journal
https://read.qxmd.com/read/38644511/pulmonary-dimorphic-fungal-infections-among-hiv-aids-non-tb-patients-with-chronic-cough-in-kampala-uganda
#1
JOURNAL ARTICLE
Prossy Kiconco, Beatrice Achan, Moses Sanya, Irene Najjingo, Alfred Okeng, Freddie Bwanga
INTRODUCTION: Dimorphic fungi cause infection following the inhalation of spores into the pulmonary system. In the lower respiratory tract, the conidia transform into yeasts, which are engulfed by alveolar macrophages and may be destroyed without disease manifestation. However, in some immunocompromised individuals, they may persist and cause active fungal disease characterized by formation of granulomas in the infected tissues, which may mimic Mycobacterium tuberculosis (MTB). OBJECTIVE: To determine the prevalence of pulmonary dimorphic fungal infections among HIV/AIDS patients with non-TB chronic cough at Mulago National Referral and Teaching Hospital in Kampala, Uganda...
April 2024: Mycoses
https://read.qxmd.com/read/38606896/systematic-review-on-efficacy-and-safety-of-empirical-versus-pre-emptive-antifungal-therapy-among-children-with-febrile-neutropenia-reveals-paucity-of-data
#2
REVIEW
Meenakshi Sachdeva, Meenakshi Malik, Pranita Pradhan, Kulbir Kaur, Sarita Dogra, Joseph L Mathew
BACKGROUND: Two approaches are used to manage invasive fungal disease (IFD) in febrile neutropenic patients viz. empirical therapy (without attempting to confirm the diagnosis), or pre-emptive therapy (after screening tests for IFD). OBJECTIVE: This systematic review was undertaken to compare these approaches in children. METHODS: We searched PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, CINAHL, Clinical Trial Registries and grey literature, for randomized controlled trials (RCT) comparing empirical versus pre-emptive antifungal therapy in children with FN suspected to have IFD...
April 2024: Mycoses
https://read.qxmd.com/read/38606891/global-prevalence-of-onychomycosis-in-general-and-special-populations-an-updated-perspective
#3
REVIEW
Aditya K Gupta, Tong Wang, Shruthi Polla Ravi, Avantika Mann, Mary A Bamimore
BACKGROUND: Onychomycosis is a chronic nail disorder commonly seen by healthcare providers; toenail involvement in particular presents a treatment challenge. OBJECTIVE: To provide an updated estimate on the prevalence of toenail onychomycosis. METHODS: We conducted a literature search using PubMed, Embase and Web of Science. Studies reporting mycology-confirmed diagnoses were included and stratified into (a) populations-based studies, and studies that included (b) clinically un-suspected and (c) clinically suspected patients...
April 2024: Mycoses
https://read.qxmd.com/read/38584320/low-toxicity-contributes-to-sporothrix-globosa-invade-the-skin-of-patients-in-low-epidemic-areas-of-china
#4
JOURNAL ARTICLE
Yuying Qu, Yahui Feng, Shaodong Bian, Yang Yang, Dongmei Li, Weida Liu, Dongmei Shi
OBJECTIVE: This study aims to assess the clinical characteristics of sporotrichosis in low-endemic areas of China, including the prevalence geography, genotypic traits of patients, clinical manifestations, and strain virulence and drug sensitivities. The objective is to improve the currently used clinical management strategies for sporotrichosis. METHODS: Retrospective data were collected from patients diagnosed with sporotrichosis through fungal culture identification...
April 2024: Mycoses
https://read.qxmd.com/read/38570912/comparison-of-dermoscopic-characteristics-on-toenail-onychomycosis-in-psoriatic-and-non-psoriatic-patients-a-prospective-study
#5
JOURNAL ARTICLE
Shiqi Wang, Wei Chen, Fang Liu, Ruoyu Li
BACKGROUND: Psoriatic patients may experience the coexistence of onychomycosis (OM). However, the evaluation of OM in psoriatics has been hindered by potential clinical differences from OM in non-psoriatics. OBJECTIVE: To assess and compare dermoscopic features between toenail OM in psoriatic and in non-psoriatic patients. PATIENTS AND METHODS: Between September 2020 and September 2023, dermoscopy was conducted on 183 affected toenails by OM in psoriatics and 232 affected toenails by OM in non-psoriatics in two centres...
April 2024: Mycoses
https://read.qxmd.com/read/38551121/the-sphingolipid-inhibitor-myriocin-increases-candida-auris-susceptibility-to-amphotericin-b
#6
JOURNAL ARTICLE
Hanna Stieber, Lara Junghanns, Hannah Wilhelm, Maria Batliner, Alexander Maximilian Aldejohann, Oliver Kurzai, Ronny Martin
BACKGROUND: The emergence of the pathogenic yeast Candida auris is of global concern due to its ability to cause hospital outbreaks and develop resistance against all antifungal drug classes. Based on published data for baker's yeast Saccharomyces cerevisiae, sphingolipid biosynthesis, which is essential for maintaining membrane fluidity and formation of lipid rafts, could offer a target for additive treatment. METHODS: We analysed the susceptibility of C. auris to myriocin, which is an inhibitor of the de novo synthesis of sphingolipids in eukaryotic cells in comparison to other Candida species...
April 2024: Mycoses
https://read.qxmd.com/read/38551114/patients-with-recurrent-vulvovaginal-candidiasis-exhibit-a-decrease-in-both-the-fungicidal-activity-of-neutrophils-and-the-proliferation-of-peripheral-blood-mononuclear-cells
#7
JOURNAL ARTICLE
Jeiser Marcelo Consuegra-Asprilla, Carolina Rodríguez-Echeverri, Daniela Herrera Posada, Beatriz L Gómez, Ángel González
BACKGROUND: Recurrent vulvovaginal candidiasis (RVVC) is an important and underestimated fungal infection. OBJECTIVE: We aimed to determine the fungicidal and proliferative capacities of neutrophils and peripheral blood mononuclear cells (PBMCs), respectively and the clinical and microbiological characteristics of a cohort of Colombian patients diagnosed with RVVC. METHODS: A cross-sectional study was conducted. A total of 66 women were included (40 diagnosed with RVVC and 26 healthy women [HW])...
April 2024: Mycoses
https://read.qxmd.com/read/38551112/dermatophytes-and-skin-dermatophytoses-in-southeast-asia-first-epidemiological-survey-from-cambodia
#8
JOURNAL ARTICLE
Silke Uhrlaß, Sithach Mey, Daniela Koch, Hanna Mütze, Constanze Krüger, Michel Monod, Pietro Nenoff
BACKGROUND: Dermatomycoses count to the most frequent dermatoses in Cambodia. OBJECTIVES: The aim of this survey was to investigate the occurrence of dermatophytes in this Southeast Asian country. METHODS: From June 2017 to July 2018, skin scrapings were taken from 67 patients with superficial dermatophytosis for mycological diagnostics. Identification of dermatophytes was confirmed by sequencing of the 'internal transcribed spacer'-(ITS) region of the rDNA, and the gene of the Translation Elongation Factor (TEF)-1α...
April 2024: Mycoses
https://read.qxmd.com/read/38551063/distribution-of-aspergillus-species-and-prevalence-of-azole-resistance-in-clinical-and-environmental-samples-from-a-spanish-hospital-during-a-three-year-study-period
#9
JOURNAL ARTICLE
Jose Lucio, Laura Alcazar-Fuoli, Horacio Gil, Samuel Cano-Pascual, Sara Hernandez-Egido, Maria Soledad Cuetara, Emilia Mellado
BACKGROUND: Surveillance studies are crucial for updating trends in Aspergillus species and antifungal susceptibility information. OBJECTIVES: Determine the Aspergillus species distribution and azole resistance prevalence during this 3-year prospective surveillance study in a Spanish hospital. MATERIALS AND METHODS: Three hundred thirty-five Aspergillus spp. clinical and environmental isolates were collected during a 3-year study. All isolates were screened for azole resistance using an agar-based screening method and resistance was confirmed by EUCAST antifungal susceptibility testing...
April 2024: Mycoses
https://read.qxmd.com/read/38544313/risk-factors-associated-with-fluconazole-resistance-in-candida-parapsilosis-candidemia-a-case-case-study
#10
JOURNAL ARTICLE
Sabri Atalay, Derya Çağlayan, Eren Arkalı, Ufuk Sönmez, Pınar Şamlıoğlu
BACKGROUND: Candida species are among the most important invasive pathogens in intensive care units (ICUs). Non-albicans species including Candida parapsilosis (C. parapsilosis) has increased in recent years. Fluconazole is the leading antifungal agent but resistance is a concern among C. parapsilosis species. OBJECTIVES: The aim of this study was to determine the factors associated with fluconazole resistance in patients with candidemia due to C. parapsilosis in ICUs...
March 2024: Mycoses
https://read.qxmd.com/read/38503713/aspergillus-nodules-natural-history-and-the-effect-of-antifungals
#11
JOURNAL ARTICLE
Chris Kosmidis, Mahmoud Achira, Jeremy Yong, Chris Harris, Rohit Bazaz
BACKGROUND: Aspergillus nodules are classified as a subset of chronic pulmonary aspergillosis. The optimal management approach is not known as their natural evolution following biopsy, the rate of progression to chronic cavitary pulmonary aspergillosis (CCPA) and the effect of antifungal treatment have not been described. OBJECTIVES: To describe the clinical course of patients diagnosed with Aspergillus nodules and the effect of antifungal treatment. PATIENTS/METHODS: We present a series of 23 patients with histologically confirmed Aspergillus nodules and describe serial imaging, antifungal treatment and progression to other diagnoses...
March 2024: Mycoses
https://read.qxmd.com/read/38488272/immunohistochemical-analysis-of-chronic-and-recurrent-dermatophytosis
#12
JOURNAL ARTICLE
Ramesh M Bhat, Monisha Madhumita, Nisha J Marla, Jyothi Jayaraman
BACKGROUND: Dermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis. OBJECTIVES: We aimed to compare the population of various immune cells in specimens of chronic recurrent dermatophytosis and those with acute superficial dermatophytosis...
March 2024: Mycoses
https://read.qxmd.com/read/38483073/card9-mutations-in-patients-with-fungal-infections-an-update-from-the-last-5%C3%A2-years
#13
JOURNAL ARTICLE
Maryanna da Silva Dantas, Maria Eduarda Carvalho Cintra, Fabíola Lucini, James Venturini, Gleyce Hellen de Almeida de Souza, Luana Rossato
BACKGROUND: Autosomal recessive deficiency in the caspase recruitment domain-containing protein 9 (CARD9) is a congenital immunological condition that leads to susceptibility to mucocutaneous and invasive fungal infections. There is growing incidence of fungal infections in patients with CARD9 deficiency, a phenomenon that is increasingly recognised. OBJECTIVES: This study aimed to assess the frequency, geographic distribution and nature of mutations in patients with CARD9 deficiency, based on published papers in the literature until March 2023...
March 2024: Mycoses
https://read.qxmd.com/read/38483066/responses-of-keratinocytes-to-trichophyton-mentagrophyte-infection-based-on-whole-transcriptome-analysis
#14
JOURNAL ARTICLE
Fangfang Zang, Zhangxu Wang, Yuanxue Yang, Ziyao Xiao, Zhaodan Wu, Jia Zhang, Bishibei Li, Jiayu Zheng, Xixi Zhu, Ying Wan, Ran Wang, Wudian Xiao
BACKGROUND: Dermatophytosis is an intractable superficial mycosis in humans and animals mainly caused by Trichophyton mentagrophytes (T. mentagrophytes), with a global prevalence of about 20%. Keratinocytes are the most abundant participants in skin immunity, and they also play a role in the first-line defence against T. mentagrophytes. However, no studies of keratinocyte responses against T. mentagrophytes infection based on the whole transcriptome have been reported...
March 2024: Mycoses
https://read.qxmd.com/read/38477367/baseline-chest-computed-tomography-for-diagnosis-of-invasive-aspergillosis-in-patients-with-acute-myeloid-leukaemia-treated-with-intensive-chemotherapy-a-retrospective-single-centre-cohort-study
#15
JOURNAL ARTICLE
Emilie Janssens, Sammy Huygens, Ine Moors, Anke Delie, Tessa Kerre, Yannick Vande Weygaerde, Eva Van Braeckel, Jerina Boelens, Lieve Morbée, Alexander Schauwvlieghe
BACKGROUND: Invasive pulmonary aspergillosis (IPA) is a relatively common infection in patients with acute myeloid leukaemia (AML), and is associated with high mortality rates. Optimising early detection is key to reduce the burden of IPA in this population. In this retrospective cohort study, we evaluated the added value of baseline chest CT before start of classical induction chemotherapy. METHODS: Adult patients receiving first-line intensive chemotherapy for AML were included if a baseline chest CT scan was available (±7 days)...
March 2024: Mycoses
https://read.qxmd.com/read/38438313/fluconazole-resistant-candida-parapsilosis-genotypes-from-hospitals-located-in-five-spanish-cities-and-one-in-italy-description-of-azole-resistance-profiles-associated-with-the-y132f-erg11p-substitution
#16
JOURNAL ARTICLE
Aina Mesquida, Eva Alcoceba, Eduardo Padilla, Aída Ramírez, Paloma Merino, Fernando González-Romo, Elena De Carolis, Maurizio Sanguinetti, María de Los Ángeles Mantecón-Vallejo, María Muñoz-Algarra, Teresa Durán-Valle, Ana Pérez-Ayala, Elia Gómez-García-de-la-Pedrosa, María Del Carmen Martínez-Jiménez, Miguel Ángel Sánchez-Castellano, Inmaculada Quiles-Melero, María Soledad Cuétara, Aída Sánchez-García, Patricia Muñoz, Pilar Escribano, Jesús Guinea
BACKGROUND: Fluconazole-resistant Candida parapsilosis is a matter of concern. OBJECTIVES: To describe fluconazole-resistant C. parapsilosis genotypes circulating across hospitals in Spain and Rome and to study their azole-resistance profile associated with ERG11p substitutions. PATIENTS/METHODS: We selected fluconazole-resistant C. parapsilosis isolates (n = 528 from 2019 to 2023; MIC ≥8 mg/L according to EUCAST) from patients admitted to 13 hospitals located in five Spanish cities and Rome...
March 2024: Mycoses
https://read.qxmd.com/read/38429226/pan-azole-resistant-meyerozyma-guilliermondii-clonal-isolates-harbouring-a-double-f126l-and-l505f-mutation-in-erg11
#17
JOURNAL ARTICLE
Jérémy Moreau, Thierry Noël, Kévin Point, Frédéric Tewes, Luc Deroche, Jonathan Clarhaut, Valérie Fitton-Ouhabi, Estelle Perraud, Sandrine Marchand, Julien M Buyck, Kévin Brunet
BACKGROUND: Meyerozyma guilliermondii is a yeast species responsible for invasive fungal infections. It has high minimum inhibitory concentrations (MICs) to echinocandins, the first-line treatment of candidemia. In this context, azole antifungal agents are frequently used. However, in recent years, a number of azole-resistant strains have been described. Their mechanisms of resistance are currently poorly studied. OBJECTIVE: The aim of this study was consequently to understand the mechanisms of azole resistance in several clinical isolates of M...
March 2024: Mycoses
https://read.qxmd.com/read/38429225/glucocorticoids-as-a-risk-factor-for-infection-and-adverse-outcomes-in-non-hiv-and-non-transplant-patients-with-cryptococcal-meningitis
#18
JOURNAL ARTICLE
Luke Kim, Carolina Ferraz, Michaele Francesco Corbisiero, Sarah Gorvetzian, Carlos Franco-Paredes, Martin Krsak, Leland Shapiro, George R Thompson, Daniel B Chastain, Jose Tuells, Andrés F Henao-Martínez
BACKGROUND: Cryptococcal meningitis (CM), an opportunistic fungal infection affecting immunocompromised hosts, leads to high mortality. The role of previous exposure to glucocorticoids as a risk factor and as an outcome modulator has been observed, but systematic studies are lacking. OBJECTIVE: The primary aim of this study is to evaluate the impact of glucocorticoid use on the clinical outcomes, specifically mortality, of non-HIV and non-transplant (NHNT) patients diagnosed with CM...
March 2024: Mycoses
https://read.qxmd.com/read/38414346/activity-of-amorolfine-or-ciclopirox-in-combination-with-terbinafine-against-pathogenic-fungi-in-onychomycosis-results-of-an-in%C3%A2-vitro-investigation
#19
JOURNAL ARTICLE
Martin Schaller, Birgit Walker, Schafiq Nabhani, Astrid Odon, Simon Riel, Andreas Jäckel
BACKGROUND: Onychomycoses are difficult-to-treat fungal infections with high relapse rates. Combining oral and topical antifungal drugs is associated with higher success rates. Additive or synergistic modes of action are expected to enhance treatment success rates. OBJECTIVES: Investigation of the combined effects of antifungal drugs in vitro with different modes of action and application on clinical isolates from mycotic nails. METHODS: Isolates of Trichophyton rubrum, Trichophyton interdigitale and Scopulariopsis brevicaulis were collected from infected toenail specimens of patients with onychomycosis...
March 2024: Mycoses
https://read.qxmd.com/read/38414309/incidence-and-prevalence-of-chronic-pulmonary-aspergillosis-in-patients-with-post-tuberculosis-lung-abnormality-results-from-a-community-survey-in-north-india
#20
JOURNAL ARTICLE
Kathirvel Soundappan, Inderpaul Singh Sehgal, Nidhi Prabhakar, Samriti Rana, Rajesh Raju, Sahajal Dhooria, Kuruswamy Thurai Prasad, Valliappan Muthu, Shivaprakash M Rudramurthy, Arunaloke Chakrabarti, Mandeep Garg, Ritesh Agarwal
BACKGROUND: Post-tuberculosis lung abnormality (PTLA) is the most common risk factor for developing chronic pulmonary aspergillosis (CPA). However, the prevalence and incidence of CPA in PTLA patients in India remain unknown. OBJECTIVES: We aimed to ascertain the incidence and prevalence of CPA in subjects with PTLA. METHODS: We identified a cohort of pulmonary tuberculosis who completed anti-tuberculosis therapy (ATT) before November 2019 from the records of the 12 tuberculosis treatment centers attached to the national program...
March 2024: Mycoses
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