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Journal of Biomaterials Applications

Jianguo Gao, Lingxiao Chen, Ruogu Qi, Zhihua Zhou, Zaian Deng, Jue Shi, Tao Qin, Shengzhe Zhao, Yuna Qian, Jianliang Shen
Combination of chemotherapy and small interfering RNA (siRNA)-based nanotherapeutics could cooperatively and effectively suppress multiple drug resistance in cancer development. Particularly, nano-delivery systems that efficiently encapsulate two or more therapeutic payloads to the tumor-targeted sites have been proven significantly. Here, we prepared a micellar nanoparticle formed by monomethoxy poly (ethylene glycol)-block-poly(ε-caprolactone)-block-poly(L-lysine)/cholesterol (mPEG-b-PCL-b-PLL/Chol, further abbr...
April 10, 2019: Journal of Biomaterials Applications
Yi Zhong, Wenlong Yang, Zi Yin Pan, Shu Pan, Si Quan Zhang, Zhi Hao Wang, Sijia Gu, Hongcan Shi
To establish the procedures of genipin-linked scaffold for in situ tracheal reconstruction in a rabbit model, and to demonstrate whether stem cells can be further differentiated in the bioreactor in vivo. It will further provide an experimental and theoretical foundation for clinical application. Previously, in vitro evaluation proved the detergent-enzymatic method effectively removed stromal epithelial cells, and the number of nuclei was reduced significantly ( p < 0.05). The content of type II collagen was not statistically reduced ( p > 0...
April 10, 2019: Journal of Biomaterials Applications
Sajad Bahrami, Nafiseh Baheiraei, Majid Mohseni, Mehdi Razavi, Atefeh Ghaderi, Behnam Azizi, Navid Rabiee, Mahdi Karimi
Myocardial infarction is one of the major causes of mortality throughout the world. Cardiac scaffolds are tissue-engineered structures for the treatment of myocardial infarction and are employed for tissue support and cell delivery to the injured region. In this study, we fabricated nanostructured graphene foams as porous and biocompatible cardiac tissue-engineering scaffolds. Three-dimensional graphene foam and two-dimensional graphene were fabricated using chemical vapor deposition. We showed that the nickel etching had no effect on the structural appearance of the three-dimensional graphene foam...
April 8, 2019: Journal of Biomaterials Applications
Hai Chi, Meng Kong, Guangjun Jiao, Wenliang Wu, Hongming Zhou, Lu Chen, Yini Qiao, Hongliang Wang, Wenzheng Ma, Yunzhen Chen
Silicon, an element, has been reported to possess various osteogenic biological functions. However, the precise cellular action mechanism of silicon in osteogenesis is elusive. Here, we examine whether autophagy is associated with the osteogenic differentiation and mineralization of preosteoblasts stimulated by orthosilicic acid (unique soluble form of silicon). The autophagy induced by silicon was detected via autophagy-related protein expression. The correlation between orthosilicic acid-induced autophagy and the osteogenic process was verified by the autophagy inhibitor 3-methyladenine...
April 8, 2019: Journal of Biomaterials Applications
Juan Cai, Keyang Qian, Xueliang Zuo, Wuheng Yue, Yinzhu Bian, Ju Yang, Jia Wei, Wenying Zhao, Hanqing Qian, Baorui Liu
Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. To overcome these shortcomings, we developed poly(lactic acid/glycolic) (PLGA) nanoparticles loaded with TXT and LY294002. PLGA facilitated the accumulation of TXT and LY294002 at the tumor sites...
April 5, 2019: Journal of Biomaterials Applications
Raasti Naseem, Liguo Zhao, Vadim Silberschmidt, Yang Liu, Ollie Scaife, Helen Willcock, Senthil Eswaran, Syed Hossainy
Polymeric stent is a temporary cardiovascular scaffold, made of biodegradable poly (l-lactic) acid, to treat coronary artery stenosis, with expected resorption by the human body over two to three years. In this paper, the mechanical properties of a polymeric stent over two-year in vitro degradation were studied and characterised using atomic force microscopy and nanoindentation techniques, complemented with analyses of weight loss, gel permeation chromatography and differential scanning calorimetry. Atomic force microscopy assessed stent degradation at the surface, whilst nanoindentation was able to investigate the property at a greater depth into the material...
April 5, 2019: Journal of Biomaterials Applications
Fengzhen Zhou, Wenjing Wang, Huiling Guo
Many studies have reported that silver has excellent antibacterial properties. However, silver ions can easily react with oxygen to form Ag2 O, thus leading to a color change and a reduction in its anti-microbial characteristics. In this study, silver triethanolamine- (ST) loaded PVB/CO solution was prepared as a potential candidate liquid bandage. PVB/CO/ST retained high transparency after exposure to light for 12 months, which allowed convenient inspection of the wound bed without removal of the dressing...
April 1, 2019: Journal of Biomaterials Applications
Jiangyu Cai, Li Zhang, Jun Chen, Shiyi Chen
Anterior cruciate ligament reconstruction using polyethylene terephthalate artificial ligaments is one of the research hotspots in sports medicine but it is still challenging to achieve biological healing. The purpose of this study was to modify polyethylene terephthalate ligament with silk fibroin through ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/N-hydroxysuccinimide (NHS) crosslink and to investigate the performance of graft remodeling in vitro and in vivo. After silk fibroin coating, changes in the surface properties of ligament were characterized by scanning electron microscopy, attenuated total reflectance-Fourier transform infrared spectroscopy and water contact angle measurements...
March 18, 2019: Journal of Biomaterials Applications
Ajinkya A Shitole, Prabhanjan S Giram, Piyush W Raut, Priyanka P Rade, Anand P Khandwekar, Neeti Sharma, Baijayantimala Garnaik
Biomaterials used as blood-contacting material must be hemocompatible and exhibit lower thrombotic potential while maintaining hemostasis and angiogenesis. With the aim of developing thromboresistant, hemocompatible nanofibrous scaffolds, polyurethane/polyethylene glycol scaffolds incorporated with 1, 5, and 10 wt% Clopidogrel were fabricated and evaluated for their physiochemical properties, biocompatibility, hemocompatibility, and antithrombotic potential. The results of physicochemical characterization revealed the fabrication of nanometer-sized scaffolds with smooth surfaces...
March 18, 2019: Journal of Biomaterials Applications
Chong Cheng, Cheng Li, Xulong Zhu, Wei Han, Jianhui Li, Yi Lv
Hepatocellular carcinoma (HCC) is one of the most common and malignant cancers and has no effective therapeutic approaches. Chemotherapeutic drug doxorubicin (DOX) is widely used for HCC therapy, but its application is limited by the clinical toxicity. In the present study, an Fe3 O4 -ZIF-8 magnetic nano-composite was fabricated and used for DOX delivery for HCC therapy. The morphology, structure and property of Fe3 O4 -ZIF-8 nano-composites were evaluated by scanning electron microscopy, transmission electron microscopy and N2 adsorption-desorption isotherms studies...
March 16, 2019: Journal of Biomaterials Applications
Beibei Zhang, Qi Liu, Mengyuan Liu, Peipei Shi, Lichong Zhu, Lu Zhang, Ruifang Li
Mesoporous silica nanoparticles have been extensively explored in anticancer nanomedicine due to their excellent biodegradability, which is one important focus in their further clinical translations. However, the traditional design concepts based on the functional modification with active groups cannot significantly improve the controlled drug release efficiency and anticancer effect. Herein, a molecularly organic-inorganic hybrid mesoporous silica nanoparticle (HMSN) nanocarrier coated with hyaluronic acid (HA) and polyethyleneimine (PEI) was constructed for the gene/chemo-synergetic therapy of breast cancer...
March 16, 2019: Journal of Biomaterials Applications
Juan J Martínez-Sanmiguel, Diana G Zarate-Triviño, Rene Hernandez-Delgadillo, Astrid L Giraldo-Betancur, Nayely Pineda-Aguilar, Sergio A Galindo-Rodríguez, Moisés A Franco-Molina, Sara P Hernández-Martínez, Cristina Rodríguez-Padilla
Biomaterials are often used in orthopedic surgery like cavity fillings. However, related complications often require long-term systemic antibiotics, device removal, and extended rehabilitation. Hydroxyapatite/silver (HA/Ag) composites have been proposed as implantation biomaterials owing to the osteogenic properties of hydroxyapatite and to the antimicrobial efficiency of silver. Nevertheless, higher silver concentrations induce cytotoxic effects. The aim of this study was to synthesize and characterize HA/Ag nanocomposites that will allow us to use lower concentrations of silver nanoparticles with better antimicrobial efficiency and anti-inflammatory properties...
March 16, 2019: Journal of Biomaterials Applications
Zohora Iqbal, Steven Kim, Jarrett Moyer, Willieford Moses, Emily Abada, Nathan Wright, Eun Jung Kim, Jaehyun Park, William H Fissell, Shuvo Roy
Highly uniform silicon nanopore membranes were developed for applications in implantable bioartificial organs. A robust, readily scalable, non-fouling surface coating is required to enhance silicon nanopore membrane hemocompatibility. However, the coating must be ultrathin to keep the nanopores from occluding. Recently, zwitterionic brush polymers have demonstrated significantly lower fouling under biological conditions. In this study, we explore ultrathin zwitterionic poly(sulfobetaine methacrylate) (pSBMA) surface coating at sub-5 nm thickness...
March 12, 2019: Journal of Biomaterials Applications
Yang Chen, Jinhe Dou, Huijun Yu, Chuanzhong Chen
Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing process. Alloying is an effective method to slow down the corrosion rate. However, currently magnesium alloys used as biomaterials are mostly commercial alloys without considering cytotoxicity from the perspective of biosafety...
March 9, 2019: Journal of Biomaterials Applications
Rashed Almouse, Xin Wen, Sungsoo Na, Gregory Anderson, Dong Xie
This study reports synthesis and attachment of a novel antibacterial and hydrophilic polymer onto a polyvinylchloride surface via a simple and mild surface coating technique. The compound 3,4-dichloro-5-hydroxy-2(5H)-furanone was derivatized and copolymerized with N-vinylpyrrolidone. The copolymer was then covalently coated onto polyvinylchloride surface. 3T3 mouse fibroblast cells and bacterium Pseudomonas aeruginosa were used to evaluate surface adhesion and antibacterial activity. Results showed that the polymer-modified polyvinylchloride surface not only exhibited significantly decreased 3T3 fibroblast cell adhesion with a 64-84% reduction but also demonstrated significantly decreased P...
March 6, 2019: Journal of Biomaterials Applications
Xiaoqiang Shang, Yun Long Li, Hao Chen, Lisha Yu, Zhugang Wang, Liping Xiao, Jie Fan
Zeolite is a multifunctional material, which recently exhibited promising prospects in emerging biological and medical applications. This study reported a new bio-inorganic hybrid of zeolite-fibrin clot composite serving as haemostatic agent in haemophilia A. The zeolite-fibrin clot composite promoted haemocompatibility and helped to achieve short clotting time both in vitro (22 ± 3 s vs. >600 s) and in vivo (4.5 min vs. >60 min) compared to control in coagulation factor VIII deficiency bleeding model...
February 28, 2019: Journal of Biomaterials Applications
Cornelia Wiegand, Martin Abel, Uta-Christina Hipler, Peter Elsner, Michael Zieger, Julia Kurz, Hans P Wendel, Sandra Stoppelkamp
BACKGROUND: Application of controlled in vitro techniques can be used as a screening tool for the development of new hemostatic agents allowing quantitative assessment of overall hemostatic potential. MATERIALS AND METHODS: Several tests were selected to evaluate the efficacy of cotton gauze, collagen, and oxidized regenerated cellulose for enhancing blood clotting, coagulation, and platelet activation. RESULTS: Visual inspection of dressings after blood contact proved the formation of blood clots...
February 21, 2019: Journal of Biomaterials Applications
Liancheng Xu, Yibing Guo, Yan Huang, Yang Xu, Yuhua Lu, Zhiwei Wang
Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mellitus and promoting insulin independence in patients, its widespread implementation has been severely constrained by instances of post-transplantation islet cell death, rejection, and severe adverse immune responses...
February 21, 2019: Journal of Biomaterials Applications
Barbara Jadach, Agnieszka Feliczak-Guzik, Izabela Nowak, Bartłomiej Milanowski, Hanna Piotrowska-Kempisty, Marek Murias, Janina Lulek
SBA-16 and two modified SBA-16 type ordered mesoporous silica were used as the carriers for ibuprofen (anti-inflammatory drug) and furosemide (loop diuretic drug). Modification of the solid carrier was prepared with chitosan or N-3[(amino(poly-propylenoxy)]aminopropyltrimethoxysilane. The samples of carriers and carrier-drug loaded materials were characterized by X-ray diffraction, N2 adsorption, Fourier-transform infrared spectroscopy, thermogravimetry, and differential scanning calorimetry. The release profiles of active pharmaceutical ingredients were performed in media with different pH in the USP 2 apparatus as well as in two biorelevant media (fasted state simulated gastric fluid and fasted state small intestinal fluid) in USP 4 apparatus...
February 21, 2019: Journal of Biomaterials Applications
Wei Fu, Peng Xu, Bei Feng, Yang Lu, Jie Bai, Jialiang Zhang, Wenjie Zhang, Meng Yin
The biocompatibility and bioactivity of injectable acellular extracellular matrix nominates its use as an optimal candidate for cell delivery, serving as a reconstructive scaffold. In this study, we investigated the feasibility of preparing a blood vessel matrix (BVM) hydrogel, which revealed its pro-angiogenic effects in vitro and its therapeutic effects in an in vivo skin flap model. Aortic and abdominal aortic arteries from pigs were acellularized by Triton-X 100 and confirmed by hematoxylin and eosin and 4,6-diamidino-2-phenylindole staining...
February 21, 2019: Journal of Biomaterials Applications
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