilingiris, Dimitrios T Boumpas, Athanasios G Tzioufas, Charalampos Papagoras, Konstantinos Ritis, Panagiotis Skendros
No abstract text is available yet for this article.
May 28, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38801732/trend-in-prevalence-associated-risk-factors-and-longitudinal-outcomes-of-sarcopenia-in-china-a-national-cohort-study
#5
JOURNAL ARTICLE
Weida Qiu, Anping Cai, Liwen Li, Yingqing Feng
AIMS: To estimate the contemporary trend in the prevalence of sarcopenia and evaluate its risk factors and the longitudinal associations with multiple chronic conditions and mortality among Chinese middle-aged and older adults. METHODS: This was a nationwide, prospective cohort study using data from the China Health and Retirement Longitudinal Study. The definition of sarcopenia was based on the Asian Working Group for Sarcopenia 2019 algorithm. In the cross-sectional analysis, we estimated the trend in the weighted prevalence of sarcopenia from 2011 to 2015 and examined the associated risk factors for sarcopenia severity in 2011...
May 27, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38738988/masld-and-mash-at-the-crossroads-of-hepatology-trials-and-cardiorenal-metabolic-trials
#6
REVIEW
Faiez Zannad, Arun J Sanyal, Javed Butler, João Pedro Ferreira, Nicolas Girerd, Veronica Miller, Ambarish Pandey, Chirag R Parikh, Vlad Ratziu, Zobair M Younossi, Stephen A Harrison
Steatotic liver disease (SLD) is a worldwide public health problem, causing considerable morbidity and mortality. Patients with SLD are at increased risk for major adverse cardiovascular (CV) events, type 2 diabetes mellitus and chronic kidney disease. Conversely, patients with cardiometabolic conditions have a high prevalence of SLD. In addition to epidemiological evidence linking many of these conditions, there is evidence of shared pathophysiological processes. In December 2022, a unique multi-stakeholder, multi-specialty meeting, called MOSAIC (Metabolic multi Organ Science Accelerating Innovation in Clinical Trials) was convened to foster collaboration across metabolic, hepatology, nephrology and CV disorders...
May 13, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38704820/platelets-as-an-inter-player-between-hyperlipidaemia-and-atherosclerosis
#7
REVIEW
Nailin Li
Platelet hyperreactivity and hyperlipidaemia contribute significantly to atherosclerosis. Thus, it is desirable to review the platelet-hyperlipidaemia interplay and its impact on atherogenesis. Native low-density lipoprotein (nLDL) and oxidized LDL (oxLDL) are the key proatherosclerotic components of hyperlipidaemia. nLDL binds to the platelet-specific LDL receptor (LDLR) ApoE-R2', whereas oxLDL binds to the platelet-expressed scavenger receptor CD36, lectin-type oxidized LDLR 1 and scavenger receptor class A 1...
May 5, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38698538/high-throughput-molecular-assays-for-inclusion-in-personalised-oncology-trials-state-of-the-art-and-beyond
#8
JOURNAL ARTICLE
Anders Edsjö, Hege G Russnes, Janne Lehtiö, David Tamborero, Eivind Hovig, Albrecht Stenzinger, Richard Rosenquist
In the last decades, the development of high-throughput molecular assays has revolutionised cancer diagnostics, paving the way for the concept of personalised cancer medicine. This progress has been driven by the introduction of such technologies through biomarker-driven oncology trials. In this review, strengths and limitations of various state-of-the-art sequencing technologies, including gene panel sequencing (DNA and RNA), whole-exome/whole-genome sequencing and whole-transcriptome sequencing, are explored, focusing on their ability to identify clinically relevant biomarkers with diagnostic, prognostic and/or predictive impact...
May 2, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38693641/epigenetic-reprograming-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-narrative-of-latent-viruses
#9
JOURNAL ARTICLE
Eirini Apostolou, Anders Rosén
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease presenting with severe fatigue, post-exertional malaise, and cognitive disturbances-among a spectrum of symptoms-that collectively render the patient housebound or bedbound. Epigenetic studies in ME/CFS collectively confirm alterations and/or malfunctions in cellular and organismal physiology associated with immune responses, cellular metabolism, cell death and proliferation, and neuronal and endothelial cell function. The sudden onset of ME/CFS follows a major stress factor that, in approximately 70% of cases, involves viral infection, and ME/CFS symptoms overlap with those of long COVID...
May 1, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38664991/effectiveness-of-integrated-person-centered-interventions-for-older-people-s-care-review-of-swedish-experiences-and-experts-perspective
#10
JOURNAL ARTICLE
Mariam Kirvalidze, Anne-Marie Boström, Ann Liljas, Megan Doheny, Anne Hendry, Brendan McCormack, Laura Fratiglioni, Sulin Ali, Zahra Ebrahimi, Sölve Elmståhl, Maria Eriksdotter, Pascal Gläske, Lena-Karin Gustafsson, Åsa Hedberg Rundgren, Helena Hvitfeldt, Carin Lennartsson, Lena Marmstål Hammar, Gunnar H Nilsson, Peter Nilsson, Joakim Öhlén, Anna Sandgren, Annika Söderman, Karl Swedberg, Nicoline Vackerberg, Davide Liborio Vetrano, Helle Wijk, Janne Agerholm, Amaia Calderón-Larrañaga
Older adults have multiple medical and social care needs, requiring a shift toward an integrated person-centered model of care. Our objective was to describe and summarize Swedish experiences of integrated person-centered care by reviewing studies published between 2000 and 2023, and to identify the main challenges and scientific gaps through expert discussions. Seventy-three publications were identified by searching MEDLINE and contacting experts. Interventions were categorized using two World Health Organization frameworks: (1) Integrated Care for Older People (ICOPE), and (2) Integrated People-Centered Health Services (IPCHS)...
April 25, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38659304/preoperative-prediction-of-metastatic-pheochromocytoma-and-paraganglioma-using-clinical-genetic-and-biochemical-markers-a-cohort-study
#11
JOURNAL ARTICLE
Seung Shin Park, Chang Ho Ahn, Seunghoo Lee, Woochang Lee, Won Woong Kim, Yu-Mi Lee, Su Jin Kim, Tae-Yon Sung, Kyu Eun Lee, Jung Hee Kim, Seung Hun Lee, Jung-Min Koh
BACKGROUND: The prevalence of metastatic pheochromocytoma and paraganglioma (PPGL) is approximately 15%-20%. Although there are indicators to assess metastatic risks, none of them predict metastasis reliably. Therefore, we aimed to develop and validate a scoring system using clinical, genetic, and biochemical risk factors to preoperatively predict the metastatic risk of PPGL. METHODS: In the cross-sectional cohort (n = 180), clinical, genetic, and biochemical risk factors for metastasis were identified using multivariate logistic regression analysis, and a novel scoring system was developed...
April 24, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38654517/early-transfusion-patterns-improve-the-molecular-international-prognostic-scoring-system-ipss-m-prediction-in-myelodysplastic-syndromes
#12
JOURNAL ARTICLE
Maria Creignou, Elsa Bernard, Alessandro Gasparini, Anna Tranberg, Gabriele Todisco, Pedro Luis Moura, Elisabeth Ejerblad, Lars Nilsson, Hege Garelius, Petar Antunovic, Fryderyk Lorenz, Bengt Rasmussen, Gunilla Walldin, Teresa Mortera-Blanco, Monika Jansson, Magnus Tobiasson, Chiara Elena, Jacqueline Ferrari, Anna Gallì, Sara Pozzi, Luca Malcovati, Gustaf Edgren, Michael J Crowther, Martin Jädersten, Elli Papaemmanuil, Eva Hellström-Lindberg
BACKGROUND: The Molecular International Prognostic Scoring System (IPSS-M) is the new gold standard for diagnostic outcome prediction in patients with myelodysplastic syndromes (MDS). This study was designed to assess the additive prognostic impact of dynamic transfusion parameters during early follow-up. METHODS: We retrieved complete transfusion data from 677 adult Swedish MDS patients included in the IPSS-M cohort. Time-dependent erythrocyte transfusion dependency (E-TD) was added to IPSS-M features and analyzed regarding overall survival and leukemic transformation (acute myeloid leukemia)...
April 23, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38629919/gestational-diabetes-mellitus-is-associated-with-greater-incidence-of-dementia-during-long-term-post-partum-follow-up
#13
JOURNAL ARTICLE
Yang Zhang, Darui Gao, Ying Gao, Jing Li, Chenglong Li, Yang Pan, Yongqian Wang, Junqing Zhang, Fanfan Zheng, Wuxiang Xie
BACKGROUND: The impact of gestational diabetes mellitus (GDM) on incident dementia is unknown. Our aim was to evaluate the relationship between GDM and all-cause dementia and the mediating effects of chronic diseases on this relationship. METHODS: This prospective cohort study included women from the UK Biobank who were grouped based on GDM history. Multivariate Cox proportional hazard models were used to explore the associations between GDM and dementia. We further analysed the mediating effects of chronic diseases on this relationship and the interactions of covariates...
April 17, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38606956/bilateral-inferior-petrosal-sinus-sampling-in-the-differential-diagnosis-of-acth-dependent-cushing-s-syndrome-a-reappraisal
#14
REVIEW
Majid Valizadeh, Behnaz Abiri, Farhad Hosseinpanah, Ashley Grossman
Cushing's syndrome (CS) is a rare disorder, once exogenous causes have been excluded. However, when diagnosed, the majority of cases are adrenocorticotropic hormone (ACTH)-dependent, of which a substantial minority are due to a source outside of the pituitary, ectopic ACTH syndrome (EAS). Differentiating among pituitary-dependent CS, Cushing's disease (CD) and an ectopic source can be problematic. Because non-invasive tests in the evaluation of CS patients often lack adequate sensitivity and specificity, bilateral inferior petrosal sinus sampling (BIPSS), a minimally invasive procedure performed during the investigation of ACTH-dependent CS, can be extremely helpful...
April 12, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38575552/the-gratitude-paradox
#15
EDITORIAL
Marie Chisholm-Burns, Richard N Formica
No abstract text is available yet for this article.
April 4, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38561603/impact-of-nutritional-support-routes-on-mortality-in-acute-pancreatitis-a-network-meta-analysis-of-randomized-controlled-trials
#16
JOURNAL ARTICLE
Ping-Han Hsieh, Tsung-Chieh Yang, Enoch Yi-No Kang, Pei-Chang Lee, Jiing-Chyuan Luo, Yi-Hsiang Huang, Ming-Chih Hou, Shih-Ping Huang
BACKGROUND: Nutritional administration in acute pancreatitis (AP) management has sparked widespread discussion, yet contradictory mortality results across meta-analyses necessitate clarification. The optimal nutritional route in AP remains uncertain. Therefore, this study aimed to compare mortality among nutritional administration routes in patients with AP using consistency model. METHODS: This study searched four major databases for relevant randomized controlled trials (RCTs)...
April 1, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38539241/escalated-complement-activation-during-hospitalization-is-associated-with-higher-risk-of-60-day-mortality-in-sars-cov-2-infected-patients
#17
JOURNAL ARTICLE
Andreas Barratt-Due, Kristin Pettersen, Tuva Børresdatter-Dahl, Jan Cato Holter, Renathe H Grønli, Anne Ma Dyrhol-Riise, Tøri Vigeland Lerum, Aleksander Rygh Holten, Kristian Tonby, Marius Trøseid, Ole H Skjønsberg, Beathe Kiland Granerud, Lars Heggelund, Anders Benjamin Kildal, Camilla Schjalm, Trond Mogens Aaløkken, Pål Aukrust, Thor Ueland, Tom Eirik Mollnes, Bente Halvorsen
BACKGROUND: The complement system, an upstream recognition system of innate immunity, is activated upon SARS-CoV-2 infection. To gain a deeper understanding of the extent and duration of this activation, we investigated complement activation profiles during the acute phase of COVID-19, its persistence post-recovery and dynamic changes in relation to disease severity. METHODS: Serial blood samples were obtained from two cohorts of hospitalized COVID-19 patients (n = 457)...
March 27, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38528394/association-of-hospital-treated-infectious-diseases-and-infection-burden-with-cardiovascular-diseases-and-life-expectancy
#18
JOURNAL ARTICLE
Jiazhen Zheng, Can Ni, S W Ricky Lee, Fu-Rong Li, Jinghan Huang, Rui Zhou, Yining Huang, Gregory Y H Lip, Xianbo Wu, Shaojun Tang
BACKGROUND: The association of a broad spectrum of infectious diseases with cardiovascular outcomes remains unclear. OBJECTIVES: We aim to provide the cardiovascular risk profiles associated with a wide range of infectious diseases and explore the extent to which infections reduce life expectancy. METHODS: We ascertained exposure to 900+ infectious diseases before cardiovascular disease (CVD) onset in 453,102 participants from the UK Biobank study...
March 25, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38528373/serum-t-50-predicts-cardiovascular-mortality-in-individuals-with-type-2-diabetes-a-prospective-cohort-study
#19
JOURNAL ARTICLE
Amarens van der Vaart, Coby Eelderink, Harry van Goor, Jan-Luuk Hillebrands, Charlotte A Te Velde-Keyzer, Stephan J L Bakker, Andreas Pasch, Peter R van Dijk, Gozewijn D Laverman, Martin H de Borst
BACKGROUND AND AIMS: Individuals with type 2 diabetes (T2D) have a higher risk of cardiovascular disease, compared with those without T2D. The serum T50 test captures the transformation time of calciprotein particles in serum. We aimed to assess whether serum T50 predicts cardiovascular mortality in T2D patients, independent of traditional risk factors. METHODS: We analyzed 621 individuals with T2D in this prospective cohort study. Cox regression models were performed to test the association between serum T50 and cardiovascular and all-cause mortality...
March 25, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38606904/reframing-prediabetes-a-call-for-better-risk-stratification-and-intervention
#20
REVIEW
Sun H Kim
Prediabetes is an intermediate state of glucose homeostasis whereby plasma glucose concentrations are above normal but below the threshold of diagnosis for diabetes. Over the last several decades, criteria for prediabetes have changed as the cut points for normal glucose concentration and diagnosis of diabetes have shifted. Global consensus does not exist for prediabetes criteria; as a result, the clinical course and risk for type 2 diabetes vary. At present, we can identify individuals with prediabetes based on three glycemic tests (hemoglobin A1c, fasting plasma glucose, and 2-h plasma glucose during an oral glucose tolerance test)...
June 2024: Journal of Internal Medicine
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