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International Journal of Radiation Biology

Yinhui Pei, Hui Gao, Lin Li, Xin An, Qinyou Tian
Purpose The present study aims to evaluate the effect of cell phone radiation on neutrophil of mice. Materials and methods 40 male BALB/C mice were randomly broken up into 4 groups as control, blank control, TD-CDMA and LTE-Advanced groups respectively. Mice were exposed to cell phone radiation for a period of 6 weeks. Then numbers of neutrophil were detected by fully automatic haematology analyzer. Soft agar diffusion method was performed to assess the chemotaxis of neutrophils while the phagocytosis of neutrophils was determined by measuring the staphylococcus albus phagocytosis percentage...
April 23, 2019: International Journal of Radiation Biology
Masako Bando, Tetsuhiro Kinugawa, Yuichiro Manabe, Miwako Masugi, Hiroo Nakajima, Kazuyo Suzuki, Yuichi Tsunoyama, Takahiro Wada, Hiroshi Toki
PURPOSE: This is a paper based on a talk given in the BER2018 conference by M. Bando. We first emphasize the importance of collaborations among scientists in various fields for the low dose/dose-rate effects on biological body. We make comparisons of quantitative estimations of mutation caused by the radiation exposure on various animals and plants using one mathematical model. We derive the importance of the spontaneous mutation at the DNA level, which provides the key to understand the biological evolution...
April 23, 2019: International Journal of Radiation Biology
Mariana E Mendes, Julyanne C G Mendonça, Aida M G Andrade, Laís M Silva, Alyne M S Nascimento, Julianne C F Lima, Júlio C G Silva, Suy Hwang, Ana M M A Melo, Jorge E Gonzalez, Manuel Higueras, Joan F Barquinero, Neide Santos, Fabiana F Lima
PURPOSE: The goal was to compare the micronucleus (MN) and dicentric plus ring chromosomes (D + R) assays for dose assessment in cases of partial body irradiations (PBI). MATERIALS AND METHODS: We constructed calibration curves for each assay at doses ranging from 0 to 5 Gy. In order to simulate partial-body exposures, blood samples from two donors were irradiated with 0.5, 1, 2 and 4 Gy and the ratios of irradiated to unirradiated blood were 25, 50, and 100%...
April 22, 2019: International Journal of Radiation Biology
Shikha Mohan, Damodar Gupta
PURPOSE: Inula racemosa, a Trans-Himalayan plant is an important medicinal herb. In the present study, the radio-modulatory efficacy of aqueous root extract of I. racemosa was investigated. MATERIALS AND METHODS: Normal Kidney Epithelium cells were treated with extract (50-200 µg/ml) and exposed to 3 Gy of γ-radiation, while C57BL/6 mice were administered with extract (300-600 mg/kg BW) intraperitoneally prior to exposure to 7.5 Gy of γ-radiation to assess radiation modulatory efficacy...
April 18, 2019: International Journal of Radiation Biology
B Salbu, H C Teien, O C Lind, K E Tollefsen
PURPOSE: A number of nuclear and radiological sources have contributed or are still contributing to the release of a series of stressors such as radionuclides in combination with trace metals and even organic chemicals. To assess the impact of mixed contamination, a limited number of stressors are usually evaluated one by one. We have therefore evaluated the benefit of using the multiple stressor concept focusing on key topics within radioecology such as the source term and deposition, ecosystem interactions and exposure, biological uptake and effects including adverse outcome pathway, as a basis for assessing impact and risk...
April 11, 2019: International Journal of Radiation Biology
Min-Kyu Lee, Jae Il Lyu, Min Jeong Hong, Dong-Gun Kim, Jung Min Kim, Jin-Baek Kim, Seok Hyun Eom, Bo-Keun Ha, Soon-Jae Kwon
PURPOSE: The aims were to determine the optimal gamma ray dose for faba bean (Vicia faba) and to identify genetic variation and indel mutation frequency among mutants using target region amplification polymorphism (TRAP) markers. MATERIALS AND METHODS: Seeds from 10 elite lines were irradiated with gamma rays (50-700 Gy), and germination, survival rate, and representative morphological traits were measured. Extent of DNA damage was investigated using comet assays, and TRAP markers were used to evaluate genetic variation, genetic diversity, and mutation frequencies...
April 9, 2019: International Journal of Radiation Biology
Sumi Yokoyama, Nobuyuki Hamada, Norio Tsujimura
PURPOSE: In 2011, the International Commission on Radiological Protection (ICRP) recommended an equivalent dose limit for the lens of the eye of 20 mSv/year, averaged over defined periods of 5 years, with no single year exceeding 50 mSv for occupational exposure in planned exposure situations. Since then, there have been extensive discussions toward regulatory implementation of such a new occupational lens dose limit. This paper provides an overview of the recent discussions toward regulatory implementation and the current status of the studies related to radiation exposure of the lens and its effect in Japan...
April 9, 2019: International Journal of Radiation Biology
Xiangdong Wang, Wenzhi Tu, Chen Dong, Jiamei Fu, Juan Wang, Chunlin Shao, Jianghong Zhang
PURPOSE: To investigate the relationship between autophagy and radiation damage of human hepatoma cells and to explore the role of reactive oxygen species (ROS). MATERIALS AND METHODS: HepG2 cells were exposed to X-rays, then the protein expressions of microtubule-associated protein 1 light chain 3 (LC3) and poly ADP-ribose polymerase-1 (PARP-1) were measured by Western blot assay, the formation of autophagosomes was detected by an autophagy detection kit, the intracellular ROS level was measured by flow cytometer, and DNA damage was evaluated by the incidence of micronuclei (MN)...
April 9, 2019: International Journal of Radiation Biology
Claudia Peitzsch, Ina Kurth, Nadja Ebert, Anna Dubrovska, Michael Baumann
PURPOSE: Despite technological improvement and advances in biology-driven patient stratification, many patients still fail radiotherapy resulting in loco-regional and distant recurrence. Tumor heterogeneity remains a key challenge to effective cancer treatment, and reliable stratification of cancer patients for prediction of outcomes is highly important. Intratumoral heterogeneity is manifested at the different levels, including different tumorigenic properties of cancer cells. Since John Dick and coauthors isolated leukemia initiating cells in 1990th , the populations of tumor initiating or cancer stem cells (CSCs) were identified and characterized also for a broad spectrum of solid tumor types...
March 21, 2019: International Journal of Radiation Biology
Paul N Schofield, Ulrike Kulka, Soile Tapio, Bernd Grosche
PURPOSE: Over the past 60 years a great number of very large datasets have been generated from the experimental exposure of animals to external radiation and internal contamination. This accumulation of "big data" has been matched by increasingly large epidemiological studies from accidental and occupational radiation exposure, and from plants, humans and other animals affected by environmental contamination. We review the creation, sustainability and reuse of this legacy data, and discuss the importance of Open data and biomaterial archives for contemporary radiobiological sciences, radioecology and epidemiology...
March 19, 2019: International Journal of Radiation Biology
Igor Koturbash, Robert J Griffin
No abstract text is available yet for this article.
March 11, 2019: International Journal of Radiation Biology
Andrew Minchinton, Kevin Benniwith, Richard Hill
No abstract text is available yet for this article.
March 5, 2019: International Journal of Radiation Biology
Chai Hong Rim, Soonil Koun, Hae-Chul Park, Suk Lee, Chul Yong Kim
INTRODUCTION: Radioprotectors can enhance the efficacy of cancer radiotherapy, but their clinical use remains uncommon. The present study aimed to assess the radioprotective potential of mistletoe extract (commercial name: Abnoba Viscum), a well-known complementary cancer medicine, in zebrafish larvae. MATERIALS AND METHODS: Wild-type AB zebrafish embryos at 4 hours-post-fertilization were exposed to 5 Gy 9-MeV electron beam irradiation after being treated for 1 h with 4 mMl/L amifostine or 0...
March 5, 2019: International Journal of Radiation Biology
Enakshi D Sunassee, Dean Tan, Nathan Ji, Renee Brady, Eduardo G Moros, Jimmy J Caudell, Slav Yartsev, Heiko Enderling
PURPOSE: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been shown to yield excellent data fits at the cost of non-identifiability and clinically unrealistic results. MATERIALS AND METHODS: We develop a mathematical model based on a proliferation saturation index (PSI) that is a measurement of pre-treatment tumor volume-to-carrying capacity ratio that modulates intrinsic tumor growth and radiation response rates...
March 4, 2019: International Journal of Radiation Biology
John D Boice
BACKGROUND: Understanding the health consequences of exposure to radiation received gradually over time is critically needed. The National Aeronautics and Space Administration (NASA) bases its safety standards on the acute exposures received by Japanese atomic bomb survivors. Such a brief exposure differs appreciably from the chronic radiation received during a two to three year mission to Mars. NASA also applies an individual risk-based system for radiation protection that accounts for age, sex, smoking history and individual life styles...
March 4, 2019: International Journal of Radiation Biology
Byung Kil Park, Ju Hee Lee, Ho Won Seo, Kwang-Seok Oh, Jeong Hyun Lee, Byung Ho Lee
PURPOSE: The present study aimed to investigate the potential protective effects of icariin both in vivo and in vitro, an active flavonoid glucoside derived from medicinal herb Epimedium, and its possible mechanisms against radiation-induced injury. METHODS: Male C57BL/6 mice were exposed to lethal dose (7 Gy) or sub-lethal dose (4 Gy) of whole body radiation by X-ray at a dose rate of ∼0.55 Gy/min, and icariin was given three times at 24 h and 30 min before and 24 h after the irradiation...
March 4, 2019: International Journal of Radiation Biology
Shayenthiran Sreetharan, Lisa Stoa, Mary Ellen Cybulski, Devon E Jones, Abigail H Lee, Adomas V Kulesza, Sujeenthar Tharmalingam, Douglas R Boreham, T C Tai, Joanna Y Wilson
PURPOSE: Developmental programming involves an adverse intrauterine environment which can result in offspring phenotype changes following birth. The developmental programming of hypertension has been reported to possibly involve oxidative stress at the cellular level. Ionizing radiation produces oxidative stress, even at low doses, and irradiation of animals is often coupled with potential sources of maternal stress such as transportation of animals or repeated handling. MATERIALS AND METHODS: Pregnant C57Bl/6J mice were irradiated on gestational day 15 with 5-1000 mGy137 Cs gamma radiation...
March 4, 2019: International Journal of Radiation Biology
Andrzej Wojcik, Mats Harms-Ringdahl
PURPOSE: Radiation biology is a branch of the radiation research field which focuses on studying radiation effects in cells and organisms. Radiation can be used in biological investigations for two, mutually non-exclusive reasons: 1) to study biological processes by perturbing their functioning (qualitative approach) and 2) to assess consequences of radiation-induced damage (quantitative approach). While the former approach has a basic research character, the latter has an applied character that is driven by needs of medical applications and radiological protection...
March 4, 2019: International Journal of Radiation Biology
John D Boice, Sarah S Cohen, Michael T Mumma, Elizabeth D Ellis
PURPOSE: The study of low dose and low-dose rate exposure is of immeasurable value in understanding the possible range of health effects from prolonged exposures to radiation. The Million Person Study of Low-Dose Health Effects (MPS) was designed to evaluate radiation risks among healthy American workers and veterans who are more representative of today's populations than are the Japanese atomic bomb survivors exposed briefly to high-dose radiation in 1945. A million persons were needed for statistical reasons to evaluate low-dose and dose-rate effects, rare cancers, intakes of radioactive elements, and differences in risks between women and men...
March 4, 2019: International Journal of Radiation Biology
Dajana Todorović, Larisa Ilijin, Marija Mrdaković, Milena Vlahović, Aleksandra Filipović, Anja Grčić, Vesna Perić-Mataruga
PURPOSE: The main goal of this study was to analyze the long - term effects of static (SMF) and extremely low frequency magnetic field (ELF MF) on nymphal gut mass and antioxidant biomarkers in this tissue of cockroach Blaptica dubia. MATERIALS AND METHODS: One month old nymphs were exposed to magnetic field (MF) for 5 months in three experimental groups: control, exposure to a SMF (110 mT) and exposure to ELF MF (50 Hz, 10 mT). RESULTS: The gut masses of the MF groups were significantly lower when compared to control...
March 1, 2019: International Journal of Radiation Biology
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