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Journal of Internal Medicine

Orly Avnery, Mar Martin, Alessandra Bura-Riviere, Giovanni Barillari, Lucia Mazzolai, Isabelle Mahé, Pablo Javier Marchena, Peter Verhamme, Manuel Monreal, Martin H Ellis
BACKGROUND: Patients with venous thromboembolism (VTE) secondary to transient risk factors may develop VTE recurrences after discontinuing anticoagulation. Identifying at-risk patients could help to guide the duration of therapy. METHODS: We used the RIETE database to assess the prognostic value of d-dimer testing after discontinuing anticoagulation to identify patients at increased risk for recurrences. Transient risk factors were classified as major (postoperative) or minor (pregnancy, estrogen use, immobilization or recent travel)...
August 8, 2019: Journal of Internal Medicine
O M P Jolobe
No abstract text is available yet for this article.
August 1, 2019: Journal of Internal Medicine
Charlotte Salmon, Florence Conus, Marie-Élise Parent, Andrea Benedetti, Marie-Claude Rousseau
BACKGROUND: Most risk factors for lymphoma identified so far relate to immunosuppression, but its etiology remains unclear. OBJECTIVES: We investigated whether Bacillus Calmette-Guérin (BCG) vaccination is associated with lymphoma, overall and separately for Hodgkin's (HL) and non-Hodgkin's lymphoma (NHL). METHODS: A cohort of 400,611 subjects born in the province of Québec, Canada, between 1970 and 1974 was used. Information on BCG vaccination was extracted from the Quebec BCG vaccination registry...
July 30, 2019: Journal of Internal Medicine
Haesuk Park, Ghadeer K Dawwas, Xinyue Liu, Mindie H Nguyen
BACKGROUND: As the prevalence of non-alcoholic fatty liver disease (NAFLD) escalates, understanding its potential impact on the development of chronic kidney disease (CKD) is needed. OBJECTIVE: To determine the longitudinal association of NAFLD with the development of advanced CKD in the United States. METHODS: A retrospective cohort analysis of the Truven Health MarketScan Database (2006-2015) was conducted. We used Cox proportional hazards models to compare the risk of developing CKD stages 3-5 in NAFLD versus non-NAFLD patients, identified by ICD-9 codes, after 1:3 propensity score (PS) matching...
July 29, 2019: Journal of Internal Medicine
Monisha Samuel, Susanne Gabrielsson
Extracellular vesicles, especially exosomes, have been explored for cancer immunotherapy. The initial studies made use of autologous B cell or dendritic cell derived exosomes, with the idea that MHC-peptide complexes on the exosomal surface would stimulate an MHC-restricted cancer-specific immune response. This was also verified in mouse systems, while the effects in human clinical systems were more modest. Several studies have explored the mechanisms for exosomal T cell activation, and a picture emerges where the antigen presenting cells, possibly both B cells and dendritic cells of the recipient are needed to induce a potent T cell response to exosomes...
July 29, 2019: Journal of Internal Medicine
G M Egeland, R Akerkar, R Kvåle, G Sulo, G S Tell, I J Bakken, M Ebbing
BACKGROUND: The prognosis of unexplained chest pain patients provides valuable information for evaluation of health services. OBJECTIVE: To examine prognosis of unexplained chest pain. METHODS: Using data from in- and outpatient hospital visits in Norway of patients discharged with a main diagnosis of unexplained chest pain (ICD-10: R072-R074) in 2010-2012, the 1-year incidence of coronary heart disease (CHD), any cardio-vascular disease (CVD) and mortality was evaluated...
July 19, 2019: Journal of Internal Medicine
Clara Vigneron, Aldéric Lécluse, Thomas Ronzière, Laurence Bouillet, Isabelle Boccon-Gibod, Stéphane Gayet, Emilie Doche, Didier Smadja, Silvia Di Legge, Frédéric Dumont, Marie Gaudron, Ioana Ion, Sébastien Marcel, Mathieu Sévin, Mihaela Bustuchina Vlaicu, David Launay, Isaure Arnaud, Philippe Girard-Madoux, Chérif Héroum, Sébastien Lefèvre, Guillaume Marc, Michael Obadia, Denis Sablot, Igor Sibon, Laurent Suissa, Delphine Gobert, Olivier Detante, Sonia Alamowitch, Olivier Fain, Nicolas Javaud
BACKGROUND: Bradykinin-mediated angioedema is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknow and management is discussed. OBJECTIVES: To clarify risk factors associated with bradykinin-mediated angioedema after thrombolysis for acute ischemic stroke. METHODS: In a case-control study conducted at a French reference center for bradykinin angiœdema, patients with thrombolysis for acute ischemic stroke and a diagnosis of bradykinin-mediated angiœdema, were compared to controls treated with thrombolysis treatment without angiœdema...
July 18, 2019: Journal of Internal Medicine
Daniel A Duprez, David R Jacobs
Inflammation is a common mechanism in many chronic diseases, including cancer and cardiovascular disease. Numerous studies have shown that high-sensitivity C-reactive protein (hsCRP), one of the most frequently studied inflammatory markers, is associated with chronic inflammatory-related disease, cardiovascular disease, cancer and mortality [1]. While hs-CRP is a single marker of inflammation, GlycA is a composite biomarker that reflects the glycosylation states of several of the most abundant acute-phase proteins [2]...
July 15, 2019: Journal of Internal Medicine
R Loera-Valencia, A Cedazo-Minguez, P Kenigsberg, G Page, A Duarte, P Giusti, M Zusso, P Robert, G B Frisoni, A Cattaneo, M Zille, J Boltze, N Cartier, L Buee, G Johansson, B Winblad
Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a global epidemic and so far, there is no cure nor treatment to alter its progression. The most important feature of the disease is neuronal death and loss of cognitive functions, caused probably from several pathological processes in the brain. The main neuropathological features of AD are widely described: amyloid beta (Aβ) plaques and neurofibrillary tangles of the aggregated protein tau, which contribute to the disease. Nevertheless, AD brains suffer from a variety of alterations in function, such as energy metabolism, inflammation, and synaptic activity...
July 8, 2019: Journal of Internal Medicine
Megan Conroy, Jonathan Sellors, Mark Effingham, Thomas J Littlejohns, Chris Boultwood, Lorraine Gillions, Cathie L M Sudlow, Rory Collins, Naomi E Allen
Ready access to health research studies is becoming more important as researchers, and their funders, seek to maximise the opportunities for scientific innovation and health improvements. Large-scale population-based prospective studies are particularly useful for multidisciplinary research into the causes, treatment and prevention of many different diseases. UK Biobank has been established as an open-access resource for public health research, with the intention of making the data as widely available as possible in an equitable and transparent manner...
July 8, 2019: Journal of Internal Medicine
Justin R Ortiz
Pregnancy increases a woman's risk of severe influenza illness. This association has been consistently shown in many different settings and with pandemic and seasonal influenza viruses. Young children are also at increased risk for severe influenza illness, and there are no influenza vaccines licensed for use in infants younger than six months of age. This article is protected by copyright. All rights reserved.
July 8, 2019: Journal of Internal Medicine
Théo Crosson, Katiane Roversi, Mohammad Balood, Rahmeh Othman, Maryam Ahmadi, Jo-Chiao Wang, Paula Juliana Seadi Pereira, Maryam Tabatabaei, Réjean Couture, Tuany Eichwald, Alexandra Latini, Rui D Prediger, Manu Rangachari, Corey R Seehus, Simmie L Foster, Sébastien Talbot
The host evolves redundant mechanisms to preserve physiological processing and homeostasis. These functions range from sensing internal and external threats, creating a memory of the insult and generating reflexes which aim to resolve inflammation. Impairment in such functioning leads to chronic inflammatory diseases. By interacting through a common language of ligands and receptors, the immune and sensory nervous systems work in concert to accomplish such protective functions. While this bidirectional communication helps to protect from danger, it can contribute to disease pathophysiology...
July 7, 2019: Journal of Internal Medicine
Jonathan Golledge, Joseph V Moxon, Tejas P Singh, Matthew J Bown, Kevin Mani, Anders Wanhainen
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and human epidemiology, genetic and observational studies over the last few decades have highlighted the potential of a number of drug therapies, including medications that lower blood pressure, correct dyslipidemia, or inhibit thrombosis, inflammation or matrix remodeling, as approaches to managing small AAA. This review summarizes prior AAA pathogenesis data from animal and human studies aimed at identifying targets for the development of drug therapies...
July 6, 2019: Journal of Internal Medicine
Pontus Naucler, Birgitta Henriques-Normark, Jonas Hedlund, Ilias Galanis, Fredrik Granath, Åke Örtqvist
BACKGROUND: There is limited evidence on the impact of pneumococcal conjugate vaccine childhood immunization programs (PCV-CIP) on community-acquired pneumonia (CAP) in individuals with underlying diseases. METHODS: A nation-wide cohort study using Swedish health registers to assess the incidence of hospitalisation with all-cause (AC-CAP) and pneumococcal or lobar (PL-CAP) CAP between 2005-2015. RESULTS: In total, 303,691 episodes of AC-CAP occurred, of which 14,225 were PL-CAP...
July 6, 2019: Journal of Internal Medicine
W Gao, W Cao, J Lv, C Yu, T Wu, S Wang, L Meng, D Wang, Z Wang, Z Pang, M Yu, H Wang, X Wu, Z Dong, F Wu, G Jiang, X Wang, Y Liu, J Deng, L Lu, L Li
The Chinese National Twin Registry (CNTR) currently includes data from 61 566 twin pair from 11 provinces or cities in China. Of these, 31 705, 15 060 and 13 531 pairs are monozygotic, same-sex dizygotic and opposite-sex dizygotic pairs, respectively, determined by opposite sex or intrapair similarity. Since its establishment in 2001, the CNTR has provided an important resource for analysing genetic and environmental influences on chronic diseases especially cardiovascular diseases. Recently, the CNTR has focused on collecting biologic specimens from disease-concordant or disease-discordant twin pairs or from twin pairs reared apart...
July 4, 2019: Journal of Internal Medicine
Eke G Gruppen, Setor K Kunutsor, Lyanne M Kieneker, Bert van der Vegt, Margery A Connelly, Geertruida H de Bock, Ron T Gansevoort, Stephan J L Bakker, Robin P F Dullaart
OBJECTIVE: Chronic diseases are associated with an inflammatory response. We determined the association of two inflammatory markers, GlycA and high sensitivity C-reactive protein (hsCRP), with overall and cause-specific mortality in a cohort of men and women. METHODS: Cox regression analyses were used to examine associations of GlycA and hsCRP with all-cause, cancer and cardiovascular mortality in 5,526 subjects (PREVEND cohort; average follow-up 12.6 years). RESULTS: GlycA was associated with all-cause mortality (n=838), independent of clinical risk factors and hsCRP (hazard ratio 1...
July 1, 2019: Journal of Internal Medicine
C Gunduz, O Kacmaz Basoglu, J Hedner, M R Bonsignore, H Hein, R Staats, I Bouloukaki, G Roisman, A Pataka, P Sliwinski, O Ludka, J L Pepin, L Grote
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. METHODS: The cross-sectional analysis included 11 892 patients (age 51.9 ± 12.5 years, 70% male, body mass index (BMI) 31.3 ± 6.6 kg/m2 , mean oxygen desaturation index (ODI) 23...
July 1, 2019: Journal of Internal Medicine
D Mølgaard-Nielsen, T K Fischer, T G Krause, A Hviid
BACKGROUND: In randomized trials, it has been found that maternal influenza vaccination reduces influenza infections in both women and their infants. However, these trials have been performed in low-resource settings, and evidence from high-resource settings is limited. METHODS: Nested within a register-based cohort of all women giving birth in Denmark between 2010 and 2016 (n = 357 810 births), we conducted two case-control studies using a test-negative design of all pregnant women and their infants, respectively, tested for influenza virus with reverse transcriptase-polymerase chain reaction...
July 1, 2019: Journal of Internal Medicine
Peter Saliba-Gustafsson, Matteo Pedrelli, Karl Gertow, Olivera Werngren, Vanessa Janas, Shirin Pourteymour, Damiano Baldassarre, Elena Tremoli, Fabrizio Veglia, Rainer Rauramaa, Andries J Smit, Philippe Giral, Sudhir Kurl, Matteo Pirro, Ulf de Faire, Steve E Humphries, Anders Hamsten, Isabel Gonçalves, Marju Orho-Melander, Anders Franco-Cereceda, Jan Borén, Per Eriksson, Joëlle Magné, Paolo Parini, Ewa Ehrenborg
BACKGROUND: Hyperlipidemia is a major risk factor for cardiovascular disease and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. OBJECTIVE: We sought to delineate putative beneficial effects of the Pro251 variant of perlipin-2 on subclinical atherosclerosis and the mechanism by which it acts...
June 28, 2019: Journal of Internal Medicine
Lynette M Smith, J Christopher Gallagher
BACKGROUND: It is questionable as to whether total serum 25 hydroxyvitamin D (T25D) levels are lower in African Americans. We measured serum T25D, free 25hydroxyvitamin D (F25D), and serum parathyroid hormone (PTH) in African American and Caucasian women and studied the effect of vitamin D dosing to determine if differences by race or age occur. METHODS: Healthy young and older Caucasian and African American women who were vitamin D insufficient were randomized in two clinical trials to escalating daily doses of vitamin D from 400 IU - 4800IU and placebo for 12 months...
June 18, 2019: Journal of Internal Medicine
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