Yan Liu, Linming Zhang, Mingda Ai, Di Xia, Hongyu Chen, Ruijing Pang, Rong Mei, Lianmei Zhong, Ling Chen
BACKGROUND: SLIT and NTRK-like protein-5(SLITRK5) is one of the six members of SLITRK protein family, which is widely expressed in central nervous system (CNS). In brain, SLITRK5 plays important roles in neurite outgrowth, dendritic branching, neuron differentiation, synaptogenesis and signal transmission of neurons. Epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures. The pathophysiological mechanism of epilepsy remains unclear. Neuronal apoptosis, abnormal nerve excitatory transmission and synaptic remodeling are thought to be involved in the development of epilepsy...
February 22, 2023: Synapse