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Journals Journal of Investigative Surge...

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research

https://read.qxmd.com/read/38346856/statement-of-retraction-liver-x-receptors-activation-attenuates-ischemia-reperfusion-injury-of-liver-graft-in-rats
#1
(no author information available yet)
No abstract text is available yet for this article.
December 2024: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38323630/posttranscriptional-regulation-of-intestinal-mucosal-growth-and-adaptation-by-noncoding-rnas-in-critical-surgical-disorders
#2
REVIEW
Cassandra A Cairns, Lan Xiao, Jian-Ying Wang
The human intestinal epithelium has an impressive ability to respond to insults and its homeostasis is maintained by well-regulated mechanisms under various pathophysiological conditions. Nonetheless, acute injury and inhibited regeneration of the intestinal epithelium occur commonly in critically ill surgical patients, leading to the translocation of luminal toxic substances and bacteria to the bloodstream. Effective therapies for the preservation of intestinal epithelial integrity and for the prevention of mucosal hemorrhage and gut barrier dysfunction are limited, primarily because of a poor understanding of the mechanisms underlying mucosal disruption...
December 2024: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38224012/the-hif-1%C3%AE-pkm2-feedback-loop-in-relation-to-egfr-mutational-status-in-lung-adenocarcinoma
#3
JOURNAL ARTICLE
Yuan Wang, Hongguang Lian, Jiajun Li, Man Zhao, Zengfang Hao, Xue Zheng, Linyuan Zhao, Jinfeng Cui
OBJECTIVE: Gene mutations in tumor cells can lead to several unique metabolic phenotypes, which are crucial for the proliferation of cancer cells. EGFR mutation (EGFR-mt) is the main oncogenic driving mutation in lung adenocarcinoma (LUAD). HIF-1 α and PKM2 are two key metabolic regulatory proteins that can form a feedback loop and promote cancer growth by promoting glycolysis. Here, the linkage between EGFR mutational status and HIF-1α/PKM2 feedback loop in LUAD were evaluated...
December 2024: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38199978/anterior-posterior-and-anterior-posterior-approaches-for-the-treatment-of-thoracolumbar-burst-fractures-a-network-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Yuchen Duan, Dagang Feng, Jun Chen, Yamei Wu, Tong Li, Leiming Jiang, Yong Huang
PURPOSE: To compare the clinical and radiological results of the anterior approach versus the posterior approach versus the anterior-posterior approach for the treatment of thoracolumbar burst fractures. METHODS: The network meta-analysis was performed in accordance with the PRISMA Statement. Electronic searches of PubMed and Embase were conducted up to June 22, 2023, for relevant randomized controlled trials. STATA13.0 was used to perform network meta-analysis...
December 2024: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38159563/effects-of-mesalamine-combined-with-live-combined-bifidobacterium-lactobacillus-and-enterococcus-capsules-on-intestinal-mucosa-barrier-function-and-intestinal-microbiota-in-mildly-active-crohn-s-disease-patients
#5
RANDOMIZED CONTROLLED TRIAL
Meiqin Shen, Yingqi Shi, Zhenming Ge, Junbo Qian
Objective: This study is aimed at investigating the impact of mesalamine combined with Live combined Bifidobacterium, Lactobacillus and Enterococcus capsules on intestinal mucosa barrier function and intestinal microbiota in mildly active Crohn's disease patients. Methods: Ninety-six Crohn's disease patients in mild activity period were randomized into the control group (treated with mesalamine) and the observation group (treated with mesalamine combined with Live combined Bifidobacterium, Lactobacillus and Enterococcus capsules) ( n  = 48)...
December 2024: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38234036/survival-and-prognosis-for-patients-with-rectal-melanomas-in-the-united-states-a-seer-based-study
#6
JOURNAL ARTICLE
Fan Zhang, Boqi Xu, Yao Peng, Runda Wu, Shan Tong, Zhongqi Mao
PURPOSE: Limited attention was paid to focus on rectal melanomas (RM). This study aimed to evaluate the survival rate and prognostic factors of RM. METHODS: The data for patients with RM from Surveillance, Epidemiology, and End Results (SEER) database were used to analyze tumor survival. Kaplan-Meier method and log-rank test were employed to estimate cancer-specific survival (CSS) and overall survival (OS). A nomogram was established based on the risk factors of survival by the forest plot for multivariate Cox regression analysis...
January 8, 2024: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38047456/association-of-mir-203-expression-with-prognostic-value-in-patients-with-esophageal-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Qirun Cheng, Lipeng Chen, Liping Ni
OBJECTIVE: This study aims to investigate the association between miR-203 expression and the prognostic value in patients with esophageal cancer by the method of systematic review and meta-analysis. METHODS: We searched PubMed, Web of Science, Embase, and Cochrane Library to collect studies on the relationship between miR-203 expression and the prognostic value of esophageal cancer up to July 2023. Stata 15.0 statistical software was used for data analysis. Hazard ratio (HR) and 95% confidence interval (CI) were used as effect sizes...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38010813/avoiding-excessive-physical-restraints-to-reduce-icu-pseudo-delirium
#8
JOURNAL ARTICLE
Taotao Liu
No abstract text is available yet for this article.
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/38010393/comparison-of-intraoperative-endplate-injury-between-mini-open-lateral-lumbar-interbody-fusion-llif-and-transforaminal-lumbar-interbody-fusion-tlif-and-analysis-of-risk-factors-a-retrospective-study
#9
JOURNAL ARTICLE
Xiaowei Jing, Zhiyuan Gong, Ning Zhang, Zhengkuan Xu, Xiaowen Qiu, Fangcai Li, Wei Liu, Qingfeng Hu, Qixin Chen
OBJECTIVE: The study aimed to compare the incidence of intraoperative endplate injury in patients who underwent Transforaminal interbody fusion (TLIF) and mini-open lumbar interbody fusion (LLIF) surgery. The independent risk factors related to endplate injury in LLIF procedure were analyzed. METHODS: A total of 199 patients who underwent LLIF ( n  = 106) or TLIF ( n  = 93) surgery from June 2019 to September 2021 were reviewed. The endplate injury was assessed by postoperative sagittal CT scan...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37970828/comparison-between-endoscopic-submucosal-dissection-and-transanal-endoscopic-microsurgery-in-early-rectal-neuroendocrine-tumor-patients-a-meta-analysis
#10
REVIEW
Fu-Gang Wang, Ying Jiang, Chao Liu, Hong Qi
PURPOSE: To compare the effectiveness, safety and cost-effectiveness of endoscopic submucosal dissection (ESD) with transanal endoscopic microsurgery (TEM) in early rectal neuroendocrine tumor (RNET) patients. This article will provide reliable evidence for surgeons in regards to clinical decision-making. METHODS: Systematic literature retrieval was performed in Pubmed, Embase and Cochrane database from 2013/4/30 to 2023/4/30. Methodology validation was performed by using the Newcastle-Ottawa Scale (NOS)...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37852750/percutaneous-functional-spinal-unit-cementoplasty-versus-posterior-spinal-fixation-with-vertebroplasty-for-symptomatic-chronic-osteoporotic-vertebral-fractures-a-retrospective-study-with-a-2-year-follow-up
#11
JOURNAL ARTICLE
Youdi Xue, Zhifa Lun, Jie Feng, Weixiang Dai
PURPOSE: To compare the clinical efficacy of percutaneous functional spinal unit cementoplasty (PFSUP) and posterior spinal fixation combined with vertebroplasty (PSF + VP) for the treatment of symptomatic chronic osteoporotic vertebral fractures (SCOVFs). METHOD: Thirty-one patients with SCOVFs were included in this retrospective study and divided into PFSUP ( n  = 14) and PSF + VP ( n  = 17) groups. Visual analog scores (VAS) and Oswestry Disability Index (ODI) were recorded before and after surgery and at the last follow-up...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37828756/verteporfin-suppresses-yap-induced-glycolysis-in-breast-cancer-cells
#12
JOURNAL ARTICLE
Hong Chen, Ling-Fei Zhang, Ying Miao, Yun Xi, Xuefei Li, Mo-Fang Liu, Min Zhang, Biao Li
OBJECTIVE: The inhibition of the Hippo pathway through targeting the Yes-associated protein (YAP) presents a novel and promising approach for treating tumors. However, the efficacy of YAP inhibitors in the context of breast cancer (BC) remains incompletely understood. Here, we aimed to investigate the involvement of YAP in BC's metabolic reprogramming and reveal the potential underlying mechanisms. To this end, we assessed the function of verteporfin (VP), a YAP-TEAD complex inhibitor, on the glycolytic activity of BC cells...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37813399/femoral-neck-system-versus-three-cannulated-screws-for-fixation-of-femoral-neck-fractures-in-younger-patients-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Shuang G Yan, Yiliang Cui, Di Li, Fanxiao Liu, Xingyi Hua, Florian Schmidutz
OBJECTIVE: To compare the clinical results of a new femoral neck system (FNS) and cannulated compression screws (CCS) for the treatment of femoral neck fractures in younger patients. METHODS: Retrospective study was performed in younger patients with femoral neck fractures that were treated with FNS or CCS from August 2017 to August 2022. The hip functional outcomes were assessed with the Harris hip score (HHS). Secondary outcomes included the surgical time, surgical blood loss, satisfaction visual analog scale (VAS), fluoroscopy frequency, fracture healing time and complications...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37813392/novel-insights-about-synergistic-effect-of-zamzam-water-with-sgl2-inhibitors-on-wound-healing-in-stz-induced-diabetic-rats-the-role-of-anti-inflammatory-and-proangiogenic-effects
#14
JOURNAL ARTICLE
Medhat Taha, Sara T Elazab, Ammar Qutub, Omer Abdelbagi, Tourki A S Baokbah, Gomaa S Ahmed, Randa A Zaghloul, Alaa Jameel A Albarakati, Naeem F Qusty, Omar Babateen, Abdullah G Al-Kushi
Background: Hyperglycemia usually impairs wound healing by dysregulating the inflammatory response and angiogenesis. This study aimed to examine the synergistic effect of dapagliflozin and Zamzam water (ZW) on the healing of diabetic wounds and to explore their anti-inflammatory and proangiogenic effects. Materials and methods: A full-thickness excisional wound was made on the backs of all groups after two weeks of diabetes induction. Forty rats were divided into five groups, with eight rats per group; Group 1: Control non-diabetic rats; Group II: Untreated diabetic rats; Group III: Diabetic rats drinking ZW; Group IV: Diabetic rats receiving an oral dose of 1 mg/kg dapagliflozin; and Group V: Received both dapagliflozin and ZW...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37813390/mini-review-tendon-exposed-wound-treatments
#15
REVIEW
Zhuan Deng, Zhi-Sheng Long, Gang Chen
BACKGROUND: Tendon-exposed wounds are complex injuries with challenging reconstructions and no unified treatment mode. Furthermore, insufficient tissue volume and blood circulation disorders affect healing, which increases pain for the patient and affects their families and caretakers. REVIEW: As modern medicine advances, considerable progress has been made in understanding and treating tendon-exposed wounds, and current research encompasses both macro-and micro-studies...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37733404/outcomes-of-holmium-laser-cryoablation-and-budesonide-inhalation-for-treating-severe-central-airway-stenosis-in-infants
#16
JOURNAL ARTICLE
Lei Zhang, Shuhua Yuan, Chunhong Pan, Jing Zhang, Jinhong Wu, Yong Yin
BACKGROUND: Central airway stenosis (CAS) in infants is characterized by dysphonia, dyspnea, cyanosis, repeated apnea, and infection. This case series study aimed to evaluate the safety and efficacy of holmium laser, cryoablation and budesonide inhalation in treating infants with severe CAS. METHODS: This retrospective study reviewed medical records data of 28 infants with severe CAS who underwent holmium laser treatment with cryoablation and/or balloon dilatation and budesonide inhalation therapy at Shanghai Children's Medical Center between June 2014 and May 2020...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37733388/active-intra-abdominal-drainage-following-abdominal-digestive-system-surgery-a-meta-analysis-and-systematic-review
#17
REVIEW
Minghui Zheng, Ting Niu, Junfeng Peng, Ligang Shi, Chenghao Shao
BACKGROUND: Our objective is to compare the early outcomes associated with passive (gravity) drainage (PG) and active drainage (AD) after surgery. METHODS: Studies published until April 28, 2022 were retrieved from the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Web of Science databases. RESULTS: Nine studies with 14,169 patients were identified. Two groups had the same intra-abdominal infection rate (RR: 0.55; P  = 0...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37731247/neural-invasion-is-an-independent-prognostic-factor-in-young-and-lymph-node-negative-gastric-cancer-patients-underwent-curative-gastrectomy
#18
JOURNAL ARTICLE
Linjun Wang, Yiwen Xia, Tianlu Jiang, Ying Li, Yikai Shen, Jie Lin, Fengyuan Li, Weizhi Wang, Diancai Zhang, Hao Xu, Li Yang, Zekuan Xu
BACKGROUND: The prognostic significance of neural invasion (NI) in gastric cancer (GC) has not been established. This study is to investigate the characteristic and prognostic value of NI in GC. METHODS: 592 patients who had undergone gastrectomy for GC were retrospectively analyzed. NI was defined when cancer cells infiltrated into the perineurium or neural fascicles by hematoxylin and eosin staining of surgical specimens. NI and the other clinical factors were analyzed...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37527815/s100-calcium-binding-protein-a8-functions-as-a-tumor-promoting-factor-in-renal-cell-carcinoma-via-activating-nf-%C3%AE%C2%BAb-signaling-pathway
#19
JOURNAL ARTICLE
Shu-Hui Wang, Yan-Jie Xia, Jing Yu, Chun-Yan He, Jie-Ru Han, Ji-Xiang Bai
BACKGROUND: Renal cell carcinoma (RCC), arising from the renal tubular epithelium, is one of the most common types of genitourinary malignancies. Based on the Gene Expression Omnibus (GEO) database (GSE100666), S100 calcium-binding protein A8 (S100A8) was highly expressed in RCC tissues. S100A8, an inflammatory regulatory factor, has emerged as an important mediator associated with the occurrence and development of cancer. MATERIALS AND METHODS: The Gene Expression Omnibus (GEO) database was used to identify the key genes and investigate the main signaling pathways in RCC...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/37455016/expression-of-mir-425-5p-in-pancreatic-carcinoma-and-its-correlation-with-tumor-immune-microenvironment
#20
JOURNAL ARTICLE
Shuo Jian, Dehua Kong, Jieli Tian
Background: Pancreatic carcinoma (PC) is a global health threat with a high death rate. miRNAs are implicated in tumor initiation and progression. This study explored the expression of miR-425-5p in PC patients and its correlation with tumor immune microenvironment (TIME). Method: miR-425-5p expression in cancer tissues and adjacent non-tumor tissues of PC patients was examined by RT-qPCR. The levels of immune cells and cytokines were measured by flow cytometry and ELISA. The correlation of miR-425-5p with TNM stage and TIME was assessed by Spearman method...
December 2023: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
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