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Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre

https://read.qxmd.com/read/38599178/ganoderma-lucidum-and-hypericum-perforatum-exhibit-anti-inflammatory-antioxidant-and-anti-androgen-effect-in-rat-model-of-experimental-polycystic-ovarian-syndrome
#1
JOURNAL ARTICLE
Gülin Okay, Pınar Kırıcı, Nihal Mavral, Zeynep Ece Utkan Korun, Ebru Annac, Selçuk Kaplan
UNLABELLED: Since chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS), we aimed to investigate Ganoderma lucidum polysaccharide (GLP) and Hypericum perforatum (HP), anti-inflammatory and antioxidant activity have been identified in several pathologies due to their polyphenolic components, on ovarian tissue in rat model of experimental PCOS. MATERIALS AND METHODS: Forty-two Sprague-Dawley female rats were divided into 6 groups with 7 animals in each group as listed below; Group 1: Control, Group 2: PCOS, Group 3: PCOS + HP, Group 4: HP only, Group 5: PCOS+ GLP, Group 6: GLP only...
April 10, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38593764/the-predictive-value-of-plasma-sodium-and-other-laboratory-parameters-in-determining-complicating-appendicitis-in-children
#2
JOURNAL ARTICLE
Zlatan Zvizdic, Asmir Jonuzi, Una Glamoclija, Semir Vranic
OBJECTIVE: Finding a reliable preoperative predictor of complicated acute appendicitis (AA) has been a challenging diagnostic problem. The present study aimed to identify potential factors that may predict complicated AA in the pediatric emergency department (ED) based on routine, widely available laboratory tests on admission to the ED, including plasma sodium concentration. METHODS: We retrospectively reviewed clinical and laboratory data of pediatric patients with AA who underwent emergency surgery at our department between January 2020 and December 2022...
April 9, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38593751/additive-effects-of-citrus-juice-flavonoid-naringenin-and-statins-on-herg-channels-expressed-in-xenopus-oocytes
#3
Dmytro Isaev, Keun-Hang Susan Yang, Murat Oz
OBJECTIVE: Naringenin, a major flavonoid found in citrus juice, has been shown to inhibit HERG channels and cause QT prolongation. Statins, the most commonly used class of cholesterol reducing drugs, have also been reported to inhibit HERG channels and prolong QT interval in patients using these drugs. However, the interaction between naringenin and statins on the function of HERG channels has not been studied. MATERIALS AND METHODS: In the present study, we expressed HERG channels in Xenopus oocytes and tested the effects of naringenin and statins separately and combined on HERG channels...
April 9, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38569485/outcome-of-colorectal-robotic-surgery-in-newly-established-robotic-surgery-center-a-case-series
#4
JOURNAL ARTICLE
Ahmed A Alkhamis, Diaa M Soliman, Khaled A Alsadder, Hashem M Busalha, Ahmad S Alrashed, Bader H Alshaban, Salman K Alsafran, Sulaiman M Almazeedi
INTRODUCTION: The robotic platform compared to laparoscopy has proven to have similar postoperative outcomes, however its adoption in the Middle East has been slow and there is limited data regarding outcomes with its use in small newly established robotic colorectal programs. Our aim was to report our experience and outcomes of robotic colorectal surgery performed by fellowship-trained robotic colorectal surgeons and compare them to larger, more experienced centers. METHODS: This is retrospective review of data collected between November 2021 and March 2023 from a tertiary health care referral center...
April 3, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38565090/igfbp5-promotes-neuronal-apoptosis-in-a-6-ohda-toxicant-model-of-parkinson-s-disease-by-inhibiting-the-sonic-hedgehog-signalling-pathway
#5
JOURNAL ARTICLE
Shenglong Guo, Qi Lei, Qian Yang, Ruili Chen
INTRODUCTION: Parkinson's disease (PD) is a most common neurodegenerative disease worldwide. Studies have shown that insulin-like growth factor-binding protein 5 (IGFBP5) may contribute to methamphetamine-induced neurotoxicity and neuronal apoptosis in PC-12 cells and rat striatum. Here, we studied the expression and role of IGFBP5 in the 6-OHDA-toxicant model of PD. METHODS: PC-12 and SH-SY5Y cells were exposed to 50 μM 6-OHDA for 24 h. qRT-PCR, western blotting, CCK-8 assay, EdU staining, annexin V staining, and immunofluorescence were performed to study the effects of IGFBP5 specific siRNAs...
April 2, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38560979/discordance-in-phenotypic-and-genotypic-susceptibility-testing-for-streptomycin-due-to-nonsynonymous-nonsense-deletion-frame-shift-mutations-in-gidb-among-clinical-mycobacterium-tuberculosis-isolates-in-kuwait
#6
JOURNAL ARTICLE
Noura M Al-Mutairi, Suhail Ahmad, Eiman Mokaddas
OBJECTIVE: Increasing reports of resistance to newer anti-tuberculosis drugs have prompted the search for other alternative drugs. Streptomycin could be used for the treatment of drug-resistant tuberculosis if susceptibility of Mycobacterium tuberculosis isolate to streptomycin could be accurately detected. We performed phenotypic and genotypic drug susceptibility testing (DST) of 118 M. tuberculosis isolates for streptomycin. MATERIALS AND METHODS: Fifty pansusceptible and 68 multidrug-resistant M...
April 1, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38527444/the-emerging-role-of-ai-in-patient-education-a-comparative-analysis-of-llm-accuracy-for-pelvic-organ-prolapse
#7
JOURNAL ARTICLE
Sakine Rahimli Ocakoglu, Burhan Coskun
OBJECTIVE: This study aimed to evaluate the accuracy, completeness, precision, and readability of outputs generated by three Large Language Models (LLMs): GPT by OpenAI, BARD by Google, and Bing by Microsoft, in comparison to patient education material on Pelvic Organ Prolapse (POP) provided by the Royal College of Obstetricians and Gynecologists (RCOG). METHODS: A total of 15 questions were retrieved from the RCOG website and input into the three LLMs. Two independent reviewers evaluated the outputs for accuracy, completeness, and precision...
March 25, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38508158/pharmaceutical-polygon-fingerprinting-matrix-system-pharmp-fm-a-potential-tool-for-pharmaceutical-quality-control
#8
JOURNAL ARTICLE
Fatema Elamrawy, Nada A Helal, Basant A Abou-Taleb, Ghada Elagouri, Olivia Vattelana, Mohamed I Nounou
Background & Purpose A new discriminatory system for evaluating the quality of pharmaceuticals is described in this paper as the Pharmaceutical Polygon Fingerprint Matrix system (PharmP-FM). To assess the quality of various pharmaceutical formulations and dosage forms, PharmP-FM uses both qualitative and quantitative fingerprinting techniques. The system expands on the SeDeM expert system, which was initially created to evaluate the suitability of powder for direct compression. PharmP-FM creates a graphical representation of the product's pharmaceutical quality using a set of input parameters...
March 20, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38508157/in-vitro-activity-of-dalbavancin-and-fourteen-other-antimicrobial-agents-against-toxigenic-clostridioides-difficile-clinical-isolates-in-a-greek-tertiary-care-hospital
#9
JOURNAL ARTICLE
Sofia Maraki, Viktoria Eirini Mavromanolaki, Dimitra Stafylaki, Evangelia Iliaki-Giannakoudaki, Anna Kasimati
OBJECTIVE: Clostridioides difficile is a major cause of healthcare-associated diarrhea worldwide. For years, metronidazole and vancomycin were considered the standard treatment for C. difficile infection (CDI). However, they are increasingly being associated with treatment failure and recurrence. In this study we investigated the in vitro activity of dalbavancin and fourteen other antimicrobials against 155 toxigenic C. difficile isolates originating from patients with C. difficile-associated diarrhea...
March 20, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38498997/oral-rinses-some-kill-and-some-cripple-candida-albicans
#10
JOURNAL ARTICLE
Homa Darmani, Dua'a Riyad Husain Al-Saleh
OBJECTIVES: Oral healthcare professionals play a crucial role in guiding patients toward evidence-based choices among the many available oral rinses. In this study, we explored how specific oral rinse formulations affect the viability and modulate critical virulence traits of the opportunistic fungal pathogen Candida albicans. MATERIALS AND METHODS: We assessed the effects of these oral rinses on the production of germ tube, production of phospholipase and hemolysin, as well as biofilm formation...
March 18, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38484723/social-media-misinformation-about-pregnancy-and-covid-19-vaccines-a-systematic-review
#11
Mahnoor Malik, Natasha Bauer-Maison, Giuliana Guarna, Rohan D DSouza
OBJECTIVE: To identify common social media misconceptions about COVID-19 vaccination in pregnancy, explain the spread of misinformation, and identify solutions to guide clinical practice and policy. METHODOLOGY: A systematic review was conducted and the databases Embase and Medline were searched from December 2019 until February 8, 2023, using terms related to social media, pregnancy, COVID-19 vaccines and misinformation. The inclusion criteria were: original research studies and discuss misinformation about COVID-19 vaccination during pregnancy on social media...
March 14, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38484713/diagnostic-methods-for-helicobacter-pylori
#12
REVIEW
Liana Cristina Melo Carneiro Costa, Maria das Graças Carvalho, Ana Cristina La Guárdia Custódio Pereira, Rafael Gonçalves Teixeira Neto, Lívia Carolina Andrade Figueiredo, Melina Barros-Pinheiro
H. pylori infection is a significant global health concern. It cannot be diagnosed based solely on the patient's medical history and symptoms, and laboratory and imaging tests are often required to confirm the diagnosis. Both non-invasive and invasive methods are available for diagnosing H. pylori infection, including conventional and advanced detection techniques. It is not uncommon for patients to present with false-negative results due to the use of inadequate investigation methodologies, which prevents the adoption of appropriate clinical management...
March 14, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38479367/the-modulation-of-euglycemic-endocrine-and-exocrine-pancreatic-secretions-in-iron-deficiency
#13
JOURNAL ARTICLE
Mohammad A Bani-Ahmad, Noor E Abu Tayyem
OBJECTIVES: The contribution of pancreatic secretions in iron metabolism is elucidated. Still, the clinical outcomes of iron deficiency on pancreatic function are debatable. This study aimed to investigate the modulation of euglycemic endocrine and exocrine pancreatic excretions in response to variations in iron availability. SUBJECTS AND METHODS: A total of one hundred and seventy (N=170) adult subjects with variable extents of serum iron levels were included. Serum levels of insulin, glucagon, insulin-to-glucagon ratio (IGR), and amylase were determined...
March 13, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38471490/alzheimer-s-disease-a-suitable-case-for-treatment-with-precision-medicine
#14
REVIEW
Ernest K J Pauwels, Gerard J Boer
Alzheimer's disease (AD) is the most common cause of neurodegenerative impairment in elderly people. Clinical characteristics include short-term memory loss, confusion, hallucination, agitation, and behavioural disturbance. Owing to evolving research in biomarkers AD can be discovered at early onset, but the disease is currently considered a continuum, which suggests that pharmacotherapy is most efficacious in the preclinical phase, possibly 15 - 20 years before discernible onset. Present developments in AD therapy aim to respond to this understanding and go beyond the drug families that relieve clinical symptoms...
March 12, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38471466/the-impact-of-educational-status-on-the-occurrence-of-colonic-diverticula-insights-from-an-austrian-cohort-study
#15
JOURNAL ARTICLE
Andreas Völkerer, Sarah Wernly, Georg Semmler, Maria Flamm, Konrad Radzikowski, Leonora Datz, Elmar Aigner, Christian Datz, Bernhard Wernly
OBJECTIVE: Education often reflects socioeconomic status. Research indicates that lower socioeconomic status may increase the risk of diverticulosis, and ccording to data from the USA, diverticular disease is a significant and costly health problem. Our study explores the link between educational level and colonic diverticula occurrence. SUBJECT AND METHODS: We conducted a cohort study on 5,532 asymptomatic Austrian patients who underwent colonoscopy, categorizing them by education level using the updated Generalized International Standard Classification of Education (GISCED)...
March 12, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38442703/advancements-in-hla-typing-techniques-and-their-impact-on-transplantation-medicine
#16
REVIEW
Jeethu Anu Geo, Reem Ameen, Salem Al Shemmari, Jibu Thomas
HLA typing serves as a standard practice in hematopoietic stem cell transplantation to ensure compatibility between donors and recipients, preventing the occurrence of allograft rejection and graft-versus-host disease. Conventional laboratory methods that have been widely employed in the past few years, including Sequence-Specific Primer PCR and Sequencing Based Typing (SBT), currently face the risk of becoming obsolete. This risk stems not only from the extensive diversity within HLA genes but also from the rapid advancement of Next Generation Sequencing and third-generation sequencing technologies...
March 5, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38402870/whole-genome-sequencing-applications-in-clinical-microbiology
#17
REVIEW
Abu Salim Mustafa
The success in determining the whole genome sequence of a bacterial pathogen was first achieved in 1995 by determining the complete nucleotide sequence of Haemophilus influenzae Rd using the chain-termination method established by Sanger et al. in 1977 and automated by Hood et al. in 1987. However, this technology was laborious, costly, and time-consuming to obtain whole genome sequences. Since 2004, high-throughput next-generation sequencing technologies have been developed, which are highly efficient, require less time, and are cost-effective to perform whole genome sequencing (WGS) of all organisms, including bacterial pathogens...
February 23, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38359814/long-term-mortality-and-sglt2-inhibitors-in-type-2-diabetes-with-and-without-renal-impairment-an-observational-cohort-study
#18
JOURNAL ARTICLE
Abdullah Al-Muhaiteeb, Barrak Alahmad, Mohamed Abu-Farha, Jehad Abubaker, Thangavel A Thanaraj, Hamad Ali, Fahd Al-Mulla, Mohammad Qaddoumi
UNLABELLED: AAim: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have emerged as a vital part of management of type 2 diabetes, as they have been shown to have both cardiovascular and renal benefits along with an improved survival rate in several randomized clinical trials. We designed a retrospective cohort study to investigate the impact of SGLT2 inhibitors on mortality among type 2 diabetes patients. METHODS: Patients with type 2 diabetes who presented to the Dasman Diabetes Institute in Kuwait were followed from January 1st, 2015, until January 20th, 2023...
February 15, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38359804/the-effect-of-citric-and-ascorbic-acids-as-anti-biofilm-and-anti-capsular-agents-on-multidrug-resistant-acinetobacter-baumannii
#19
JOURNAL ARTICLE
Ingy El-Soudany, Nancy Attia, Rasha Emad, Shahinda Rezk
OBJECTIVE: Acinetobacter baumannii (A. baumannii) is an opportunistic bacterium with multiple virulence factors, including capsule and biofilm, and is known for its high drug resistance. Anti-virulence natural substances have been suggested as novel alternatives to conventional antibiotics. We aimed to evaluate the effect of citric acid and ascorbic acid as anti-biofilm and anti-capsular agents against multidrug resistant (MDR) A. baumannii clinical isolates. MATERIALS AND METHODS: Twenty-eight A...
February 15, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38350432/the-effects-of-neuroactive-steroids-on-myelin-in-health-and-disease
#20
REVIEW
Samah Kalakh, Abdeslam Mouihate
Myelin plays a pivotal role in the efficient transmission of nerve impulses. Disruptions in myelin integrity are associated with numerous neurological disorders, including multiple sclerosis. In the central nervous system (CNS), myelin is formed by oligodendrocytes. Remyelination refers to the re-formation of the damaged myelin sheath by newly formed oligodendrocytes. Steroids have gained attention for their potential modulatory effects on myelin in both health and disease. Steroids are traditionally associated with endocrine functions, but their local synthesis within the nervous system has generated significant interest...
February 13, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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