Andjela Stekic, Dejan Stevic, Tamara Dokmanovic, Marina Anastasov, Danica Popovic, Jelena Stanojevic, Milica Zeljkovic Jovanovic, Ivana Stevanovic, Nadezda Nedeljkovic, Milorad Dragic
Experimental autoimmune encephalomyelitis (EAE) is widely used animal model of multiple sclerosis (MS). The disease is characterized by demyelination and neurodegeneration triggered by infiltrated autoimmune cells and their interaction with astrocytes and microglia. While neuroinflammation is most common in the spinal cord and brainstem, it is less prevalent in the cerebellum, where it predisposes to rapid disease progression. Because the induction and progression of EAE are tightly regulated by adenosinergic signaling, in the present study we compared the adenosine-producing and -degrading enzymes, ecto-5'-nucleotidase (eN/CD73) and adenosine deaminase (ADA), as well as the expression levels of adenosine receptors A1 R and A2A R subtypes in nearby areas around the fourth cerebral ventricle-the pontine tegmentum, the choroid plexus (CP), and the cerebellum...
April 15, 2024: Molecular Neurobiology