Journals Journal of Photochemistry and ...

Journal of Photochemistry and Photobiology. B, Biology
Nika Žurga, Thomas Moragues, Andrew J deMello
In 2018, Ashwin and co-workers presented a method for the selective and sensitive detection of Pd2+ based on variations in the fluorescence of coumarin (C460). Herein, we re-evaluate the ability of C460 to probe Pd2+ concentration via a systematic reproduction of the experiments reported in the original publication and the performance of additional control experiments. Our analysis indicates that C460 is in fact not a fluorescence sensor for Pd2+ , but rather can act as a pH sensor over a restricted pH range...
September 1, 2023: Journal of Photochemistry and Photobiology. B, Biology
Flávia Amanda Pedroso de Morais, Rodolfo Bento Balbinot, Amanda Beatriz Kawano Bakoshi, Danielle Lazarin-Bidoia, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Gonçalves, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Wilker Caetano, Celso Vataru Nakamura
Biomodified coated-lipid vesicles were obtained using the DPPC lipid (L) and F127 copolymer linked covalently with spermine (SN), biotin (BT), and folic acid (FA), resulting in LF127-SN, LF127-BT, and LF127-FA nanoplatforms. The photosensitizer hypericin (HY) was incorporated into the nanosystem by a thin-film method and characterized by dynamic light scattering, zeta potential, encapsulation efficiency, and transmission electronic microscopy. The results provided a good level of stability for all nanoplatforms for at least 5 days as an aqueous dispersion...
September 1, 2023: Journal of Photochemistry and Photobiology. B, Biology
Ashok Priyadarshi, Gaurav K Keshri, Asheesh Gupta
A thermal burn is the most frequent, distressing form of trauma. Globally, there is a critical necessity to explore novel therapeutic strategies for burn wound care. Combination therapy has marked therapeutic efficacy in positively regulating various phases of wound repair. Photobiomodulation (PBM) is a biophysical, non-thermal therapeutic healing modality to treat chronic non-healing wounds. It hypothesized that PBM using combined NIR wavelengths may absorb through different cellular photoacceptors with varying degrees of tissue penetration, which can potentially regulate the pace of healing...
September 2023: Journal of Photochemistry and Photobiology. B, Biology
Rogowski Paweł, Urban Aleksandra, Romanowska Elżbieta
This study aimed to examine enzymatic kinetics of photosystem II (PSII) of maize mesophyll chloroplasts using the artificial electron acceptor 2,6-dichloro-1,4-benzoquinone (DCBQ) as a substrate. We extended Michealis-Menten kinetics model assuming that DCBQ can accept electrons from PSII in two ways: from a QB directly or from QA by docking in the QB site. We used a Clark oxygen electrode for measuring the PSII activity, depending on the concentration of DCBQ. We found that: [1] DCBQ acts as an electron acceptor or [2] as an inhibitor for PSII...
August 25, 2023: Journal of Photochemistry and Photobiology. B, Biology
Bruno Silva de Rezende, Thiago Franca, Maykko Antônyo Bravo de Paula, Herbert Patric Kellermann Cleveland, Cícero Cena, Carlos Alberto do Nascimento Ramos
Bovine brucellosis diagnosis is a major problem to be solved; the disease has a tremendous economic impact with significant losses in meat and dairy products, besides the fact that it can be transmitted to humans. The sanitary measures instituted in Brazil are based on disease control through diagnosis, animal sacrifice, and vaccination. Although the currently available diagnostic tests show suitable quality parameters, they are time-consuming, and the incidence of false-positive and/or false-negative results is still observed, hindering effective disease control...
August 25, 2023: Journal of Photochemistry and Photobiology. B, Biology
Sara Sansaloni-Pastor, Norbert Lange
The therapeutic properties of 5-aminolevulinic acid (5-ALA) have been extensively studied for cancer detection and treatment using photodynamic therapy (PDT). When administered externally, 5-ALA is converted to protoporphyrin IX (PpIX) in cancer cells, which generates reactive oxygen species (ROS) upon exposure to light. This process enables targeted cell death induction and cancer detection. Given the highly conserved nature of heme biosynthesis over billions of years, we hypothesized that natural mechanisms might exist to prevent excessive accumulation of PpIX or heme resulting from 5-ALA overload...
August 24, 2023: Journal of Photochemistry and Photobiology. B, Biology
Ken Woo, So Young Park, Andrew Padalhin, Hyun Seok Ryu, Celine Dg Abueva
In this study, the effect of photobiomodulation (PBM) treatment using 630 nm light emitting diode (LED) array (continuous wave type, 10 mW power) on tonsil-derived mesenchymal stem cells (TMSCs) and its interaction with RAW 264.7 macrophage cells via co-culture in vitro were investigated. PBM treatment was used as a priming method for TMSCs to improve therapeutic efficacy. TMSCs were subjected to multi-dose PBM treatments before co-culture with M1 activated (1 μg/mL lipopolysaccharide, LPS) macrophage cells with total energy doses of 0, 15, 30, and 60 J...
August 9, 2023: Journal of Photochemistry and Photobiology. B, Biology
A S Fernandes, J L Mazzei, H Evangelista, M R C Marques, E R A Ferraz, I Felzenszwalb
No abstract text is available yet for this article.
July 29, 2023: Journal of Photochemistry and Photobiology. B, Biology
Celina Pihl, Katja M S Bendtsen, Henrik E Jensen, Flemming Andersen, Peter Bjerring, Merete Haedersdal, Catharina M Lerche
Ultraviolet radiation is the primary risk factor for keratinocyte carcinoma. Because of increasing incidence rates, new methods of photoprotection must be explored. Oral supplementation with photoprotective compounds presents a promising alternative. Phytochemical compounds like hesperidin methyl chalcone, phloroglucinol, and syringic acid are particularly of interest because of their antioxidant properties. Our primary outcome was to evaluate the effects of oral phytochemicals on photocarcinogenesis with time until tumour onset as the primary endpoint...
July 22, 2023: Journal of Photochemistry and Photobiology. B, Biology
Dan-Hong Li, Sam Wilson, Giulia Mastroianni, Alexander V Ruban
In plants, the major light-harvesting antenna complex (LHCII) is vital for both light harvesting and photoprotection in photosystem II. Previously, we proposed that the thylakoid membrane itself could switch LHCII into the photoprotective state, qE, via a process known as hydrophobic mismatch. The decrease in the membrane thickness that followed the formation of ΔpH was a key fact that prompted this idea. To test this, we made proteoliposomes from lipids with altered acyl chain length (ACL). Here, we show that ACL regulates the average chlorophyll fluorescence lifetime of LHCII...
July 20, 2023: Journal of Photochemistry and Photobiology. B, Biology
Loris Busch, Marius Kröger, Johannes Schleusener, Anna Lena Klein, Silke B Lohan, Martin Guttmann, Cornelia M Keck, Martina C Meinke
The application of a far-ultraviolet C (UVC) light emitting diode (LED) of 233 nm showed significant bactericidal efficacy at an applied dose between 20 and 80 mJ cm-2 as reported recently. In addition, only minor epidermal DNA lesions were observed in ex vivo human skin and in vitro epidermal models <10% of the minimal erythema dose of UVB radiation. To broaden the potential range of applications of such systems, e.g. to include postoperative application on wounds for the purpose of decontamination, we assessed how a disruption of normal anatomic skin structure and function influences the skin damage induced by light from 233 nm far-UVC LEDs...
July 18, 2023: Journal of Photochemistry and Photobiology. B, Biology
Francesca Laneri, Claudia Conte, Cristina Parisi, Ovidio Catanzano, Aurore Fraix, Fabiana Quaglia, Salvatore Sortino
Curcumin (CUR) is a naturally occurring pigment extensively studied due to its therapeutic activity and delivered by suitable nanocarriers to overcome poor solubility in aqueous media. The significant absorption of CUR in the visible blue region has prompted its use as a potential phototherapeutic agent in treating infectious and cancer diseases, although the mechanism underlying the phototoxic effects is still not fully understood. This contribution investigates the photobehaviour of CUR within polymeric micelles, microemulsions, and zein nanoparticles, chosen as biocompatible nanocarriers, and human serum albumin as a representative biomolecule...
July 11, 2023: Journal of Photochemistry and Photobiology. B, Biology
Hong Bae Kim, Moon-Ho Kang, Ku Youn Baik, Jae Eun Kim, Sang Bae Park, Pill-Hoon Choung, Jong Hoon Chung
Blue light is used less in photobiomodulation than red or near-infrared light because of concerns about its high energy. However, some reports have suggested that blue light releases NO from nitrosated proteins, affects cell signal regulation, and promotes stem cell differentiation. Because blue and red lights could have different mechanisms of action, their combination is expected to have new consequences. In this study, human dental pulp stem cells (hDPSCs) were sequentially exposed to blue and near-infrared light to study their effects on proliferation, osteogenic differentiation, and immunomodulation...
July 7, 2023: Journal of Photochemistry and Photobiology. B, Biology
Lily X Li, Ruth H Nissly, Anand Swaminathan, Ian M Bird, Nina R Boyle, Meera Surendran Nair, Denver I Greenawalt, Abhinay Gontu, Victoria S Cavener, Ty Sornberger, James D Freihaut, Suresh V Kuchipudi, William P Bahnfleth
Ultraviolet germicidal irradiation (UVGI) is a highly effective means of inactivating many bacteria, viruses, and fungi. UVGI is an attractive viral mitigation strategy against coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the coronavirus disease-2019 (COVID-19) pandemic. This investigation measures the susceptibility of two human coronaviruses to inactivation by 254 nm UV-C radiation. Human coronavirus NL63 and SARS-CoV-2 were irradiated in a collimated, dual-beam, aqueous UV reactor...
July 5, 2023: Journal of Photochemistry and Photobiology. B, Biology
Gustavo Scanavachi, Koji Kinoshita, Tayana M Tsubone, Rosangela Itri
It is well-known that oxidative damage in red blood cell (RBC) usually causes morphological changes and increased membrane rigidity. Although many studies have focused on investigating how RBC responds to a photodynamic stimulus, the intermediate steps between membrane damage and hemolysis are not reported. To give a comprehensive insight into changes of RBC membrane property under different oxidative damage levels, we employed the photoactivation of CisDiMPyP porphyrin that primarily generates singlet oxygen 1 O2 as oxidant species...
July 3, 2023: Journal of Photochemistry and Photobiology. B, Biology
Feiying Wu, Xinyu Xia, Ting Lei, Huiying Du, Hui Hua, Wei Liu, Bin Xu, Tianyao Yang
Due to continuous exposure to ultraviolet B(UVB) radiation, eye lenses are constantly subjected to oxidative stress that induces lens epithelial cell (LEC) apoptosis, which has been associated with the inactivation of Sirtuin1 (SIRT1). It is well-established that NFE2L2 has a major protective effect on UVB-induced oxidative stress and damage. However, whether UVB radiation affects oxidative/antioxidative imbalance and damages LECs by inactivating the protective NFE2L2-mediated antioxidative stress pathway through inhibition of SIRT1 is unknown...
June 30, 2023: Journal of Photochemistry and Photobiology. B, Biology
Megan J Mackintosh, Piotr Lodowski, Pawel M Kozlowski
CarH is a cobalamin-based photoreceptor which has attracted significant interest due to its complex mechanism involving its organometallic coenzyme-B12 chromophore. While several experimental and computational studies have sought to understand CarH's mechanism of action, there are still many aspects of the mechanism which remain unclear. While light is needed to activate the Co-C5' bond, it is not entirely clear whether reaction pathway involves singlet or triplet diradical states. A recent experimental study implicated triplet pathway and importance of intersystem crossing (ISC) as a viable mechanistic route for photoproduct formation in CarH...
June 26, 2023: Journal of Photochemistry and Photobiology. B, Biology
Behzad Pourbadiei, Mohammd Ali Aghajani Monghari, Hamidreza Mohajeri Khorasani, Ali Pourjavadi
Interpenetrated network (IPN) hydrogels with desired mechanical properties were prepared based on gelatin. A copolymer of dimethyl aminoethyl methacrylate (DMAEMA) with 2-Acrylamido-2-methylpropane sulfonic acid (AMPS) in gelatin was chemically cross-linked with methylene bis acrylamide (MBA) to form a semi-IPN hydrogel. Also, IPN hydrogel is fabricated from the AMPS-co-DMAEMA and gelatin in the presence of ferric ions with both chemical and physical cross-linkers. According to the compression test, the metal-ligand interaction has a remarkable impact on the mechanical strength of hydrogel...
June 22, 2023: Journal of Photochemistry and Photobiology. B, Biology
Alaaeldin Mahmoud, Sherif Elbasuney, Yasser H El-Sharkawy
Dental caries (DC) is a chronic illness that affects 2 billion individuals worldwide, with 520 million of those suffering from it in their primary teeth. It is apparent that early DC detection and subsequent minimally invasive therapy are crucial clinical requirements. The first reversible clinical indication of demineralization is dental white spot (DWS) lesions. However, diagnosing DWS poses extreme challenges for practitioners. In this investigation, a customized laser-induced fluorescence system with a hyperspectral imaging (HI) camera and a non-ionization laser light supply was created for DWS localization and early DC detection...
June 21, 2023: Journal of Photochemistry and Photobiology. B, Biology
Pei-Dan You, Cheng-Ren Ouyang, Fei Lu, Chao Zeng, Hong-Die Cai, Guo-Sheng Shi, Lihong Liu, Chun-Qiong Zhou
A novel croconic acid-bisindole dye CR-630 with a morpholine ring showed good water-solubility and obvious lysosome-targeting. The protonation of the nitrogen atom in the indole and lysosome-targeting of morpholine ring let it exhibit stronger pH-responsive NIR/PA imaging and photothermal effect in the lysosome acidic microenvironment (pH 4.0-5.5) than in the tumor acidic microenvironment. In the animal study, compound CR-630 could NIRF/PA image in the tumor tissues in 1.5-2.0 h, effectively inhibit the growth of the tumor, and even ablate the tumor at the drug dose of 1 mg/kg...
June 16, 2023: Journal of Photochemistry and Photobiology. B, Biology
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