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Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research

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https://read.qxmd.com/read/31012339/genetic-analysis-reveals-complete-androgen-insensitivity-syndrome-in-female-children-surgically-treated-for-inguinal-hernia
#1
Nurin A Listyasari, Gorjana Robevska, Ardy Santosa, Aurore Bouty, A Z Juniarto, Jocelyn van den Bergen, Katie L Ayers, Andrew H Sinclair, Sultana Mh Faradz
BACKGROUND: Complete androgen insensitivity syndrome (CAIS) is a congenital condition caused by genetic defects in the androgen receptor (AR) gene located on the X chromosome, which lead to a phenotypical female individual with a 46, XY karyotype. Early diagnosis of CAIS is essential for proper clinical management, allows assessment of familial risk and contributes to healthcare decisions. However, diagnosis of CAIS can be overlooked in girls with inguinal hernia, resulting in inappropriate management...
April 23, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30987482/modified-extraperitoneal-uterosacral-ligament-suspension-in-preventing-cuff-prolapse-risk-after-vaginal-hysterectomy-4-clamp-method
#2
Pınar Kadiroğulları, KeremDoğa Seckin
OBJECTIVES: The extraperitoneal uterosacral ligament suspension (ULS) can be performed during the removal of the uterus in vaginal hysterectomy to prevent cuff prolapse. In this study, we evaluated the modified extraperitoneal ULS technique in terms of preventing cuff prolapse. Methods/Technique: Forty patients with second and third-stage uterine prolapse who were operated were included in the study. During routine vaginal hysterectomy procedure performed on patients, after sacrouterine ligaments which are the first-bites and uteroovarian and round ligaments which are the last-bites have been sutured and knotted, these ligaments were marked with 4-distinct clamps to make the right and left, upper and lower separation...
April 15, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30966835/the-effect-of-pre-emptive-dexketoprofen-administration-on-postoperative-pain-management-in-patients-with-ultrasound-guided-interscalene-block-in-arthroscopic-shoulder-surgery
#3
U Demir, I Ince, M Aksoy, A Dostbil, M A Arı, M M Sulak, M Kose, M Tanios, O Ozmen
BACKGROUND: Postoperative pain is an important problem for patients undergoing shoulder surgery. Our study investigated analgesic efficacy, duration of analgesia, postoperative analgesic use and patient satisfaction with the use of preemptive intravenous dexketoprofen for interscalene block in addition to general anesthesia in arthroscopic shoulder surgery. METHODS: 60 patients, scheduled for arthroscopic shoulder surgery were randomized (30 patients each) into either: - control group (Group1) or dexketoprofen group (Group 2)...
April 9, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30957569/outcomes-at-2-years-follow-up-after-hip-arthroscopy-combining-bone-marrow-concentrate
#4
Eila Rivera, Roberto Seijas, Mónica Rubio, Montserrat García-Balletbó, Jose Manuel Vilar, Patricia Laiz Boada, Ramón Cugat
INTRODUCTION: The cartilage injuries are related to femoroacetabular impingement (FAI). The prognostic of the injury depends on the grade of itself. Using bone marrow concentrate (BMC), which contains stem cells, is related to the improvement in diverse tissues. The purpose of this study was to evaluate the improvement of the patients after a FAI arthroscopic intervention using BMC. We compared the results to those of a previous cohort of patients who had identical surgery but without BMC...
April 7, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30947574/short-term-outcomes-of-three-port-laparoscopic-right-hemicolectomy-versus-five-port-laparoscopic-right-hemicolectomy-with-a-propensity-score-matching-analysis
#5
Yi Shi, Zijia Song, Yifei Gu, Yaqi Zhang, Tao Zhang, Ren Zhao
PURPOSE: The aim of this study is to compare the short-term and pathological outcomes of TPLRC (Three-port laparoscopic right hemicolectomy) and FPLRC (Five-port laparoscopic right hemicolectomy), using propensity score matching analysis. METHODS: One hundred and sixty-eight patients who accepted laparoscopic right hemicolectomy with either three ports or five ports from January 2013 to October 2017 were non-randomly selected and analyzed retrospectively. Propensity score matching model was used to eliminate the patients' selection bias between two groups...
April 4, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30947571/influence-of-surgical-procedures-on-serum-paraoxonase-1-related-variables-and-markers-of-inflammation-in-hospitalized-patients
#6
Simona Iftimie, Ana Escribano, Ariadna Díez-Sans, Isabela Albiciuc, Anna Hernández-Aguilera, Isabel Fort-Gallifa, Ana Felisa López-Azcona, Jordi Camps, Jorge Joven, Antoni Castro
PURPOSE: Surgical stress is a phenomenon not completely understood from the biochemical point of view, although it produces alterations in the oxidative balance and inflammatory status. The present study aimed to investigate the alterations of the circulating levels of paraoxonase-1 (PON1)-related variables and markers of inflammation in hospitalized patients who underwent surgery. METHODS: We recruited 285 hospitalized patients. Of those, 115 were hospitalized due to a surgical intervention and 170 for reasons other than surgery...
April 4, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30945580/rapamycin-inhibits-nf-%C3%AE-b-activation-by-autophagy-to-reduce-catabolism-in-human-chondrocytes
#7
Yibin Liu, Xiaojun Li, Aunhua Jin
BACKGROUND AND AIM: Osteoarthritis is a disease that is accompanied by inflammation and catabolic disorders in the cartilage. Rapamycin is a good autophagy activator and has an inhibitory effect on inflammation, and autophagy can remove waste generated by catabolic disorders and delay the destruction of cartilage by inflammation. This study was designed to evaluate the effect of rapamycin upon the catabolism in human chondrocytes and unravel underlying mechanism. METHODS AND RESULTS: C57 mice and SW1353 cells were cultured and osteoblastic arthritis was formed by destabilization of the medial meniscus surgery; 10 ng/ml of IL-1β was added to the cells to produce inflammatory chondrocytes, and a non-cytotoxic concentration of 20 nM Rapamycin was used as the self-activator...
April 4, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30922136/position-of-coracoid-button-predicts-loss-of-reduction-in-acromioclavicular-joint-dislocation-patients-treated-with-the-suture-button
#8
Xian-Bin Yu, Tong Li, Wei Hu, Hua Chen, Yao-Sen Wu, Liao-Jun Sun
BACKGROUND: Loss of reduction is the most common complication after acromioclavicular (AC) joint dislocation treated with the suture-button. Some predictors of it are known, but finding new predictors is an ongoing process. In this study, we evaluate the importance of the position of the coracoid button. MATERIALS AND METHODS: Between April 2010 and February 2017, 186 patients with AC joint dislocation were identified. All patients were managed with the same surgical technique and postoperative protocol...
March 28, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30917713/the-application-of-t-spot-tb-assay-for-early-diagnosis-of-active-tuberculosis-in-chronic-kidney-disease-patients-receiving-immunosuppressive-treatment
#9
Haitao Wang, Songlan Wang, Lengnan Xu, Yonghui Mao
BACKGROUND: The current study investigated the clinical application of the T-SPOT.TB assay for detecting tuberculosis (TB) infection in chronic kidney disease patients treated with immunosuppressive therapy. METHODS: Clinical data from 91 patients were retrospectively analyzed. The rate of positive T-SPOT.TB results and spot numbers were compared before and after treatment. Clinical characteristics that may affect the test results were also investigated. RESULTS: Two active TB cases were observed after immunosuppressive treatment, and eight patients with negative T-SPOT...
March 27, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30917712/acupoint-massage-can-effectively-promote-the-recovery-of-gastrointestinal-function-after-gynecologic-laparoscopy
#10
Di Ruan, Jingjing Li, Junchang Liu, Dandan Li, Ning Ji, Cheng Wang, Yujiang Qu, Yongtao Li
OBJECTIVE: To investigate the effect of acupoint massage on the recovery of gastrointestinal function in patients after laparoscopic surgery for gynecologic indications. METHODS: A total of 160 patients, who underwent gynecologic laparoscopy from December 2015 to January 2017, were recruited. Half of the patients received standard postoperative nursing (i.e., the control group); while the other half received acupoint massage in addition to the standard care (i.e...
March 27, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30913929/dexmedetomidine-ameliorates-post-cpb-lung-injury-in-rats-by-activating-the-pi3k-akt-pathway
#11
Jian Li, Xuejiao Dou, Dongdong Li, Miao He, Ming Han, Hong Zhang
PURPOSE: To investigate the protective effects of dexmedetomidine (Dex) on post cardiopulmonary bypass (CPB) lung injury in rats and to explore the possibility of underlying mechanisms involving phosphatidylinositol 3-kinase (PI3K)/Akt. MATERIALS AND METHODS: Forty healthy male Sprague-Dawley rats were randomly divided into five groups (n = 8 for each). A left lung ischemia-reperfusion injury model of CPB was established in all five groups. Rats were given saline, dexmedetomidine (Dex), dimethyl sulfoxide (DMSO), wortmannin (Wtm), and Dex plus Wtm during the CPB process, in Group Saline, Dex, DMSO, Wtm, and Dex + Wtm, respectively...
March 26, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30909770/acute-aortic-dissection-in-young-adult-patients-clinical-characteristics-management-and-perioperative-outcomes
#12
Shuai Zhu, Tie Zheng, Zhi-Yu Qiao, Li Chen, Jia-Fu Ou, Wei-Gang Fang, Cheng-Nan Li, Lei Chen, Wei-Guo Ma, Jun Zheng, Yong-Min Liu, Li-Zhong Sun, Xue-Jun Sun, Jun-Ming Zhu
BACKGROUND: Acute aorta dissection (AD) is a fatal emergency, however, studies addressing the clinical characteristics, management, and outcome of acute AD in young adult patients aged under 45 years in China are very few. METHODS: A retrospective study including 490 patients with acute AD as the final diagnosis was conducted. Patients' demographics, clinical characteristics, medical history, and laboratory and diagnostic imaging findings were retrieved from medical records...
March 25, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30909762/the-benefits-of-preserving-the-coracoid-process-and-its-attachments
#13
COMMENT
Zhengan Hao
No abstract text is available yet for this article.
March 25, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30909760/brief-commentary-on-the-article-the-efficacy-of-recombinant-platelet-derived-growth-factor-on-beta-tricalcium-phosphate-to-regenerate-femoral-critical-sized-segmental-defects-longitudinal-in-vivo-micro-ct-study-in-a-rat-model
#14
COMMENT
Krzysztof Gaweda
No abstract text is available yet for this article.
March 25, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30909758/biochemical-histopathologic-and-genotoxic-effects-of-ethanol-extract-of-salvia-hypargeia-fisch-mey-on-incisional-and-excisional-wounded-diabetic-rats
#15
Yusuf Ozay, Sevda Guzel, Ebru Gokalp Ozkorkmaz, Meltem Kumas, Cosar Uzun, Zuhal Yıldırım, Ayla Celik, Yusuf Camlıca, Onder Yumrutas, Gizem Guler, Nurten Erdal, Bahar Tasdelen, Havva Didem Celikcan, Ahmet Kahraman
PURPOSE: Nonhealing wounds are a serious problem of diabetic patients. Salvia species are traditionally used for the treatment of wounds. The aim of the study was to investigate the effects of ointment prepared with ethanol extract obtained from the aerial parts of Salvia hypargeia, an endemic plant from Turkey, on diabetic rat incisional and excisional skin wounds. MATERIALS AND METHODS: Male Wistar albino rats (n: 60) were divided into five groups. Diabetes was induced and two concentrations (0...
March 25, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30909757/investigating-the-role-of-minimally-invasive-surgery-in-patients-with-chronic-pulmonary-disease
#16
COMMENT
Virginia Figgiaconi, Giorgio Bogani, Federico Piccioni, Valentina Chiappa, Francesco Raspagliesi
No abstract text is available yet for this article.
March 25, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30907217/c14orf166-is-a-biomarker-for-predicting-hepatocellular-carcinoma-recurrence
#17
Jianxu Chen, Jiandi Chen, Yihang Gong, Baojia Zou, Xialei Liu, Lei Ding, Jiaxing Huang, Baimeng Zhang, Jian Li
AIM: Chromosome 14 open reading frame 166 (C14orf166) acts as a transcriptional repressor and is correlated with centrosome architecture manipulation. Nevertheless, the function of C14orf166 in hepatocellular carcinoma (HCC) progression remains unclear. We aimed to investigate the role C14orf166 plays in HCC and further compared the prognostic value of C14orf166 with that of clinicopathological features. METHODS: C14orf166 expression was evaluated in a human liver cell line, HCC cell lines, HCC tissues and adjacent noncancerous liver tissues with qRT-PCR, western blot and immunohistochemistry...
March 24, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30907197/an-efficacy-comparison-of-two-hemostatic-agents-in-a-porcine-liver-bleeding-model-gelatin-thrombin-flowable-matrix-versus-collagen-thrombin-powder
#18
Paul Slezak, Claudia Keibl, Heinz Redl, Dirk Labahn, Heinz Gulle
PURPOSE: Management of bleeding during surgery can be aided by the application of topical hemostatic agents. This study compared the hemostatic efficacy of a new powder agent containing collagen, chondroitin sulfate, and thrombin (PCCT) with a flowable gelatin-thrombin matrix with smooth particles (SmGM) in a porcine liver bleeding model. MATERIALS AND METHODS: Lesions 4-6 mm deep and ∼10 mm in diameter were created in porcine livers and treated with either SmGM or PCCT...
March 24, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30907191/direct-peritoneal-resuscitation-reduces-lung-injury-and-caspase-8-activity-in-brain-death
#19
Jessica L Weaver, Jessica E Schucht, Paul J Matheson, Amy J Matheson, Cameron A Ghazi, Cynthia D Downard, Richard Neal Garrison, Jason W Smith
BACKGROUND: Acute brain death (ABD) is associated with inflammation and lung injury. Direct peritoneal resuscitation (DPR) improves blood flow to the vital organs after ABD. DPR reduces lung injury, but the mechanism for this is unknown. METHODS: Male Sprague-Dawley rats were randomized to five groups (n = 8/group): (1) Sham (no ABD); (2) Targeted intravenous fluid (TIVF) (ABD plus enough IVF to maintain a MAP of 80 mmHg) at 2 hours post-resuscitation (RES); (3) ABD + TIVF + DPR (TIVF and 30 cc intraperitoneal 2...
March 24, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://read.qxmd.com/read/30907189/a-gene-related-nomogram-for-preoperative-prediction-of-lymph-node-metastasis-in-colorectal-cancer
#20
Shuxun Wei, Jia Zang, Youpeng Jia, Aona Chen, Yayun Xie, Jian Huang, Zheng Li, Gang Nie, Hui Liu, Fuchen Liu, Wenchao Gao
PURPOSE: To develop and validate a gene-related nomogram for predicting the risk of lymph node (LN) metastasis preoperatively in patients with colorectal cancer (CRC). METHODS: RNA-seq data of 581 CRC and 51 normal cases with clinical features were downloaded from TCGA database. In the evaluation cohort with 381 CRC cases, the LASSO regression was used to reduce dimensionality of gene signatures extracted to build gene score. A gene-related nomogram was performed based on the multivariable logistic regression analysis...
March 24, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
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