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Journal of Biomaterials Applications

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https://read.qxmd.com/read/31088193/corrigendum
#1
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May 15, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31088184/in-vivo-endothelialization-and-neointimal-hyperplasia-assessment-after-angioplasty-of-sheep-carotid-artery-with-a-novel-polycarbonate-polyurethane-patch
#2
Houman Jalaie, Julia Steitz, Mamdouh Afify, Mohammad Esmaeil Barbati, Konrad Hoeft, Mona Ali Mahmoud Assar, Benita Hermanns-Sachweh, Rene H Tolba, Michael J Jacobs, Karina Schleimer
The aim of this study was to compare two variants of a novel polycarbonate polyurethane prosthesis with polyethylene terephthalate (Dacron) prosthesis in an established sheep model of carotid patch angioplasty. Two variants of the polycarbonate polyurethane prosthesis were used: (1) Polycarbonate polyurethane equal (PCU-e) prosthesis consisted of a multilayered porous structure with equal internal and external layers; (2) Polycarbonate polyurethane with more porous inner layers (PCU-mp) prosthesis had more porous inner layers than external layers...
May 14, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31088183/cerium-containing-%C3%AE-calcium-sulfate-hemihydrate-bone-substitute-promotes-osteogenesis
#3
Haibo Xiang, Yu Wang, Hong Chang, Shenyu Yang, Mei Tu, Xianrong Zhang, Bin Yu
Bone substitute offers a promising strategy for the reconstruction of large bone defects. It may be feasible to develop a better substitute material by enhancing the osteoinductivity and delaying the degradation of α-calcium sulfate hemihydrate. In this study, nano cerium oxide was incorporated with α-calcium sulfate hemihydrate at weight ratios of 5 and 10% to form nano cerium oxide-containing α-calcium sulfate hemihydrate. Extracts from α-calcium sulfate hemihydrate, 5 and 10% nano cerium oxide-containing α-calcium sulfate hemihydrate were prepared for in vitro treatment of cells...
May 14, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31084233/ph-responsive-hyaluronic-acid-nanoparticles-coloaded-with-sorafenib-and-cisplatin-for-treatment-of-hepatocellular-carcinoma
#4
Wei Zhang, Jinzhen Cai, Bin Wu, Zhongyang Shen
Hepatocellular carcinoma is one of the severest malignant tumors with high mortality in patients. Sorafenib, a first-line drug, is extensively used for treating hepatocellular carcinoma. However, the efficacy of this chemotherapy treatment is limited in clinically due to the obstacles including rapid drug clearance from blood circulation, tumor drug resistance, and obvious adverse effects. To address those problems mentioned above, pH-sensitive hyaluronic acid nanoparticles were synthesized by crosslinking hyaluronic acid with cisplatin and encapsulating with sorafenib...
May 13, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31079557/the-target-therapeutic-effect-of-functionalized-graphene-oxide-nanoparticles-graphene-oxide-polyethylene-glycol-folic-acid-1-pyrenemethylamine-hydrochloride-mediated-rna-interference-of-hif-1%C3%AE-gene-in-human-pancreatic-cancer-cells
#5
Renming Wan, Yufen Luan, Zhouquan Wu, Shengming Deng, Mingya Peng, Longbao Xu, Yiwei Wu, Xihu Qin, Guanglei Fan
The folate receptor-targeted graphene oxide gene transfection nanoparticles (graphene oxide-polyethylene glycol-folic acid-1-pyrenemethylamine hydrochloride) were prepared and used to deliver RNAi that specifically target the HIF-1α expression in pancreatic cancer Patu8988 cells. The gene expressions of HIF-1α and glucose transporter-1 (Glut-1) were determined by Western blot and reverse transcription PCR (RT-PCR). The transwell invasion chamber method was used to determine the invasive ability of Patu8988 cells, and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the proliferation of Patu8988 cells before and after transfection...
May 12, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31060420/latent-stem-cell-stimulating-therapy-for-regeneration-of-chronic-tympanic-membrane-perforations-using-igfbp2-releasing-chitosan-patch-scaffolds
#6
Hoon Seonwoo, Seung Won Kim, Beomyong Shin, Kyoung-Je Jang, Myungchul Lee, Oak-Sung Choo, Mi-Jin Choi, Jangho Kim, Ki-Taek Lim, Jeong Hun Jang, Jong Hoon Chung, Yun-Hoon Choung
Chronic tympanic membrane perforation is a tubotympanic disease caused by traumatic or inflammatory factors. To date, numerous therapeutic methods have been used to heal tympanic membrane perforations. However, stem cell-based therapies have been used only rarely for the regeneration of chronic tympanic membrane perforations, because tympanic membrane is always exposed to the external environment. Therefore, the use of latent stem cells to treat the tympanic membrane may be possible for the regeneration of chronic tympanic membrane perforations...
May 6, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31053039/anti-inflammatory-effect-of-rosuvastatin-using-diblock-amphiphilic-copolymer-synthesis-characterization-in-vitro-and-in-vivo-study
#7
Mozhgan Aghajanzadeh, Farhang Ghannad, Mostafa Zamani, Sina Andalib, Hossein Danafar
In this study, we synthesized methoxy poly(ethylene glycol)-poly(ε-caprolactone) diblock copolymers as water soluble nanocarriers to investigate the in vivo anti-inflammatory characteristic of rosuvastatin-loaded nanocarriers. For determining the structure of prepared nanocarriers, we used proton nuclear magnetic resonance, gel permeation chromatography, Fourier-transform infrared spectroscopy, atomic force microscopy, and dynamic scanning calorimetry method. Nano-precipitation method was used for loading of rosuvastatin into copolymeric nanocarriers...
May 3, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31046511/nano-amorphous-calcium-phosphate-doped-with-citrate-fabrication-structure-and-evaluation-of-the-biological-performance
#8
Xiao Mei Wang, Yonggang Yan, Hao Hao Ren, Shu Yang Li
Amorphous calcium phosphate, a precursor phase of the bone mineral in vertebrates, is limited owing to its instability. A simple wet-chemical precipitation method was developed in this study to prepare stable and nanosized amorphous calcium phosphates doped with citrate using orthophosphoric acid, anhydrous critic acid, and anhydrous calcium chloride as the raw materials in an alcohol system at room temperature. The structure of the obtained nanosized amorphous calcium phosphate doped with citrate was evaluated by an X-ray diffraction analysis, Fourier transform-infrared spectroscopy, X-ray photoelectron spectrometry, high-resolution transmission electron microscopy and selected area electron diffraction...
May 2, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31046510/dopamine-assisted-immobilization-of-peptide-arginine-glycine-aspartic-acid-to-enhance-the-cellular-performances-of-mc3t3-e1-cells-of-carbon-carbon-composites
#9
Xiaoling Yang, Xue Liu, Qianqian Wu, Xu Lv, Bo Li, Hongzhe Sun, Wenfeng Xu, Xiaoling Liao
Due to their excellent biocompatibility and suitable elastic modulus, carbon-carbon composites have excellent prospects for a wide range of applications such as artificial joints and bone replacements. However, the hydrophobicity and poor bioactivity limit their application in bone repair and substitution. Herein, a two-step surface modification of carbon-carbon composites was proposed to overcome these disadvantages. A polydopamine (PDA) layer was first deposited on the surface of carbon-carbon composites, followed by covalent coupling with arginine-glycine-aspartic acid (RGD) in varying concentrations...
May 2, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31042123/copper-nanoparticles-stabilized-with-cashew-gum-antimicrobial-activity-and-cytotoxicity-against-4t1-mouse-mammary-tumor-cell-line
#10
Adriany Amorim, Ana Carolina Mafud, Silvania Nogueira, Joilson Ramos- Jesus, Alyne Rodrigues de Araújo, Alexandra Plácido, Maria Brito Neta, Michel Muálem Moraes Alves, Fernando Aécio Amorim Carvalho, Daniel Dias Rufino Arcanjo, Sacha Braun, Marta Sánchez-Paniagua López, Beatriz López-Ruiz, Cristina Delerue-Matos, Yvonne Mascarenhas, Durcilene Silva, Peter Eaton, José Roberto Souza Almeida Leite
Copper nanoparticles stabilized with cashew (CG-CuNPs) were synthesized by reduction reaction using ascorbic acid and sodium borohydride, using the cashew gum (CG) as a natural polymer stabilizer. Dynamic light scattering, atomic force microscopy, Fourier-transform infrared spectroscopy, UV-Vis spectrophotometry, and x-ray diffraction were used to characterize the nanoparticles (CG-CuNPs), and copper was quantified by electrochemical measurement. The UV-vis spectra of the CG-CuNPs confirmed the formation of nanoparticles by appearance of a surface plasmon band at 580 nm after 24 h of reaction...
May 1, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31042122/bioactive-tetracalcium-phosphate-magnesium-phosphate-composite-bone-cement-for-bone-repair
#11
Jingxian Liu, Jianguo Liao, Yanqun Li, Zhengpeng Yang, Qiwei Ying, Yufen Xie, Aiguo Zhou
In order to acquire a tetracalcium phosphate/magnesium phosphate (TTCP/MPC) composite bone cement that combines the excellent bioactivity of TTCP and high mechanical strength of MPC, the cement was made and the compressive strength, phase composition of hardened cement, degradation in vitro, and tissue responses in vivo by implantation of TTCP/MPC in bone defect of rabbits were investigated. The results showed that TTCP/MPC was with a markedly better mechanical property than MPC. Moreover, compared with MPC, TTCP/MPC showed significantly delayed degradability in simulated body fluid...
May 1, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31027447/effects-of-bio-inspired-bioglass-collagen-magnesium-composites-on-bone-repair
#12
Paulo Roberto Gabbai-Armelin, Hueliton Wilian Kido, Kelly Rossetti Fernandes, Carlos Alberto Fortulan, Ana Claudia Muniz Renno
Bone disorders and fractures affect millions of people worldwide. In critical situations, proper healing may not happen which may lead to non-union fractures. Consequently, the development of new clinical approaches is necessary. In this context, the present work developed bioglass/collagen/magnesium composites in order to mimic natural bone, toward the enhancement of material mechanical properties, but keeping bioactivity and performance of bioglass and collagen. So, the aim of this investigation was to explore the biological outcomes of bioglass/collagen/magnesium composites over bone repair, using tibial defect in Wistar rats...
April 26, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31027446/bombyx-mori-silk-based-materials-with-implication-in-skin-repair-sericin-versus-regenerated-silk-fibroin
#13
Dihan Su, Shenglong Ding, Weiliang Shi, Xuefeng Huang, Libo Jiang
Recently, regenerated silk fibroin is one of the most investigated silk-based materials for tissue engineering. However, it needs complex preparation process and will irresistibly denature to solid state with time, which is the biggest challenge to produce in large scale and widely use it as commercial material. In this work, industrially produced sericin, silk fibroin amino acid, and silk fibroin powder were investigated on its physico-chemical and biological properties compared with laboratory prepared regenerated silk fibroin, in order to excavate the potential application in biomedical and therapeutical fields...
April 26, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31023127/acid-labile-hyperbranched-poly-ortho-ester-amido-amine-as-efficient-gene-carriers-preparation-characterization-and-in-vitro-evaluation
#14
Shuting Li, Liefeng Hu, Jun Wang, Guo Yan, Xin Wang, Dapeng Li, Xiaoli Zeng, Rupei Tang
Cationic polymers have become one of the most promising synthetic vectors for gene transfection, however, their translation to the clinic has been severely hampered because of their high cytotoxicity and polyplex instability in serum. Herein, we report the design and synthesis of a new type of pH-sensitive hyperbranched poly(ortho ester amido amine) (HPOEAMAM) by the use of ortho ester bonds to give a non-viral vector with high efficiency and safety in two-dimensional (2D) cells and three-dimensional (3D) multicellular tumor spheroids...
April 25, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31014208/applications-of-starch-and-its-derivatives-in-bioceramics
#15
Joanna Mastalska-Popławska, Marek Sikora, Piotr Izak, Zuzanna Góral
The recent developments in the area of using starch in ceramics cover such fields like ceramic powders synthesis, where starch can be a polymerizing agent in sol-gel method or substrate for carbon spheres in hydrothermal synthesis, traditional ceramics manufacturing in which starch and its derivatives are being used as binders, rheological modifiers or even strengthening agents, as well as porous ceramics and bioceramics where starch plays mostly a role of pore forming agent. Due to the low dimensional changes occurring during the consolidation process, starch can help to control porosity of the bioceramics, which leads to better mechanical properties of the final product...
April 23, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31006317/a-novel-3d-printed-silk-fibroin-based-scaffold-facilitates-tracheal-epithelium-proliferation-in-vitro
#16
Nongping Zhong, Tao Dong, Zhongchun Chen, Yongwei Guo, Zhengzhong Shao, Xia Zhao
The functional epithelial regeneration is important for repairing tracheal defects. However, the potential of 3D-printed SF-based scaffolds for tracheal epithelial regeneration is still unknown. In this study, we developed a novel silk fibroin-based scaffold prepared by 3D printing of silk fibroin/hydroxypropyl methyl cellulose (SF/HPMC) thixotropic hydrogel and evaluated the tracheal epithelium proliferation on this scaffold in vitro. Combined with the freeze-dried technology, the 3D-printed SF/HPMC scaffolds had porous structures in the printed bars...
April 20, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/31006316/importance-of-the-free-amine-groups-in-acellular-scaffold-during-tissue-repairing-or-regeneration-process
#17
Tengfei Pan, Jian Tao, Qingqiang Meng, Wei Zhao, Bingkui Song, Shuting Qi
In addition to serve as a physical scaffold, acellular scaffold should be involved in tissue repair processes such as hemostasis, inflammation, proliferation, and remodeling/regeneration as a bioactive material. The biological activities of acellular scaffold related to free amine groups may have a great influence on tissue repairing process after in situ implantation. In order to investigate the role of free amine groups in acellular scaffold on tissue repairing/regeneration process, the amine-blocked acellular scaffolds and amine-unblocked acellular scaffolds were prepared by using bovine pericardia...
April 20, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30991878/sol-gel-preparation-of-anti-bacterial-and-bioactive-glass-ceramics
#18
Beijing Xue, Wenhao Wang, Litong Guo, Zhongxuan Zhang, Jiaxi Meng, Xueyu Tao, Xuanru Ren, Zhangsheng Liu, Yinghuai Qiang
Glass-ceramics were synthesized through the sol-gel method. The Thermogravimetry & Differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD), BET, Scanning electron microscope (SEM), bioactivity and turbidometric tests were used to characterize the properties of the glass-ceramics. The TG-DSC results showed that the nitrates could be decomposed completely when the bioactive glass xerogel precursor was heat treated at 750°C. The synthesized glass-ceramic powders had an average particle size of about 3 μm to 20 μm with nanopores on the surface...
April 16, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30987507/targeted-pharmacokinetics-of-polymeric-micelles-modified-with-glycyrrhetinic-acid-and-hydrazone-bond-in-h22-tumor-bearing-mice
#19
Yan Zheng, Shudan Shi, Yaru Liu, Yandan Zhao, Yuqi Sun
Liver cancer is one of the most common malignant tumors. Chemotherapy drugs have been widely used in the anti-hepatoma research. However, low targeting efficiency and serious adverse reaction are their main drawbacks. Liver tumor was proved to have a slightly acidic microenvironment (pH 4.5-5.5) and many glycyrrhetinic-acid-specific binding sites. Therefore, in the present study, the glycyrrhetinic acid- and hydrazone bond-modified micelles were designed. mPEG-HZ-PLA and GA-PEG-PLA copolymer were synthesized to prepare glycyrrhetinic-acid-modified pH-sensitive polymeric micelles (GA-PEG-HZ-PLA)...
April 16, 2019: Journal of Biomaterials Applications
https://read.qxmd.com/read/30987506/evaluation-of-comparative-soft-tissue-response-to-bone-void-fillers-with-antibiotics-in-a-rabbit-intramuscular-model
#20
Rema A Oliver, Vedran Lovric, Chris Christou, William R Walsh
Management of osseous and soft tissue dead space can be a significant challenge in the clinical setting. Calcium sulphate and calcium phosphate-based biomaterials are increasingly being used as alternatives to PMMA for local release of antibiotics, in particular to fill dead space following surgical debridement. This study aims to observe the in-vivo absorption characteristics and tissue response of three commercially available calcium sulphate-based materials combined with gentamicin in an established soft tissue rabbit model...
April 16, 2019: Journal of Biomaterials Applications
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