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Journal of Human Hypertension

Abhishek Goyal, Kanika Narang, Gautam Ahluwalia, P M Sohal, Bhupinder Singh, Shibba T Chhabra, Naved Aslam, Bishav Mohan, Gurpreet S Wander
The clinical and experimental data on seasonal variation in blood pressure is mainly from office and home blood pressure (BP) monitoring studies. There are few studies from temperate climates on seasonal changes with ambulatory blood pressure (ABP) monitoring and none from India. This is a prospective, observational study among healthy adults. ABP was measured in four different seasons in 28 subjects. Mean arterial pressure (MAP), ambulatory systolic blood pressure (SBP), and ambulatory diastolic blood pressure (DBP) were significantly higher in winter compared to summer season...
February 12, 2019: Journal of Human Hypertension
Virginia Boccardi, Mohsen Taghizadeh, Sina Amirjani, Sadegh Jafarnejad
The aim of the comprehensive meta-analysis was to systematically explore the reductive effect of α-lipoic acid (ALA) supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP). The related records were selected from PubMed, Scopus, EMBASE, Cochrane library, and Persian databases including SID and Magiran from earliest date 1980 until August 2018. The heterogeneities were assessed by I2 test (I2 < 50%) and χ2 test on Cochrane's Q statistic. Standardized mean difference (SMD) and their 95% confidence intervals (CIs) were estimated for change in SBP and DBP...
February 11, 2019: Journal of Human Hypertension
Jing Fu, Chunfang Li, Wenli Gou, Arier Lee, Xuelan Li, Qi Chen
Today the only effective "treatment" for preeclampsia is to deliver at the optimal time for both maternal and foetal well-being. Studies reported that severe preeclampsia can benefit from the expectant management including mild preeclampsia between 34 and 37 weeks. However it is unclear whether mild preeclampsia before 34 weeks also benefits from the expectant management. Data on 274 women with mild preeclampsia before 37 weeks of gestation were retrospectively collected and analysed. Blood pressure and proteinuria at time of onset were not clinically associated with delivery time...
February 11, 2019: Journal of Human Hypertension
Elena Critselis, Christina Chrysohoou, Natasa Kollia, Ekavi N Georgousopoulou, Dimitrios Tousoulis, Christos Pitsavos, Demosthenes B Panagiotakos
The study evaluated the extent to which high normal blood pressure (HNBP), elevated BP, and Stage 1 hypertension predict 10-year incidence of cardiovascular disease (CVD). A population-based, prospective cohort study was conducted among 3042 randomly selected Greek adults, aged 18-89 years. Following 10-years follow-up (2002-2012), incidence of non-fatal and fatal CVD (ICD-10) was achieved in 2020 participants. The analytic sample (n = 1403) excluded hypertensive patients. At baseline, the prevalence rate of HNBP, elevated BP, and Stage 1 hypertension was 44...
February 11, 2019: Journal of Human Hypertension
Aihua Wu, Martin Wolley, Michael Stowasser
Renal salt handling has a profound effect on body fluid and blood pressure (BP) maintenance as exemplified by the use of diuretic medications to treat states of volume expansion or hypertension. It has recently been proposed that a low potassium (K+ ) intake turns on a "renal K+ switch" which increases sodium (Na+ ) and chloride (Cl- ) reabsorption, causing salt-retention, and in susceptible individuals, this causes hypertension. A signaling network, involving with-no-lysine (WNK) kinases, underpins the switch activity to coordinate aldosterone's two essential actions (K+ secretion and Na+ retention)...
February 5, 2019: Journal of Human Hypertension
Thomaitsa Nika, Stella Stabouli, Konstantinos Kollios, Kyriaki Papadopoulou-Legbelou, Nikoleta Printza, Christina Antza, Fotios Papachristou, Vasilios Kotsis
This school-based screening study assessed the prevalence of high blood pressure (BP) levels according to the European Society of Hypertension (ESH) 2016 guidelines. Moreover, risk factors for BP elevation, and the effect of geographic and seasonal factors on BP screening were investigated. BP and anthropometric measurements were obtained from 2832 children and adolescents, aged 6-18 years, during the period 2013-2016. Three BP measurements were performed using a mercury sphygmomanometer, and the mean of the last two was used for the analysis...
January 21, 2019: Journal of Human Hypertension
Daiji Nagayama, Yasuhiro Watanabe, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
This study aimed to investigate the association of cardio-ankle vascular index (CAVI), an arterial stiffness parameter, with four blood pressure (BP) indices, systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP) and mean BP (MBP), in real-world population including untreated hypertension. We analyzed the cross-sectional data from 23,257 Japanese subjects (12,729 men and 10,528 women, aged 47.1 years) without a past history of cardiovascular disease, stroke, hypertension, diabetes or dyslipidemia. Gender differences in four BP indices were slight, but significant for SBP, DBP and MBP...
January 18, 2019: Journal of Human Hypertension
A Tagetti, S Bonafini, T Ohlsson, G Engström, P Almgren, P Minuz, G Smith, O Melander, C Fava
A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdominal (AAA) aortic aneurysm. More than 25,000 people from the Swedish Malmo Diet and Cancer Study had information on at least 24 SNPs and were followed up for a median ≥ 18 years...
January 18, 2019: Journal of Human Hypertension
Shiva Raj Mishra, Saruna Ghimire, Nipun Shrestha, Archana Shrestha, Salim S Virani
With an aim to examine the socio-economic inequalities in prevalence, awareness, treatment, and control of hypertension, this study analyzed 14,823 adults, 15 years or older with blood pressure measured, in the 2016 Nepal Demographic Health Survey. Multi-variable logistic regression and Lorenz curves were used to explore the inequalities. The prevalence of hypertension was 19.5% (95% CI: 18.3-20.7). Further, of the total hypertensive, the prevalence of hypertension awareness, treatment and control was 40.0% (95% CI: 37...
January 18, 2019: Journal of Human Hypertension
Carina Ureche, Laura Tapoi, Simona Volovat, Luminita Voroneanu, Mehmet Kanbay, Adrian Covic
First described in 1998, apelin is one of the endogenous ligands of the apelinergic receptor. Since its discovery, its possible role in human physiology and disease has been intensively studied. Apelin is a native cardioprotective agent that the body synthesizes to create atheroprotective, antihypertensive, and regenerative effects in the body. By antagonizing the RAA system, apelin could play an important role in heart failure and hypertension. It is also involved in myocardial protection against ischemia/reperfusion injury, post-ischemic remodeling, and myocardial fibrosis...
January 18, 2019: Journal of Human Hypertension
Masanari Kuwabara, Koichiro Niwa, Minoru Ohno, Ichiro Hisatome
The desirable distribution of three major nutrients intake to prevent hypertension is not established. This study is to clarify the relationship between the prevalence of hypertension and the rate of intake of three major nutrients. This is a large-scale cross-sectional study. We analyzed Japanese subjects who had their annual medical examination at St Luke's International Hospital, Tokyo from January 2004 to June 2010. The amount of three major nutrients and salt intake were checked by a questionnaire method, and this study clarified the relationship between the prevalence of hypertension and the rate of three major nutrients with adjustment for age, sex, body mass index (BMI), smoking, dyslipidemia, diabetes mellitus, hyperuricemia, and salt intake...
January 15, 2019: Journal of Human Hypertension
Maryam Akbari, Vahidreza Ostadmohammadi, Naghmeh Mirhosseini, Kamran B Lankarani, Reza Tabrizi, Zahra Keshtkaran, Russel J Reiter, Zatollah Asemi
The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the potential effect of melatonin supplementation on blood pressure in patients with metabolic disorders. The following databases were searched until June 2018: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Two reviewers independently assessed the eligibility of retrieved studies, extracted data from included trials, and evaluated the risk of bias of included studies...
January 15, 2019: Journal of Human Hypertension
Hemlata Pisal, Kamini Dangat, Karuna Randhir, Amrita Khaire, Savita Mehendale, Sadhana Joshi
Micronutrients like vitamin B12 and folate play an important role in nucleic acid metabolism, cell growth, and are important determinants of fetal growth. The present study examined the levels of maternal and cord plasma folate, vitamin B12 , homocysteine, and their association with birth outcome in women with preeclampsia (PE). This study includes 450 normotensive control (NC) and 350 women with PE. PE women were further classified into women delivering at term (n = 224) and preterm (n = 126). Maternal and cord blood was collected at delivery...
January 15, 2019: Journal of Human Hypertension
Elias Sanidas, Charalampos Grassos, Dimitrios P Papadopoulos, Maria Velliou, Kostas Tsioufis, Marina Mantzourani, Despoina Perrea, Dimitrios Iliopoulos, John Barbetseas, Vasilios Papademetriou
Blood pressure (BP) is a physiological parameter with short- and long-term variability caused by complex interactions between intrinsic cardiovascular (CV) mechanisms and extrinsic environmental and behavioral factors. Available evidence suggests that not only mean BP values are important, but also BP variability (BPV) might contribute to CV events. Labile hypertension (HTN) is referred to sudden rises in BP and it seems to be linked with unfavorable outcomes. The aim of this article was to review and summarize recent evidence on BPV phenomenon, unraveling the labile HTN concept along with the prognostic value of these conditions...
January 15, 2019: Journal of Human Hypertension
Saruna Ghimire, Shiva Raj Mishra, Binaya Kumar Baral, Meghnath Dhimal, Karen E Callahan, Bihungum Bista, Krishna Kumar Aryal
Both the noncommunicable diseases (NCDs) burden and the population of older adults are increasing in Nepal. This study aims to estimate the prevalence of behavioral and biological risk factors of common NCDs among Nepali older adults aged 60-69 years. A subsample analysis of data from the 2013 Nepal STEPwise approach to Surveillance (STEPS) survey was conducted with 526 older adults aged 60-69 years. STEPS sample weighting and domain analyses were used to include the entire sample for variance estimation and to obtain prevalence estimates and corresponding 95% confidence intervals (CI) for our selected population of older adults...
January 15, 2019: Journal of Human Hypertension
Qian-Hui Guo, Iram Faqir Muhammad, Yan Borné, Chang-Sheng Sheng, Margaretha Persson, Ji-Guang Wang, Gunnar Engström, Yan Li, Peter M Nilsson
Carotid-femoral pulse wave velocity (cfPWV) and its risk factors may differ between various populations. Few studies have compared the risk profiles associated with cfPWV in different ethnic populations. The study population included 4321 subjects from Shanghai, China (n = 1272, age 75.0 ± 6.5 years, female 57.3%) and Malmö, Sweden (n = 3049, age 72.5 ± 5.5 years, female 60.4%). cfPWV was measured using the SphygmoCor device in both cohorts, with some difference in the determination of pulse transmission distance...
January 15, 2019: Journal of Human Hypertension
Hui-Juan Zuo, Ji-Xiang Ma, Jin-Wen Wang, Xiao-Rong Chen, Lei Hou
A series of guidelines concerning hypertension emphasize the importance of follow-up in patients' management. The aim of this study was to assess the impact of routine follow-up on blood pressure (BP) control. A total of 1511 patients with hypertension aged ≥ 35 years were selected randomly from 17 communities in two cities and four townships located in Shandong and Jiangsu provinces in China. About half of the patients visited the community clinic four or more times yearly; follow-up was conducted by telephone for 43...
January 15, 2019: Journal of Human Hypertension
Mahnaz Rezaei, Abbas Mohammadpour-Gharehbagh, Mehrnaz Narooei-Nejad, Batool Teimoori, Mojgan Mokhtari, Mehrnaz Mehrabani, Minoo Yaghmaei, Darya Najafi, Saeedeh Salimi
Evidence showed that microRNA biosynthesis plays the main role in pathogenesis of several diseases including Preeclampsia (PE). Therefore, microRNA processing enzymes may involve in PE predisposition. The aim of the present study was to evaluate the relation between DROSHA rs10719 and rs6877842 polymorphisms and mRNA expression in the placenta of PE women and controls. This study recruited 110 PE women and 115 age matched normotensive pregnant women for genotyping of DROSHA polymorphisms and analyzing of mRNA expression...
January 10, 2019: Journal of Human Hypertension
Yiqun Wu, Yijie Ma, Keye Wu, Wei Zhao, Huanqing Hu, Qi Yang, Aiqun Huang, Dafang Chen
The influences of blood pressure in early to mid-pregnancy on the risk of small-for-gestational-age (SGA) birth are not clear. Our objective was to examine the associations of the blood pressure levels at 10 and 18 gestational weeks with the risk of SGA birth. Data were obtained from the Chinese Maternal and Newborn's Health Monitoring System (MNHMS). In total, 50745 Chinese women who delivered a single live infant at a gestational age of between 28 and 42 weeks were included in this analysis. Blood pressure, birth outcome and other related information were obtained during antenatal visits by obstetricians...
January 10, 2019: Journal of Human Hypertension
Xin-Zhu Tong, Wan-Fu Cui, Yan Li, Chen Su, Yi-Jia Shao, Jia-Wen Liang, Zi-Ting Zhou, Chan-Juan Zhang, Jian-Ning Zhang, Xiao-Yu Zhang, Wen-Hao Xia, Jun Tao
Although previous data showed that remote ischemic preconditioning (RIPC) has beneficial effect on blood pressure (BP) reduction, the efficacy of RIPC-induced decline in BP and the favorable humoral factors in hypertension is elusive. This present study is performed to evaluate whether RIPC reduces BP, improves microvascular endothelial function and increases circulating hSDF-1α generation in hypertension. Fifteen hypertensive patients received 3 periods of 5-min inflation/deflation of the forearm with a cuff on the upper arm daily for 30 days...
January 10, 2019: Journal of Human Hypertension
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