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Cellular Signalling

Jaeyoon Kim, Elisabetta Daré, Subu Surendran Rajasekaran, Sung Ho Ryu, Per-Olof Berggren, Christopher J Barker
No abstract text is available yet for this article.
February 8, 2019: Cellular Signalling
Ting Wang, Hong Zhou, Yudan Chen, Peng Zhang, Ting Wang
In our previous study, the oxLDL/β2 GPI/anti-β2 GPI complex was demonstrated to further enhance the foam cell formation and migration of VSMC, as well as the expression of inflammatory cytokines, via the TLR4/NF-κB pathway. However, sparse information is available on other pro-atherogenic pathogenic effects of the oxLDL/β2 GPI/anti-β2 GPI complex, such as effects on proliferation and apoptosis. In the present study, we focused on the biphasic effects and underlying mechanisms of the oxLDL/β2 GPI/anti-β2 GPI complex on VSMC survival...
February 7, 2019: Cellular Signalling
Dongxin Tang, Zhu Yang, Fengxi Long, Li Luo, Bing Yang, Ruyi Zhu, Xianan Sang, Gang Cao
Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA known to be highly expressed in several tumors. In colorectal cancer (CRC), MALAT1 promotes cell proliferation, metastasis, and invasion in vitro and in vivo. This study aimed to investigate the effect of MALAT1 on the proliferation, migration, and drug sensitivity of CRC cells in vitro and in vivo and the mechanisms involved therein. We observed increased expression of MALAT1 in six CRC cell lines compared to that in normal cells, suggesting its involvement in CRC progression...
February 1, 2019: Cellular Signalling
Yusuke Higashi, Srinivas Mummidi, Sergiy Sukhanov, Tadashi Yoshida, Makoto Noda, Patrice Delafontaine, Bysani Chandrasekar
Minocycline, a tetracycline antibiotic, is known to exert vasculoprotective effects independent of its anti-bacterial properties; however the underlying molecular mechanisms are not completely understood. Reversion Inducing Cysteine Rich Protein with Kazal Motifs (RECK) is a cell surface expressed, membrane anchored protein, and its overexpression inhibits cancer cell migration. We hypothesized that minocycline inhibits platelet-derived growth factor (PDGF)-induced human aortic smooth muscle cell (SMC) proliferation and migration via RECK upregulation...
February 1, 2019: Cellular Signalling
Yanting Zou, Shuyu Li, Zhengliang Li, Dongqiang Song, Shuncai Zhang, Qunyan Yao
Epithelial-mesenchymal transition (EMT) has emerged as a vital process in embryogenesis, carcinogenesis, and tissue fibrosis. Transforming growth factor-beta 1 (TGF-β1)-mediated signaling pathways play important roles in the EMT process. MicroRNA-146a (miR-146a) has been suggested as a significant regulatory molecule in fibrogenesis. Therefore, the present study aimed to evaluate the effect of miR-146a on the EMT of hepatocytes and to investigate the role of overexpressing miR-146a on rat hepatic fibrosis...
January 31, 2019: Cellular Signalling
Nok Him Fung, Corrina Grima, Samuel S Widodo, Andrew H Kaye, Clarissa A Whitehead, Stanley S Stylli, Theo Mantamadiotis
In cancer, complex intracellular and intercellular signals constantly evolve for the advantage of the tumour cells but to the disadvantage of the whole organism. Decades of intensive research have revealed the critical roles of cellular signalling pathways in regulating complex cell behaviours which influence tumour development, growth and therapeutic response, and ultimately patient outcome. Most studies have focussed on specific pathways and the resulting tumour cell function in a rather linear fashion, partly due to the available methodologies and partly due to the traditionally reductionist approach to research...
January 30, 2019: Cellular Signalling
Yuefei Jin, Minghua Zhu, Yanli Guo, Daniel Foreman, Feifei Feng, Guangcai Duan, Weidong Wu, Weiguo Zhang
Persistent exposure to ambient fine particulate matter (PM2.5 ) can exacerbate allergic diseases in humans. Mast cells play an important role in allergic inflammation in peripheral tissues, such as skin, mucosa, and lung. Engagement of the high-affinity Fc receptor leads to mast cell degranulation, releasing a variety of highly active mediators including histamine, leukotrienes, and inflammatory cytokines. How PM2.5 exposure affects mast cell activation and function remains largely unknown. To characterize the effect of PM2...
January 29, 2019: Cellular Signalling
Lei Gao, Huatao Chen, Cuimei Li, Yaoyao Xiao, Dan Yang, Manhui Zhang, Dong Zhou, Wei Liu, Aihua Wang, Yaping Jin
Endoplasmic reticulum (ER) stress and circadian clockwork signaling pathways mutually regulate various cellular functions, but the details regarding the cross-talk between these pathways in mammalian cells are unclear. In this study, whether perturbation of ER stress signaling affects the cellular circadian clockwork and transcription of clock-controlled genes was investigated in NIH3T3 mouse fibroblasts. An NIH3T3 cell model stably expressing luciferase (Luc) under the control of the Bmal1 clock gene promoter was established using a lentiviral system...
January 28, 2019: Cellular Signalling
Antonia K Roseweir, Arfon G M T Powell, Sheryl L Horstman, Jitwadee Inthagard, James H Park, Donald C McMillan, Paul G Horgan, Joanne Edwards
BACKGROUND: In colorectal cancer (CRC), inflammatory responses have been reported to associate with patient survival. However, the specific signalling pathways responsible for regulating inflammatory responses are not clear. Src family kinases (SFKs) impact tumourigenic processes, including inflammation. METHODS: The relationship between SFK expression, inflammatory responses and cancer specific survival (CSS) in stage I-III CRC patients was assessed using immunohistochemistry on a 272 patient discovery cohort and an extended 822 patient validation cohort...
January 23, 2019: Cellular Signalling
Stanislovas S Jankauskas, Dickson W L Wong, Richard Bucala, Sonja Djudjaj, Peter Boor
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types, including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered MIF expression has been associated with a multitude of diseases ranging from inflammatory disorders like sepsis, lupus and rheumatoid arthritis to organ pathologies such as heart failure, myocardial infarction, acute kidney injury, organ fibrosis and a number of malignancies. The implication of MIF in these diseases was supported by numerous animal studies...
January 22, 2019: Cellular Signalling
Yan Weng, Jingwen Wang, Zhifu Yang, Miaomiao Xi, Jialin Duan, Chao Guo, Ying Yin, Ryosuke Segawa, Takahiro Moriya, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Aidong Wen, Noriyasu Hirasawa
Thymic stromal lymphopoietin (TSLP), a master switch of allergic inflammation, plays an important role in the pathogenesis of allergic diseases. Although many compounds upregulate TSLP expression in vivo or in vitro, most of them are pollutants or toxicants. In the previous study, for the first time, we found that a steroid alkaloid derivative 02F04, which has a unique skeletal structure compared with other TSLP-inducing chemicals, significantly induced TSLP production in mouse keratinocytes. However, it is not investigated thoroughly that how 02F04 produces TSLP and why...
January 18, 2019: Cellular Signalling
Tuan Anh Vuong, Sang-Jin Lee, Young-Eun Leem, Jae-Rin Lee, Gyu-Un Bae, Jong-Sun Kang
Neuritogenesis is a critical event for neuronal differentiation and neuronal circuitry formation during neuronal development and regeneration. Our previous study revealed a critical role of a guidance receptor BOC in a neuronal differentiation and neurite outgrowth. However, regulatory mechanisms for BOC signaling pathway remain largely unexplored. In the current study, we have identified Small glutamine-rich tetratricopeptide repeat (TPR)-containing b (SGTb) as a BOC interacting protein through yeast two-hybrid screening...
January 9, 2019: Cellular Signalling
Xin-Yue Zhang, Hsun-Ming Chang, Hua Zhu, Rui-Zhi Liu, Peter C K Leung
Bone morphogenetic protein 6 (BMP6) and transforming growth factor-β1 (TGF-β1) are key intraovarian regulators that play essential roles in regulating mammalian follicular function and promoting oocyte maturation. Furin, a member of the subtilisin-like proprotein convertase family, promotes the activation of diverse functional proteins by cleaving protein precursors in the secretory pathway. The aim of this study was to investigate the effect and underlying molecular mechanisms by which BMP6 regulates the expression of furin to increase TGF-β1 production...
January 8, 2019: Cellular Signalling
Erawan Borkham-Kamphorst, Eddy Van de Leur, Ute Haas, Ralf Weiskirchen
Unfolded protein response (UPR) is an adaptive mechanism allowing the endoplasmic reticulum (ER) to react to an accumulation of unfolded proteins in its lumen, also known as ER stress. The UPR is interconnected with inflammation through several pathways such as reactive oxygen species (ROS) production resulting from the protein folding or alternatively, activation of nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) via IRE1, or induction of acute phase response (APR). Lipocalin 2 (LCN2) is one of the APR proteins induced under inflammatory conditions and up-regulated during ER stress...
January 4, 2019: Cellular Signalling
M Van Gils, L Nollet, Ewout Verly, N Deianova, O M Vanakker
Pseudoxanthoma elasticum is an autosomal recessive genodermatosis with variable expression, due to mutations in the ABCC6 or ENPP1 gene. It is characterized by elastic fiber mineralization and fragmentation, resulting in skin, eye and cardiovascular symptoms. Significant advances have been made in the last 20 years with respect to the phenotypic characterization and pathophysiological mechanisms leading to elastic fiber mineralization. Nonetheless, the substrates of the ABCC6 transporter - the main cause of PXE - remain currently unknown...
January 4, 2019: Cellular Signalling
Hangwei Fu, Rui Dong, Yida Zhang, Jianhua Xu, Menggang Liu, Ping Chen
Tmub1 (transmembrane and ubiquitin-like domain-containing 1) plays negative roles in rat hepatocyte proliferation, but its underlying molecular mechanisms in liver regeneration regulation have yet to be revealed. Here, we show that in vivo transfection of Tmub1 overexpression vectors impaired mouse liver regeneration after partial hepatectomy (PHx). Loss- and gain-of-function analyses in human hepatocyte Lo2 cells indicated that Tmub1 inhibits the phosphorylation of STAT3 and the activation of STAT3 signaling...
January 2, 2019: Cellular Signalling
Takumi Ueda, Yuri Kohama, Hiroshi Sakurai
Proteins encoded by immediate-early response (IER) family genes, IER2, IER5, and IER5L, share homology at their N-terminal regions. IER5 binds to protein phosphatase 2A (PP2A) and enhances dephosphorylation of PP2A target proteins such as heat shock factor HSF1. Here, we show the expression of IER family genes and the target protein-specific function of IER proteins. The IER homology regions of IER2 and IER5L are required for the interaction with PP2A. Expression of IER2 and IER5L in cells leads to reduced phosphorylation of HSF1 and derepression of its transcriptional activity...
December 29, 2018: Cellular Signalling
Wenjie Han, Ning Li, Jun Liu, Yongchen Sun, Xi Yang, Yu Wang
BACKGROUND: Hepatocellular carcinoma (HCC) is a common tumor malignancy threatening a significant number of people worldwide. Although microRNAs (miRNAs) have been shown to play essential role in tumorigenesis, little is known about their role in T cells functions during HCC progression. METHODS: The abundances of miR-26b-5p were detected in HCC tissues or cells, T cells and H22 cells by quantitative real-time polymerase chain reaction (qRT-PCR). Regulation effect of miR-26b-5p on proviral integrations of moloney virus 2 (PIM2) was investigated by qRT-PCR, western blot (WB) and immunohistochemical analysis...
December 26, 2018: Cellular Signalling
Johanna Säll, Florentina Negoita, Björn Hansson, Franziska Kopietz, Wilhelm Linder, Annie M L Pettersson, Mikael Ekelund, Jurga Laurencikiene, Eva Degerman, Karin G Stenkula, Olga Göransson
AIMS/HYPOTHESIS: Salt-inducible kinase 2 (SIK2) is downregulated in adipose tissue from obese or insulin-resistant individuals and inhibition of SIK isoforms results in reduced glucose uptake and insulin signalling in adipocytes. However, the regulation of SIK2 itself in response to insulin in adipocytes has not been studied in detail. The aim of our work was to investigate effects of insulin on various aspects of SIK2 function in adipocytes. METHODS: Primary adipocytes were isolated from human subcutaneous and rat epididymal adipose tissue...
December 23, 2018: Cellular Signalling
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