journal
https://read.qxmd.com/read/39001666/statement-of-retraction-oral-carnitine-supplementation-influences-mental-health-parameters-and-biomarkers-of-oxidative-stress-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#1
https://read.qxmd.com/read/38991099/analyzing-the-infertility-burden-of-polycystic-ovarian-syndrome-in-china-a-comprehensive-age-period-cohort-analysis-with-future-burden-prediction-1990-2030
#2
JOURNAL ARTICLE
DongYi Shen, Yang Wang, PanWei Hu, Cong Qi, Hong Yang
OBJECTIVE: Polycystic ovarian syndrome (PCOS) is a common but complex endocrine disorder widely linked to infertility and miscarriage. This study assessed the correlation between PCOS and infertility. METHODS: Using the latest data from the Global Burden of Disease 2019 database, we conducted an in-depth assessment of the disease burden attributed to PCOS in China. This analysis was performed using the joinpoint regression, age-period-cohort, and autoregressive integrated moving average (ARIMA) models...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38976762/ultra-low-dose-continuous-combined-estradiol-and-dydrogesterone-in-postmenopausal-women-a-pooled-safety-and-tolerability-analysis
#3
RANDOMIZED CONTROLLED TRIAL
Tetiana Tatarchuk, John C Stevenson, Qi Yu, Elke Kahler, Marcelo Graziano Custodio, Mulan Ren, Rossella E Nappi, Viktoriya Karpova, Tommaso Simoncini
Objective: To assess the safety and tolerability of ultra-low dose estradiol and dydrogesterone (E0.5 mg/D2.5 mg) among postmenopausal women. Methods: This pooled analysis of data from three clinical studies assessed the effects of continuous combined ultra-low-dose estradiol and dydrogesterone among postmenopausal women. Participants received E0.5 mg/D2.5 mg or placebo for 13 weeks (double-blind, randomized, European study), E0.5 mg/D2.5 mg or placebo for 12 weeks (double-blind, randomized, Chinese study), or E0...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38976752/low-serum-hepcidin-levels-in-women-with-polycystic-ovary-syndrome-evidence-from-meta-analysis
#4
REVIEW
Jieou Nong, Hua Li, Yunfei Yang, Qiujie Lu, Yifan Sun, Qi Yin, Hongying He
BACKGROUND: Iron metabolism plays a significant role in the development of metabolic disorders in women with polycystic ovary syndrome (PCOS). Despite the importance of hepcidin, a key iron regulator, current research on serum hepcidin levels in PCOS patients shows conflicting results. METHODS: PubMed, Embase, Web of Science, Cochrane Library and the China National Knowledge Infrastructure (CNKI) database were systematically searched from their inception to 9 September 2023...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38976721/association-of-dietary-glycemic-index-and-glycemic-load-with-the-risk-of-gestational-diabetes-mellitus-a-systematic-review-and-dose-response-meta-analysis
#5
JOURNAL ARTICLE
Yu Zhang, Huanrong Feng, Xuefeng Li, Qiong Chen, Ruyue Shao, Chengli Wang, Yimeng Gao
OBJECTIVE: To comprehensively assess the dose-response association between dietary glycemic index (GI) and glycemic load (GL) and gestational diabetes mellitus (GDM) risk. METHODS: PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang, and VIP databases were searched up to May 29, 2024. Studies with at least three exposure categories were included. Dose-response analysis was also performed when covariates were adjusted in the included studies. RESULTS: Thirteen studies involving 39,720 pregnant women were included...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38946430/telomerase-activity-telomere-length-and-the-euploidy-rate-of-human-embryos
#6
JOURNAL ARTICLE
Maria Longo, Ermanno Greco, Ilaria Listorti, Maria Teresa Varricchio, Katerina Litwicka, Cristiana Arrivi, Cecilia Mencacci, Pierfrancesco Greco
BACKGROUND: Telomeres maintain chromosome stability, while telomerase counteracts their progressive shortening. Telomere length varies between cell types, with leukocyte telomere length (LTL) decreasing with age. Reduced telomerase activity has been linked to reproductive issues in females, such as low pregnancy rates and premature ovarian failure, with recent studies indicating correlations between telomere length in granulosa cells and IVF outcomes. OBJECTIVES: The study aims to explore the relationship between telomere length, telomerase activity, and euploid blastocyst rate in infertile women undergoing IVF/ICSI PGT-A cycles...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38946301/thyroid-ultrasonic-changes-relate-to-implantation-failure-in-euthyroid-women-with-thyroid-autoimmunity-undergoing-in-vitro-fertilization-intracytoplasmic-sperm-injection
#7
JOURNAL ARTICLE
Jiahui Wang, Wei Zhou, Jincheng Li, Shuo Zhang, Tong Wu, Zhiyi Song, Chenxi Li, Zengxiang Ma, Yingxin Zhang
OBJECTIVE: To determine whether ultrasonic manifestations of Hashimoto's thyroiditis (HT) related to embryo qualities or pregnancy outcomes in women with thyroid autoimmunity (TAI) undergoing in vitro fertilization/intracytoplasmic sperm injection. METHODS: Our study was a retrospective cohort study. A total of 589 euthyroid women enrolled from January 2017 to December 2019. 214 TAI women and 375 control women were allocated in each group according to serum levels of thyroid peroxidase antibodies (TPOAb) and/or anti-thyroglobulin antibodies (TgAb)...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38946245/clinical-parameters-that-predict-a-premature-lh-rise-in-patients-undergoing-ovarian-stimulation-for-ivf
#8
JOURNAL ARTICLE
Maya Nasatzky, Yonathan Belicha, Ofer Fainaru
Background: Normal reproductive function requires adequate regulation of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion. During ovarian stimulation for in-vitro fertilization (IVF), some patients will demonstrate an early rise in LH despite being treated with a gonadotropin releasing-hormone (GnRH) antagonist, sometimes necessitating cycle cancellation. Previous studies have demonstrated a possible link between a premature LH rise with ovarian response to gonadotropins. We sought to determine what clinical parameters can predict this premature LH rise and their relative contribution...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38946240/effect-of-body-mass-index-on-progesterone-level-on-trigger-day-in-gonadotropin-releasing-hormone-antagonist-cycles
#9
JOURNAL ARTICLE
Yating Sun, Aizhen Zhu
OBJECTIVE: To investigate the effect of body mass index (BMI) on progesterone (P) level on trigger day in gonadotropin-releasing hormone antagonist (GnRH-ant) cycles. METHODS: This study was a retrospective cohort study. From October 2017 to April 2022, 412 in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) patients who were treated with GnRH-ant protocol for controlled ovarian hyperstimulation (COH) in the reproductive center of our hospital were selected as the research objects...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38946226/unmet-needs-in-abnormal-uterine-bleeding-due-to-ovulatory-dysfunction
#10
REVIEW
Tommaso Simoncini, Hisham Arab, Nataliia Pedachenko, Qinjie Tian, Fernando Pineda, Balamba Puranam, Rubina Sohail, Maria Celeste Osorio Wender
Ovulatory disorders are a common cause of abnormal uterine bleeding in women of reproductive age. The International Federation of Gynecology and Obstetrics currently offers a causal classification system for ovulatory disorders but does not provide clear management recommendations. There remains regional disparity in treatment practices, often influenced by institutional and insurance regulations as well as cultural and religious practices. A panel of experts evaluated current gaps in ovulatory disorder management guidelines and discussed potential strategies for addressing these unmet needs...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38913119/systemic-testosterone-for-the-treatment-of-female-sexual-interest-and-arousal-disorder-fsiad-in-the-postmenopause
#11
REVIEW
Laura Ribera Torres, Sònia Anglès-Acedo, Laura López Chardi, Eduard Mension Coll, Camil Castelo-Branco
INTRODUCTION: Female sexual interest and arousal disorder (FSIAD) is the most prevalent female sexual dysfunction in the postmenopause. OBJECTIVE: The aim of this review is to provide a summary of the currently available evidence on the use of testosterone in the treatment of FSIAD in postmenopausal women. METHODS: A narrative review on the topic was performed. Only randomized controlled trials (RCTs) and systematic reviews and meta-analysis were considered...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38913084/the-association-between-female-sexual-function-and-metabolic-features-of-the-polycystic-ovary-syndrome-in-turkish-women-of-reproductive-age
#12
JOURNAL ARTICLE
Meral Cevik Dogan, Tevfik Yoldemir
OBJECTIVE: To investigate the association between female sexual function and metabolic features among women with polycystic ovary syndrome (PCOS) during reproductive age. METHOD: This was a cross-sectional study in which 288 women with PCOS and 180 women without PCOS between the ages of 20 and 40 years were evaluated. All women had serum total testosterone, androstenedione, DHEA-S, fasting glucose, total cholesterol, HDL-C, LDL-C, and triglyceride levels analyzed...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38835267/network-meta-analysis-of-four-common-immunomodulatory-therapies-for-the-treatment-of-patients-with-thin-endometrium
#13
JOURNAL ARTICLE
Lifei Li, Zhijian Kou, Fei Zhao, Yan Wang, Xuehong Zhang
OBEJECTIVE: To compare the effectiveness of endometrial receptivity and pregnancy outcomes of four common immunomodulatory therapies for patients with thin endometrium. METHOD: This systematic review and network meta-analysis using a literature search up to January 2024, to identify relevant trials comparing endometrial receptivity and pregnancy outcomes of human chorionic gonadotropin (hCG), platelet-rich plasma (PRP), infusion of granulocyte colony-stimulating factor (IG-CSF), and peripheral blood mononuclear cell (PBMC) for patients with thin endometrium...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38835150/the-effect-of-subclinical-hypothyroidism-on-hormonal-and-metabolic-profiles-and-ovarian-morphology-in-patients-with-polycystic-ovary-syndrome-a-cross-sectional-study
#14
JOURNAL ARTICLE
Dongmei Shi, Juan Du, Huixian Kang, Liping Feng, Fang Liu
OBJECTIVES: Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are prevalent gynecological conditions. However, the interrelationship between the two remains elusive. This study aims to elucidate the association between these conditions and determine the potential impact of SCH on the physiological and metabolic characteristics of patients with PCOS. METHODS: This cross-sectional study enrolled 133 patients with PCOS from our Hospital. Participants were categorized into two groups: those with PCOS + SCH ( n  = 58) and those with PCOS ( n  = 75)...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38833172/transfer-of-preclinical-study-data-on-the-influence-of-cimicifuga-racemosa-on-functional-changes-in-the-hippocampus-during-menopause
#15
REVIEW
Petra Stute, Hans-Heinrich Henneicke-von Zepelin, Petra Nicken
Menopausal transition in women involves complex neurobiochemical changes linked to ovarian dysfunction, resulting in symptoms like vasomotor symptoms (VMS), sleep disturbances, anxiety, and cognitive impairments. Hormone replacement therapy is the first-line treatment. However, many women are reluctant to use HRT or have contraindications toward HRT and seek for alternatives. Non-hormonal therapies with extracts of Cimicifuga racemosa rhizomes like the isopropanolic extract (iCR, black cohosh) offer a promising alternative...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38828774/statement-of-retraction-clomiphene-citrate-combined-with-metformin-versus-letrozole-for-induction-of-ovulation-in-clomiphene-resistant-polycystic-ovary-syndrome-a-randomized-clinical-trial
#16
(no author information available yet)
No abstract text is available yet for this article.
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38818662/sirt2-dependent-dkk1-deacetylation-aggravates-polycystic-ovary-syndrome-by-targeting-the-tgf-%C3%AE-1-smad3-signaling-pathway
#17
JOURNAL ARTICLE
Lan Chen, Caixia Kong
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a prevalent metabolic and endocrine condition in females of reproductive age. This work was to discover the underlying role of Dickkopf 1 (DKK1) and its putative regulating mechanism in P COS. METHODS: Mice recieved dehydroepiandrosterone (DHEA) injection to establish the in vivo P COS model.Hematoxylin and eosin (H&E) staining was performed for histological analysis. RT-qP CR and Western blotting were used to detect gene and protein expression...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38818646/menstrual-pattern-in-polycystic-ovary-syndrome-and-hypothalamic-pituitary-ovarian-axis-immaturity-in-adolescents-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Lea T S Zuchelo, Mayara S Alves, Edmund C Baracat, Isabel C E Sorpreso, José M Soares
OBJECTIVE: To analyze differences in the menstrual pattern, age at menarche, and body mass index (BMI) in adolescents with Hypothalamic-Pituitary-Ovarian (HPO) axis immaturity and Polycystic Ovary Syndrome (PCOS) through a systematic review and meta-analysis. METHODS: The PubMed, EMBASE, Web of Science, Virtual Health Library, Scopus databases were searched using combinations of descriptors. Study quality was assessed using the Newcastle-Ottawa Scale. For data analysis, the results were grouped into PCOS group and NPCOS group (HPO axis immaturity)...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38813955/psychological-stressors-involved-in-the-pathogenesis-of-premature-ovarian-insufficiency-and-potential-intervention-measures
#19
REVIEW
Ying-Pei Xu, Ji-Chun Fu, Zhi-Lin Hong, De-Fei Zeng, Chao-Qin Guo, Ping Li, Jin-Xiang Wu
Premature ovarian insufficiency (POI) is a common gynecological endocrine disease, which seriously affects women's physical and mental health and fertility, and its incidence is increasing year by year. With the development of social economy and technology, psychological stressors such as anxiety and depression caused by social, life and environmental factors may be one of the risk factors for POI. We used PubMed to search peer-reviewed original English manuscripts published over the last 10 years to identify established and experimental studies on the relationship between various types of stress and decreased ovarian function...
December 2024: Gynecological Endocrinology
https://read.qxmd.com/read/38813954/nonalcoholic-fatty-liver-disease-risk-in-polycystic-ovary-syndrome-patients
#20
EDITORIAL
Ana M Fernández-Alonso, Peter Chedraui, Faustino R Pérez-López
No abstract text is available yet for this article.
December 2024: Gynecological Endocrinology
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