journal
https://read.qxmd.com/read/38417636/vgll1-stabilization-of-cytoplasmic-taz-promotes-egfr-expression-and-maintains-tumor-initiating-cells-in-breast-cancer-independent-of-tead
#21
JOURNAL ARTICLE
Shubhashree Parimita, Amitava Das, Sanjoy Samanta
Vestigial-like family member 1 (VGLL1) is one of the X-linked genes whose expression is elevated in basal-like breast cancer (BLBC) because of X-chromosome isodisomy. As an approach towards understanding its function, we performed correlation study using transcript data of breast cancer patients from cBioPortal for Cancer Genomics. Our analysis identified EGFR as the most correlated transcript with VGLL1. We demonstrate that VGLL1 promotes EGFR expression and increases the frequency of breast tumor initiating cells (CD44high/+ CD24low/- )...
February 28, 2024: Cellular Signalling
https://read.qxmd.com/read/38417637/approaches-and-challenges-in-identifying-quantifying-and-manipulating-dynamic-mitochondrial-genome-variations
#22
JOURNAL ARTICLE
Fei Li, Run Xiang, Yue Liu, Guoliang Hu, Quanbo Jiang, Tao Jia
Mitochondria, the cellular powerhouses, possess their own unique genetic system, including replication, transcription, and translation. Studying these processes is crucial for comprehending mitochondrial disorders, energy production, and their related diseases. Over the past decades, various approaches have been applied in detecting and quantifying mitochondrial genome variations with also the purpose of manipulation of mitochondria or mitochondrial genome for therapeutics. Understanding the scope and limitations of above strategies is not only fundamental to the understanding of basic biology but also critical for exploring disease-related novel target(s), as well to develop innovative therapies...
February 26, 2024: Cellular Signalling
https://read.qxmd.com/read/38417635/mm9_circ_014683-regulates-microglia-polarization-through-canonical-nf%C3%AE%C2%BAb-signaling-pathway-in-diabetic-retinopathy
#23
JOURNAL ARTICLE
Tingting Chen, Congyao Wang, Wenhui Zhu, Fenfen Yu, Xia Dong, Yihua Su, Jingwen Huang, Lijun Huo, Pengxia Wan
Diabetic retinopathy (DR) is still the major cause of visual loss in working-aged people, one of the critical pathological processes are retinal microglia-mediated inflammation. Our previous study demonstrated that enhanced M1 microglial polarization was involved in retinal inflammation in DR, but the detailed mechanism needs further investigation. Circular RNAs (circRNAs) are important kind of noncoding RNAs involved in the regulation of various cell biological processes. Herein, the circRNA expression profiles of BV2 mouse microglia treated with or without glucose were detected, and a total of 347 differentially expressed circRNAs were identified in glucose-treated BV2 cells...
February 26, 2024: Cellular Signalling
https://read.qxmd.com/read/38417634/low-shear-stress-induces-macrophage-infiltration-and-aggravates-aneurysm-wall-inflammation-via-ccl7-ccr1-tak1-nf-%C3%AE%C2%BAb-axis
#24
JOURNAL ARTICLE
Heng Wei, Guijun Wang, Qi Tian, Chengli Liu, Wenrui Han, Jianfeng Wang, Peibang He, Mingchang Li
BACKGROUND: This study aimed to elucidate the mechanism by which wall shear stress (WSS) influences vascular walls, accounting for the susceptibility of intracranial aneurysms (IAs) to rupture. METHOD: We collected blood samples from the sacs of 24 ruptured and 28 unruptured IAs and analyzed the expression of chemokine CCL7 using enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression analyses were employed to assess clinical data, aneurysm morphology, and hemodynamics in both groups...
February 26, 2024: Cellular Signalling
https://read.qxmd.com/read/38417633/adaptor-protein-hip-55-promotes-macrophage-m1-polarization-through-promoting-ap-1-complex-activation
#25
JOURNAL ARTICLE
Jingwei Bian, Yuzhong Zhu, Panhui Tian, Qiqi Yang, Zijian Li
Overwhelming macrophage M1 polarization induced by malfunction of the renin-angiotensin-aldosterone system (RAAS) initiates inflammatory responses, which play a crucial role in various cardiovascular diseases. However, the underlying regulatory mechanism remains elusive. Here, we identified adaptor protein HIP-55 as a critical regulator of macrophage M1 polarization. The expression of HIP-55 was upregulated in M1 macrophage induced by Ang II. Overexpression of HIP-55 significantly promoted Ang II-induced macrophage M1 polarization, whereas genetic deletion of HIP-55 inhibited the Ang II-induced macrophage M1 polarization...
February 26, 2024: Cellular Signalling
https://read.qxmd.com/read/38408550/uptake-pathways-of-cell-penetrating-peptides-in-the-context-of-drug-delivery-gene-therapy-and-vaccine-development
#26
JOURNAL ARTICLE
Moataz Dowaidar
Cell-penetrating peptides have been extensively utilized for the purpose of facilitating the intracellular delivery of cargo that is impermeable to the cell membrane. The researchers have exhibited proficient delivery capabilities for oligonucleotides, thereby establishing cell-penetrating peptides as a potent instrument in the field of gene therapy. Furthermore, they have demonstrated a high level of efficiency in delivering several additional payloads. Cell penetrating peptides (CPPs) possess the capability to efficiently transport therapeutic molecules to specific cells, hence offering potential remedies for many illnesses...
February 24, 2024: Cellular Signalling
https://read.qxmd.com/read/38401776/identification-of-biomimetic-nanoplatform-mediated-delivery-of-si-isg15-for-treatment-of-triple-negative-breast-cancer
#27
JOURNAL ARTICLE
Feiran Wang, Nannan Zhang, Ruishu Niu, Yunpeng Lu, Wei Zhang, Zhixian He
Triple-negative breast cancer (TNBC) is recognized as the most malicious form of breast cancer and exhibits an alarming tendency for recurrence, a heightened propensity for metastasis, and an overwhelmingly grim prognosis. Therefore, effective therapy approaches for TNBC are urgently required. In this study, the interferon-stimulated gene 15 (ISG15) expression level was analyzed by bioinformatics and verified by Western blot analysis. The effects of ISG15 on the proliferation and metastasis of TNBC cells were assessed using MTT, Colony formation, EdU, Transwell, and Flow cytometry assays...
February 22, 2024: Cellular Signalling
https://read.qxmd.com/read/38395185/glial-cx43-hemichannels-and-neuronal-panx1-hemichannels-and-p2x7-receptors-orchestrates-presynaptic-homeostatic-plasticity
#28
JOURNAL ARTICLE
Alberto Rafael, Marina Tizzoni, Cristian Justet, Andrea Cairus, Verónica Abudara, Nathalia Vitureira
The emerging role of glial cells in modulating neuronal excitability and synaptic strength is a growing field in neuroscience. In recent years, a pivotal role of gliotransmission in homeostatic presynaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor. However, very little is known about the glial non-vesicular ATP-release pathway and how ATP participates in the modulation of synaptic strength. Here, we investigated the functional changes occurring in neurons upon chronic inactivity and the role of the purinergic signaling, connexin43 and pannexin1 hemichannels in this process...
February 21, 2024: Cellular Signalling
https://read.qxmd.com/read/38395184/pan-cancer-analysis-reveals-potential-immunological-and-prognostic-roles-of-coa6-in-human-cancers-and-preliminary-exploration-of-coa6-in-bladder-cancer
#29
JOURNAL ARTICLE
Hong Luo, Zhiyong Wang
BACKGROUND: Cytochrome C oxidase assembly factor 6 (COA6) is significantly involved in the progression of cancer and is aberrantly expressed in disease. Nevertheless, the comprehensive analysis of COA6 using many omics techniques, and its impact on the prognosis and immunological microenvironment of cancer patients, remains unexplored. METHODS: We gathered data from 33 cancer cases and conducted a thorough analysis of abnormalities in COA6 gene expression. This analysis included examining its relevance to disease, its diagnostic and prognostic value, pathway enrichment, the immune microenvironment, its association with immune checkpoints, and its ability to predict patient response to immunotherapy and natural small molecule drugs that target the COA6 protein...
February 21, 2024: Cellular Signalling
https://read.qxmd.com/read/38395183/loc644656-promotes-cisplatin-resistance-in-cervical-cancer-by-recruiting-znf143-and-activating-the-transcription-of-e6-ap
#30
JOURNAL ARTICLE
Min Li, Jie Chen, Hong Zhang, Yi Zhang, Jiahui Wang, Zongji Shen, Youguo Chen, Wenjie Hou, Chi Chi
Cisplatin resistance remains a persistent challenge in cervical cancer (CC) treatment. Molecular biomarkers have garnered attention for their association with cisplatin resistance in various diseases. Long non-coding RNAs (lncRNAs) exert significant influence on CC development. This study explores the role of LOC644656 in regulating cisplatin resistance in CC. Parental and cisplatin-resistant CC cells underwent cisplatin treatment. Functional assays assessed cell proliferation and apoptosis under different conditions...
February 21, 2024: Cellular Signalling
https://read.qxmd.com/read/38387687/lncrna-host2-promotes-nsun2-mediated-breast-cancer-progression-via-interaction-with-elavl1
#31
JOURNAL ARTICLE
Xuehui Wang, Diya Liu, Kaiyao Hua, Lin Fang
Breast cancer (BC) is the most prevalent malignant tumor in women worldwide with high morbidity and mortality. NSUN2, a crucial RNA methyltransferase, plays a pivotal role in regulating the proliferation and metastasis of tumor cells. Our study demonstrated that NSUN2 is upregulated in BC tissues and cell lines, and its high expression is associated with a poor prognosis in BC patients. Knockout of NSUN2 exerted inhibitory effects on the proliferation and migration of BC cells in vitro and in vivo. Mechanistic investigations revealed that the RNA-binding protein ELAVL1 can bind to NSUN2 mRNA and increase its stability...
February 20, 2024: Cellular Signalling
https://read.qxmd.com/read/38387686/uptake-of-ox-ldl-by-binding-to-lrp6-mediates-oxidative-stress-induced-bmscs-senescence-promoting-obesity-related-bone-loss
#32
JOURNAL ARTICLE
Senxiong Meng, Zhuan Wang, Xiaonan Liu, Ke Shen, Yuan Gu, Bin Yu, Lei Wang
Obesity has long been thought to a main cause of hyperlipidemia. As a systemic disease, the impact of obesity on organs, tissues and cells are almost all negative. However, the relationship between obesity and bone loss is most controversial. On the one hand, obesity has long been thought to a positive effect on bone due to increased mechanical loading on the skeleton, conducive to increase bone mass to accommodate the extra weight. On the other hand, obesity-related metabolic oxidative modification of low-density lipoprotein (LDL) in vivo caused the gradual increase of oxidized LDL (ox-LDL) in the bone marrow microenvironment...
February 20, 2024: Cellular Signalling
https://read.qxmd.com/read/38382691/cenpa-promotes-glutamine-metabolism-and-tumor-progression-by-up-regulating-slc38a1-in-endometrial-cancer
#33
JOURNAL ARTICLE
Shuang Li, Zihui Zhang, Zhifang Li, Lian Yang, Jianfeng Liu, Yujie Liu, Yancai Liu, Yanmei Hou, Mei Mei, Yuqin Huang
Glutamine addiction is a significant hallmark of metabolic reprogramming in tumors and is crucial to the progression of cancer. Nevertheless, the regulatory mechanisms of glutamine metabolism in endometrial cancer (EC) remains elusive. In this research, we found that elevated expression of CENPA and solute carrier family 38 member 1 (SLC38A1) were firmly associated with worse clinical stage and unfavorable outcomes in EC patients. In addition, ectopic overexpression or silencing of CENPA could either enhance or diminish glutamine metabolism and tumor progression in EC...
February 19, 2024: Cellular Signalling
https://read.qxmd.com/read/38373669/platelet-rich-plasma-derived-extracellular-vesicles-inhibit-nf-%C3%AE%C2%BAb-nlrp3-pathway-mediated-pyroptosis-in-intervertebral-disc-degeneration-via-the-malat1-microrna-217-sirt1-axis
#34
JOURNAL ARTICLE
Xueqiang Tao, Fen Xue, Jiayuan Xu, Wenbo Wang
BACKGROUND: Intervertebral disc degeneration (IDD) is a main contributor to lower back pain, and compression stress-induced apoptosis of nucleus pulposus (NP) cells and extracellular matrix (ECM) degradation has been implicated in the IDD progression. The functions of platelet-rich plasma (PRP)-derived extracellular vesicles (PRP-EVs) in regulating these biological processes remain unclear in IDD. Here, we aimed to investigate the key role of long noncoding RNA (lncRNA) MALAT1 incorporated in PRP-EVs in IDD...
February 17, 2024: Cellular Signalling
https://read.qxmd.com/read/38373668/imaging-of-extracellular-and-intracellular-atp-in-pancreatic-beta-cells-reveals-correlation-between-glucose-metabolism-and-purinergic-signalling
#35
JOURNAL ARTICLE
Seyed M Ghiasi, Nynne M Christensen, Per A Pedersen, Emil Z Skovhøj, Ivana Novak
Adenosine triphosphate (ATP) is a universal energy molecule and yet cells release it and extracellular ATP is an important signalling molecule between cells. Monitoring of ATP levels outside of cells is important for our understanding of physiological and pathophysiological processes in cells/tissues. Here, we focus on pancreatic beta cells (INS-1E) and test the hypothesis that there is an association between intra- and extracellular ATP levels which depends on glucose provision. We imaged real-time changes in extracellular ATP in pancreatic beta cells using two sensors tethered to extracellular aspects of the plasma membrane (eATeam3...
February 17, 2024: Cellular Signalling
https://read.qxmd.com/read/38373667/clinical-value-of-molecular-subtypes-identification-based-on-anoikis-related-lncrnas-in-castration-resistant-prostate-cancer
#36
JOURNAL ARTICLE
Kailei Chen, Yunxuan Zhang, Chengyong Li, Yuenan Liu, Qi Cao, Xiaoping Zhang
BACKGROUND: Anoikis is a distinctive type of apoptosis. It is involved in tumor progression and metastasis. But its function in castration-resistant prostate cancer remains veiled. We aimed to develop a prognostic indicator based on anoikis-related long non-coding RNAs (arlncRNAs) and to investigate their biological function in castration-resistant prostate cancer (CRPC). MATERIAL AND METHOD: Differentially expressed anoikis-related genes were extracted from two CRPC datasets, GSE51873, and GSE78201...
February 17, 2024: Cellular Signalling
https://read.qxmd.com/read/38369266/artesunate-loaded-solid-lipid-nanoparticles-resist-esophageal-squamous-cell-carcinoma-by-inducing-ferroptosis-through-inhibiting-the-akt-mtor-signaling
#37
JOURNAL ARTICLE
Yu Xia, Yixin Tang, Zhixin Huang, Nantian Ke, Yue Zheng, Wanzhen Zhuang, Yi Zhang, Xiaoqing Yin, Mingshu Tu, Jianlin Chen, Yingshu Wang, Yi Huang
Esophageal squamous cell carcinoma (ESCC) is a severe malignancy with high incidence and mortality rate in China, while the application of standard chemotherapeutic drugs for ESCC meets the barriers of high toxicity and multiple drug resistance (MDR). In recent years, the anticancer effects of artesunate (ART), a Chinese medicine monomer have gained extensive attentions due to its characteristics of low toxicity, high potency, and reversal of MDR. In this study, we develop the artesunate-loaded solid lipid nanoparticles (SLNART) to overcome the poor water solubility and bioavailability of ART, further improving the efficiency of ART on ESCC treatment...
February 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38369265/pan-cancer-analysis-predicts-cant1-as-a-potential-prognostic-immunologic-biomarker
#38
JOURNAL ARTICLE
Wei Yang, Zhidong Liu, Ting Liu
BACKGROUND: CANT1, calcium-activated nucleotidase 1, was reported to be upregulated in certain tumors. However, the function mechanism of CANT1 in pan-cancer is still unclear. METHODS: We utilized the Cancer Genome Atlas Program (TCGA) and UALCAN databases to analyze CANT1 expression at the level of mRNA, protein, and promoter methylation in pan-cancer, and the cBioportal database to study the frequency of gene changes for CANT1. Wilcoxon rank-sum test was applied to discuss the correlation between CANT1 and clinicopathological features in different types of tumor...
February 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38369264/deciphering-disulfidptosis-uncovering-a-lncrna-based-signature-for-prognostic-assessment-personalized-immunotherapy-and-therapeutic-agent-selection-in-lung-adenocarcinoma-patients
#39
JOURNAL ARTICLE
Chao Ma, Huan Zhao, Yang Sun, Weizheng Ding, Hui Wang, Yixin Li, Zhuoyu Gu
BACKGROUND: Disulfidptosis, a recently identified type of regulated cell death, plays critical roles in various biological processes of cancer; however, whether they can impact the prognosis of lung adenocarcinoma (LUAD) remains to be fully elucidated. We aimed to adopt this concept to develop and validate a lncRNA signature for LUAD prognostic prediction. METHODS: For this study, the TCGA-LUAD dataset was used as the training cohort, and multiple datasets from the GEO database were pooled as the validation cohort...
February 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38367792/reactive-oxygen-species-signalling-in-the-deterioration-of-quality-of-mammalian-oocytes-cultured-in-vitro-protective-effect-of-antioxidants
#40
JOURNAL ARTICLE
Ashutosh N Pandey, Pramod K Yadav, Karupannan V Premkumar, Meenakshi Tiwari, Ajai K Pandey, Shail K Chaube
The in vitro fertilization (IVF) is the first choice of infertile couples worldwide to plan for conception. Besides having a significant advancement in IVF procedure, the success rate is still poor. Although several approaches have been tested to improve IVF protocol, minor changes in culture conditions, physical factors and/or drug treatment generate reactive oxygen species (ROS) in oocytes. Due to large size and huge number of mitochondria, oocyte is more susceptible towards ROS-mediated signalling under in vitro culture conditions...
February 15, 2024: Cellular Signalling
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