journal
https://read.qxmd.com/read/37730102/znf746-promotes-m2-macrophage-polarisation-and-favours-tumour-progression-in-breast-cancer-via-the-jagged1-notch-pathway
#1
JOURNAL ARTICLE
Lu Liu, Wen-Yue Zhao, Xin-Yu Zheng
Breast cancer (BC) is a major threat to women's health. BC is a heterogeneous disease and treatment strategies and outcomes differ between subtypes. Investigating the molecular mechanisms of BC will help to identify potential therapeutic targets and develop new therapies. Here we report that zinc finger protein 746 (ZNF746), a Krüppel-associated box and zinc finger protein, exhibits tumour-promoting properties in BC. Functional experiments (cell growth, colony formation, cell cycle analysis, and transwell analysis) were used to evaluate the proliferation, migration, and invasion capacity of BC cells...
September 18, 2023: Cellular Signalling
https://read.qxmd.com/read/37722521/rotavirus-circumvents-the-antiviral-effects-of-protein-isgylation-via-proteasomal-degradation-of-ube1l
#2
JOURNAL ARTICLE
Rakesh Sarkar, Upayan Patra, Arpita Mukherjee, Suvrotoa Mitra, Satoshi Komoto, Mamta Chawla-Sarkar
Among the ramified cellular responses elicited in response to pathogenic stimuli, upregulation and covalent conjugation of an Ubiquitin-like modifier ISG15 to lysine residues of target proteins (ISGylation) through sequential action of three enzymes E1 (Ube1L), E2 (Ube2L6) and E3 (Herc5) have emerged as an important regulatory facet governing innate immunity against numerous viral infections. In the present study, we investigated the interplay between host ISGylation system and Rotavirus (RV). We observed that RV infection upregulates the expression of free ISG15 but prevents protein ISGylation...
September 16, 2023: Cellular Signalling
https://read.qxmd.com/read/37717714/comprehensive-analysis-of-subtypes-and-risk-model-based-on-complement-system-associated-genes-in-ccrcc
#3
JOURNAL ARTICLE
Yang Li, Muzhapaer Maimaiti, Bowen Yang, Zeyi Lu, Qiming Zheng, Yudong Lin, Wenqin Luo, Ruyue Wang, Lifeng Ding, Huan Wang, Xianjiong Chen, Zhehao Xu, Mingchao Wang, Gonghui Li, Lei Gao
BACKGROUND: Immune therapy is widely used in treating clear cell renal cell carcinoma (ccRCC), yet identifying patient subgroups that are expected to response remains challenging. As complement system can mediate immune effects, including the progression of tumors, a correlation between complement system and immune therapy may exist. METHODS: Based on 11 complement system associated genes (CSAGs) identified from The Cancer Genome Atlas (TCGA), we performed unsupervised clustering and classified the tumors into two different complement system (CS) patterns...
September 15, 2023: Cellular Signalling
https://read.qxmd.com/read/37717713/sirtuin1-inhibits-calcium-oxalate-crystal-induced-kidney-injury-by-regulating-tlr4-signaling-and-macrophage-mediated-inflammatory-activation
#4
JOURNAL ARTICLE
Chen Duan, Haoran Liu, Xiaoqi Yang, Jianhe Liu, Yaoliang Deng, Tao Wang, Jinchun Xing, Zhiquan Hu, Hua Xu
Sirtuin1 (Sirt1) activation significantly attenuated calcium oxalate (CaOx) crystal deposition and renal inflammatory injury by regulating renal immune microenvironment. Here, to elucidate the molecular mechanism underlying the therapeutic effects of Sirt1 on macrophage related inflammation and tubular epithelial cells (TECs) necrosis, we constructed a macrophage and CaOx monohydrate (COM)-stimulated tubular cell co-culture system to mimic immune microenvironment in kidney and established a mouse model of CaOx nephrocalcinosis in wild-type and myeloid-specific Sirt1 knockout mice...
September 15, 2023: Cellular Signalling
https://read.qxmd.com/read/37714446/oncogenic-pathways-refine-a-new-perspective-on-the-classification-of-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Yuyuan Zhang, Zaoqu Liu, Jie Li, Bailu Wu, Xin Li, Mengjie Duo, Hui Xu, Long Liu, Xiaoxing Su, Xuhua Duan, Peng Luo, Jian Zhang, Zhen Li
BACKGROUND: Genetic alterations in oncogenic pathways are critical for cancer initiation, development, and treatment resistance. However, studies are limited regarding pathways correlated with prognosis, sorafenib, and transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). METHODS: In this study, 1928 patients from 11 independent datasets and a clinical in-house cohort were screened to explore the relationships among canonical pathway alterations in HCC patients...
September 13, 2023: Cellular Signalling
https://read.qxmd.com/read/37714445/targeting-sdcbp2-in-acute-myeloid-leukemia
#6
JOURNAL ARTICLE
Yan Du, Lan-Lan Li, Feihu Chen, Yan Du
Acute myeloid leukemia (AML) remains a biologically heterogeneous disease with high morbidity and mortality under the existing treatment strategies. Our previous study showed that E2A might be a potential therapeutic target for AML, but the underlying mechanism was unclear. Here, we found that SDCBP2 might be a target gene of E2A through RNA-seq combined ChIP-seq screening. This was also demonstrated by Co-IP experiment. Furthermore, the expression of E2A and SDCBP2 were increased in both AML cell lines and patient samples...
September 13, 2023: Cellular Signalling
https://read.qxmd.com/read/37704095/fenretinide-induces-apoptosis-and-synergises-the-apoptosis-inducing-effect-of-gemcitabine-through-inhibition-of-key-signalling-molecules-involved-in-a549-cell-survival-in-in-silico-and-in-vitro-analyses
#7
JOURNAL ARTICLE
Hazem A Al-Bustany, Hawzheen A Muhammad, Mahmoud A Chawsheen, Phil R Dash
Fenretinide is a synthetic retinoid compound, which induces apoptosis via generating reactive oxygen species (ROS) and modulating PI3K/Akt/mTOR signalling pathway. We hypothesise that fenretinide's mechanism of action in triggering apoptosis may involve other targets, beside mTOR signalling pathway and it may augment apoptosis inducing effects of chemotherapeutic drugs in lung cancer. Time-lapse microscopy and Western blotting were used to evaluate apoptosis and apoptotic marker cleaved-Caspase 3 in A549 cells...
September 11, 2023: Cellular Signalling
https://read.qxmd.com/read/37696708/corrigendum-to-erythropoietin-ameliorates-cognitive-deficits-by-improving-hippocampal-and-synaptic-damage-in-streptozotocin-induced-diabetic-mice-cellular-signalling-106-2023-110614
#8
Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Chen
No abstract text is available yet for this article.
September 9, 2023: Cellular Signalling
https://read.qxmd.com/read/37690661/klf9-plays-a-critical-role-in-gr-dependent-metabolic-adaptations-in-cardiomyocytes
#9
JOURNAL ARTICLE
Chandni Thakkar, Saleena Alikunju, Nandita Niranjan, Wajiha Rizvi, Ali Abbas, Maha Abdellatif, Danish Sayed
Glucocorticoids through activation of the Glucocorticoid receptor (GR) play an essential role in cellular homeostasis during physiological variations and in response to stress. Our genomic GR binding and transcriptome data from Dexamethasone (Dex) treated cardiomyocytes showed an early differential regulation of mostly transcription factors, followed by sequential change in genes involve in downstream functional pathways. We examined the role of Krüppel-like factor 9 (Klf9), an early direct target of GR in cardiomyocytes...
September 8, 2023: Cellular Signalling
https://read.qxmd.com/read/37690660/exosome-derived-mir-372-5p-promotes-stemness-and-metastatic-ability-of-crc-cells-by-inducing-macrophage-polarization
#10
JOURNAL ARTICLE
Xiuru Shi, Ke Wei, Yulun Wu, Lingyu Mao, Wenhao Pei, Haitao Zhu, Yinxiang Shi, Shiwen Zhang, Shuang Tao, Jing Wang, Siyan Pang, Huilan Mao, Wenrui Wang, Qingling Yang, Changjie Chen
Colorectal cancer (CRC) is the most common malignancy in the digestive system, and tumor metastasis is the main cause of death in clinical patients with CRC. It has been shown that exosomes promote phenotypic changes in macrophages and tumor metastasis in the CRC tumor microenvironment. In this study, we used miRNA-seq technology to screen out the highly expressed miR-372-5p among the miRNAs differentially expressed in plasma exosomes of clinical CRC patients. It was found that miR-372-5p highly expressed in HCT116 exosomes could be phagocytosed by macrophages and promote their polarization into M2 macrophages by regulating the PTEN/AKT pathway...
September 8, 2023: Cellular Signalling
https://read.qxmd.com/read/37690659/downregulation-of-arntl-in-renal-tubules-of-diabetic-db-db-mice-reduces-kidney-injury-by-inhibiting-ferroptosis
#11
JOURNAL ARTICLE
Zhimei Peng, Hua Xiao, Hanyong Liu, Hongtao Jin, Hualin Ma, Liping Sun, Xinzhou Zhang
BACKGROUND: The prevalence of ferroptosis in diabetic kidney tubules has been documented, yet the underlying mechanism remains elusive. The aim of this study was to ascertain the pivotal gene linked to ferroptosis and establish a novel target for the prevention and management of diabetic kidney disease (DKD). METHODS: Transcriptomics data (GSE184836) from DKD mice (C57BLKS/J) were retrieved from the GEO database and intersected with ferroptosis-related genes from FerrDb...
September 8, 2023: Cellular Signalling
https://read.qxmd.com/read/37679267/-erythropoietin-ameliorates-cognitive-deficits-by-improving-hippocampal-and-synaptic-damage-in-streptozotocin-induced-diabetic-mice-cellular-signalling-106-2023-110614
#12
Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Chen
No abstract text is available yet for this article.
September 6, 2023: Cellular Signalling
https://read.qxmd.com/read/37666286/mirna-epithelial-mesenchymal-axis-emt-axis-as-a-key-player-in-cancer-progression-and-metastasis-a-focus-on-gastric-and-bladder-cancers
#13
JOURNAL ARTICLE
Ameer S Sahib, Amjid Fawzi, Rahman S Zabibah, Nisar Ahmad Koka, Shaymaa Abdulhameed Khudair, Faris Anad Muhammad, Doaa A Hamad
The metastasis a major hallmark of tumors that its significant is not only related to the basic research, but clinical investigations have revealed that majority of cancer deaths are due to the metastasis. The metastasis of tumor cells is significantly increased due to EMT mechanism and therefore, inhibition of EMT can reduce biological behaviors of tumor cells and improve the survival rate of patients. One of the gaps related to cancer metastasis is lack of specific focus on the EMT regulation in certain types of tumor cells...
September 2, 2023: Cellular Signalling
https://read.qxmd.com/read/37659727/a-tumor-infiltrating-immune-cells-related-pseudogenes-signature-based-on-machine-learning-predicts-outcomes-and-immunotherapy-responses-in-ovarian-cancer
#14
JOURNAL ARTICLE
Yuyuan Zhang, Manman Guo, Libo Wang, Siyuan Weng, Hui Xu, Yuqing Ren, Long Liu, Chunguang Guo, Quan Cheng, Peng Luo, Jian Zhang, Xinwei Han
Previous researches have provided evidence for the significant involvement of pseudogenes in immune-related functions across different types of cancer. However, the mechanisms by which pseudogenes regulate immunity in ovarian cancer (OV) and their potential impact on clinical outcomes remain unclear. To address this gap in knowledge, our study utilized a novel computational framework to analyze a total of 491 samples from three public datasets. We employed a combination of 10 machine-learning algorithms to construct a signature known as the tumor-infiltrating immune cells-related pseudogenes signature (TIICPS)...
August 31, 2023: Cellular Signalling
https://read.qxmd.com/read/37657587/aberrant-expression-of-peli1-caused-by-jagged1-accelerates-the-malignant-phenotype-of-pancreatic-cancer
#15
JOURNAL ARTICLE
Wenyang Zhou, Yuying Hu, Baosheng Wang, Lina Yuan, Jia Ma, Xiangpeng Meng
Pancreatic cancer is one of the most aggressive cancers. PELI1 has been reported to promote cell survival and proliferation in multiple cancers. As of now, the role of PELI1 in pancreatic cancer is largely unknown. Here, we found that the PELI1 mRNA was higher expressed in pancreatic tumor tissues than in adjacent normal tissues, and the high PELI1 level in pancreatic cancer patients had a short survival time compared with the low level. Moreover, the results showed that PELI1 promoted cell proliferation, migration, and invasion, and inhibited apoptosis in vitro...
August 30, 2023: Cellular Signalling
https://read.qxmd.com/read/37657586/14-3-3%C3%AE-targets-%C3%AE-catenin-nuclear-translocation-to-maintain-mitochondrial-homeostasis-and-promote-the-balance-between-proliferation-and-apoptosis-in-cisplatin-induced-acute-kidney-injury
#16
JOURNAL ARTICLE
Zhaoxing Sun, Yichun Ning, Huan Wu, Shulan Guo, Xiaoyan Jiao, Ji Ji, Xiaoqiang Ding, Xiaofang Yu
Cisplatin is a chemotherapeutic agent that is used extensively to treat solid tumors; however, its clinical application is limited by side effects, especially nephrotoxicity. Cisplatin-induced acute kidney injury (AKI) is characterized by DNA damage, cell-cycle arrest, and mitochondrial oxidative stress. Recent research demonstrated that 14-3-3ζ plays an important role in cancers, nerve disease, and kidney disease, although the regulatory mechanisms underlying cisplatin-induced AKI have yet to be fully elucidated...
August 30, 2023: Cellular Signalling
https://read.qxmd.com/read/37652395/signal-sequence-receptor-subunit-3-a-novel-indicator-of-immunosuppressive-tumor-microenvironment-and-clinical-benefits-from-immunotherapy
#17
JOURNAL ARTICLE
Qin Hu, Gujie Wu, Huiyun Ma, Jiaxin Zhang, Zheng Yang
BACKGROUND: Signal sequence receptor subunit 3 (SSR3), a translocation-associated protein complex, plays a vital role in various diseases. However, its involvement in human cancers remains unclear. METHODS: We conducted a comprehensive analysis by integrating data from multiple sources, including the Cancer Genome Atlas, Cancer Cell Lineage Encyclopedia, Genotype Tissue Expression, Human Protein Atlas, cBioPortal, TIMER, and ImmuCellAI. Additionally, we incorporated data from a clinical trial, two immunotherapy cohorts, and in vitro experiments to investigate SSR3's impact on cancer prognosis and immune response...
August 29, 2023: Cellular Signalling
https://read.qxmd.com/read/37640196/protein-kinase-b-akt-blockade-inhibits-lh-hcg-mediated-17-20-lyase-but-not-17%C3%AE-hydroxylase-activity-of-cyp17a1-in-mouse-leydig-cell-steroidogenesis
#18
JOURNAL ARTICLE
Elia Paradiso, Clara Lazzaretti, Samantha Sperduti, Beatrice Melli, Tommaso Trenti, Simonetta Tagliavini, Laura Roli, Fabio D'Achille, Ester Beltrán-Frutos, Manuela Simoni, Livio Casarini
Androgens are produced by adrenal and gonadal cells thanks to the action of specific enzymes. We investigated the role of protein kinase B (Akt) in the modulation of Δ4 steroidogenic enzymes' activity, in the mouse Leydig tumor cell line mLTC1. Cells were treated for 0-24 h with the 3 × 50% effective concentration of human luteinizing hormone (LH) and choriogonadotropin (hCG), in the presence and in the absence of the specific Akt inhibitor 3CAI. Cell signaling analysis was performed by bioluminescence resonance energy transfer (BRET) and Western blotting, while the expression of key target genes was investigated by real-time PCR...
August 26, 2023: Cellular Signalling
https://read.qxmd.com/read/37640195/hdac1-inhibits-beige-adipocyte-mediated-thermogenesis-through-histone-crotonylation-of-pgc1a-ucp1
#19
JOURNAL ARTICLE
Dingyuan Tian, Xiaojiao Zeng, Yihui Gong, Yin Zheng, Jun Zhang, Zhongming Wu
Obesity, one of the most serious public health issues, is caused by the imbalance of energy intake and energy expenditure. Increasing energy expenditure via induction of adipose tissue browning has become an appealing strategy to treat obesity and associated metabolic complications. Histone modifications have been confirmed to regulate cellular energy metabolism. Their biochemical mechanism of thermogenesis in adipose tissue, however, is incompletely understood. Herein, we report that class I histone deacetylases (HDAC) inhibitor MS275 increased PGC1α/UCP1 protein levels in inguinal white adipose tissue (iWAT) concomitant with elevated energy expenditure, reduced obesity and ameliorated glucose tolerance compared to control littermates...
August 26, 2023: Cellular Signalling
https://read.qxmd.com/read/37640194/cx3cl1-represses-autophagy-via-cx3cr1-camkii%C3%AE-hdac4-rubicon-axis-and-exacerbates-chronic-intermittent-hypoxia-induced-kupffer-cell-apoptosis
#20
JOURNAL ARTICLE
Yayong Li, Yuanguo Chen, Xiao Xiao, Silei Deng, Jingjie Kuang, Yina Wang
BACKGROUND: Nocturnal hypoxemia is an established factor in the pathogenesis and exacerbation of term metabolic (dysfunction) associated fatty liver disease (MAFLD). Kupffer cells (KCs) are resident macrophages in the liver, and their activity is closely related to the progress of MAFLD. KC insufficient autophagy is involved in MAFLD pathogenesis. Herein, the regulatory mechanism of KC autophagy under chronic intermittent hypoxia (CIH) condition was investigated. METHODS: Primary KCs and hepatic stellate cells (HSCs) were isolated from mouse liver...
August 26, 2023: Cellular Signalling
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