journal
https://read.qxmd.com/read/37706434/the-ameliorating-effects-of-guizhi-fuling-wan%C3%A2-combined-with-rosiglitazone-in-a-rat-ovarian-model-of-polycystic-ovary-syndrome-by-the-pi3k-akt-nf-%C3%AE%C2%BAb-and-nrf2-ho-1-pathways
#1
JOURNAL ARTICLE
Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan
OBJECTIVE: GuizhiFulingWan (GFW) has been reported to be effective against polycystic ovary syndrome (PCOS) by possessing oxidative stress and inflammation which related to PI3K/AKT/NF-κB, Nrf2/HO-1 pathway. This study aims to probe the effects and mechanisms of GFW combined with rosiglitazone on PCOS via PI3K/AKT/NF-κB and Nrf2/HO-1 pathways. METHODS: A rat PCOS model established by dehydroepiandrosterone (DHEA) injection. The experiment was allocated to control, DHEA, GFW, rosiglitazone, GFW + rosiglitazone groups...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37673102/association-between-endometriosis-and-metabolic-syndrome-a-cross-sectional-study-based-on-the-national-health-and-nutrition-examination-survey-data
#2
JOURNAL ARTICLE
Baijia Li, Yuxue Zhang, Liuhang Zhang, Lingyan Zhang
BACKGROUND: Endometriosis has been reported to be associated with metabolism-related diseases, such as hypercholesterolemia and diabetes, while no studies have reported the association between endometriosis and metabolic syndrome. OBJECTIVE: This study aims to explore the association between endometriosis and metabolic syndrome. Also, the association between endometriosis and single metabolic syndrome indicator was explored. METHODS: This was a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES)...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37673099/prevalence-of-metabolic-syndrome-and-its-components-in-chinese-women-with-premature-ovarian-insufficiency
#3
JOURNAL ARTICLE
Jing Jin, Xiangyan Ruan, Lin Hua, Alfred O Mueck
OBJECTIVES: To assess the prevalence of metabolic syndrome (MetS) and its components in Chinese women with premature ovarian insufficiency (POI) and to explore the metabolic profile of Chinese women with POI. METHODS: 118 POI women aged 20-38 years and 151 age-and-BMI-matched control women were recruited. Measurements included body height, weight, waist circumference (WC), hip circumference (HC), blood pressure, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG) and fasting insulin (FINS)...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37666276/overcoming-barriers-to-oral-contraception-in-italy-an-expert-opinion-to-empower-women
#4
REVIEW
Rossella E Nappi, Manuela Farris, Achille Gallina Toschi, Raffaella Michieli, Francesca Moccia, Nicoletta Orthmann, Emilio Arisi
Oral contraceptives are among the most commonly used contraceptive methods. However, Italian women underused reliable hormonal contraceptives as compared with other European women. There is a need to streamline access to oral contraception, with expected benefits on emotional well-being of women and potential savings for health system in Italy. Indeed, women can only access to oral contraceptives through mandatory medical prescription. This is one of the most important barrier experienced by women. We hereby provide an expert opinion on the potential reclassification, extending pharmacy services to include responsible and appropriate use of POP, as an opportunity also in Italy to increase the use of safe and effective contraceptive methods...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37647939/mutation-of-aspartic-acid-262-on-estrogen-receptor-abrogates-estradiol-signaling-pathway
#5
JOURNAL ARTICLE
Xingyan Xu, Haowei Yu, Shuihao Zhu, Ping Li, Xiaosa Li, Yongqi Gao, Yixiao Xiang, Guojun Zhao, Tommaso Simoncini, Huiping Lin
OBJECTIVE: ERα (estrogen receptor alpha) exerts nuclear genomic actions and membrane-initiated non-genomic effects. The mutation of aspartic acid into alanine in vitro revealed the critical role of aspartic acid 258 (corresponding to mouse amino acid site 262) of ERα for non-nuclear function. Our previous in vitro study revealed that this mutation blocked estrogen's non-genomic effects on vascular endothelial H2 S release. Here, we studied the in vivo role of the aspartic acid 262 of ERα in the reproductive system and in the vascular tissue...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37625443/comparisons-of-different-treatment-outcomes-in-ivf-et-patients-with-hydrosalpinx-a-retrospective-study
#6
REVIEW
Beibei Bi, Xiao Han, Wei Dai, Lanlan Fang, Hao Shi, Linli Hu
AIMS: To explore suggestions for clinicians on the most effective treatment for hydrosalpinx undergoing IVF-ET. MATERIALS AND METHODS: We reviewed 936 women with hydrosalpinx and 6715 tubal infertile women without hydrosalpinx who underwent IVF/ICSI between January 2014 and August 2019 in our center. Hydrosalpinx patients received different treatments including laparoscopic surgery (only salpingectomy and proximal tubal occlusion/ligation were included), ultrasonic-guided aspiration and hysteroscopic tubal occlusion...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37624969/a-prospective-study-on-the-endometrium-properties-and-the-pregnancy-rate-of-infertile-women-with-thin-endometrium-receiving-fructus-ligustri-lucidi-used-in-traditional-chinese-medicine
#7
JOURNAL ARTICLE
Xiangyan Ruan, Zhongting Xu, Xin Xu, Yu Yang, Jiaojiao Cheng, Suiyu Luo, Min Min, Meng Li, Luping Zhang, Rui Ju, Fengyu Jin, Alfred Otto Mueck
OBJECTIVE: To evaluate whether Zi Gui Nv Zhen capsules (ZGNZC) can increase the fertility rate of Chinese women with infertility due to thin endometrium. METHODS: Prospective, randomized, open-labeled 3-monthly study; 104 patients (aged 20-40 years) receiving either ZGNZC (experimental group, n  = 55) or not (control group, n  = 49). Main outcomes: thickness/type of the endometrium during ovulation and pregnancy rate. Between-group analysis (A) compares the experimental vs...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37608764/differences-in-neonatal-adverse-outcomes-among-women-with-gestational-diabetes-mellitus-managed-by-diet-or-medication-a-propensity-score-matched-analysis-of-a-population-based-sample
#8
JOURNAL ARTICLE
George Mnatzaganian, Marietta Taylor, Fan He, Nicola Yuen, H David McIntyre, Mark Woodward, Liangkun Ma, Rachel R Huxley
OBJECTIVE: Neonatal outcomes in women with and without medically managed gestational diabetes mellitus (GDM) were compared after accounting for differences in maternal baseline characteristics using a propensity score (PS) analysis. METHODS: Women without preexisting diabetes, delivering singletons during 2010-2017 in a large hospital, were eligible for inclusion. Using nearest-neighbour PS matching, women with non-pharmacological managed GDM were matched with women whose GDM was medically managed...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37599373/hormonal-and-natural-contraceptives-a-review-on-efficacy-and-risks-of-different-methods-for-an-informed-choice
#9
REVIEW
Andrea R Genazzani, Tiziana Fidecicchi, Domenico Arduini, Andrea Giannini, Tommaso Simoncini
The debate about contraception has become increasingly important as more and more people seek safe and effective contraception. More than 1 billion women of reproductive age worldwide need a method of family planning, and wellbeing, socio-economic status, culture, religion and more influence the reasons why a woman may ask for contraception. Different contraceptive methods exist, ranging from 'natural methods' (fertility awareness-based methods - FABMs) to barrier methods and hormonal contraceptives (HCs). Each method works on a different principle, with different effectiveness...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37553809/trimester-specific-reference-intervals-of-serum-homocysteine-levels-for-pregnant-women-a-longitudinal-study-in-china
#10
JOURNAL ARTICLE
Hai Liu, Qing Li, Ting Liu, Yuanting Tang, Fan Yu
OBJECTIVE: To investigate the physiological changes of serum homocysteine (Hcy) levels and to establish trimester-specific reference intervals of serum Hcy levels for Chinese pregnant women. METHOD: According to the guideline of the Clinical and Laboratory Standards Institute (CLSI) C28-A3 document, 476 healthy women were recruited in West China Second University Hospital, Sichuan University from January 2021 to October 2021. Among them, 120 were non-pregnant, 118 were in the first trimester, 120 were in the second and 118 were in the third trimester of gestation...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37553011/autophagy-dependent-ferroptosis-is-involved-in-the-development-of-endometriosis
#11
JOURNAL ARTICLE
Hui Li, Huadi Yang, Shenyi Lu, Xinyan Wang, Xinhe Shi, Peiyu Mao
OBJECTIVE: Endometriosis (EMS) is an estrogen-dependent condition with unclear pathogenesis. Recent findings suggest implicate autophagy and ferroptosis in EMS development. METHODS: We assessed autophagy and ferroptosis proteins in EMS patients using immunohistochemistry and western blot and established an EMS rat model through allograft endometrial transplantation, confirmed via hematoxylin and eosin staining and epithelial-mesenchymal transition -related proteins...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37550858/one-abnormal-value-or-vomiting-after-oral-glucose-tolerance-test-in-pregnancy-incidence-and-impact-on-maternal-fetal-outcomes
#12
JOURNAL ARTICLE
Humberto Navarro-Martinez, Juana-Antonia Flores-Le Roux, Gemma Llauradó, Lucia Gortazar, Antonio Payà, Laura Mañé, Juan Pedro-Botet, David Benaiges
OBJECTIVE: To analyze pregnancy outcomes of women with one abnormal value (OAV) during oral glucose tolerance test (OGTT) or OGTT-intolerance, compared with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) pregnant women, according to whether they received any health intervention or not. METHODS: An observational retrospective study was designed including pregnant women who gave birth at Hospital del Mar, Barcelona (Spain) during December/2014-July/2018...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37537884/rapid-reduction-of-adenomyosis-coexisting-with-leiomyoma-volume-during-treatment-with-relugolix
#13
JOURNAL ARTICLE
Keitaro Yamanaka, Keiichi Washio, Akiko Uchida, Yuki Sasagawa, Masashi Nishimoto, Yui Yamasaki, Satoshi Nagamata, Yoshito Terai
OBJECTIVE: This study elucidated the efficacy of Relugolix (REL) on the reduction of uterine volume and clinical symptoms for the treatment of adenomyosis. METHODS: We conducted a retrospective cohort study of patients who received REL (40 mg for about 20 weeks) and who underwent a hysterectomy for adenomyosis or fibroids. We divided patients into two groups: adenomyosis coexisting with fibroids (Group A) and fibroids only (Group B); the groups were determined by a postoperative pathological examination...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37524309/metabolic-characteristics-of-obese-patients-with-polycystic-ovarian-syndrome-a-meta-analysis
#14
JOURNAL ARTICLE
Xiaotian Pan
OBJECTIVE: Though recent studies have pointed out different manifestations between obese and nonobese patients with polycystic ovarian syndrome (PCOS), there is no clear evidence to confirm this viewpoint. Therefore, the metabolic characteristics of obese and nonobese patients with PCOS were systematically compared through meta-analysis in this study. METHODS: Data were searched from PubMed, Web of Science, Embase, Cochrane Library, CNKI, and Wanfang databases. Articles on obese and nonobese patients with PCOS published from database inception to January 2022 were included...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37486308/acute-spontaneous-non-hemorrhagic-adrenal-infarction-in-pregnancy-case-report-and-literature-review
#15
REVIEW
Sara Ornaghi, Federica Fernicola, Elisabetta Marelli, Mario Perotti, Filiberto Di Gennaro, Irene Cameroni, Eloisa M Mariani, Angela I Pincelli, Elisabetta Colciago, Irene Cetin, Patrizia Vergani
Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely recognition is pivotal to ensuring optimal outcomes. Here we describe a case of spontaneous unilateral NHAI diagnosed in a singleton pregnant woman at 32 weeks' gestation at our centre and provide the findings of an extensive literature review on the topic. We identified 22 articles describing 31 NHAI cases in 30 obstetric patients: NHAI occurs more frequently on the right side and in the third trimester, and diagnosis is formulated more than 24 h after clinical presentation in 50% of cases; second-level imaging is always necessary to reach a definitive diagnosis and start appropriate treatment...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37478894/prevalence-of-menopausal-symptoms-and-severity-related-factors-among-mid-aged-paraguayan-women-as-measured-with-the-10-item-cervantes-scale
#16
JOURNAL ARTICLE
Sandra C Sánchez-Zarza, Anastasia K Armeni, Peter Chedraui, Faustino R Pérez-López, Antonio W D Gavilanes
Objective: To determine the prevalence of menopausal symptoms and factors related to severity in mid-aged women. Methods: Cross-sectional study in which 216 urban-living women from Asunción-Paraguay (40-60 years) were surveyed with the 10 item Cervantes Scale (CS-10) and a general questionnaire (personal and partner data). Results: Median (interquartile range [IQR]) age of the sample was 48 [9] years, 48.1% were postmenopausal, 8.8% used menopausal hormone therapy, 39.4% psychotropic drugs, 43.5% had hypertension, 6...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37439005/ovarian-reserve-analysis-in-subfertile-women-based-on-physical-ultrasound-and-hormonal-parameters
#17
JOURNAL ARTICLE
Sudakshina Chakrabarti
Purpose : Despite the availability of several markers for the evaluation of ovarian reserve, the correlation between the markers has not been reported clearly in the existing studies. Therefore, this study investigated the level of subfertility by comparing the physical parameters such as age and BMI in the subfertile women. In addition, the study compared the ultrasound and hormonal parameters with the physical parameters in subfertile women. Methods : A total of 200 subfertile patients presented to outpatient department were considered in this study...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37395213/talin1-regulates-glucose-metabolism-and-endometrial-receptivity-via-glut-4-in-patients-with-polycystic-ovary-syndrome-and-insulin-resistance
#18
JOURNAL ARTICLE
Jingjing Li, Saiqiong Chen, Rongyan Qin, Xin Liu, Li Fan, Mengjun Wei, Jiajia Wei, Jiajing Lin, Fengque Zheng
Objectives : Talin1 is a cytoskeletal protein and is localized between cells and the extracellular matrix. This study aimed to investigate the mechanism by which Talin1 affects glucose metabolism and endometrial receptivity via glucose transporter proteins-4 (GLUT-4) in patients with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Methods: We examined the expression of Talin1 and GLUT4 in the receptive endometrium of PCOS-IR and control patients. GLUT4 expression was examined after silencing and overexpression of Talin1 in Ishikawa cells...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37393931/effect-of-blastocyst-morphology-on-the-incidence-of-monozygotic-twinning-pregnancy-after-single-blastocyst-transfer
#19
JOURNAL ARTICLE
Xiaofei Ge, Jiaxin Zhang, Hao Shi, Zhiqin Bu
Aims: To explore whether blastocyst morphology [blastocyst stage, inner cell mass (ICM), and trophectoderm (TE) grading] impacts the occurrence of monozygotic twinning (MZT) after single blastocyst transfer (SBT). Materials and methods: A single-center retrospective cohort study was conducted including all clinical pregnancies after single blastocyst transfer between January 2015 and September 2021 ( n  = 9229). Blastocyst morphology was assessed using Gardner grading system. MZT was defined as more than one gestational sac (GS), or two or more fetal heartbeats in a single GS via ultrasound at 5-6 gestational weeks...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37369250/metabolomics-analysis-in-endometriosis-patients-is-it-a-step-toward-the-future
#20
EDITORIAL
Stefano Angioni, Stefania Saponara, Salvatore Giovanni Vitale
No abstract text is available yet for this article.
December 2023: Gynecological Endocrinology
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