Miaomiao Pei, Nanzhu Xu, Jiaying Li, Xuehua Liu, Luyu Zhang, Wushuang Xiao, Zhen Yu, Ping Yang, Ying Peng, Jieming Zhang, Linjie Hong, Xiaosheng Wu, Weimei Tang, Zhizhao Lin, Fachao Zhi, Guoxin Li, Aimin Li, Side Liu, Ye Chen, Li Xiang, Jianjiao Lin, Jide Wang
Long non-coding RNAs (lncRNAs) have been implicated in gastric cancer (GC) carcinogenesis and progression. However, the role of linc00501 in GC growth and metastasis remains unclear. In this study, we found that linc00501 was frequently upregulated in GC cells and tissues and was closely related to adverse GC clinicopathological features. Aberrant overexpression of linc00501 promoted GC cell proliferation, invasion, and metastasis both in vitro and in vivo. Mechanistically, linc00501 stabilized client protein STAT3 from deubiquitylation by directly interacting with cancer chaperone protein HSP90B1...
May 6, 2023: Cellular Signalling