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Journals Diseases of the Esophagus : Of...

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus

https://read.qxmd.com/read/38679488/expression-of-inducible-nitric-oxide-synthase-nitrotyrosine-eosinophilic-peroxidase-eotaxin-3-and-galectin-3-in-patients-with-gastroesophageal-reflux-disease-eosinophilic-esophagitis-and-in-healthy-controls-a-semiquantitative-image-analysis-of-3-3-diaminobenzidine
#21
JOURNAL ARTICLE
John Plate, Mogens Bove, Helen M Larsson, Elisabeth Norder Grusell, Nabanita Chatterjee, Leif E Johansson, Henrik Bergquist
Eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) share many histopathological features; therefore, markers for differentiation are of diagnostic interest and may add to the understanding of the underlying mechanisms. The nitrergic system is upregulated in GERD and probably also in EoE. Esophageal biopsies of patients with EoE (n = 20), GERD (n = 20), and healthy volunteers (HVs) (n = 15) were exposed to antibodies against inducible nitric oxide synthase (iNOS), nitrotyrosine, eosinophilic peroxidase, eotaxin-3, and galectin-3...
April 28, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38678385/contemporary-outcomes-of-left-thoraco-abdominal-esophagectomy-due-to-cancer-in-the-esophagus-or-gastroesophageal-junction-a-multicenter-cohort-study
#22
JOURNAL ARTICLE
F Klevebro, S Ash, C Mueller, G M Garbarino, S S Gisbertz, M I van Berge Henegouwen, Y Mandeville, L Ferri, A Davies, N Maynard, D E Low
Surgery for cancer of the esophagus or gastro-esophageal junction can be performed with a variety of minimally invasive and open approaches. The left thoracoabdominal esophagectomy (LTE) is an open technique that gives an opportunity to operate in the chest and abdomen with excellent exposure of the gastro-esophageal junction through a single incision, and there is currently no equivalent minimally invasive technique available. The aim of this multi-institutional review was to study a large contemporary international study cohort of patients treated with LTE...
April 28, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38670809/mucosal-impedance-as-a-diagnostic-tool-for-gastroesophageal-reflux-disease-an-update-for-clinicians
#23
JOURNAL ARTICLE
Matthew Marshall-Webb, Jennifer C Myers, David I Watson, Tim Bright, Taher I Omari, Sarah K Thompson
Mucosal impedance is a marker of esophageal mucosal integrity and a novel technique for assessing esophageal function and pathology. This article highlights its development and clinical application for gastroesophageal reflux disease (GERD), Barrett's esophagus, and eosinophilic esophagitis. A narrative review of key publications describing the development and use of mucosal impedance in clinical practice was conducted. A low mean nocturnal baseline impedance (MNBI) has been shown to be an independent predictor of response to anti-reflux therapy...
April 26, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38670808/centralization-and-quality-control-in-esophageal-cancer-surgery-a-way-forward-in-europe
#24
JOURNAL ARTICLE
Maurits R Visser, Mark I van Berge Henegouwen, Richard van Hillegersberg
No abstract text is available yet for this article.
April 26, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38670807/western-european-variation-in-the-organization-of-esophageal-cancer-surgical-care
#25
JOURNAL ARTICLE
Maurits R Visser, Daan M Voeten, Suzanne S Gisbertz, Jelle P Ruurda, Michael P Achiam, Magnus Nilsson, Sheraz R Markar, Manuel Pera, Riccardo Rosati, Guillaume Piessen, Philippe Nafteux, Christian A Gutschow, Peter P Grimminger, Jari V Räsänen, John V Reynolds, Hans-Olaf Johannessen, Pedro Vieira, Michael Weitzendorfer, Aristotelis Kechagias, Mark I van Berge Henegouwen, Richard van Hillegersberg
Reasons for structural and outcome differences in esophageal cancer surgery in Western Europe remain unclear. This questionnaire study aimed to identify differences in the organization of esophageal cancer surgical care in Western Europe. A cross-sectional international questionnaire study was conducted among upper gastrointestinal (GI) surgeons from Western Europe. One surgeon per country was selected based on scientific output and active membership in the European Society for Diseases of the Esophagus or (inter)national upper GI committee...
April 26, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38661378/association-of-perioperative-oral-swallowing-function-with-post-esophagectomy-outcomes-and-nutritional-statuses-in-patients-with-esophageal-cancer
#26
JOURNAL ARTICLE
Sohei Matsumoto, Kohei Wakatsuki, Hiroshi Nakade, Tomohiro Kunishige, Shintaro Miyao, Satoko Aoki, Akinori Tsujimoto, Takanari Tatsumi, Masahiro Soga, Masayuki Sho
Dysphagia after esophagectomy is a serious complication; however, no method has been established to accurately assess swallowing function. We evaluated the association of swallowing function tests with patients' post-esophagectomy complications and nutritional statuses. We retrospectively reviewed the data of 95 patients with esophageal cancer who underwent esophagectomy between 2016 and 2021. We performed perioperative swallowing function tests, including the repetitive saliva swallowing test (RSST), maximum phonation time (MPT), and laryngeal elevation (LE)...
April 25, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38659256/safety-and-efficacy-of-esoflip-dilation-in-patients-with-esophageal-dysmotility-a-systematic-review
#27
JOURNAL ARTICLE
Umair Iqbal, Michael Yodice, Zohaib Ahmed, Hafsa Anwar, Syeda Faiza Arif, Wade M Lee-Smith, David L Diehl
Esophageal manometry is utilized for the evaluation and classification of esophageal motility disorders. EndoFlip has been introduced as an adjunctive test to evaluate esophagogastric junction (EGJ) distensibility. Treatment options for achalasia and EGJ outflow obstruction (EGJOO) include pneumatic dilation, myotomy, and botulinum toxin. Recently, a therapeutic 30 mm hydrostatic balloon dilator (EsoFLIP, Medtronic, Minneapolis, MN, USA) has been introduced, which uses impedance planimetry technology like EndoFlip...
April 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38587429/metabolic-dysfunction-associated-steatotic-liver-disease-and-risk-of-esophageal-cancer-in-patients-with-diabetes-mellitus-a-nationwide-cohort-study
#28
JOURNAL ARTICLE
Yeong Jeong Jeon, Kyungdo Han, Seung Woo Lee, Ji Eun Lee, Junhee Park, In Young Cho, Jong Ho Cho, Dong Wook Shin
Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with type 2 diabetes and a developing several cancers including esophageal cancer (EC). However, the association between MASLD and EC in diabetic patients has not been investigated. Therefore, we aimed to investigate the relation between MASLD and developing EC in diabetic patients. This was a population-based retrospective cohort study of data from the Korean National Health Insurance Service (NHIS). A total of 1,904,468 subjects diagnosed with diabetes who underwent NHIS-provided health checkups from 2009 to 2012 were included...
April 8, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38582609/esophagogastroduodenoscopy-findings-that-do-no-not-explain-dysphagia-are-associated-with-underutilization-of-high-resolution-manometry
#29
JOURNAL ARTICLE
Sydney Pomenti, John Nathanson, Meaghan Phipps, Chino Aneke-Nash, David Katzka, Daniel Freedberg, Daniela Jodorkovsky
In patients with dysphagia that is not explained by upper endoscopy, high-resolution esophageal manometry (HRM) is the next logical step in diagnostic testing. This study investigated predictors of failure to refer for HRM after an upper endoscopy that was performed for but did not explain dysphagia. This was a retrospective cohort study of patients >18 years of age who underwent esophagogastroduodenoscopy (EGD) for dysphagia from 2015 to 2021. Patients with EGD findings that explained dysphagia (e.g. esophageal mass, eosinophilic esophagitis, Schatzki ring, etc...
April 6, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38580314/risk-of-metastasis-among-patients-diagnosed-with-high-risk-t1-esophageal-adenocarcinoma-who-underwent-endoscopic-follow-up
#30
JOURNAL ARTICLE
Benjamin Charles Norton, Nasar Aslam, Andrea Telese, Apostolis Papaefthymiou, Shilpi Singh, Vinay Sehgal, Miriam Mitchison, Marnix Jansen, Matthew Banks, David Graham, Rehan Haidry
Esophagectomy and lymphadenectomy have been the standard of care for patients at high risk (HR) of lymph node metastasis following a diagnosis of early esophageal adenocarcinoma (OAC) after endoscopic resection (ER). However, recent cohorts suggest lymph node metastasis risk is lower than initially estimated, suggesting organ preservation with close endoscopic follow-up is a viable option. We report on the 3- and 5-year risk of lymph node/distant metastasis among patients diagnosed with early HR-T1 OAC undergoing endoscopic follow-up...
April 5, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38553783/adjuvant-treatment-patterns-for-pt3n0m0-esophageal-cancer-undergoing-surgery
#31
JOURNAL ARTICLE
Su Pei, Jiang-Qiong Huang, Huan-Wei Liang, Yang Liu, Long Chen, Bin-Bin Yu, Wei Huang, Xin-Bin Pan
To assess adjuvant treatment patterns on survival in patients with pT3N0M0 esophageal cancer who underwent esophagectomy without neoadjuvant chemoradiotherapy. Stage pT3N0M0 esophageal cancer patients were assessed between 2000 and 2020 from the Surveillance, Epidemiology, and End Results databases. Kaplan-Meier analysis was used to compare overall survival (OS) among various treatment patterns. We identified 445 patients: 252 (56.6%) received surgery alone, 85 (19.1%) received surgery+chemoradiotherapy, 80 (18...
March 28, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38553782/outcomes-of-repeated-endoscopic-submucosal-dissection-for-superficial-esophageal-squamous-cell-carcinoma-on-endoscopic-resection-scar
#32
JOURNAL ARTICLE
Yasuaki Furue, Yusuke Yoda, Keisuke Hori, Keiichiro Nakajo, Tomohiro Kadota, Tatsuro Murano, Kensuke Shinmura, Hiroaki Ikematsu, Tomonori Yano
BACKGROUND: Endoscopic submucosal dissection (ESD) can be performed for superficial esophageal cancer. However, performing ESD for superficial esophageal cancer on a previous endoscopic resection scar may be difficult. METHODS: We compared the outcomes between ESD for superficial esophageal cancers on previous endoscopic resection scar (group A) and that for naïve lesions (group B). The study included outcomes of ESD, cumulative incidence of local failure, and predictors of the occurrence of local failure in ESD patients with squamous cell carcinoma (SCC)...
March 28, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525940/management-of-esophageal-anastomotic-leaks-a-systematic-review-and-network-meta-analysis
#33
JOURNAL ARTICLE
William Murray, Mathew G Davey, William Robb, Noel E Donlon
There is currently no consensus as to how to manage esophageal anastomotic leaks. Intervention with endoscopic vacuum-assisted closure (EVAC), stenting, reoperation, and conservative management have all been mooted as potential options. To conduct a systematic review and network meta-analysis (NMA) to evaluate the optimal management strategy for esophageal anastomotic leaks. A systematic review was performed as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines with extension for NMA...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525938/impact-of-aspirin-use-on-rates-of-metastasis-in-patients-with-esophageal-cancer-insights-from-the-national-inpatient-sample
#34
JOURNAL ARTICLE
Jay Patel, Tejasvini Khanna, Aalam Sohal, Armaan Dhaliwal, Hunza Chaudhry, Shivam Kalra, Ishandeep Singh, Dino Dukovic, Kanwal Bains
Despite advancing treatment methods, esophageal cancer (EC) maintains a high mortality rate and poor prognosis. Through various mechanisms, aspirin has been suggested to have a chemopreventive effect on EC. However, the long-term impact, particularly regarding the rate of metastasis, needs to be further elucidated. NIS 2016-2020 was used to identify adult patients (age > 18 years) with EC using ICD-10 codes. Patients with missing demographics and mortality were excluded. Patients were stratified into two groups based on aspirin use...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525937/eosinophilic-esophagitis-prevalence-incidence-and-presenting-features-a-22-year-population-based-observational-study-from-southwest-sweden
#35
JOURNAL ARTICLE
J Plate, T Söderbergh, J Bergqvist, C Lingblom, H Bergquist, H Larsson
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that affects both children and adults. Symptoms in adults are mainly esophageal dysphagia, which ranges from mild symptoms to acute food bolus obstruction of the esophagus. Diagnosis is defined as symptoms of esophageal dysfunction and ≥ 15 eosinophils/high power field (HPF) in at least one of the biopsies taken from the esophagus. EoE appears to be increasing in both prevalence and incidence. The aim of this study was to investigate the prevalence, incidence, and presenting symptoms of patients with EoE within the catchment area of Northern Älvsborg County Hospital in Trollhättan...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525936/pilot-study-evaluating-salivary-bile-acids-as-a-diagnostic-biomarker-of-laryngopharyngeal-reflux
#36
JOURNAL ARTICLE
Amanda J Krause, Madeline Greytak, Marco Kessler, Rena Yadlapati
Bile acids in refluxate contribute to esophageal and laryngeal symptoms and are quantifiable. The aim of this study was to compare salivary bile acid concentrations across healthy controls and symptomatic patients (esophageal or laryngeal) with or without objective gastroesophageal reflux disease (GERD). This prospective study enrolled adults into three groups: esophageal symptoms (heartburn, regurgitation, chest pain); laryngeal symptoms (cough, throat clearing, sore throat, dysphonia); and controls. Symptomatic patients primarily underwent prolonged wireless reflux monitoring off acid suppression and were categorized as symptomatic no GERD (acid exposure time <4%) or esophageal/laryngeal symptoms with GERD (acid exposure time ≥4%)...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525934/predictors-of-textbook-outcome-following-oesophagogastric-cancer-surgery
#37
JOURNAL ARTICLE
Ganesh K Velayudham, Alexander Dermanis, Sivesh K Kamarajah, Ewen A Griffiths
Textbook outcome (TO) is a composite measure representing an ideal perioperative course, which has been utilized to assess the quality of care in oesophagogastric cancer (OGC) surgery. We aim to determine TO rates among OGC patients in a UK tertiary center, investigate predictors of TO attainment, and evaluate the relationship between TO and survival. A retrospective analysis of a prospectively collected departmental database between 2006 and 2021 was conducted. Patients that underwent radical OGC surgery with curative intent were included...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38525929/research-gap-in-esophageal-achalasia-a-narrative-review
#38
JOURNAL ARTICLE
Edoardo Vincenzo Savarino, Renato Salvador, Matteo Ghisa, Amir Mari, Francesca Forattini, Andrea Costantini, Roberto De Giorgio, Giovanni Zaninotto
In recent years, new translational evidence, diagnostic techniques, and innovative therapies have shed new light on esophageal achalasia and revamped the attention on this relatively rare motility disorder. This narrative review aims to highlight the most recent progress and the areas where further research is needed. The four senior authors identified five topics commonly discussed in achalasia management: i.e. pathogenesis, role of functional lumen imaging probe in the diagnostic flow chart of achalasia, how to define the outcome of achalasia treatments, how to manage persistent chest pain after the treatment, and if achalasia patients' may benefit from a regular follow-up...
March 24, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38521967/concurrent-abnormal-non-acid-reflux-is-associated-with-additional-chronic-rejection-risk-in-lung-transplant-patients-with-increased-acid-exposure
#39
JOURNAL ARTICLE
Wai-Kit Lo, Mayssan Muftah, Hilary J Goldberg, Nirmal Sharma, Walter W Chan
Acid reflux has been associated with allograft injury and rejection in lung transplant patients; however, the pathogenic role of non-acid reflux remains debated. We aimed to evaluate the impact of concurrent abnormal non-acid reflux with acid reflux on chronic rejection in lung transplant patients with acid reflux. This was a retrospective cohort study of lung transplant recipients who underwent pre-transplant combined impedance-pH study off acid suppression. Only subjects with acid exposure >4% were included...
March 23, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://read.qxmd.com/read/38493308/diagnosis-and-treatment-of-junctional-cancer-from-a-global-perspective
#40
JOURNAL ARTICLE
Bas P L Wijnhoven, Ewen A Griffiths
No abstract text is available yet for this article.
March 15, 2024: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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