Xin Yu, Binkui Yang, Bin Chen, Qi Wu, Zhengrong Ren, Dongsheng Wang, Tao Yuan, Hao Ding, Chao Ding, Yang Liu, Lei Zhang, Zhongyang Sun, Jianning Zhao
Wear particle-induced osteoclast over-activation is a major contributor to periprosthetic osteolysis and aseptic loosening, which can cause pathological bone loss and destruction. Hence, inhibiting excessive osteoclast-resorbing activity is an important strategy for preventing periprosthetic osteolysis. Formononetin (FMN) has been shown to have protective effects against osteoporosis, but no previous study has evaluated the effects of FMN on wear particle-induced osteolysis. In this study, we found that FMN alleviated CoCrMo alloy particles (CoPs)-induced bone loss in vivo and inhibited the formation and bone-resorptive function of osteoclasts in vitro...
March 7, 2023: Cellular Signalling