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Journal of Internal Medicine

Tanja Zeller, Sebastian Appelbaum, Kari Kuulasmaa, Tarja Palosaari, Stefan Blankenberg, Pekka Jousilahti, Veikko Salomaa, Mahir Karakas
INTRODUCTION: The relevance of low testosterone concentrations for incident coronary heart disease (CHD) and mortality has been discussed in various studies. Here we evaluate the predictive value of low baseline testosterone levels in a large population-based cohort. METHODS: We measured the serum levels of testosterone in 7,671 subjects (3,710 male, 3,961 female) of the population-based FINRISK97 study. RESULTS: The median follow-up (FU) was 13...
May 23, 2019: Journal of Internal Medicine
Yu Peng, Jieqiong Li, Panpan Zhang, Xia Zhang, Linyi Peng, Hua Chen, Jiaxin Zhou, ShangZhu Zhang, Huaxia Yang, Jinjing Liu, Huifang Guo, Jing Li, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Yunyun Fei, Wen Zhang
OBJECTIVES: The aim of this study was to investigate the predictive factors for relapse of IgG4-related disease (IgG4-RD) and observe the long-term clinical outcomes in patients with IgG4-RD. METHODS: We included in the present analysis 122 patients who were newly diagnosed with IgG4-RD, treated with glucocorticoid (GC) monotherapy or GC and immunosuppressant combination therapy, and followed for at least 3 years. Clinical relapse, response and side effects were recorded...
May 23, 2019: Journal of Internal Medicine
Johan Lundberg, Rikard Grankvist, Staffan Holmin
Since the establishment of the Seldinger technique for secure entry to the vascular system, there has been a rapid evolution in imaging and catheters that has made the arteries and veins internal routes to any place in the body for interventions. It is curious that a general exit from the vasculature in a similar manner has not been proposed earlier. Possibly, the simplest reason, is that accidental perforation of the vasculature by guide wire or catheter is a feared adverse event in endovascular intervention...
May 20, 2019: Journal of Internal Medicine
B Winblad, M Ankarcrona, G Johansson, P Novak, E Peter Thelin, H Zetterberg, K Blennow
No abstract text is available yet for this article.
May 15, 2019: Journal of Internal Medicine
P Zimmet, K G M M Alberti, N Stern, C Bilu, A El-Osta, H Einat, N Kronfeld-Schor
The Metabolic Syndrome is a cluster of cardio-metabolic risk factors and comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes. It is responsible for huge socio-economic costs with its resulting morbidity and mortality in most countries. The underlying aetiology of this clustering has been the subject of much debate. More recently, significant interest has focussed on the involvement of the circadian system, a major regulator of almost every aspect of human health and metabolism...
May 13, 2019: Journal of Internal Medicine
Amanda J Berberich, Ahmed Ziada, Guang Yong Zou, Robert A Hegele
BACKGROUND: Severe hypertriglyceridemia (serum triglyceride >10 mmol/L) is implicated in ~9% of acute pancreatitis cases. Certain guidelines list severe hypertriglyceridemia as an indication for plasmapheresis. OBJECTIVE: We assembled the natural trajectory of triglyceride levels in patients with acute pancreatitis due to severe hypertriglyceridemia who were managed conservatively without plasmapheresis to evaluate the effectiveness of this approach. METHODS: A retrospective chart review was performed on 22 hospital admissions for acute pancreatitis episodes considered to be caused by severe hypertriglyceridemia...
May 11, 2019: Journal of Internal Medicine
M Leggio, A Villano, A Fusco
No abstract text is available yet for this article.
May 9, 2019: Journal of Internal Medicine
D Arvidsson, J Fridolfsson, M Börjesson
Accelerometers are commonly used in clinical and epidemiological research for more detailed measures of physical activity and to target the limitations of self-report methods. Sensors are attached at the hip, wrist and thigh, and the acceleration data are processed and calibrated in different ways to determine activity intensity, body position and/or activity type. Simple linear modelling can be used to assess activity intensity from hip and thigh data, whilst more advanced machine-learning modelling is to prefer for the wrist...
April 16, 2019: Journal of Internal Medicine
M Bonaccio, A Di Castelnuovo, S Costanzo, A De Curtis, M Persichillo, C Cerletti, M B Donati, G de Gaetano, L Iacoviello
BACKGROUND: There is poor knowledge on the association between combined lifestyles with mortality risk among individuals at high risk, and little is known on the biological mechanisms that could be on the pathway. METHODS: Longitudinal analysis on 22 839 individuals from the Moli-sani Study (Italy, 2005-2010). Among them, we identified 5200 elderly individuals (≥65 year), 2127 subjects with diabetes and 1180 with cardiovascular disease (CVD) at baseline. A healthy lifestyle score (HLS) was calculated, allocating 1 point for each of the following: abstention from smoking; adherence to Mediterranean diet; physical activity; absence of abdominal obesity...
April 16, 2019: Journal of Internal Medicine
T Sugiyama
No abstract text is available yet for this article.
April 11, 2019: Journal of Internal Medicine
J A Mossman, A A Pacey
No abstract text is available yet for this article.
April 10, 2019: Journal of Internal Medicine
Artur Fedorowski
Not so long time ago, in 1930s, younger and, in particular, female patients presenting with a myriad of such symptoms as palpitations, non-specific chest pain, weakness, insomnia, faintness, dizziness, irritability and flushes were seen as representative of "cardiac neurosis"[1]. The "cardiac neurosis" was believed to be a psychosomatic disorder but the term is largely forgotten by modern cardiology. And there is a good reason for it. This article is protected by copyright. All rights reserved...
April 10, 2019: Journal of Internal Medicine
O M P Jolobe
No abstract text is available yet for this article.
April 9, 2019: Journal of Internal Medicine
Mårten Risling, Douglas Smith, Thor D Stein, Eric Peter Thelin, Elisa R Zanier, Maria Ankarcrona, Per Nilsson
Traumatic brain injury (TBI) is caused by a head impact with a force exceeding regular exposure from normal body movement which the brain normally can accommodate. People affected include, but are not restricted to, sport athletes in American football, ice hockey, boxing as well as military personnel. Both single and repetitive exposures may affect the brain acutely and can lead to chronic neurodegenerative changes including chronic traumatic encephalopathy (CTE) associated with the development of dementia...
April 8, 2019: Journal of Internal Medicine
Gunnar C Hansson
This review describes the organization and importance of mucus in the intestine and lungs in relation to the diseases cystic fibrosis, ulcerative colitis and COPD. The inner surfaces of the body are protected by mucus built around polymeric glycoproteins called mucins. In the disease Cystic Fibrosis (CF), the small intestinal mucus is in contrast the normal attached to the epithelium, explaining the intestinal problems at this disease. The inner of the two mucus layers of colon is normally impenetrable to bacteria, keeping the commensals away from and protecting the epithelium...
April 8, 2019: Journal of Internal Medicine
H Horwitz, K P Dalhoff, J T Andersen
No abstract text is available yet for this article.
April 8, 2019: Journal of Internal Medicine
M Leggio, C Tiberti, M Armeni, G Limongelli, A Mazza
No abstract text is available yet for this article.
April 8, 2019: Journal of Internal Medicine
Daisuke Kamimura, Masaaki Murakami
The systemic regulation of immune reactions by the nervous system is well studied and depends on the release of hormones. Some regional regulations of immune reactions, on the other hand, depend on specific neural pathways. Better understanding of these regulations will expand therapeutic applications for neuroimmune and organ-to-organ functional interactions. Here we discuss one regional neuroimmune interaction, the gateway reflex, which converts specific neural inputs into local inflammatory outputs in the CNS...
April 7, 2019: Journal of Internal Medicine
Geeti P Arora, Mikael Åkerlund, Charlotte Brøns, Gunn-Helen Moen, Niko S Wasenius, Christine Sommer, Anne K Jenum, Peter Almgren, Richa G Thaman, Marju Orho-Melander, Johan Eriksson, Elisabeth Qvigstad, Kåre Birkeland, Kerstin Berntorp, Allan A Vaag, Leif Groop, Rashmi B Prasad
OBJECTIVE: Gestational diabetes mellitus (GDM) is a transient form of diabetes characterized by impaired insulin secretion and action during pregnancy. Population-based differences in prevalence exist which could be explained by phenotypic and genetic differences. The aim of this study was to examine these differences in pregnant women from Punjab, India and Scandinavia. METHODS: 85 GDM/T2D loci in European and/or Indian populations from previous studies were assessed for association with GDM based on Swedish GDM criteria in 4018 Punjabi Indian and 507 Swedish pregnant women...
March 27, 2019: Journal of Internal Medicine
Lina Rydén, Anna Zettergren, Nazib M Seidu, Xinxin Guo, Silke Kern, Kaj Blennow, Henrik Zetterberg, Simona Sacuiu, Ingmar Skoog
BACKGROUND: Atrial fibrillation increases risk of stroke, and thus risk of cognitive impairment and dementia. Emerging evidence suggests an association also in the absence of stroke. We aimed to examine the association between atrial fibrillation and incident dementia, with and without exclusion of individuals with stroke, and if sex and genetic factors modify the possible association. METHODS: In 2000-2001, a population-based sample of 70-year-olds (N=561) underwent comprehensive somatic and neuropsychiatric examinations, as part of the Gothenburg H70 Birth Cohort Studies...
March 20, 2019: Journal of Internal Medicine
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