Joshua G Kovoor, Clara K Chow, Abdul Salam, Ruth Webster, Louise Shiel, Mark R Nelson, Jacquita S Affandi, Peter Hay, Michael Burke, Gemma A Figtree, Tim Usherwood, Christopher M Reid, Markus P Schlaich, Anthony Rodgers, Emily R Atkins
Single-pill combination therapy containing four quarter-dose medications for high blood pressure improves BP control compared to monotherapy, however patient-reported acceptance of the quadpill as a treatment strategy remains undescribed. We collected within-trial feedback and interviewed participants from the quadruple ultra-low-dose treatment for hypertension (QUARTET) trial to characterise patient attitudes to this intervention. All trial participants were asked about ease and preference for the quadpill and provided an opportunity to give further comments on the trial at 12 weeks (trial primary endpoint) and 52 weeks extended follow-up...
May 14, 2024: Journal of Human Hypertension
Lebo F Gafane-Matemane, Ashleigh Craig, Ruan Kruger, Omotayo S Alaofin, Lisa J Ware, Erika S W Jones, Andre Pascal Kengne
Recent global and regional reports consistently confirm the high and increasing prevalence of hypertension in sub-Saharan Africa (SSA), with poor detection, treatment, and control rates. This narrative review summarises the burden of hypertension in SSA and recent findings from community-based hypertension management strategies. We further outline prominent risk factors according to recent data and associated underlying mechanisms for hypertension development. An extensive review of literature showed that most countries have reported on the prevalence of hypertension during 2017-2023, despite limitations linked to the lack of nationally representative studies, heterogeneity of sampling and data collection methods...
May 2, 2024: Journal of Human Hypertension
Ahmad Neyazi, Abdul Qadim Mohammadi, Mehrab Neyazi, Shashank Timilsina, Bijaya Kumar Padhi, Mark D Griffiths
In recent decades, hypertension has become the foremost risk factor for disability-adjusted life years (DALYs). The present study investigated the relationship between quality of life, depression, and hypertension among hospitalized patients in Afghanistan. A cross-sectional survey was administered from September 3, 2022, to February 2, 2023, in the Herat and Mazar-e-Sharif provinces of Afghanistan (N = 2059). The prevalence of depression symptoms was 65.8%, and hypertension was 20.9%. Multiple regression analysis indicated that moderate physical functioning, poor role-physical, higher bodily pain, poor general health, poor social functioning, lower role-emotional, and poor mental health significantly predicted depression...
April 29, 2024: Journal of Human Hypertension
Isabella Hunjan, Alice Umulisa, Gianfranco Parati, Mario G Bianchetti, Gregorio P Milani, Bienvenu Muvunyi, Evariste Ntaganda, Dragana Radovanovic, Clara Stroppa, Paolo Suter, Franco Muggli
In rural sub-Saharan Africa, knowledge of non-communicable diseases such as high blood pressure (BP) is rather limited. This report provides information about a BP screening in Mata Sector, a rural region in Southern Province of Rwanda. Community-based, house-to-house screening was performed between February and July 2020 on more than 7000 inhabitants. The screening was conducted by a local team composed by 20 community health care workers, five community health care supervisors, and one nurse with hypertension surveillance training...
April 24, 2024: Journal of Human Hypertension
Katerina Massengale, Yanyan Xu, Harold Snieder, Shaoyong Su, Xiaoling Wang
Altered blood pressure (BP) circadian rhythmicity has been increasingly linked with cardiovascular risk. However, little is known about BP circadian rhythm change with age and its possible sociodemographic, anthropometric, and genetic moderators. Twenty-four-hour ambulatory BP was measured up to 16 times over a 23-year period in 339 European Americans (EAs) and 293 African Americans (AAs), with an average age of 15 years at the initial visit. BP circadian rhythms were indexed by amplitude and percent rhythm (a measure of rhythm integrity) and calculated using Fourier analysis...
April 16, 2024: Journal of Human Hypertension
Yang Zhao, Xueru Fu, Yamin Ke, Yuying Wu, Pei Qin, Fulan Hu, Ming Zhang, Dongsheng Hu
Our aim was to examine the independent and joint associations of estimated cardiorespiratory fitness (CRF) and its changes and obesity with risk of hypertension in a rural Chinese population. A prospective cohort including 9848 adults without hypertension at baseline was enrolled. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated by logistic regression models. Restricted cubic splines were used to model the dose-response relationship. During 6 years follow-up, 2,019 individuals developed hypertension...
April 10, 2024: Journal of Human Hypertension
Päivi A Lempiäinen, Antti Ylitalo, Heikki Huikuri, Y Antero Kesäniemi, Olavi H Ukkola
Non-dipping blood pressure (BP) pattern is a predictor for cardiovascular (CV) events and mortality. We evaluated dipping status change and its association with incidence of non-fatal CV events in middle-aged subjects. The OPERA study was carried out during the years 1991-1993, with a follow-up study 21.7 years later. In this study, we included 452 participants with 24-h ambulatory BP measurements (ABPM) available in both surveys. The study population was divided into four groups according to the dipping pattern change: dipping-dipping (n = 152/33...
April 3, 2024: Journal of Human Hypertension
Nicolás Roberto Robles, Francesco Fici, Guido Grassi
No abstract text is available yet for this article.
March 21, 2024: Journal of Human Hypertension
Stephen D Persell, Lauren Anthony, Yaw A Peprah, Ji Young Lee, Jim Li, Hironori Sato, Lucia C Petito
This pragmatic matched cohort study using EHR data extended the follow up to 18 months for BP outcomes comparing individuals prescribed remote patient monitoring (n = 288) and temporally-matched controls (n = 1152) from six primary care practices. After 18 months, the RPM-prescribed cohort had greater BP control < 140/90 mm Hg (RPM cohort: 71.5%, control cohort: 51.9%, p < 0.001) and lower systolic BP (131.6 versus 136.0 mm Hg, p = 0...
March 6, 2024: Journal of Human Hypertension
Paul Olowoyo, Anastase Dzudie, Akinkunmi Paul Okekunle, Reginald Obiako, Ana Mocumbi, Hind Beheiry, Gianfranco Parati, Daniel T Lackland, Fred S Sarfo, Augustine Odili, Abiodun M Adeoye, Kolawole Wahab, Charles Agyemang, Norman Campbell, Andre Pascal Kengne, Paul K Whelton, Pierpaolo Pellicori, Ad Adams Ebenezer, Oladimeji Adebayo, Oladotun Olalusi, Ayodele Jegede, Ezinne Uvere, Olayinka Adebajo, Baffour Awuah, Andrew Moran, Bryan Williams, Tomasz J Guzik, Collins Kokuro, Fred Bukachi, Okechukwu S Ogah, Christian Delles, Pasquale Maffia, Rufus Akinyemi, Prebo Barango, Dike Ojji, Mayowa Owolabi
The prevalence of hypertension, the commonest risk factor for preventable disability and premature deaths, is rapidly increasing in Africa. The African Control of Hypertension through Innovative Epidemiology, and a Vibrant Ecosystem [ACHIEVE] conference was convened to discuss and initiate the co-implementation of the strategic solutions to tame this burden toward achieving a target of 80% for awareness, treatment, and control by the year 2030. Experts, including the academia, policymakers, patients, the WHO, and representatives of various hypertension and cardiology societies generated a 12-item communique for implementation by the stakeholders of the ACHIEVE ecosystem at the continental, national, sub-national, and local (primary) healthcare levels...
February 29, 2024: Journal of Human Hypertension
Yingting Zuo, Shuohua Chen, Xue Tian, Shouling Wu, Anxin Wang
It has not been fully investigated whether improved arterial stiffness (AS) can reduce the clinical outcomes risk in community population-based study. In this prospective study, a total of 5247 individuals with abnormal AS (at baseline) and repeated brachial-ankle pulse wave velocity (baPWV) measurement before 2018 years were enrolled from the Kailuan Study. According the second baPWV measurement, we divided the participants into two groups, improved AS (defined as transfer elevated AS status to normal) and persistent AS (defined as maintaining elevated AS status)...
February 27, 2024: Journal of Human Hypertension
Andrew O Agbaje
This study examined the mediating effect of total body fat mass, lean mass, blood pressure (BP) and insulin resistance on the associations of sedentary time (ST), light physical activity (LPA) and moderate-to-vigorous PA (MVPA) with carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT) and carotid elasticity in 1574 adolescents from the Avon Longitudinal Study of Parents and Children birth cohort, UK. ST, LPA and MVPA were assessed with ActiGraph accelerometer. ST and LPA were sex-categorised in tertiles as low (reference), moderate and high, while MVPA was categorised as <40 min/day (reference), 40-<60 min/day and ≥60 min/day...
February 26, 2024: Journal of Human Hypertension
Alexander S Macdonald, Alex McConnachie, David Alexander Dickie, Philip M Bath, Kirsten Forbes, Terence Quinn, Niall M Broomfield, Krishna Dani, Alex Doney, Keith W Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Paul Guyler, Ahamad Hassan, Mark Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Jesse Dawson
Blood Pressure Variability (BPV) is associated with cardiovascular risk and serum uric acid level. We investigated whether BPV was lowered by allopurinol and whether it was related to neuroimaging markers of cerebral small vessel disease (CSVD) and cognition. We used data from a randomised, double-blind, placebo-controlled trial of two years allopurinol treatment after recent ischemic stroke or transient ischemic attack. Visit-to-visit BPV was assessed using brachial blood pressure (BP) recordings. Short-term BPV was assessed using ambulatory BP monitoring (ABPM) performed at 4 weeks and 2 years...
April 2024: Journal of Human Hypertension
Liping Huang, Qiang Li, Jason Hy Wu, Maoyi Tian, Xuejun Yin, Jie Yu, Yishu Liu, Xinyi Zhang, Yangfeng Wu, Ellie Paige, Kathy Trieu, Matti Marklund, Anthony Rodgers, Bruce Neal
The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major cardiovascular events and total mortality with the use of potassium-enriched salt. The contribution of sodium reduction versus potassium increase to these effects is unknown. We identified four different data sources describing the association between sodium reduction, potassium supplementation and change in SBP. We then fitted a series of models to estimate the SBP reductions expected for the differences in sodium and potassium intake in SSaSS, derived from 24-h urine collections...
February 21, 2024: Journal of Human Hypertension
Susanna M Kuneinen, Hannu Kautiainen, Mikael O Ekblad, Päivi E Korhonen
The aim of this study was to investigate if mortality during a 13-year follow-up varied between normotensive subjects, screen-detected hypertensive subjects, and subjects with antihypertensive medication at baseline. A population-based screening and intervention program identified 2659 apparently healthy, middle-aged cardiovascular-risk persons in southwestern Finland. Screen-detected hypertension was verified by home blood pressure measurements. Lifestyle counseling was provided for all participants and preventive medications were started or intensified if needed...
February 20, 2024: Journal of Human Hypertension
Rebecca Hanna
No abstract text is available yet for this article.
February 20, 2024: Journal of Human Hypertension
Ge Tian, Rong Zhou, Xingzhi Guo, Rui Li
Observational studies have indicated that high blood pressure (BP) may be a risk factor to frailty. However, the causal association between BP and frailty remains not well determined. The purpose of this bi-directional two-sample Mendelian randomization (MR) study was to investigate the causal relationship between BP and frailty. Independent single nucleotide polymorphisms (SNPs) strongly (P < 5E-08) associated with systolic BP (SBP), diastolic BP (DBP), and pulse pressure (PP) were selected as instrumental variables...
February 15, 2024: Journal of Human Hypertension
Daniel González-Devesa, Silvia Varela, Jose C Diz-Gómez, Carlos Ayán-Pérez
This study aimed to systematically review the available evidence on the effects of Pilates training programs on blood pressure in hypertensive patients. Randomized clinical trials and comparative studies were searched in four electronic databases until September 2023 (updated December 2023). The methodological quality of included studies was assessed using the Physiotherapy Evidence Database and Methodological Index for Non-Randomized Studies scales. A total of 4 randomized clinical trials and 7 comparative studies were included, showing a low (n = 1), hight (n = 6), and good (n = 4) methodological quality...
February 15, 2024: Journal of Human Hypertension
Willington Amutuhaire, Fred Collins Semitala, Isaac Derick Kimera, Christabellah Namugenyi, Frank Mulindwa, Rebecca Ssenyonjo, Rodgers Katwesigye, Frank Mugabe, Gerald Mutungi, Isaac Ssinabulya, Jeremy I Schwartz, Anne R Katahoire, Lewis S Musoke, George A Yendewa, Chris T Longenecker, Martin Muddu
In this cohort study, we determined time to blood pressure (BP) control and its predictors among hypertensive PLHIV enrolled in integrated hypertension-HIV care based on the World Health Organization (WHO) HEARTS strategy at Mulago Immunosuppression Clinic in Uganda. From August 2019 to March 2020, we enrolled hypertensive PLHIV aged [Formula: see text]18 years and initiated Amlodipine 5 mg mono-therapy for BP (140-159)/(90-99) mmHg or Amlodipine 5 mg/Valsartan 80 mg duo-therapy for BP ≥ 160/90 mmHg...
February 1, 2024: Journal of Human Hypertension
Biggie Baffour-Awuah, Melody Man, Karla F Goessler, Véronique A Cornelissen, Gudrun Dieberg, Neil A Smart, Melissa J Pearson
Blood pressure (BP) management reduces the risk of cardiovascular disease (CVD). The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating and maintaining blood volume and pressure. This analysis aimed to investigate the effect of exercise training on plasma renin, angiotensin-II and aldosterone, epinephrine, norepinephrine, urinary sodium and potassium, BP and heart rate (HR). We systematically searched PubMed, Web of Science, and the Cochrane Library of Controlled Trials until 30 November 2022...
February 2024: Journal of Human Hypertension
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