journal
https://read.qxmd.com/read/38522808/deciphering-the-role-of-glycosaminoglycans-in-gpcr-signaling
#1
JOURNAL ARTICLE
Sofya Savransky, Alex D White, Jean-Pierre Vilardaga
G protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential components of the cell surface that regulate physiological processes in the body. GPCRs are the most extensive family of transmembrane receptors that control cellular responses to extracellular stimuli, while GAGs are polysaccharides that contribute to the function of the extracellular matrix (ECM). Due to their proximity to the plasma membrane, GAGs participate in signal transduction by interacting with various extracellular molecules and cell surface receptors...
March 22, 2024: Cellular Signalling
https://read.qxmd.com/read/38522807/e2f8-cenpl-pathway-contributes-to-homologous-recombination-repair-and-chemoresistance-in-breast-cancer
#2
JOURNAL ARTICLE
Shan Wang, Yuhong Xia, Yu Sun, Wei Wang, Lianfeng Shan, Zhongbo Zhang, Chenghai Zhao
Chemoresistance poses a significant obstacle to the treatment of breast cancer patients. The increased capacity of DNA damage repair is one of the mechanisms underlying chemoresistance. Bioinformatic analyses showed that E2F8 was associated with cell cycle progression and homologous recombination (HR) repair of DNA double-strand breaks (DSBs) in breast cancer. E2F8 knockdown suppressed cell growth and attenuated HR repair. Accordingly, E2F8 knockdown sensitized cancer cells to Adriamycin and Cisplatin. Centromere protein L (CENPL) is a transcriptional target by E2F8...
March 22, 2024: Cellular Signalling
https://read.qxmd.com/read/38521179/e3-ubiquitin-ligase-chip-interacts-with-transferrin-receptor-1-for-degradation-and-promotes-cell-proliferation-through-inhibiting-ferroptosis-in-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Miaomiao Shao, Kangwei Qi, Lanxin Wang, Xiaoxuan Yu, Qingyu Zhang, Long Yu, Lan Wang, Caiting Yang, Lu Fan
Hepatocellular carcinoma (HCC) is the major form of liver malignancy with high incidence and mortality. Identifying novel biomarkers and understanding regulatory mechanisms underlying the development and progression of HCC are critical for improving diagnosis, treatment and patient outcomes. Carboxyl terminus of Hsc-70-interacting protein (CHIP) is a well-described U-box-type E3 ubiquitin ligase which promotes the ubiquitination and degradation of numerous tumor-associated proteins. Recent studies have shown that CHIP can play as a tumor-suppressor gene or an oncogene in different kinds of malignancies...
March 21, 2024: Cellular Signalling
https://read.qxmd.com/read/38513808/unraveling-the-mechanism-in-l-caldesmon-regulating-the-osteogenic-differentiation-of-pdlscs-an-innovative-perspective
#4
JOURNAL ARTICLE
Yuejia Li, Ziyi Mei, Pingmeng Deng, Sha Zhou, Aizhuo Qian, Xiya Zhang, Jie Li
Maxillofacial bone defect is one of the common symptoms in maxillofacial, which affects the function and aesthetics of maxillofacial region. Periodontal ligament stem cells (PDLSCs) are extensively used in bone tissue engineering. The mechanism that regulates the osteogenic differentiation of PDLSCs remains not fully elucidated. Previous studies demonstrated that l-Caldesmon (l-Cad, or Cald1) might be involved in the osteogenic differentiation of PDLSCs. Here, the mechanism by which Cald1 regulates the osteogenic differentiation of PDLSCs is investigated...
March 19, 2024: Cellular Signalling
https://read.qxmd.com/read/38508350/the-piezo1-mir-155-5p-gdf6-smad2-3-signaling-axis-is-involved-in-inducing-the-occurrence-and-progression-of-osteoarthritis-under-excessive-mechanical-stress
#5
JOURNAL ARTICLE
Chaoren Qin, Yan Feng, Zhaowei Yin, Changjiang Wang, Rui Yin, Yang Li, Kai Chen, Tianqi Tao, Kaibin Zhang, Yiqiu Jiang, Jianchao Gui
OBJECTIVE: To elucidate the molecular mechanism of overloading-induced osteoarthritis (OA) and to find a novel therapeutic target. METHODS: We utilized human cartilage specimens, mouse chondrocytes, a destabilization of the medial meniscus (DMM) mouse model, and a mouse hindlimb weight-bearing model to validate the role of overloading on chondrocyte senescence and OA development. Then, we observed the effect of PIEZO1-miR-155-5p-GDF6-SMAD2/3 signaling axis on the preservation of joint metabolic homeostasis under overloading in vivo, in vitro and ex vivo by qPCR, Western blot, enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, immunofluorescence, SA-β-gal staining, CCK8 assay, et al...
March 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38508349/mzb1-regulates-cellular-proliferation-mitochondrial-dysfunction-and-inflammation-and-targets-the-pi3k-akt-signaling-pathway-in-acute-pancreatitis
#6
JOURNAL ARTICLE
Mengtao Xu, Yong Feng, Xuelian Xiang, Li Liu, Guodu Tang
BACKGROUND: Acute pancreatitis (AP) is a pathological condition characterized by the premature release and activation of trypsinogens and other enzyme precursors. In severe cases, the mortality rates are in the range of 20-30% and may even be as high as 50%. Though various prophylaxes are available for AP, the mechanism of its progression is unclear. Marginal zone B and B-1 cell-specific protein 1 (MZB1) is found in the endoplasmic reticulum (ER) where it is expressed exclusively in the B cells there...
March 18, 2024: Cellular Signalling
https://read.qxmd.com/read/38499232/microglial-uptake-of-hadscs-exo-mitigates-neuroinflammation-in-ich
#7
JOURNAL ARTICLE
Lanqing Zhao, Jinwei Li
Intracerebral hemorrhage (ICH) is associated with secondary neuroinflammation, leading to severe central nervous system damage. Exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs-Exo) have shown potential therapeutic effects in regulating inflammatory responses in ICH. This study aims to investigate the role of hADSCs-Exo in ICH and its underlying mechanism involving miRNA-mediated regulation of formyl peptide receptor 1 (FPR1). Flow cytometry was used to identify hADSCs and extract exosomes...
March 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38492625/exploration-of-gut-microbiome-and-inflammation-a-review-on-key-signalling-pathways
#8
JOURNAL ARTICLE
Manisha Nigam, Kanchan Devi, Henrique D M Coutinho, Abhay Prakash Mishra
The gut microbiome, a crucial component of the human system, is a diverse collection of microbes that belong to the gut of human beings as well as other animals. These microbial communities continue to coexist harmoniously with their host organisms and perform various functions that affect the host's general health. Each person's gut microbiota has a unique makeup. The gut microbiota is well acknowledged to have a part in the local as well as systemic inflammation that underlies a number of inflammatory disorders (e...
March 16, 2024: Cellular Signalling
https://read.qxmd.com/read/38493883/the-regulatory-role-of-mirna-and-lncrna-on-autophagy-in-diabetic-nephropathy
#9
JOURNAL ARTICLE
Siming Yu, Yue Li, Xinxin Lu, Zehui Han, Chunsheng Li, Xingxing Yuan, Dandan Guo
Diabetic nephropathy (DN) is a serious complication of diabetes that causes glomerular sclerosis and end-stage renal disease, leading to ascending morbidity and mortality in diabetic patients. Excessive accumulation of aberrantly modified proteins or damaged organelles, such as advanced glycation end-products, dysfunctional mitochondria, and inflammasomes is associated with the pathogenesis of DN. As one of the main degradation pathways, autophagy recycles toxic substances to maintain cellular homeostasis and autophagy dysregulation plays a crucial role in DN progression...
March 15, 2024: Cellular Signalling
https://read.qxmd.com/read/38493882/wdr4-promotes-hcc-pathogenesis-through-n-7-methylguanosine-by-regulating-and-interacting-with-mettl1
#10
JOURNAL ARTICLE
Rui Dong, Chuanxu Wang, Bo Tang, Yayu Cheng, Xuehui Peng, Xiaomin Yang, Bing Ni, Jing Li
BACKGROUND: The N7-methylguanosine (m7G), a modification at defined internal positions within tRNAs and rRNAs, is correlated with tumor progression. Methyltransferase like 1 (METTL1)/ WD repeat domain 4 (WDR4) mediated tRNA m7G modification, which could alter many oncogenic mRNAs translation to promote progress of multiple cancer types. However, whether and how the internal mRNA m7G modification is involved in tumorigenesis remains unclear. METHODS: The immunohistochemistry assay was conducted to detect the expression of WDR4 and METTL1 in hepatocellular carcinoma (HCC) and the expression of both genes whether contributes to the prognosis of the survival rate of HCC patients...
March 15, 2024: Cellular Signalling
https://read.qxmd.com/read/38492624/circ_0007534-promotes-cholangiocarcinoma-stemness-and-resistance-to-anoikis-through-ddx3x-mediated-positive-feedback-regulation-of-parental-gene-ddx42
#11
JOURNAL ARTICLE
Sidi Liu, Canghai Guan, Xiangjun Sha, Xin Gao, Xinlei Zou, Chengru Yang, Xinmiao Zhang, Xiangyu Zhong, Xingming Jiang
Cholangiocarcinoma (CCA) is a malignancy with an extremely poor prognosis, and much remains unknown about its pathogenesis and treatment modalities. Circular RNA (circRNA) has been proven to play regulatory roles in various tumorigenesis, yet its potential function and mechanism in cholangiocarcinoma require further investigation. This study is the first to identify the aberrant expression and functional role of a novel circRNA, circ_0007534, derived from the DDX42 gene, in cholangiocarcinoma. Compared to the normal control group, the expression of circ_0007534 was significantly elevated in the tissues and cells with CCA and that high expression correlated with lymph node invasion and poor prognosis...
March 14, 2024: Cellular Signalling
https://read.qxmd.com/read/38484942/deciphering-alternative-splicing-events-and-their-therapeutic-implications-in-colorectal-cancer
#12
JOURNAL ARTICLE
Wenbo Ding, Qianni Xiao, Yanzhe Yue, Shuyu Chen, Xiangjian She, Bei Pan, Linpeng Zhou, Yujuan Yin, Youyue Li, Shukui Wang, Mu Xu
Colorectal cancer (CRC) is one of the most common malignant tumors with complex molecular regulatory mechanisms. Alternative splicing (AS), a fundamental regulatory process of gene expression, plays an important role in the occurrence and development of CRC. This study analyzed AS Percent Spliced In (PSI) values from 49 pairs of CRC and normal samples in the TCGA SpliceSeq database. Using Lasso and SVM, AS features that can differentiate colorectal cancer from normal were screened. Univariate COX regression analysis identified prognosis-related AS events...
March 12, 2024: Cellular Signalling
https://read.qxmd.com/read/38479556/early-b-cell-factor-3-ebf3-attenuates-parkinson-s-disease-through-directly-regulating-contactin-associated-protein-like-4-cntnap4-transcription-an-experimental-study
#13
JOURNAL ARTICLE
Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra of patients with PD. However, whether EBF3 is implicated in dopaminergic neuron death during PD has not yet been investigated...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38479555/comp-promotes-pancreatic-fibrosis-by-activating-pancreatic-stellate-cells-through-cd36-erk-akt-signaling-pathways
#14
JOURNAL ARTICLE
Yi Wang, Hai-Tao Li, Gang Liu, Chuan-Shen Jiang, Yan-Hong Ni, Jing-Hui Zeng, Xia Lin, Qing-Yun Wang, Da-Zhou Li, Wen Wang, Xiang-Peng Zeng
BACKGROUND: Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an extracellular matrix (ECM) glycoprotein, cartilage oligomeric matrix protein (COMP) is critical for collagen assembly and ECM stability and recent studies showed that COMP exert promoting fibrosis effect in the skin, lungs and liver. However, the role of COMP in activation of PSCs and pancreatic fibrosis remain unclear...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38471617/microrna-125b-1-3p-mediates-autophagy-via-the-rragd-mtor-ulk1-signaling-pathway-and-mitigates-atherosclerosis-progression
#15
JOURNAL ARTICLE
Xin Chen, Yanhong Cao, Yining Guo, Jing Liu, Xiaohan Ye, Huan Li, Lu Zhang, Wenwei Feng, Shaoxiang Xian, Zhongqi Yang, Lingjun Wang, Ting Wang
Atherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The significance of microRNA (miR)-125b-1-3p in cardiovascular disease is well-established; however, its precise role in regulating autophagy and impact on atherosclerosis in vascular smooth muscle cells (VSMCs) remain unclear. Here, we observed reduced autophagic activity and decreased miR-125b expression during atherosclerosis progression...
March 10, 2024: Cellular Signalling
https://read.qxmd.com/read/38467243/the-polybasic-region-in-g%C3%AE-i-proteins-relevant-or-not-insights-from-g%C3%AE-i-3-research
#16
JOURNAL ARTICLE
Beata Rysiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska, Agnieszka Polit
Heterotrimeric G proteins are responsible for signal transduction from G-protein-coupled receptors (GPCRs) to intracellular effectors. This process is only possible when G proteins are located on the inner side of the cell membrane due to the specific localization of GPCR receptors. The Gα subunit is directed to the cell membrane through several signals, including modification by fatty acid moieties, interaction with the Gβγ complex, and, as observed in some Gα proteins, the presence of basic amino acid residues in the N-terminal region...
March 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38467242/glucose-regulates-the-hmgb1-signaling-pathway-through-sirt1-in-glioma
#17
JOURNAL ARTICLE
Yu Wang, Shuai Wang, Yuhao Wang, Chengcheng Wang, Yuhang Tang, Chao Zhang, Shiqiang Hou, Dong Yu, Ning Lin
BACKGROUND: Glucose is a fundamental substance for numerous cancers, including glioma. However, its influence on tumor cells regulatory mechanisms remains uncertain. SIRT1 is a regulator of deacetylation and a key player in the progression of malignant tumors. The objective of this study was to examine the role of glucose and SIRT1 in glioma. METHODS: This study investigated the association of SIRT1 expression with clinicopathological features and prognosis in glioma patients using the TCGA database...
March 9, 2024: Cellular Signalling
https://read.qxmd.com/read/38453126/hk2-promotes-migration-and-invasion-of-intrahepatic-cholangiocarcinoma-via-enhancing-cancer-stem-like-cells-resistance-to-anoikis
#18
JOURNAL ARTICLE
Xiaojing Du, Zhuoran Qi, Yunjia Jiao, Wenzhi Wu, Qingke Huang, Xuecheng Sun, Sunkuan Hu
Cancer stem-like cells (CSLCs) and anoikis resistance play crucial roles in the metastasis of cancers. However, it remains unclear whether CSLCs are related to anoikis resistance in intrahepatic cholangiocarcinoma (ICC). Here we identified a group of stemness-related anoikis genes (SRAGs) via bioinformatic analysis of public data. Accordingly, a novel anoikis-related classification was established and it divided ICC into C1 and C2 type. Different type ICC displayed distinct prognosis, molecular as well immune characteristics...
March 5, 2024: Cellular Signalling
https://read.qxmd.com/read/38447881/brd4-promotes-lps-induced-endothelial-cells-senescence-via-activating-and-cooperating-sting-irf3-pathway
#19
JOURNAL ARTICLE
Ruigong Zhu, Lei Zhang, Hao Zhang, Zhifeng Hu
Endothelial cells (ECs) senescence is closely associated with the initiation and development of multiple age-related cardiovascular diseases. It is necessary to explore the underlying molecular mechanisms of ECs senescence, which is not only the basis to decipher cellular senescence, but also a novel therapeutic target for the endothelial senescence-related diseases. BRD4, a key epigenetic regulator, is universally related to gene expression regulation and has been reported to accelerate cell senescence. Besides, emerging evidence has suggested that the stimulator of interferon genes protein (STING) can regulate inflammatory and senescence-related diseases...
March 4, 2024: Cellular Signalling
https://read.qxmd.com/read/38432574/ampk-mediated-autophagy-pathway-activation-promotes-%C3%AE-fosb-degradation-to-improve-levodopa-induced-dyskinesia
#20
JOURNAL ARTICLE
Ke Liu, Zhaoyuan Zhang, Yu Xu, Yi Wu, Piaopiao Lian, Zhuoran Ma, Zhicheng Tang, Xiaoqian Zhang, Xiaoman Yang, Heng Zhai, Lei Zhang, Yan Xu, Xuebing Cao
BACKGROUND: Parkinson's disease patients on chronic levodopa often suffer from motor complications, which tend to reduce their quality of life. Levodopa-induced dyskinesia (LID) is one of the most prevalent motor complications, often characterized by abnormal involuntary movements, and the pathogenesis of LID is still unclear but recent studies have suggested the involvement of autophagy. METHODS: The onset of LID was mimicked by chronic levodopa treatment in a unilateral 6-hydroxydopamine (6-OHDA) -lesion rat model...
March 1, 2024: Cellular Signalling
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