journal
https://read.qxmd.com/read/36927356/thyroid-hormone-profile-in-preeclampsia-patients-a-case-control-study
#1
JOURNAL ARTICLE
Nii Ayite Aryee, Kwame Adu-Bonsaffoh, Benjamin Arko-Boham, Osbourne Quaye, Hope Asazu, Emmanuel Tagoe
Objective: Preeclamptic women are reported to have a higher incidence of thyroid dysfunction that correlates with the severity of preeclampsia. The aim of this study was to assess thyroid hormone profiles in in pregnant women with preeclampsia and gestational hypertension and the risk for thyroid dysfunction. Methods: In this study, age-matched pregnant females in the second trimester of pregnancy, diagnosed with preeclampsia (PE), gestational hypertension (GH), as cases, and apparently healthy normotensive (NT) pregnant woman as controls were recruited...
March 16, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36918022/women-s-attitudes-about-combined-hormonal-contraception-chc-induced-menstrual-bleeding-changes-influence-of-personality-traits-in-an-italian-clinical-sample
#2
JOURNAL ARTICLE
Rossella E Nappi, Lara Tiranini, David Bosoni, Laura Cucinella, Manuela Piccinino, Andrea Cumetti, Valeria Perone, Chiara Benedetto
OBJECTIVES: We investigated the attitudes to change the frequency of menstrual bleeding by using combined hormonal contraception (CHC). Personality characteristics were also explored. METHODS: We conducted a cross-sectional study in two university hospitals in northern Italy. Current, past and never CHC users ( n  = 545; age 18-44 years) completed a self-administered semi-structured questionnaire and the Ten-Item Personality Inventory (TIPI)...
March 14, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36878245/ovarian-steroid-cell-tumor-not-otherwise-specified-with-subsequent-spontaneous-pregnancy-after-tumor-removal-a-case-report-and-literature-review
#3
JOURNAL ARTICLE
Phawat Matemanosak, Krantarat Peeyananjarassri, Chitkasaem Suwanrath, Saranya Wattanakumtornkul, Satit Klangsin, Ekasak Thiangphak, Kanet Kanjanapradit
Steroid cell tumors not otherwise specified are rare sex cord-stromal tumors of the ovary that may produce various steroids and are associated with hirsutism and virilization. We report a rare case of ovarian steroid cell tumor with subsequent spontaneous pregnancy after tumor removal. A 31-year-old woman presented with secondary amenorrhea, hirsutism, and inability to conceive. Clinical and diagnostic evaluations revealed a left adnexal mass and elevated serum total testosterone and 17α-hydroxyprogesterone levels...
March 6, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36842967/isorhamnetin-inhibits-inflammatory-response-to-alleviate-dhea-induced-polycystic-ovary-syndrome-in-rats
#4
JOURNAL ARTICLE
Fei Yu, Yanfeng Xue, Yunyan Zhao, Long Zhang, Xiao He, Zheng Liu
OBJECTIVE: To explore the role of isorhamnetin on polycystic ovary syndrome (PCOS) in rats. METHODS: Sprague Dawley (SD) rats were subcutaneously injected with dehydroepiandrosteron (DHEA) to establish PCOS model. Hematoxylin and eosin (H&E) staining and TdT-mediated dUTP Nick-End Labeling (TUNEL) were used to measure histological changes and apoptosis of ovary tissues. The levels of serum hormones and inflammatory factors in ovary tissues were measured by enzyme-linked immuno sorbent assay (ELISA)...
February 26, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36828304/association-of-the-kiss1-lin28b-vdr-and-er%C3%AE-gene-polymorphisms-with-early-and-fast-puberty-in-chinese-girls
#5
JOURNAL ARTICLE
Yunwei Li, Huifeng Zhang, Qiang Li, Xinwei Huang, Xiangyang Kong
OBJECTIVES: To explore the association of KISS1 , LIN28B , vitamin D receptor ( VDR ) , and estrogen receptor α ( ERα ) gene polymorphisms and the risk of early with fast puberty (EFP) risk, and with hormone levels in EFP cases, in Chinese girls. METHODS: The analysis was based on the data of 141 girls with EFP and 152 girls without EFP. Clinical features were documented, and all SNP genotyping was conducted using SNaPshot method. Statistical analysis was performed to assess the association of the SNPs with EFP risk, and with hormone levels in EFP cases...
February 24, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36824010/resveratrol-improves-ovarian-state-by-inhibiting-apoptosis-of-granulosa-cells
#6
JOURNAL ARTICLE
Ying Liang, Mei-Ling Xu, Xing Gao, Yan Wang, Li-Nan Zhang, Ya-Cong Li, Qing Guo
AIM: Among the natural polyphenolic compounds, resveratrol (RES) is known for reducing the effects of declining reproductive power through resisting senility, anti-oxidant and anti-inflammatory, while the molecular mechanism of RES in human ovaries is unclear. We aimed to evaluate the most likely mechanisms of RES against apoptosis induced by H2 O2 in human ovary granulosa cells. METHODS: Ovarian granulosa cells from infertile women (≤35 years old) were collected...
February 23, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36822231/optimal-number-of-high-quality-cleavage-stage-embryos-for-extended-culture-to-blastocyst-stage-for-transfer-in-women-38-years-and-older
#7
JOURNAL ARTICLE
Xia Xue, Wei Li, Mingzhao Li
PURPOSE: We aimed to evaluate the pregnancy outcomes of cleavage-stage embryo transfers (ETs) for the first time and explore optimal number of high-quality cleavage-stage embryos for extended culture to blastocyst-stage in women of advanced maternal age (AMA). METHODS: We retrospectively identified 1646 AMA women ≥ age 38 years for the first fresh ETs between January 2014 and December 2020 at our hospital. Double ETs were divided into three groups as follows: DET-HH (two high-quality embryos), DET-HL (one high-quality and one low-quality embryo), and DET-LL (two low-quality embryos) groups...
February 23, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36822227/personalized-embryo-transfer-based-on-rna-sequencing-endometrial-receptivity-test-in-repeated-implantation-failure-patients-artificial-cycle-versus-natural-cycle
#8
JOURNAL ARTICLE
Mingming Shu, Shun Yao, Wei Zhong, Chunlan Song, Fu Chen, Wei Shang
INTRODUCTION: Embryo implantation provides an efficient way for patients with repeated implantation failure (RIF) to achieve pregnancy. The aim of this study is to compare the implantation outcomes of RIF patients in artificial cycle to those in natural cycle, both were treated with RNA sequencing endometrial receptivity test (rsERT) based personalized embryo implantation. METHODS: The endometrial receptivity (ER) analysis was performed using rsERT followed by personalized embryo transfer at optimal window of implantation (WOI)...
February 23, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36822223/the-ameliorative-effect-of-cangfu-daotan-decoction-on-polycystic-ovary-syndrome-of-rodent-model-is-associated-with-m6a-methylation-and-wnt-%C3%AE-catenin-pathway
#9
JOURNAL ARTICLE
Yuwei Zhang, Haili Zhou, Caifei Ding
Objective: This study investigates the effects of CangFu Daotan Decoction (CDD) on m6A methylation and Wnt/β-catenin pathway in rats with polycystic ovary syndrome (PCOS). Methods: The PCOS rat model was established by letrozole gavage. The rats were fed high-fat chow, and their body weight and blood glucose were recorded. The expressions of follicle-stimulating hormone(FSH), luteinizing hormone(LH), and testosterone(T) were quantified by ELISA. Chemical components in CDD were analyzed using UPLC-Q/TOF-MS...
February 23, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36809792/microrna-23a-3p-overexpression-represses-proliferation-and-accelerates-apoptosis-of-granular-cells-in-polycystic-ovarian-syndrome-by-targeting-hmga2
#10
JOURNAL ARTICLE
Junzi Wei, Ping Cheng, Mei Kong, Ling Zhang, Shuang Liu, Bingxue Ning, Xinlin Huang
OBJECTIVE: Granular cells (GCs) are involved in polycystic ovarian syndrome (PCOS) progression. MicroRNA (miR)-23a downregulation is linked to PCOS development. Therefore, this research explored the influences of miR-23a-3p on GC proliferation and apoptosis in PCOS. METHODS: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were conducted to examine miR-23a-3p and HMGA2 expression in GCs of patients with PCOS. Then, miR-23a-3p and/or HMGA2 expression was altered in GCs (KGN and SVOG), after which miR-23a-3p, HMGA2, Wnt2, and β-catenin expression, GC viability, and GC apoptosis were measured by RT-qPCR and western blotting, MTT assay, and flow cytometry, respectively...
February 21, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36750132/proteomic-and-bioinformatic-analysis-of-human-endometrium-from-polycystic-ovarian-syndrome-with-and-without-insulin-resistance
#11
JOURNAL ARTICLE
Xin Yang, Wang Xiaoping, Ding Nan, Zhang Jian, Li Xiaofeng, Yuan Liwei, Mengni Zhao, Fang Wang
Objective: The aim of this study was to investigate the endometrial proteomic profiles of patients with polycystic ovary syndrome (PCOS) with and without insulin resistance (IR). Method of Study: We collected 40 endometrial samples, including PCOS-IR ( n  = 21), PCOS-non-IR ( n  = 12), and control ( n  = 7). Data-independent acquisition (DIA)-based proteomics method is used to identify the expressed proteins among the three groups. The correlation between pregnancy outcomes and identified proteins was analyzed by Lasso regression...
February 7, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36734253/adenomyosis-is-an-endocrine-related-uterine-dysfunction
#12
EDITORIAL
Silvia Vannuccini, Felice Petraglia
No abstract text is available yet for this article.
February 3, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36708155/triglyceride-glucose-index-is-associated-with-metabolic-syndrome-in-women-with-polycystic-ovary-syndrome
#13
JOURNAL ARTICLE
Haiyan Yang, Yufeng Chen, Chang Liu
OBJECTIVE: To explore the correlation of triglyceride-glucose index (TyG) index with metabolic syndrome (MetS) and metabolic risk factors, and to assess the predictive value of TyG for MetS in women with PCOS. METHODS: This is a retrospective cross-sectional study that included 819 women diagnosed with PCOS and 3122 women without PCOS from January 2018 to December 2021. The definition of MetS adopted in this study was the International Diabetes Federation (IDF) criteria...
January 28, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36690019/nomac-e2-compares-to-lng-combined-oral-contraceptives-in-women-over-forty-real-world-pro-e2-study
#14
JOURNAL ARTICLE
Sophia von Stockum, Kerstin Becker, Anja Bauerfeind, Christian Franke, Franca Fruzzetti, Joaquim Calaf, Christoph Keck, Klaas Heinemann
OBJECTIVE: To investigate safety and effectiveness of NOMAC-E2 and levonorgestrel-containing COCs (COCLNG ) in users over 40. METHODS: In this large, observational study, new users1 of NOMAC-E2 and COCLNG were recruited in Europe, Australia, and Latin America and followed-up via questionnaires. Incidence of venous thromboembolism (VTE) was expressed as incidence rate (IR; events/104 women-years [WY]). Unintended pregnancy was expressed by the Pearl Index (PI; contraceptive failures/100 WY)...
January 23, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36657482/mir-761-hepcidin-gpx4-pathway-contribute-to-unexplained-liver-dysfunction-in-polycystic-ovary-syndrome-by-regulating-liver-iron-overload-and-ferroptosis
#15
JOURNAL ARTICLE
Ruoheng Zheng, Chuanping Lin, Yuchan Mao, Fan Jin
Aims: To investigate the underling mechanisms of liver dysfunction in patients with polycystic ovary syndrome (PCOS). Materials and methods: PCOS patients were enrolled according to the Amsterdam criteria while PCOS animal model was established by dihydrotestosterone (DHEA) sustained release tablet implantation on its neck. Further liver damage and iron overload were detected by HE and Prussian blue staining. The liver related enzymes, mRNA and protein levels of hepcidin and GPX4 were tested by ELISA, qRT-PCR and Western blot...
January 19, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36655409/differentiated-serum-levels-of-kr%C3%A3-ppel-like-factors-2-and-4-sp-selectin-and-se-selectin-in-patients-with-gestational-diabetes-mellitus
#16
JOURNAL ARTICLE
Hongmei Zhang, Zhigao Chen, Xiaoling Wang
OBJECTIVES: This study aims to determine serum levels of human Krüppel-like factors (KLFs), sP-selectin and sE-selectin and establish correlations between them in patients with gestational diabetes mellitus (GDM). METHODS: Twenty-six GDM patients aged between 22 and 35 years and 25 healthy pregnant women aged between 23 and 34 years were recruited. Maternal serum levels of KLF2, KLF4, and their target proteins sP-selectin, sE-selectin were measured using enzyme-linked immunosorbent assays at 24-28 weeks of gestation...
January 19, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36634704/a-case-of-polycystic-ovary-syndrome-with-inevitable-miscarriage-and-multi-site-venous-thrombosis-caused-by-hereditary-protein-c-deficiency
#17
JOURNAL ARTICLE
Minglin Zhong, Yanping Tu, Xiuhong Peng, Yue Song, Jiahe Zhou, Xiaowei Zhang, Qiuyi Xu, Li Li
BACKGROUND: Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women and raises the risk of venous thromboembolic disease (VTE), due to metabolic features and an apparent fibrinolytic state. Recent studies have shown an increased risk of VTE (1.5- to 2-fold) in patients with PCOS as compared to those without PCOS. Mutations in the Protein C (PC) gene (PROC) lead to deficiency or dysfunction of the protein, Protein C deficiency is the main clotting physiological inhibitor of protein C cofactors, and is a risk factor for venous thrombosis, which can cause a variety of events, including miscarriage...
January 12, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36617423/nomac-e2-shows-a-better-contraceptive-effectiveness-than-lng-combined-oral-contraceptives-in-women-under-25-real-world-pro-e2-study
#18
JOURNAL ARTICLE
Sophia von Stockum, Anja Bauerfeind, Kerstin Becker, Christian Franke, Franca Fruzzetti, Joaquim Calaf, Christoph Keck, Klaas Heinemann
Objective: To investigate unintended pregnancy and changes in mood, acne, and weight in NOMAC-E2 vs levonorgestrel-containing COC (COCLNG ) users under 25 years. Methods: In this large, observational study, new users (first-ever users of an eligible COC or restarting with the same or a new eligible COC after a break of at least 2 months) of NOMAC-E2 and COCLNG were recruited in 12 countries in Europe, Australia, and Latin America and followed up via questionnaires for up to 2 years. Unintended pregnancy was expressed by the Pearl Index (PI; contraceptive failures/100 women-years)...
January 8, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36599370/could-sestrin-protein-in-serum-be-a-new-marker-of-oxidative-stress-in%C3%A2-patients-with-polycystic-ovary-syndrome
#19
JOURNAL ARTICLE
Aysegul Bestel, Burak Elmas, Osman Samet Günkaya, Melih Bestel, Pınar Yalçın Bahat
OBJECTIVE: PCOS (polycystic ovary syndrome) is one of the most common endocrinological disorders and it is the threshold of many systemic disorders. There are many studies in the literature on the mechanisms that cause increased oxidation in PCOS. Sestrin protein is known to regulate the oxidation. In this study, it is aimed to examine the changes in the level of sestrin protein in women with PCOS. METHODS: A total of 60 women participated the study, 30 of whom were diagnosed with PCOS according to the Rotterdam criteria...
January 4, 2023: Gynecological Endocrinology
https://read.qxmd.com/read/36599366/obesity-in-women-s-life-role-of-glp-1-agonists
#20
EDITORIAL
Santiago Palacios
No abstract text is available yet for this article.
January 4, 2023: Gynecological Endocrinology
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