journal
https://read.qxmd.com/read/38636768/hepatitis-b-virus-x-protein-promotes-tumor-glycolysis-by-downregulating-lncrna-oip5-as1-hkdc1-in-hcc
#1
JOURNAL ARTICLE
Fan Shi, Jingjing Jiang, Baohua Wang, Liang Hong, Yongting Zhang, Yuting Meng, Xujun Zhang, Lan Gong, Jianjun Lin, Hongyan Diao
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, with Hepatitis B virus (HBV) infection being the leading cause. This study aims to investigate the role of HBV in HCC pathogenesis involving glucose metabolism. Long non-coding RNA (lncRNA) OIP5-AS1 was significantly downregulated in HBV-positive HCC patients, and its low expression indicated a poor prognosis. This lncRNA was primarily localized in the cytoplasm, acting as a tumor suppressor. HBV protein X (HBx) repressed OIP5-AS1 expression by inhibiting a ligand-activated transcriptional factor peroxisome proliferator-activated receptor α (PPARα)...
April 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38636767/current-knowledge-of-ferroptosis-in-the-pathogenesis-and-prognosis-of-oral-squamous-cell-carcinoma
#2
REVIEW
Liyuan Zhou, Youjun Wu, Yukang Ying, Yan Ding
Therapeutic strategies are the hot-spot issues in treating patients with advanced oral squamous cell carcinoma (OSCC). Mounting studies have proved that triggering ferroptosis is one of the promising targets for OSCC management. In this study, we performed a first attempt to collect the current evidence on the proposed roles of ferroptosis in OSCC through a comprehensive review. Based on clinical data from the relevant studies within this topic, we found that ferroptosis-associated tumor microenvironment, ferroptosis-related genes (FRGs), and ferroptosis-related lncRNAs exhibited a potent prognostic value for OSCC patients...
April 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38631405/mapping-the-interaction-site-for-%C3%AE-arrestin-2-in-the-prokineticin-2-receptor
#3
JOURNAL ARTICLE
R Lattanzi, I Casella, M R Fullone, M Vincenzi, D Maftei, R Miele
G protein-coupled receptors (GPCRs) are a family of cell membrane receptors that couple and activate heterotrimeric G proteins and their associated intracellular signalling processes after ligand binding. Although the carboxyl terminal of the receptors is essential for this action, it can also serve as a docking site for regulatory proteins such as the β-arrestins. Prokineticin receptors (PKR1 and PKR2) are a new class of GPCRs that are able to activate different classes of G proteins and form complexes with β-arrestins after activation by the endogenous agonists PK2...
April 15, 2024: Cellular Signalling
https://read.qxmd.com/read/38621470/anthocyanins-from-blueberry-ameliorated-arsenic-induced-memory-impairment-oxidative-stress-and-mitochondrial-biosynthesis-imbalance-in-rat-hippocampal-neurons
#4
JOURNAL ARTICLE
Xinbo Ma, Yang Liu, Bo Ding, Siqi Lu, Bangyao Ni, Yuting Chen, Liu Yang, Yanan Liu, Yuchen Zhang, Yuxi Wang, Yanmei Yang, Xiaona Liu
In this study, blueberry anthocyanins extract (BAE) was used to investigate its protective effect on arsenic-induced rat hippocampal neurons damage. Arsenic exposure resulted in elevated levels of oxidative stress, decreased antioxidant capacity and increased apoptosis in rat hippocampal brain tissue and mitochondria. Immunohistochemical results showed that arsenic exposure also significantly decreased the expression of mitochondrial biosynthesis-related factors PGC-1α and TFAM. Treatment with BAE alleviated the decrease in antioxidant capacity, mitochondrial biogenesis related protein PGC-1/NRF2/TFAM expression, and ATP production of arsenic induced hippocampal neurons in rats, and improved cognitive function in arsenic damaged rats...
April 13, 2024: Cellular Signalling
https://read.qxmd.com/read/38604345/upregulated-mir-374a-5p-drives-psoriasis-pathogenesis-through-wif1-downregulation-and-wnt5a-nf-%C3%AE%C2%BAb-activation
#5
JOURNAL ARTICLE
Jing Ma, Lu Gan, Hongying Chen, Lihao Chen, Yu Hu, Chao Luan, Kun Chen, Jiaan Zhang
BACKGROUND: Psoriasis is a chronic, inflammatory skin disease. MicroRNAs (miRNAs) are an abundant class of non-coding RNA molecules. Recent studies have shown that multiple miRNAs are abnormally expressed in patients with psoriasis. The upregulation of miR-374a-5p has been associated with psoriasis severity. However, the specific role of miR-374a-5p in the pathogenesis of psoriasis remain unclear. METHODS: qRT-PCR was employed to validate the expression of miR-374a-5p in psoriatic lesions and in a psoriasis-like cell model constructed using a mixture of M5 (IL-17A, IL-22, OSM, IL-1α, and TNF-α)...
April 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38604344/cadmium-contributes-to-cardiac-metabolic-disruption-by-activating-endothelial-hif1a-glut1-axis
#6
JOURNAL ARTICLE
Xiaoyu Zhang, Wendan Zheng, Shiyu Sun, Yang Du, Wenjuan Xu, Zongguo Sun, Fuhong Liu, Manzhi Wang, Zuohui Zhao, Ju Liu, Qiang Liu
Cadmium (Cd) is an environmental risk factor of cardiovascular diseases. Researchers have found that Cd exposure causes energy metabolic disorders in the heart decades ago. However, the underlying molecular mechanisms are still elusive. In this study, male C57BL/6 J mice were exposed to cadmium chloride (CdCl2 ) through drinking water for 4 weeks. We found that exposure to CdCl2 increased glucose uptake and utilization, and disrupted normal metabolisms in the heart. In vitro studies showed that CdCl2 specifically increased endothelial glucose uptake without affecting cardiomyocytic glucose uptake and endothelial fatty acid uptake...
April 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38604343/brd4l-cooperates-with-myc-to-block-local-tumor-invasion-via-suppression-of-s100a10
#7
JOURNAL ARTICLE
Yongyi Ma, Nan Liu, Yu Shi, Shuyan Ma, Yingjun Wang, Wen Zheng, Rong Sun, Yihua Song, Miaomiao Chen, Lishuai Qu, Renfang Mao, Yihui Fan
Targeted therapy based on BRD4 and MYC shows promise due to their well-researched oncogenic functions in cancer, but their tumor-suppressive roles are less understood. In this study, we employ a systematic approach to delete exons that encode the low-complexity domain (LCD) of BRD4L in cells by using CRISPR-Cas9. In particular, the deletion of exon 14 (BRD4-E14) results in cellular morphological changes towards spindle-shaped and loosely packed. BRD4-E14 deficient cells show increased cell migration and reduced cell adhesion...
April 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38604342/simvastatin-activates-the-spindle-assembly-checkpoint-and-causes-abnormal-cell-division-by-modifying-small-gtpases
#8
JOURNAL ARTICLE
Junna Tanaka, Hiroki Kuwajima, Ryuzaburo Yuki, Yuji Nakayama
Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, which is a rate-limiting enzyme of the cholesterol synthesis pathway. It has been used clinically as a lipid-lowering agent to reduce low-density lipoprotein (LDL) cholesterol levels. In addition, antitumor activity has been demonstrated. Although simvastatin attenuates the prenylation of small GTPases, its effects on cell division in which small GTPases play an important role, have not been examined as a mechanism underlying its cytostatic effects...
April 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38604341/transient-stimulation-of-trpmls-enhance-the-functionality-of-hdpcs-and-facilitate-hair-growth-in-mice
#9
JOURNAL ARTICLE
Jiayi Sun, Hongyan Zhang, Bo Xie, Yuqing Shen, Yuqi Zhu, Wen Xu, Beilei Zhang, Xiuzu Song
Autophagy is essential for eliminating aging and organelle damage that maintaining cellular homeostasis. However, the dysfunction of autophagy has been proven in hair loss such as AGA. Despite the crucial role of TRPML channels in regulating autophagy, their specific function in hair growth remains unclarified. To investigate the biological functions and associated molecular mechanisms of TRPMLs in hair growth, Animal experiments were conducted to confirm the function of TRLMLs activation in promoting hair growth...
April 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38604340/calix-6-arene-dismantles-extracellular-vesicle-biogenesis-and-metalloproteinases-that-support-pancreatic-cancer-hallmarks
#10
JOURNAL ARTICLE
Helon Guimarães Cordeiro, Jordana Maria Azevedo-Martins, Alessandra Valéria de Sousa Faria, Karin Juliane Pelizzaro Rocha-Brito, Renato Milani, Maikel Peppelenbosch, Gwenny Fuhler, Ângelo de Fátima, Carmen Veríssima Ferreira-Halder
Many challenges are faced in pancreatic cancer treatment due to late diagnosis and poor prognosis because of high recurrence and metastasis. Extracellular vesicles (EVs) and matrix metalloproteinases (MMPs), besides acting in intercellular communication, are key players in the cancer cell plasticity responsible for initiating metastasis. Therefore, these entities provide valuable targets for the development of better treatments. In this context, this study aimed to evaluate the potential of calix[6]arene to disturb the release of EVs and the activity of MMPs in pancreatic cancer cells...
April 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38599441/integration-analysis-of-cell-division-cycle-associated-family-genes-revealed-potential-mechanisms-of-gliomagenesis-and-constructed-an-artificial-intelligence-driven-prognostic-signature
#11
JOURNAL ARTICLE
Kai Yu, Qi Tian, Shi Feng, Yonggang Zhang, Ziqi Cheng, Mingyang Li, Hua Zhu, Jianying He, Mingchang Li, Xiaoxing Xiong
Cell division cycle-associated (CDCA) gene family members are essential cell proliferation regulators and play critical roles in various cancers. However, the function of the CDCA family genes in gliomas remains unclear. This study aims to elucidate the role of CDCA family members in gliomas using in vitro and in vivo experiments and bioinformatic analyses. We included eight glioma cohorts in this study. An unsupervised clustering algorithm was used to identify novel CDCA gene family clusters. Then, we utilized multi-omics data to elucidate the prognostic disparities, biological functionalities, genomic alterations, and immune microenvironment among glioma patients...
April 8, 2024: Cellular Signalling
https://read.qxmd.com/read/38599440/cardiac-resident-macrophages-the-core-of-cardiac-immune-homeostasis
#12
JOURNAL ARTICLE
Wenhui Cai, Lu Lian, Aolin Li, Qianqian Zhang, Mengmeng Li, Yingyu Xie, Junping Zhang
Cardiac resident macrophages (CRMs) are essential in maintaining the balance of the immune homeostasis in the heart. One of the main factors in the progression of cardiovascular diseases, such as myocarditis, myocardial infarction(MI), and heart failure(HF), is the imbalance in the regulatory mechanisms of CRMs. Recent studies have reported novel heterogeneity and spatiotemporal complexity of CRMs, and their role in maintaining cardiac immune homeostasis and treating cardiovascular diseases. In this review, we focus on the functions of CRMs, including immune surveillance, immune phagocytosis, and immune metabolism, and explore the impact of CRM's homeostasis imbalance on cardiac injury and cardiac repair...
April 8, 2024: Cellular Signalling
https://read.qxmd.com/read/38588876/inhibition-of-prmt5-mediated-regulation-of-dkk1-sensitizes-colorectal-cancer-cells-to-chemotherapy
#13
JOURNAL ARTICLE
Wafaa Abumustafa, Darko Castven, Diana Becker, Shahenaz Shaban Salih, Shaista Manzoor, Batoul Abi Zamer, Iman Talaat, Mawieh Hamad, Jens Uwe Marquardt, Jibran Sualeh Muhammad
The Dickkopf family proteins (DKKs) are strong Wnt signaling antagonists that play a significant role in colorectal cancer (CRC) development and progression. Recent work has shown that DKKs, mainly DKK1, are associated with the induction of chemoresistance in CRC and that DKK1 expression in cancer cells correlates with that of protein arginine N-methyltransferase 5 (PRMT5). This points to the presence of a regulatory loop between DKK1 and PRMT5. Herein, we addressed the question of whether PRMT5 contributes to DKK1 expression in CRC and hence CRC chemoresistance...
April 6, 2024: Cellular Signalling
https://read.qxmd.com/read/38583746/lncrna-hmox1-alleviates-renal-ischemia-reperfusion-induced-ferroptotic-injury-via-the-mir-3587-hmox1-axis
#14
JOURNAL ARTICLE
Wenqiang Tao, Yuanhua Lu, Rui Xiao, Jianguo Zhang, Ping Hu, Ning Zhao, Wei Peng, Kejian Qian, Fen Liu
Emerging evidence suggests that long non-coding RNAs (lncRNAs) play significant roles in renal ischemia reperfusion (RIR) injury. However, the specific mechanisms by which lncRNAs regulate ferroptosis in renal tubular epithelial cells remain largely unknown. The objective of this study was to investigate the biological function of lncRNA heme oxygenase 1 (lnc-HMOX1) in RIR and its potential molecular mechanism. Our findings demonstrated that the expression of HMOX1-related lnc-HMOX1 was reduced in renal tubular epithelial cells treated with hypoxia-reoxygenation (HR)...
April 5, 2024: Cellular Signalling
https://read.qxmd.com/read/38583745/circuggt2-facilitates-progression-and-cisplatin-resistance-of-bladder-cancer-through-nonhomologous-end-joining-pathway
#15
JOURNAL ARTICLE
Fang Lyu, Sihuai Huang, Zhecheng Yan, Qingliu He, Chunyu Liu, Lulin Cheng, Yukun Cong, Kang Chen, Yarong Song, Yifei Xing
The development of resistance to cisplatin (CDDP) in bladder cancer presents a notable obstacle, with indications pointing to the substantial role of circular RNAs (circRNAs) in this resistance. Nevertheless, the precise mechanisms through which circRNAs govern resistance are not yet fully understood. Our findings demonstrate that circUGGT2 is significantly upregulated in bladder cancer, facilitating cancer cell migration and invasion. Additionally, our analysis of eighty patient outcomes revealed a negative correlation between circUGGT2 expression levels and prognosis...
April 5, 2024: Cellular Signalling
https://read.qxmd.com/read/38574938/unravelling-the-molecular-interplay-sumoylation-pml-nuclear-bodies-and-vascular-cell-activity-in-health-and-disease
#16
REVIEW
Janine Berkholz, Weronika Karle
In the seemingly well-researched field of vascular research, there are still many underestimated factors and molecular mechanisms. In recent years, SUMOylation has become increasingly important. SUMOylation is a post-translational modification in which small ubiquitin-related modifiers (SUMO) are covalently attached to target proteins. Sites where these SUMO modification processes take place in the cell nucleus are PML nuclear bodies (PML-NBs) - multiprotein complexes with their essential main component and organizer, the PML protein...
April 2, 2024: Cellular Signalling
https://read.qxmd.com/read/38565413/mir-3682-3p-promotes-esophageal-cancer-progression-by-targeting-fhl1-and-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#17
JOURNAL ARTICLE
Yuxin Cai, Lingling Xia, Hangjia Zhu, Hao Cheng, Yuanyuan Tian, Liying Sun, Jun Wang, Ning Lu, Jing Wang, Yongshun Chen
BACKGROUND: Esophageal cancer (EC) is highly ranked among all cancers in terms of its incidence and mortality rates. MicroRNAs (miRNAs) are considered to play key regulatory parts in EC. Multiple research studies have indicated the involvement of miR-3682-3p and four and a half LIM domain protein 1 (FHL1) in the achievement of tumors. The aim of this research was to clarify the significance of these genes and their possible molecular mechanism in EC. METHODS: Data from a database and the tissue microarray were made to analyze the expression and clinical significance of miR-3682-3p or FHL1 in EC...
March 31, 2024: Cellular Signalling
https://read.qxmd.com/read/38565412/hsa_circ_0005320-affects-cell-proliferation-and-the-cell-cycle-via-the-igf2bp3-cdk2-axis-in-bladder-cancer
#18
JOURNAL ARTICLE
Quansong Ji, Feilu Ma, Xiling Zhang, Yili Liu, Ping Wang, Mingshan Li
BACKGROUND: Circular RNAs (circRNAs), which are covalently closed non-coding RNAs, are frequently dysregulated in cancer. However, their precise role in bladder cancer (BCa) remains largely unknown. METHODS: Expression of hsa_circ_0005320 in tissues and cell lines was detected using quantitative real-time PCR. Proliferation and colony forming capacity of BCa cells were assessed using Cell Counting Kit-8, ethynyl-labeled deoxyuridine, and colony formation assays...
March 31, 2024: Cellular Signalling
https://read.qxmd.com/read/38556030/computational-modelling-of-dynamic-camp-responses-to-gpcr-agonists-for-exploration-of-glp-1r-ligand-effects-in-pancreatic-%C3%AE-cells-and-neurons
#19
JOURNAL ARTICLE
L J Bridge, S Chen, B Jones
The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway signal transduction. Understanding of the potential of GLP-1R agonists in the treatment of type 2 diabetes may be advanced by considering the cAMP dynamics for agonists at GLP-1R in both pancreatic β-cells (important in insulin release) and neurons (important in appetite regulation)...
March 29, 2024: Cellular Signalling
https://read.qxmd.com/read/38552892/deciphering-the-role-of-smarca4-in-cardiac-disorders-insights-from-single-cell-studies-on-dilated-cardiomyopathy-and-coronary-heart-disease
#20
JOURNAL ARTICLE
Li Liu, Chengban Li, Linxing Yu, Yubo Wang, Xingshou Pan, Jianjun Huang
BACKGROUND: Dilated cardiomyopathy (DCM) and coronary heart disease (CHD) stand as two of the foremost causes of mortality. However, the comprehensive comprehension of the regulatory mechanisms governing DCM and CHD remains limited, particularly from the vantage point of single-cell transcriptional analysis. METHOD: We used the GSE121893 dataset from the GEO database, analyzing single-cell expressions with tools like DropletUtils, Seurat, and Monocle. We also utilized the GSVA package for comparing gene roles in DCM and CHD, Finally, we conducted qRT-PCR and Western blot analyses to measure the expression levels of SMARCA4, Col1A1, Col3A1 and α-SMA, and the role of SMARCA4 on fibroblasts were explored by EdU and Transwell assay...
March 27, 2024: Cellular Signalling
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