journal
https://read.qxmd.com/read/38358766/phillygenin-prevents-osteoclast-differentiation-and-bone-loss-by-targeting-rhoa
#21
JOURNAL ARTICLE
Jiahui Zhang, Tao Jiang, Yuxin Zhang, Kai Yang, Yichen Zhao, Qi Zhou, Zhuo Yang, Renhao Yang, Ruonan Ning, Tao Liu, Lianfu Deng, Xiaobing Xi, Xing Xu, Min Jiang
Forsythia suspensa tea is a popular traditional Chinese medicine decoction for its healthy and therapeutic benefits. However, its effects in bone metabolism were not clear. In recent study, we uncovered anti-osteoclastogenesis property of Phillygenin (Phi), a compound abundant in Forsythia suspensa leaves, and aimed to investigate the effect and mechanism of Phi on bone metabolism in vivo and in vitro. Lipopolysaccharides-induced murine calvaria osteolysis and ovariectomy-induced bone loss animal models were used to identify the bone-protective effect of Phi in vivo and micro-CT, pQCT, and TRAP staining were applied...
February 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38358734/herb-drug-interactions-a-short-review-on-central-and-peripheral-nervous-system-drugs
#22
REVIEW
João Bernardo, Patrícia Valentão
Herbal medicines are widely perceived as natural and safe remedies. However, their concomitant use with prescribed drugs is a common practice, often undertaken without full awareness of the potential risks and frequently without medical supervision. This practice introduces a tangible risk of herb-drug interactions, which can manifest as a spectrum of consequences, ranging from acute, self-limited reactions to unpredictable and potentially lethal scenarios. This review offers a comprehensive overview of herb-drug interactions, with a specific focus on medications targeting the Central and Peripheral Nervous Systems...
February 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38358731/anti-inflammatory-antioxidant-and-immunomodulatory-effects-of-berberis-vulgaris-and-its-constituent-berberine-experimental-and-clinical-a-review
#23
REVIEW
Farzaneh Shakeri, Sahar Kiani, Golnoosh Rahimi, Mohammad Hossein Boskabady
Berberis vulgaris (B. vulgaris or barberry) is a medicinal plant that has been used for various purposes in traditional medicine. Berberine is one of the main alkaloids isolated from B. vulgaris and other plants. Both B. vulgaris and berberine have shown anti-inflammatory, antioxidant, and immunomodulatory effects in different experimental models and clinical trials. This review aims to summarize the current evidence on the mechanisms and applications of B. vulgaris and berberine in modulating inflammation, oxidative stress, and immune responses...
February 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38358727/cichoric-acid-targets-rankl-to-inhibit-osteoclastogenesis-and-prevent-ovariectomy-induced-bone-loss
#24
JOURNAL ARTICLE
Yansi Xian, Yijie Gao, Yiji Su, Yuangang Su, Haoyu Lian, Xiaoliang Feng, Zhijuan Liu, Jinmin Zhao, Jiake Xu, Qian Liu, Fangming Song
BACKGROUND AND AIM: Osteoporosis, a systemic metabolic bone disease, is characterized by the decline of bone mass and quality due to excessive osteoclast activity. Currently, drug-targeting osteoclasts show promising therapy for osteoporosis. In this study, we investigated the effect of cichoric acid (CA) on receptor activator of nuclear kappa-B ligand (RANKL)-induced osteoclastogenesis and the bone loss induced by ovariectomy in mice. EXPERIMENTAL PROCEDURE: Molecular docking technologies were employed to examine the interaction between CA and RANKL...
February 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38358681/anticancer-and-chemopreventive-potential-of-morinda-citrifolia-l-bioactive-compounds-a-comprehensive-update
#25
REVIEW
Dusanka Kitic, Bojana Miladinovic, Milica Randjelovic, Agnieszka Szopa, Veronique Seidel, Parteek Prasher, Mousmee Sharma, Rabab Fatima, Dilek Arslan Ateşşahin, Daniela Calina, Javad Sharifi-Rad
Morinda citrifolia L., commonly known as Noni, has a longstanding history in traditional medicine for treating various diseases. Recently, there has been an increased focus on exploring Noni extracts and phytoconstituents, particularly for their effectiveness against cancers such as lung, esophageal, liver, and breast cancer, and their potential in cancer chemoprevention. This study aims to provide a comprehensive review of in vitro and in vivo studies assessing Noni's impact on cancer, alongside an exploration of its bioactive compounds...
February 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38356178/regulation-of-mitophagy-and-mitochondrial-function-natural-compounds-as-potential-therapeutic-strategies-for-parkinson-s-disease
#26
REVIEW
Hao Liang, Zhenwang Ma, Wei Zhong, Jia Liu, Kazuo Sugimoto, Hong Chen
Mitochondrial damage is associated with the development of Parkinson's disease (PD), indicating that mitochondrial-targeted treatments could hold promise as disease-modifying approaches for PD. Notably, natural compounds have demonstrated the ability to modulate mitochondrial-related processes. In this review article, we discussed the possible neuroprotective mechanisms of natural compounds against PD in modulating mitophagy and mitochondrial function. A comprehensive literature search on natural compounds related to the treatment of PD by regulating mitophagy and mitochondrial function was conducted from PubMed, Web of Science and Chinese National Knowledge Infrastructure databases from their inception until April 2023...
February 14, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38353369/unravelling-the-role-of-silibinin-in-targeting-cd44-cancer-stem-cells-therapeutic-implications-effective-strategies-and-approaches
#27
REVIEW
Shreya Lotia, Shanaya Patel, Aditi Patel, Vaishnavi Patel, Kanisha Shah, Vivek Tanavde
CD44+ cancer stem cells (CSCs) are believed to account for drug resistance and tumour recurrence due to their potential to self-renew and differentiate into heterogeneous lineages. Therefore, efficient treatment strategies targeting and eliminating these CSCs are required. The flavonolignan, Silibinin, has gained immense attention in targeting CD44+ CSCs as it alters functional properties like cell cycle arrest, apoptosis, inhibition of invasion and metastasis and also inhibits a range of molecular pathways...
February 14, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38353331/therapeutic-potential-of-tocotrienols-as-chemosensitizers-in-cancer-therapy
#28
REVIEW
Bethsebie Lalduhsaki Sailo, Suravi Chauhan, Mangala Hegde, Sosmitha Girisa, Mohammed S Alqahtani, Mohamed Abbas, Arul Goel, Gautam Sethi, Ajaikumar B Kunnumakkara
Chemoresistance is the adaptation of cancer cells against therapeutic agents. When exhibited by cancer cells, chemoresistance helps them to avoid apoptosis, cause relapse, and metastasize, making it challenging for chemotherapeutic agents to treat cancer. Various strategies like dosage modification of drugs, nanoparticle-based delivery of chemotherapeutics, antibody-drug conjugates, and so on are being used to target and reverse chemoresistance, one among such is combination therapy. It uses the combination of two or more therapeutic agents to reverse multidrug resistance and improve the effects of chemotherapy...
February 14, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38349045/isobavachalcone-a-natural-sirtuin-2-inhibitor-exhibits-anti-triple-negative-breast-cancer-efficacy-in-vitro-and-in-vivo
#29
JOURNAL ARTICLE
Ya-Li Ren, Jie-Ting Lei, Ting-Rui Zhang, Peng Lu, Dan-Dan Cui, Bo Yang, Gui-Ying Zhao, Fu Peng, Zhi-Xing Cao, Cheng Peng, Yu-Zhi Li
Triple-negative breast cancer (TNBC) is the most aggressive and lethal clinical subtype and lacks effective targeted therapies at present. Isobavachalcone (IBC), the main active component of Psoralea corylifolia L., has potential anticancer effects. Herein, we identified IBC as a natural sirtuin 2 (SIRT2) inhibitor and characterized the potential mechanisms underlying the inhibition of TNBC. Molecular dynamics analysis, enzyme activity assay, and cellular thermal shift assay were performed to evaluate the combination of IBC and SIRT2...
February 13, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38334064/correction-to-stigmasterol-regulates-microglial-m1-m2-polarization-via-the-tlr4-nf-%C3%AE%C2%BAb-pathway-to-alleviate-neuropathic-pain
#30
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38330236/futoquinol-improves-a%C3%AE-25-35-induced-memory-impairment-in-mice-by-inhibiting-the-activation-of-p38mapk-through-the-glycolysis-pathway-and-regulating-the-composition-of-the-gut-microbiota
#31
JOURNAL ARTICLE
Yuhan Zhang, Hui Chen, Mengnan Zeng, Pengli Guo, Meng Liu, Bing Cao, Ru Wang, Fengxiao Hao, Xiaoke Zheng, Weisheng Feng
Futoquinol (Fut) is a compound extracted from Piper kadsura that has a nerve cell protection effect. However, it is unclear whether Fut has protective effects in Alzheimer's disease (AD). In this study, we aimed to explore the therapeutic effect of Fut in AD and its underlying mechanism. UPLC-MS/MS method was performed to quantify Fut in the hippocampus of mice brain. The cognition ability, neuronal and mitochondria damage, and levels of Aβ1-42 , Aβ1-40 , p-Tau, oxidative stress, apoptosis, immune cells, and inflammatory factors were measured in Aβ25-35 -induced mice...
February 8, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38323338/pimpinellin-ameliorates-macrophage-inflammation-by-promoting-rnf146-mediated-parp1-ubiquitination
#32
JOURNAL ARTICLE
Liuye Yang, Meng Du, Kaiyuan Liu, Pengchao Wang, Jingbo Zhu, Fengcen Li, Ze Wang, Kai Huang, Minglu Liang
Macrophage inflammation plays a central role during the development and progression of sepsis, while the regulation of macrophages by parthanatos has been recently identified as a novel strategy for anti-inflammatory therapies. This study was designed to investigate the therapeutic potential and mechanism of pimpinellin against LPS-induced sepsis. PARP1 and PAR activation were detected by western blot or immunohistochemistry. Cell death was assessed by flow cytometry and western blot. Cell metabolism was measured with a Seahorse XFe24 extracellular flux analyzer...
February 7, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38321646/correction-to-scutellarein-alleviates-chronic-obstructive-pulmonary-disease-through-inhibition-of-ferroptosis-by-chelating-iron-and-interacting-with-arachidonate-15-lipoxygenase
#33
(no author information available yet)
No abstract text is available yet for this article.
February 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38318763/phyto-therapeutic-potential-of-withania-somnifera-molecular-mechanism-and-health-implications
#34
REVIEW
Nisha Yadav, Sandhya Tripathi, Neelam S Sangwan
Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has been used since ancient times to cure various health ailments. Withania somnifera is rich in constituents belonging to chemical classes like alkaloids, saponins, flavonoids, phenolic acids, and withanolides. Several chemotypes were identified based on their phytochemical composition and credited for their multiple bioactivities. Besides, exhibiting neuroprotective, immunomodulatory, adaptogenic, anti-stress, bone health, plant has shown promising anti-cancer properties...
February 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38317477/comments-on-unveiling-the-therapeutic-promise-of-natural-products-in-alleviating-drug-induced-liver-injury-present-advancements-and-future-prospects
#35
LETTER
Hartmut Jaeschke, Anup Ramachandran
No abstract text is available yet for this article.
February 5, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38317321/correction-to-sclareol-attenuates-angiotensin-ii-induced-cardiac-remodeling-and-inflammation-via-inhibiting-mapk-signaling
#36
Na Yang, Chunpeng Zou, Wu Luo, Diyun Xu, Mengyang Wang, Yi Wang, Gaojun Wu, Peiren Shan, Guang Liang
No abstract text is available yet for this article.
February 5, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38311336/d-pinitol-alleviates-diabetic-cardiomyopathy-by-inhibiting-the-optineurin-mediated-endoplasmic-reticulum-stress-and-glycophagy-signaling-pathway
#37
JOURNAL ARTICLE
Xiaoli Li, Xin Yu, Fei Yu, Chunli Fu, Wenqian Zhao, Xiaosong Liu, Chaochao Dai, Haiqing Gao, Mei Cheng, Baoying Li
Diabetic cardiomyopathy (DCM) is an important complication resulting in heart failure and death of diabetic patients. However, there is no effective drug for treatments. This study investigated the effect of D-pinitol (DP) on cardiac injury using diabetic mice and glycosylation injury of cardiomyocytes and its molecular mechanisms. We established the streptozotocin-induced SAMR1 and SAMP8 mice and DP (150 mg/kg/day) intragastrically and advanced glycation end-products (AGEs)-induced H9C2 cells. H9C2 cells were transfected with optineurin (OPTN) siRNA and overexpression plasmids...
February 4, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38302697/natural-products-targeting-macroautophagy-signaling-in-hepatocellular-carcinoma-therapy-recent-evidence-and-perspectives
#38
REVIEW
Yuan Chen, Xiyue Tan, Wenwen Zhang, Yubing Li, Xinyu Deng, Jinhao Zeng, Lihua Huang, Xiao Ma
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer-related mortality, continues to pose significant challenges in the realm of medical oncology, impacting both clinical drug selection and mechanistic research. Recent investigations have unveiled autophagy-related signaling as a promising avenue for HCC treatment. A growing body of research has highlighted the pivotal role of autophagy-modulating natural products in inhibiting HCC progression. In this context, we provide a concise overview of the fundamental autophagy mechanism and delineate the involvement of autophagic signaling pathways in HCC development...
February 1, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38299680/saponins-as-therapeutic-candidates-for-atherosclerosis
#39
REVIEW
Nuan Lv, Luming Wang, Miao Zeng, Yijing Wang, Bin Yu, Wenyun Zeng, Xijuan Jiang, Yanrong Suo
Drug development for atherosclerosis, the underlying pathological state of ischemic cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as steroid or triterpenoid glycosides, have shown promising therapeutic potential in the treatment of atherosclerosis. Through an exhaustive examination of scientific literature spanning from May 2013 to May 2023, we identified 82 references evaluating 37 types of saponins in terms of their prospective impacts on atherosclerosis. These studies suggest that saponins have the potential to ameliorate atherosclerosis by regulating lipid metabolism, inhibiting inflammation, suppressing apoptosis, reducing oxidative stress, and modulating smooth muscle cell proliferation and migration, as well as regulating gut microbiota, autophagy, endothelial senescence, and angiogenesis...
February 1, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38296262/efficacy-of-an-oral-suspension-containing-xyloglucan-and-pea-proteins-on-a-murine-model-of-gastroesophageal-reflux-disease
#40
JOURNAL ARTICLE
Alessio Ardizzone, Deborah Mannino, Giovanna Casili, Michela Campolo, Irene Paterniti, Marika Lanza, Alessia Filippone, Alberto Repici, Valentina Bova, Anna Paola Capra, Salvatore Cuzzocrea, Emanuela Esposito
Gastroesophageal reflux disease (GERD) is the most common foregut disease, affecting about 20% of the adult population. Esophageal epithelial barrier plays a fundamental role in the pathophysiology of GERD; however, pharmacological therapies mainly aim to reduce the acidity of the gastroesophageal environment rather than to protect esophageal tissue integrity. This study aims to evaluate the efficacy of an oral solution containing xyloglucan and pea proteins (XP) in reestablishing gastroesophageal tissue integrity and biochemical markers...
January 31, 2024: Phytotherapy Research: PTR
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