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Journal of Geriatric Psychiatry and Neurology

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https://read.qxmd.com/read/31006322/genetic-and-epigenetic-regulation-of-the-serotonin-transporter-gene-in-late-life-depression
#1
Joanne Ryan, Marie-Laure Ancelin
No abstract text is available yet for this article.
April 21, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30987514/a-validation-study-of-the-chinese-version-of-the-mini-addenbrooke-s-cognitive-examination-for-screening-mild-cognitive-impairment-and-mild-dementia
#2
Lili Yang, Xiaojia Li, Jia Yin, Nengwei Yu, Jie Liu, Fang Ye
BACKGROUND/AIMS: There are limited cognitive screening tests for the Chinese-speaking population. This study aimed to validate the Chinese version of the Mini-Addenbrooke's Cognitive Examination (M-ACE) for detecting mild cognitive impairment (MCI) and mild dementia. Its diagnostic accuracy was compared with that of Mini-Mental State Examination (MMSE). The study also evaluated the influential factors of M-ACE scores and its convergent validity against Clinical Dementia Rating Scale (CDR) and MMSE...
April 15, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30966869/inpatient-enhanced-multidisciplinary-care-effects-on-the-quality-of-life-for-parkinson-disease-a-quasi-randomized-controlled-trial
#3
Kohei Marumoto, Kazumasa Yokoyama, Tomomi Inoue, Hiroshi Yamamoto, Yuki Kawami, Ayumi Nakatani, Yoshihiro Fukazawa, Yayoi Hosoe, Aki Yamasaki, Kazuhisa Domen
OBJECTIVES: To compare the effects of inpatient enhanced multidisciplinary care (EMC) and multidisciplinary rehabilitation (MR) on the symptoms and quality of life (QOL) of patients with Parkinson disease (PD) and to clarify the relation between reduction in symptoms and the improved QOL. METHODS: This study was a quasi-randomized controlled (alternate allocation), assessor-blinded, single-center study. We recruited 80 patients with idiopathic Parkinson disease, Hoehn and Yahr stage 2 to 4, on stable medication...
April 9, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30961423/performance-and-receiver-operating-characteristics-of-the-mini-mental-state-examination-instrument-in-detecting-dementia-in-a-rapidly-aging-developing-country-jamaica
#4
Kenneth James, Camelia Thompson, Douladel Willie-Tyndale, Desmalee Holder Nevins, Roger Gibson, Peter Johnson, Julian McKoy Davis, Denise Eldemire-Shearer
OBJECTIVE: To examine the performance of the Mini-Mental State Examination (MMSE) in community-dwelling older persons in a developing country (Jamaica) undergoing rapid population aging. METHODS: An embedded validity study was conducted utilizing participants from a nationally representative sample of 2782 older persons. Standardized MMSE scores were obtained for study participants. A random selection of 170 persons with MMSE scores greater than 20 and 170 persons with scores 20 or less was done...
April 8, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30961413/neurocognitive-predictors-of-understanding-of-intentions-in-parkinson-disease
#5
Zuzana Kosutzka, Maria Kralova, Alice Kusnirova, Mariana Papayova, Peter Valkovic, Zsolt Csefalvay, Michal Hajduk
OBJECTIVES: Theory of Mind (ToM), the ability to understand other people's mental states, is essential in everyday social interactions. The relationship between cognitive domains and ToM impairment in Parkinson disease (PD) has been receiving growing attention with ambiguous findings. The objective of the current study was to ascertain which cognitive domain predicts understanding of intentions and the impact of PD-specific clinical measures on ToM performance. A secondary aim was to evaluate whether cognitive impairment mediates the relationship between severity of illness and ToM impairment...
April 8, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30947592/er%C3%AE-gene-promoter-methylation-in-cognitive-function-and-quality-of-life-of-patients-with-alzheimer-disease
#6
Kai-Xiu Li, Qin Sun, Ling-Ling Wei, Guang-Hui Du, Xue Huang, Jun-Kang Wang
OBJECTIVE: Alzheimer disease (AD) has been recognized as a progressive neurodegenerative disorder. This study aims to investigate the effects of estrogen receptor α (ERα) gene promoter methylation on the cognitive function and quality of life (QOL) of patients with AD. METHODS: A total of 132 patients with AD and 135 healthy individuals were recruited for this study. The DNA in the peripheral blood was extracted and treated with bisulfite; then methylation-specific polymerase chain reaction and reverse transcription quantitative polymerase chain reaction were performed to determine the methylation status of ERα and ERα messenger RNA (mRNA) expression, respectively...
April 4, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30913958/association-between-csf-beta-amyloid-and-apathy-in-early-stage-alzheimer-disease
#7
A Vergallo, L Giampietri, C Pagni, F S Giorgi, V Nicoletti, M Miccoli, P Libertini, L Petrozzi, U Bonuccelli, G Tognoni
AIM: Apathetic syndrome is a common clinical feature in patients with Alzheimer diseases (AD), from preclinical phases to late dementia stages, and it is strongly related to major disease outcomes. Unfortunately, no specific pharmacological treatments for apathy have been accomplished so far. Translational evidences have previously shown that a link between apathy and hallmarks of AD-related pathophysiological, that is, β-amyloid (Aβ) plaques, and neurofibrillary pathology exists. However, only few studies investigated the association between cerebrospinal fluid (CSF) core biomarkers of AD and apathy scores, finding conflicting results...
March 26, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30885037/tanshinone-iia-ameliorates-spatial-learning-and-memory-deficits-by-inhibiting-the-activity-of-erk-and-gsk-3%C3%AE
#8
Li Lin, Sarmad Sheraz Jadoon, Shang-Zhi Liu, Ru-Yi Zhang, Fan Li, Mei-Ya Zhang, Tan Ai-Hua, Qiu-Yun You, Ping Wang
BACKGROUND: Alzheimer disease (AD) is the most common type of dementia which is becoming a primary problem in the present society, but it lacks effective treatment methods and means of AD. Tanshinone IIA (Tan IIA) has been reported to have neuroprotective effects to restrain the Aβ25-35 -mediated apoptosis. However, few studies try to understand how Aβ1-42 affects hyperphosphorylation of tau and how Tan IIA regulates this process at the molecular level. METHODS: Fifty male Sprague-Dawley rats were randomly divided into 5 groups and infused through the lateral ventricle with Aβ1-42 except the control group...
March 18, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30879363/machine-learning-enhances-the-efficiency-of-cognitive-screenings-for-primary-care
#9
Boaz Levy, Courtney Hess, Jacqueline Hogan, Matthew Hogan, James M Ellison, Sarah Greenspan, Allison Elber, Kathryn Falcon, Daniel F Driscoll, Ardeshir Z Hashmi
BACKGROUND: Incorporation of cognitive screening into the busy primary care will require the development of highly efficient screening tools. We report the convergence validity of a very brief, self-administered, computerized assessment protocol against one of the most extensively used, clinician-administered instruments-the Montreal Cognitive Assessment (MoCA). METHOD: Two hundred six participants (mean age = 67.44, standard deviation [SD] = 11.63) completed the MoCA and the computerized test...
March 17, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30857453/enfeeblement-in-essential-tremor-development-and-validation-of-a-new-psychometric-measure
#10
Daniel Trujillo Diaz, Tess E K Cersonsky, Sarah Kellner, Maria Anna Zdrodowska, Ruby Hickman, Stephanie Cosentino, Joan K Monin, Elan D Louis
INTRODUCTION: Despite a growing body of knowledge regarding essential tremor (ET), past studies have fallen short in capturing the full impact of ET on patients and caregivers. We propose enfeeblement (i.e., having the qualities of being prematurely old, helpless, or debilitated) as a novel clinical outcome measure in ET. Due to the lack of enfeeblement scales for ET in the literature, we developed and validated an enfeeblement scale for ET. METHODS: The Essential Tremor Enfeeblement Survey (ETES) consists of eight 5-point Likert-type scale questions and is designed to be a caregiver-reported outcome...
March 11, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30852930/biomarker-predictors-of-delirium-in-acutely-ill-patients-a-systematic-review
#11
Monique Michels, Cleonice Michelon, Danusa Damásio, Angeles Meller Vitali, Cristiane Ritter, Felipe Dal-Pizzol
Delirium is a serious and common disorder that affects up to 80% of acutely ill patients, mainly the aged. In recent years, several studies pointed out possible biomarkers that could be used alone or in combination with other resources in the diagnosis and follow-up of critically ill patients who develop delirium. In this context, a systematic review was conducted to determine the predictive value of several biomarkers in acutely (critically and noncritically) ill adult patients with delirium. Studies that used the confusion assessment method (CAM) and CAM-intensive care unit as the diagnostic method were considered...
March 10, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30755056/corrigendum
#12
(no author information available yet)
No abstract text is available yet for this article.
February 12, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30665320/executive-functions-episodic-autobiographical-memory-problem-solving-capacity-and-depression-proposal-for-a-structural-equations-model
#13
Juan C Meléndez, Rita Redondo, Joaquin Escudero, Encarna Satorres, Alfonso Pitarque
The executive functions play an important role in storing and recovering autobiographical memories, especially episodic memories. These types of memories provide information about solutions and experiences from the past that can be utilized as examples in the present when seeking solutions to any problem. In addition, a close relationship between depression and the executive functions has been widely recognized. This study aims to elaborate a structural equations model that empirically supports the relationships among the executive functions, episodic autobiographical memory, and the adaptive capacity to solve problems, taking into account the depressed mood state...
January 21, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30651027/resilience-in-carers-of-people-with-young-onset-alzheimer-disease
#14
Nathália R S Kimura, José Pedro Simões Neto, Raquel Luiza Santos, Maria Alice Tourinho Baptista, Glória Portugal, Aud Johannessen, Maria Lage Barca, Knut Engedal, Jerson Laks, Valeska Marinho Rodrigues, Marcia C N Dourado
Young-onset Alzheimer disease (YOAD) causes psychological and emotional difficulties for carers. However, even in the face of considerable caregiving demands and burden, some carers are resistant to stress, which may be a sign of resilience. This study investigated whether the clinical symptoms of the person with YOAD might be associated with resilience in their carers. A consecutive series of 43 persons with YOAD and their 43 family caregivers were assessed. The carers showed moderate to high level of resilience, low level of anxiety and depressive symptoms, and moderate level of burden...
January 16, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30630388/the-clinical-utility-of-the-tym-and-rbans-in-a-one-stop-memory-clinic-in-singapore-a-pilot-study
#15
YanHong Dong, Melissa Tan Yi Ling, Kelly Ee Teng Ng, Aijing Wang, Esther Yee Shuang Wan, Reshma A Merchant, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Rathi Mahendran, Simon Lowes Collinson
BACKGROUND: We aimed to examine the discriminant validity of a brief self-administered cognitive screening test, the Test Your Memory (TYM) and a brief neuropsychological test, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), supplemented with executive and language tests (Color Trail Test [CTT] and modified Boston Naming Test [mBNT], respectively), in detecting cognitive impairment (CI) in a one-stop memory clinic in Singapore. METHODS: Ninety patients ≥50 years old with a diagnosis of no cognitive impairment, mild cognitive impairment, and mild Alzheimer disease were recruited from memory clinic...
January 10, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30630387/depressive-symptoms-predict-incident-dementia-in-a-community-sample-of-older-adults-results-from-the-einstein-aging-study
#16
Ali Ezzati, Mindy J Katz, Carol A Derby, Molly E Zimmerman, Richard B Lipton
BACKGROUND: There is increasing evidence that depressive symptoms are associated with increased risk of cognitive impairment and dementia in older adults. In current study, we aimed to investigate the effect of depressive symptoms on incident Alzheimer disease and all-cause dementia in a community sample of older adults. METHODS: Participants were 1219 older adults from the Einstein Aging Study, a longitudinal cohort study of community-dwelling older adults in Bronx County, New York...
January 10, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30630386/suicidal-thoughts-and-contexts-in-black-african-stroke-survivors
#17
Akin Ojagbemi, Toyin Bello, Fisayo Elugbadebo
OBJECTIVES: Poststroke suicide has not been studied in Black Africans. We assessed the characteristics and contexts of serious suicidal thoughts after first-ever stroke in Nigerians. METHODS: Using a comparative cross-sectional design, we consecutively recruited 130 stroke survivors attending rehabilitation in a large university hospital. Also included were 130 age-, sex-, and education-matched caregivers who were unrelated to stroke survivors. Along with clinical and historical details, cognitive functions, experience of serious suicidal thoughts, and major depressive disorder (MDD) were independently assessed using validated semi-structured interviews...
January 10, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30612511/the-effect-of-reminiscence-therapy-with-internet-based-videos-on-cognitive-status-and-apathy-of-older-people-with-mild-dementia
#18
Ayşe İnel Manav, Nuray Simsek
This study was carried out to assess the effects of reminiscence therapy that was supported with internet-based videos on the cognitive condition and apathy levels of older people with mild dementia living in nursing homes. This randomized controlled experimental study was conducted between May 15, 2016, and August 25, 2016, in two nursing homes in Adana, Turkey. A total of 32 people participated in this study, 16 individuals were in the intervention group and 16 individuals were in the control group. The data were collected using a Personal Information Form, the Standardized Mini-Mental State Examination (SMMSE) test, and the Apathy Rating Scale (ARS) Self-assessment Form...
January 6, 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30793663/screening-for-post-stroke-depression-and-cognitive-impairment-at-baseline-predicts-long-term-patient-centered-outcomes-after-stroke
#19
Arunima Kapoor, Krista L Lanctot, Mark Bayley, Nathan Herrmann, Brian J Murray, Richard H Swartz
BACKGROUND: Independence and reintegration into community roles are important patient-centered outcomes after stroke. Depression and cognitive impairment are common post-stroke conditions that may impair long-term function even years after a stroke. However, screening for these post-stroke comorbidities remains infrequent in stroke prevention clinics and the utility of this screening for predicting long-term higher-level function has not been evaluated. AIMS: To evaluate the ability of a validated brief Depression, Obstructive sleep apnea, and Cognitive impairment screen (DOC screen) to predict long-term (2-3 years after stroke) community participation and independence in instrumental activities of daily living post stroke...
January 2019: Journal of Geriatric Psychiatry and Neurology
https://read.qxmd.com/read/30572755/blood-thiamine-level-and-cognitive-function-in-older-hospitalized-patients
#20
Maryam Pourhassan, Bjoern Angersbach, Gero Lueg, Christiane Nicola Klimek, Rainer Wirth
AIM: We sought to identify any association between whole blood thiamine level and functional status in older hospitalized patients. METHODS: This cross-sectional study retrospectively analyzed the results of routine measurements of whole blood thiamine levels of 233 older patients who were consecutively hospitalized to a geriatric acute care ward. Nutritional status, depression, and the participants' cognitive impairment were evaluated using the Mini Nutritional Assessment-Short Form, Depression in Old Age Scale, and Montreal Cognitive Assessment, respectively...
December 20, 2018: Journal of Geriatric Psychiatry and Neurology
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