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Haining Yu, Zhen Yu, Haiyong Huang, Peng Li, Qiu Tang, Xique Wang, Shengrong Shen
The aim of the study was to address the causality links and identify specific features of the gut microbiota signatures contributing to host lipids metabolism in the presence or absence of polyene phosphatidylcholine (PPC) administration, and evaluate potential risk of PPC consumption. About 20 C57BL/6J mice were randomly allocated into two groups, normal diet group (CK) and PPC administration group (205.2 mg/kg). Compared with CK group, the contents of unsaturated fatty acids were increased and the saturated fatty acids were decreased in PPC group...
February 14, 2019: BioFactors
Hamidreza Tavakoli, Hossein Rostami, Amir Avan, Mohammad Bagherniya, Gordon A Ferns, Sayyed Saeid Khayyatzadeh, Majid Ghayour-Mobarhan
Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (ϒGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls...
February 13, 2019: BioFactors
Yu-Cong Zou, Hai-Hong Li, Guang-Gang Yang, Hai-Dong Yin, Dao-Zhang Cai, Gang Liu
Post-traumatic osteoarthritis (PTOA) of ankle joints results in pain and reduced joint function. Ghrelin, a 28-amino-acid polypeptide, has been previously identified as the first cognate natural ligand that binds to the growth hormone secretagogue receptor. In the present study, ghrelin has been validated to exert cartilage-protective and anti-inflammatory effects. The current study was aimed at investigating the potential role of the levels of serum and synovial fluid (SF) ghrelin on the severity of disease in patients suffering from ankle PTOA...
January 30, 2019: BioFactors
Xiaoxia Liu, Huiying Wang, Chao Huang, Zhaowei Meng, Wenjuan Zhang, Yongle Li, Xuefang Yu, Xin Du, Ming Liu, Jinhong Sun, Qing Zhang, Ying Gao, Kun Song, Xing Wang, Li Zhao, Yaguang Fan
Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This cross-sectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters...
January 30, 2019: BioFactors
Linwu Ran, Anna B Liu, Mao-Jung Lee, Ping Xie, Yong Lin, Chung S Yang
Tocopherols (T) and tocotrienols (T3), all existing in α, β, γ, and δ-forms, are the eight forms of vitamin E (VE). In this study, we investigated the effects of gut microbiota on the degradation and tissue levels of different VE forms by treating mice with antibiotics in drinking water for 12 days. The mice also received an intragastric (i.g.) dose of VE mixture (mVE; α-T, γ-T, δ-T, γ-T3, and δ-T3, each at a dose of 75 mg/kg) every morning. Antibiotic treatment significantly increased the blood levels of all VE forms in mice that received an i...
January 29, 2019: BioFactors
Sara Samadi, Samaneh Abolbashari, Zahra Meshkat, Amir Hooshang Mohammadpour, Theodoros Kelesidis, Aida Gholoobi, Mehrane Mehramiz, Mahla Tabadkani, Fatemeh Sadabadi, Razieh Dalirfardouei, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited...
January 29, 2019: BioFactors
Shoujiao Peng, Yanan Hou, Juan Yao, Jianguo Fang
Accumulating evidence demonstrates that oxidative stress is involved in the pathogenesis and progression of neurodegeneration. As NF-E2-related factor 2 (Nrf2) plays a crucial role in maintaining cellular redox homeostasis, small molecules with the ability in activation of Nrf2 pathway are promising neuroprotective agents. Mangiferin (Mg) is a xanthone glucoside extracted from mangoes and papayas, and has been reported to possess multiple pharmacological activities. In this study, we investigated neuroprotective effects of Mg in the neuron-like rat pheochromocytoma cell line (PC12 cells)...
January 11, 2019: BioFactors
Liping Zhang, Te Li, Xiao Miao, Lijuan Ding, Shudong Wang, Yonggang Wang
Aspirin showed both favorable efficacy and safety in the treatment of atherosclerosis (AS). This study aimed to explore the effects of Aspirin on AS treatment. Differentially expressed mRNAs in AS were screened out and visualized by R project. The mRNA expression levels of NFκB1 and its targets were detected by qRT-PCR. The protein expression levels of NFκB1, intercellular cell adhesion molecule-1 (ICAM1) and vascular cell adhesion molecule-1 (VCAM1) were detected by western blot analysis. Besides, CCK-8 and flow cytometry assay were employed to evaluate the effects of Aspirin on cell proliferation rate and cell apoptotic rate respectively...
January 11, 2019: BioFactors
Yanfeng Zhu, Yue Tong, Jianhua Wu, Yuejuan Liu, Mingjia Zhao
Prostate cancer (PC) is one of the most common cancers in male groups worldwide. Long noncoding RNAs (LncRNAs) are reported to be dysregulated in a variety of cancers, including PC. This study aimed to explore the role of LncRNA GHET1 in the pathogenesis of PC. RT-qPCR was carried out to examine the relative expression level of GHET1 in PC patients. In vitro, GHET1 siRNA (si-GHET1) was used to investigate the biological role of GHET1 in PC cell lines. Cell proliferation was detected by CCK-8 and colony formation assay, while cell cycle and cell apoptosis were analyzed using flow cytometry...
January 4, 2019: BioFactors
Romina Vargas, Bárbara Riquelme, Javier Fernández, Daniela Álvarez, Ignacio F Pérez, Pamela Cornejo, Virginia Fernández, Luis A Videla
Docosahexaenoic acid (DHA) and 3,3',5-triiodothyronine (T3 ) combined protocol affords protection against liver injury via AMPK signaling supporting energy requirements. The aim of this work was to test the hypothesis that a DHA + T3 accomplish mitochondrial adaptation through downstream upregulation of PPAR-γ coactivator 1α (PGC-1α). Male Sprague-Dawley rats were given daily oral doses of 300 mg DHA/kg or saline (controls) for three consecutive days, followed by 0.05 mg T3 /kg (or hormone vehicle) ip at the fourth day, or single dose of 0...
December 21, 2018: BioFactors
Ericka Moreno-Méndez, Alain Hernández-Vázquez, Cristina Fernández-Mejía
Several studies have shown that pharmacological concentrations of biotin decrease serum lipid concentrations and the expression of lipogenic genes. Previous studies on epididymal adipose tissue in mice revealed that 8 weeks of dietary biotin supplementation increased the protein abundance of the active form of AMPK and the inactive forms acetyl CoA carboxylase (ACC)-1 and - 2, and decreased serum free fatty acid concentrations but did not affect lipolysis. These data suggest that pharmacological concentrations of the vitamin might affect fatty acid metabolism...
December 21, 2018: BioFactors
Umberto Basile, Cecilia Napodano, Krizia Pocino, Francesca Gulli, Stefano Angelo Santini, Laura Todi, Mariapaola Marino, Gian Ludovico Rapaccini
Clinical spectrum of hepatitis C virus (HCV)-related cryoglobulinemia varies from an asymptomatic presentation to severe vasculitis and lymphoma. A recent study in HCV-negative patients suggests that low cryoglobulins (CGs) levels are responsible for severe renal and neurological complications. The aim of this study was to identify a panel of serological biomarkers associated with low levels of CGs in HCV-positive patients. We studied a population of 79 untreated patients with chronic HCV infection: 13 naïve patients without CGs; 28 patients with asymptomatic mixed cryoglobulinemia (MC) and low levels of CGs (16/28 with polyclonal type III and 12/28 with microheterogeneous type III CGs); 38 patients with symptomatic MC and high levels of type II CGs...
December 18, 2018: BioFactors
Andrea Scirè, Laura Cianfruglia, Cristina Minnelli, Desirée Bartolini, Pierangelo Torquato, Giovanni Principato, Francesco Galli, Tatiana Armeni
Glutathione is considered the major non-protein low molecular weight modulator of redox processes and the most important thiol reducing agent of the cell. The biosynthesis of glutathione occurs in the cytosol from its constituent amino acids, but this tripeptide is also present in the most important cellular districts, such as mitochondria, nucleus, and endoplasmic reticulum, thus playing a central role in several metabolic pathways and cytoprotection mechanisms. Indeed, glutathione is involved in the modulation of various cellular processes and, not by chance, it is a ubiquitous determinant for redox signaling, xenobiotic detoxification, and regulation of cell cycle and death programs...
December 18, 2018: BioFactors
Claudio Luparello, Mariangela Librizzi, Dalia M L Asaro, Ilenia Cruciata, Fabio Caradonna
Human parathyroid hormone-related protein (PTHrP) is a polyhormone that undergoes proteolytic cleavage producing smaller peptides which exert diversified biological effects. PTHrP signalization is prominently involved in breast development and physiology, but the studies have been focused onto either N-terminal species or full-length protein introduced by gene transfer techniques. Our present work investigates for the first time the effect of the mid-region PTHrP secretory form, that is, the fragment [38-94], on HB2 non-tumoral breast epithelial cells...
December 18, 2018: BioFactors
Susan Darroudi, Narges Fereydouni, Maryam Tayefi, Mahsa Ahmadnezhad, Parvin Zamani, Batool Tayefi, Jasmin Kharazmi, Shima Tavalaie, Alireza Heidari-Bakavoli, Mahmoud R Azarpajouh, Gordon A Ferns, Amir H Mohammadpour, Habibollah Esmaily, Majid Ghayour-Mobarhan
Obesity is an important feature of the metabolic syndrome and is associated with an increased risk of type 2 diabetes mellitus, cardiovascular disease, and some cancers. The aim of this study was to determine the relationship between body fat percentage and an imbalance of the prooxidant/antioxidant balance (PAB), serum superoxide dismutase (SOD1) and inflammation (serum hs-CRP) and increase risk of metabolic syndrome and diabetes mellitus. In this study, 9154 individuals were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study...
December 18, 2018: BioFactors
Paulraj Kanmani, Hojun Kim
Intestinal epithelial cells (IECs) respond to intruders and their cellular molecules by displaying inflammatory state that can be abrogated by probiotics. However, the molecular mechanisms underlying the beneficial activity of probiotic strains have yet to be elucidated. This study was conducted to investigate whether probiotic strains have immunoregulatory effects in IECs, and how they respond to bacterial lipopolysaccharide (LPS) in vitro. Caco2 cells were stimulated with LABs and followed by LPS. The expression of different cytokines that involved in toll-like receptor (TLR) signaling was analyzed...
December 11, 2018: BioFactors
Arthorn Loisruangsin, Kiyomi Hikita, Norikazu Seto, Masatake Niwa, Yoshiaki Takaya, Norio Kaneda
Human sirtuin 1 (hSIRT1) is a NAD+ -dependent deacetylase that regulates several cellular processes. Unlike resveratrol, natural polymeric phenolic compounds isolated from Vitaceae are mostly hSIRT1 inhibitors. The resveratrol tetramer, (+)-hopeaphenol ((+)-HP), and its geometric isomer, (-)-isohopeaphenol ((-)-iHP), were tested for inhibitory effects on purified hSIRT1 using a fluorescent derivative of peptide substrate p53-AMC (Fluor de Lys) and a cofactor NAD+ . The Lineweaver-Burk plots indicated that both (+)-HP and (-)-iHP were competitive inhibitors against NAD+ ...
December 11, 2018: BioFactors
Qingyao Zhu, Hongjie Yang, Peng Cheng, Qian Han
Some lncRNAs can encode small nucleolar RNAs (snoRNAs), called small nucleolar RNA host genes (SNHGs), which exert diverse regulatory effects on cellular processes. In this study, using RNA-seq and survival data in the Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma (LIHC), we examined the expression profile of some SNHG genes and explored their prognostic value in hepatocellular carcinoma (HCC). Level-3 RNA-sequencing data, the clinicopathological and survival data of patients with primary HCC were downloaded from the UCSC Xena browser (https://xenabrowser...
December 8, 2018: BioFactors
Najmeh Ahangari, Saeid Kargozar, Majid Ghayour-Mobarhan, Francesco Baino, Alireza Pasdar, Amirhossein Sahebkar, Gordon A A Ferns, Hae-Won Kim, Masoud Mozafari
Curcumin is the principal polyphenolic compound present in turmeric with broad applications in tissue engineering and regenerative medicine. It has some important inherent properties with the potential to facilitate tissue healing, including anti-inflammatory, anti-oxidant, and antibacterial activities. Therefore, curcumin has been used for the treatment of various damaged tissues, especially wound injuries. There are different forms of curcumin, among which nano-formulations are of a great importance in regenerative medicine...
December 8, 2018: BioFactors
Amanda R Gross, Theoharis C Theoharides
Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Human LAD2 MC were pre-incubated with CS, Hep, or dermatan sulfate (DS) before being stimulated by either the peptide substance P (SP, 2 μM) or the cytokine IL-33 (10 ng/mL)...
December 6, 2018: BioFactors
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