journal
https://read.qxmd.com/read/38904854/collaborative-roles-for-rac1-erm-proteins-and-pten-during-adult-sensory-axon-regeneration
#1
JOURNAL ARTICLE
Aparna Areti, Prashanth Komirishetty, Douglas W Zochodne
The role of local of growth cone (GC) manipulation in adult regenerative systems is largely unexplored despite substantial translational importance. Here we investigated collaboration among Rac1 GTPase, its partnering ERM proteins and PTEN in adult sensory neurons and adult nerve regeneration. We confirmed expression of both Rac1 and ERM in adults and noted substantial impacts on neurite outgrowth in naïve and pre-injured adult sensory neurons. PTEN inhibition added to this outgrowth. Rac1 activation acted directly on adult GCs facilitating both attractive turning and advancement...
June 21, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38900368/inhibition-of-cspg-ptp%C3%AF-activates-autophagy-flux-and-lysosome-fusion-aids-axon-and-synaptic-reorganization-in-spinal-cord-injury
#2
JOURNAL ARTICLE
Hongyu Wang, Naibo Feng, Chungeng Liu, Yongheng Xie, Zipeng Zhou, Haosen Zhao, Guozhi Xiao, Dazhi Yang
Chondroitin sulfate proteoglycans (CSPGs) and proteoglycan receptor protein tyrosine phosphatase σ (PTPσ) play a critical role in the pathology of spinal cord injury (SCI). CSPGs can be induced by autophagy inhibition in astrocyte. However, CSPG's impact on autophagy and its role in SCI is still unknown. We investigate intracellular sigma peptide (ISP) targeting PTPσ, its effects on autophagy, and synaptic reorganization in SCI. We found that ISP increased the level of autophagosome marker LC3B-II/I and decreased autophagosome degradation marker p62 in SCI, suggesting activated autophagy flux...
June 20, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38900367/all-trans-retinoic-acid-induced-cell-surface-heat-shock-protein-90-mediates-tau-protein-internalization-and-degradation-in-human-microglia
#3
JOURNAL ARTICLE
Ngoc Lan Nguyen, Thi Xoan Hoang, Jae Young Kim
This study investigates the role of all-trans retinoic acid (ATRA) in modulating the expression of heat shock protein 90 (Hsp90) and its influence on the uptake and degradation of tau proteins in immortalized human microglia cells. We demonstrate that ATRA significantly upregulates Hsp90 expression in a concentration-dependent manner, enhancing both extracellular and intracellular Hsp90 levels. Our results show that ATRA-treated cells exhibit increased tau protein uptake via caveolae/raft-dependent endocytosis pathways...
June 20, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38900366/human-microglia-like-cells-differentiated-from-monocytes-with-gm-csf-and-il-34-show-phagocytosis-of-%C3%AE-synuclein-aggregates-and-c-ebp%C3%AE-dependent-proinflammatory-activation
#4
JOURNAL ARTICLE
Andrea Llaves-López, Elia Micoli, Carla Belmonte-Mateos, Gerard Aguilar, Clara Alba, Anais Marsal, Marta Pulido-Salgado, Neus Rabaneda-Lombarte, Carme Solà, Joan Serratosa, Jose M Vidal-Taboada, Josep Saura
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial cultures. To understand the role of microglia in human disease, reliable in vitro models of human microglia are necessary. Monocyte-derived microglia-like cells (MDMi) are a promising approach. This study aimed to characterize MDMi cells generated from adult human monocytes using granulocyte-macrophage colony-stimulating factor and interleukin-34...
June 20, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38898199/metabolomics-in-depression-what-we-learn-from-preclinical-and-clinical-evidences
#5
REVIEW
Pooja Singh, Boosani Vasundhara, Nabanita Das, Ruchika Sharma, Anoop Kumar, Ashok Kumar Datusalia
Depression is one of the predominant common mental illnesses that affects millions of people of all ages worldwide. Random mood changes, loss of interest in routine activities, and prevalent unpleasant senses often characterize this common depreciated mental illness. Subjects with depressive disorders have a likelihood of developing cardiovascular complications, diabesity, and stroke. The exact genesis and pathogenesis of this disease are still questionable. A significant proportion of subjects with clinical depression display inadequate response to antidepressant therapies...
June 19, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38898198/neuroprotective-effect-of-chlorogenic-acid-in-an-animal-model-of-sporadic-alzheimer-s-disease-induced-by-streptozotocin
#6
JOURNAL ARTICLE
Jéssica Rabelo Bezerra, Tyciane de Souza Nascimento, Juliete Tavares, Mayara Sandrielly Soares de Aguiar, Maiara Virgínia Viana Maia, Geanne Matos de Andrade
Alzheimer's Disease is a degenerative neurological condition which leads to a decline in memory and cognitive function. Chlorogenic Acid (CGA) presents properties including neuroprotective, antioxidant and anti-inflammatory. The aim of this study was to examine the impact of CGA on cognitive impairments, neuroinflammation and neuronal damage in mice submitted to an experimental model of Sporadic Alzheimer Disease (SAD) induced by intracerebroventricular administration of streptozotocin (ICV-STZ). Male Swiss mice received bilateral ICV-STZ injections (3 mg/Kg) on days 1 and 3...
June 19, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38898197/an-updated-canvas-of-the-rfc1-mediated-canvas-cerebellar-ataxia-neuropathy-and-vestibular-areflexia-syndrome
#7
REVIEW
Sakshi Shukla, Kanav Gupta, Krishna Singh, Amit Mishra, Amit Kumar
Proliferation of specific nucleotide sequences within the coding and non-coding regions of numerous genes has been implicated in approximately 40 neurodegenerative disorders. Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS), a neurodegenerative disorder, is distinguished by a pathological triad of sensory neuropathy, bilateral vestibular areflexia and cerebellar impairments. It manifests in adults gradually and is autosomal recessive and multi-system ataxia. Predominantly, CANVAS is associated with biallelic AAGGG repeat expansions in intron 2 of the RFC1 gene...
June 19, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38896157/astrocytes-secreted-wnt5b-disrupts-the-blood-brain-barrier-via-ror1-jnk-c-jun-cascade-during-meningitic-escherichia-coli-infection
#8
JOURNAL ARTICLE
Xinyi Qu, Ruicheng Yang, Chen Tan, Huanchun Chen, Xiangru Wang
The blood-brain barrier (BBB) is a complex structure that separates the central nervous system (CNS) from the peripheral blood circulation. Effective communication between different cell types within the BBB is crucial for its proper functioning and maintenance of homeostasis. In this study, we demonstrate that meningitic Escherichia coli (E. coli)-induced WNT5B plays a role in facilitating intercellular communication between astrocytes and brain microvascular endothelial cells (BMECs). We discovered that astrocytes-derived WNT5B activates the non-canonical WNT signaling pathway JNK/c-JUN in BMECs through its receptor ROR1, leading to inhibition of ZO-1 expression and impairment of the tight junction integrity in BMECs...
June 19, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38896156/the-role-of-hsp90-molecular-chaperones-in-depression-potential-mechanisms
#9
REVIEW
Xuyuan Fan, Lei Sun, Ye Qin, Yuan Liu, Shusheng Wu, Longfei Du
Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human life and health worldwide. HPA axis disorder and neuroinflammation are two common biological abnormalities in MDD patients. Hsp90 is an important molecular chaperone that is widely distributed in the organism. Hsp90 binds to the co-chaperone and goes through a molecular chaperone cycle to complete its regulation of the client protein. Numerous studies have demonstrated that Hsp90 regulates how the HPA axis reacts to stress and how GR, the HPA axis' responsive substrate, matures...
June 19, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38890237/black-seed-oil-based-curcumin-nanoformulations-ameliorated-cuprizone-induced-demyelination-in-the-mouse-hippocampus
#10
JOURNAL ARTICLE
Mohammad Zubair Alam, Hala Abubaker Bagabir, Mohammad Alameen Faisal Zaher, Thamer M A Alqurashi, Badrah S Alghamdi, Mohsin Kazi, Ghulam Md Ashraf, Gadah Ali Alshahrany, Noor Ahmed Alzahrani, Rafal Mohammed Bakhalgi, Juweiriya, Mona Al-Thepyani, Hanin Abdulbaset AboTaleb, Rahaf Saeed Aldhahri, Gamal Said Abd El-Aziz, Fahad A Al-Abbasi, Loay Khaled Eibani, Faisal Jaman Alzahrani, Mohd Sajjad Ahmad Khan
Multiple sclerosis (MS) is a neurodegenerative disease characterized by the demyelination of nerves, axonal damage, and neuroinflammation. Cognition impairment, pain, and loss of mobility are some of the usual complications of MS. It has been postulated that the overproduction of proinflammatory cytokines and reactive oxygen species (ROS) are the main factors that contribute to MS pathology. Among various animal models, the cuprizone model is the most widely used model for investigating MS-related pathology...
June 18, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38890236/fyn-kinase-in-alzheimer-s-disease-unraveling-molecular-mechanisms-and-therapeutic-implications
#11
REVIEW
Shreyasi Meur, Dipanjan Karati
Alzheimer's disease, characterized by the accumulation of abnormal protein aggregates and neuronal damage in the brain, leads to a gradual decline in cognitive function and memory. As a complex neurodegenerative disorder, it involves disruptions in various biochemical pathways and neurotransmitter systems, contributing to the progressive loss of neurons and synaptic connections. The complexity of Alzheimer's signaling pathways complicates treatment, presenting a formidable challenge in the quest for effective therapeutic interventions...
June 18, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38888836/underlying-mechanism-of-lysosomal-membrane-permeabilization-in-cns-injury-a-literature-review
#12
REVIEW
Linyi Xiang, Junsheng Lou, Jiayi Zhao, Yibo Geng, Jiacheng Zhang, Yuzhe Wu, Yinuo Zhao, Zhichao Tao, Yao Li, Jianjun Qi, Jiaoxiang Chen, Liangliang Yang, Kailiang Zhou
Lysosomes play a crucial role in various intracellular pathways as their final destination. Various stressors, whether mild or severe, can induce lysosomal membrane permeabilization (LMP), resulting in the release of lysosomal enzymes into the cytoplasm. LMP not only plays a pivotal role in various cellular events but also significantly contributes to programmed cell death (PCD). Previous research has demonstrated the participation of LMP in central nervous system (CNS) injuries, including traumatic brain injury (TBI), spinal cord injury (SCI), subarachnoid hemorrhage (SAH), and hypoxic-ischemic encephalopathy (HIE)...
June 18, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38886327/treadmill-exercise-enhances-post-stroke-functional-recovery-in-mice-via-the-cx3cl1-cx3cr1-signaling-pathway
#13
JOURNAL ARTICLE
Yangyang Ge, Xiaoke Dou, Pu Chen, Jiayi Chen, Maosha Dai, Shanglong Yao, Yun Lin
To validate that treadmill exercise promotes neurofunctional recovery post ischemic stroke and to specifically explore the role of the CX3CL1/CX3CR1 signaling pathway in this treadmill-mediated recovery process. C57BL/6 J mice were used to establish a middle cerebral artery occlusion (MCAO) model. From days 5 to 28 post-stroke, the experimental group did 10-min treadmill sessions twice daily at 12 r/min; the control group remained inactive. On day 6 post-stroke, mice received three intraperitoneal injections of Bromodeoxyuridine (BrdU) or PBS...
June 18, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38884701/polypeptide-pnp2-in-corn-cervi-pantotrichum-ameliorates-cognitive-impairment-in-alzheimer-s-disease-mice-by-inhibiting-microglial-cell-activation
#14
JOURNAL ARTICLE
Hongyan Pei, Zhongmie He, Rui Du, Yi Yang, Shasha Wu, Wenyan Li, Jian Sheng, Chenyang Han
We isolated a polypeptide PNP2 from Corn Cervi Pantotrichum and investigated its effect and mechanism on cognitive impairment in Alzheimer's disease (AD) mice. Morris water maze was used to assess the degree of cognitive impairment in mice. Histopathological changes were detected by H&E staining; the expressions of inflammatory cytokines were assayed by ELISA. Western blotting was employed to detect the protein expressions. PNP2 could improve cognitive impairment, central inflammatory response, and NLRP3 signaling in AD mice...
June 17, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38878116/hippocampal-gpr35-participates-in-the-pathogenesis-of-cognitive-deficits-and-emotional-alterations-induced-by-a%C3%AE-1-42-in-mice
#15
JOURNAL ARTICLE
YuSheng Liang, Yan Yang, Zhi Jie, Xu Kang, Heng Xu, HaiWang Zhang, Xian Wu
The amyloid-beta (Aβ) aggregation in Alzheimer's disease (AD) triggers neuroinflammation, and neurodegeneration, which lead to cognitive deficits along with other neuropsychiatric symptoms, including depression and anxiety. G protein-coupled receptor 35 (GPR35) is expressed in the brain and is involved in metabolic stresses. However, the role of GPR35 in AD pathogenesis remains unknown. Herein, pharmacological blockade, shRNA-mediated knockdown or knockout of GPR35 was performed to investigate the role and mechanisms of GPR35 in Aβ1-42 -induced cognitive impairment and emotional alterations in mice...
June 15, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38877366/role-of-regulatory-t-cells-in-intracerebral-hemorrhage
#16
REVIEW
Yaxin Shang, Lei Zheng, Yunpeng Du, Tong Shang, Xueting Liu, Wei Zou
Intracerebral hemorrhage (ICH) is a common cerebrovascular disease that can lead to severe neurological dysfunction in surviving patients, resulting in a heavy burden on patients and their families. When ICH occurs, the blood‒brain barrier is disrupted, thereby promoting immune cell migration into damaged brain tissue. As important immunosuppressive T cells, regulatory T (Treg) cells are involved in the maintenance of immune homeostasis and the suppression of immune responses after ICH. Treg cells mitigate brain tissue damage after ICH in a variety of ways, such as inhibiting the neuroinflammatory response, protecting against blood‒brain barrier damage, reducing oxidative stress damage and promoting nerve repair...
June 14, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38874704/mitochondrial-uncoupling-protein-2-ameliorates-ischemic-stroke-by-inhibiting-ferroptosis-induced-brain-injury-and-neuroinflammation
#17
JOURNAL ARTICLE
Lei Wang, Xiaona Li, Lili Chen, Shenglan Mei, Qianni Shen, Lian Liu, Xuke Liu, Shichong Liao, Bo Zhao, Yannan Chen, Jiabao Hou
Ischemic stroke is a devastating disease in which mitochondrial damage or dysfunction substantially contributes to brain injury. Mitochondrial uncoupling protein-2 (UCP2) is a member of the UCP family, which regulates production of mitochondrial superoxide anion. UCP2 is reported to be neuroprotective for ischemic stroke-induced brain injury. However, the molecular mechanisms of UCP2 in ischemic stroke remain incompletely understood. In this study, we investigated whether and how UCP2 modulates neuroinflammation and regulates neuronal ferroptosis following ischemic stroke in vitro and in vivo...
June 14, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38871941/from-skin-and-gut-to-the-brain-the-infectious-journey-of-the-human-commensal-fungus-malassezia-and-its-neurological-consequences
#18
REVIEW
Bharati Naik, Jayaprakash Sasikumar, Shankar Prasad Das
The human mycobiome encompasses diverse communities of fungal organisms residing within the body and has emerged as a critical player in shaping health and disease. While extensive research has focused on the skin and gut mycobiome, recent investigations have pointed toward the potential role of fungal organisms in neurological disorders. Among those fungal organisms, the presence of the commensal fungus Malassezia in the brain has created curiosity because of its commensal nature and primary association with the human skin and gut...
June 14, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38869810/effects-of-micrornas-and-long-non-coding-rnas-on-beneficial-action-of-exercise-on-cognition-in-degenerative-diseases-a-review
#19
REVIEW
Zhen Han, Lei Zhang, Minhang Ma, Maryam Keshavarzi
Recent research has exposed a growing body of proof underscoring the importance of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in maintaining the physical composition of neurons and influencing cognitive functioning in both standard and atypical circumstances. Extensive research has been conducted on the possible application of miRNAs and lncRNAs as biomarkers for various diseases, with a particular focus on brain disorders, as they possess remarkable durability in cell-free surroundings and can endure repeated freezing and thawing processes...
June 13, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38867111/attenuation-of-nerve-agent-induced-neurodegenerative-and-neuroinflammatory-changes-in-rats-with-new-combination-treatment-of-galantamine-atropine-and-midazolam
#20
JOURNAL ARTICLE
Naveen Singh, RamaRao Golime, Abdhesh Kumar, Tuhin Roy
Acute nerve agent exposure can kill a person within minutes or produce multiple neurotoxic effects and subsequent brain damage with potential long-term adverse outcomes. Recent abuse of nerve-agents on Syrian civilians, during Japan terrorist attacks, and personal assassinations in the UK, and Malaysia indicate their potential threat to world population. Existing nerve agent antidotes offer only incomplete protection especially, if the treatment is delayed. To develop the effective drugs, it is advantageous to elucidate the underlying mechanisms of nerve agent-induced multiple neurological impairments...
June 13, 2024: Molecular Neurobiology
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