Journals Journal of Photochemistry and ...

Journal of Photochemistry and Photobiology. B, Biology
Iago P F Nunes, Romário S de Jesus, Jeovana Amorim Almeida, Wellington L R Costa, Marcos Malta, Luiz G P Soares, Paulo F de Almeida, Antônio L B Pinheiro
With the rapid development of nanotechnology, various functional nanomaterials have shown exciting potential in biomedical areas such as drug delivery, antitumor, and antibacterial therapy. These nanomaterials improve the stability and selectivity of loaded drugs, reduce drug-induced side effects, realize controlled and targeted drug release, and increase therapeutic efficacy. The increased resistance to antifungal microbicides in medical practice and their side effects stimulate interest in new therapies, such as Photodynamic Therapy (PDT), which do not generate resistance in microorganisms and effectively control the pathology...
May 20, 2024: Journal of Photochemistry and Photobiology. B, Biology
Sai Kiran Madireddi, Ranay Mohan Yadav, Mohammad Yusuf Zamal, Pushan Bag, Jerome Xavier Gunasekaran, Rajagopal Subramanyam
Plants have a protective mechanism called non-photochemical quenching to prevent damage caused by excessive sunlight. A critical component of this mechanism is energy-dependent quenching (qE). In Chlamydomonas reinhardtii, the protein expression called light-harvesting complex stress-related protein 3 (LHCSR3) is crucial for the qE mechanism. LHCSR3 expression is observed in various conditions that result in photooxidation, such as exposure to high light or nutrient deprivation, where the amount of captured light surpasses the maximum photosynthetic capacity...
May 15, 2024: Journal of Photochemistry and Photobiology. B, Biology
Che-Yi Chang, Ana Elena Aviña, Cheng-Jen Chang, Long-Sheng Lu, Yi-Yong Chong, Tzu Ying Ho, Tzu-Sen Yang
Photobiomodulation (PBM) is a well-established medical technology that employs diverse light sources like lasers or light-emitting diodes to generate diverse photochemical and photophysical reactions in cells, thereby producing beneficial clinical outcomes. In this study, we introduced an 830 nm near-infrared (NIR) laser irradiation system combined with a microscope objective to precisely and controllably investigate the impact of PBM on the migration and viability of human adipose mesenchymal stem cells (hADSCs)...
May 14, 2024: Journal of Photochemistry and Photobiology. B, Biology
Linrong Shi, Mingzhi Zhu, Ruimin Long, Shibin Wang, Pei Wang, Yuangang Liu
In recent years, there has been growing interest in size-transformable nanoplatforms that exhibit active responses to acidic microenvironments, presenting promising prospects in the field of nanomedicine for tumor therapy. However, the design and fabrication of such size-adjustable nanotherapeutics pose significant challenges compared to size-fixed nanocomposites, primarily due to their distinct pH-responsive requirements. In this study, we developed pH-activated-aggregating nanosystems to integrate chemotherapy and photothermal therapy by creating size-transformable nanoparticles based on Prussian blue nanoparticles (PB NPs) anchored with acid-responsive polyoxometalates (POMs) quantum dots via electrostatic interactions (PPP NPs)...
May 10, 2024: Journal of Photochemistry and Photobiology. B, Biology
Bo-Sen Wu, Mahnaz Mansoori, Michael Schwalb, Sadman Islam, Most Tahera Naznin, Philip Wiredu Addo, Sarah MacPherson, Valérie Orsat, Mark Lefsrud
The visible light spectrum (400-700 nm) powers plant photosynthesis and innumerable other biological processes. Photosynthesis curves plotted by pioneering photobiologists show that amber light (590-620 nm) induces the highest photosynthetic rates in this spectrum. Yet, both red and blue light are viewed superior in their influence over plant growth. Here we report two approaches for quantifying how light wavelength photosynthesis and plant growth using light emitting diodes (LEDs). Resolved quantum yield spectra of tomato and lettuce plants resemble those acquired earlier, showing high quantum utilization efficiencies in the 420-430 nm and 590-620 nm regions...
May 9, 2024: Journal of Photochemistry and Photobiology. B, Biology
Zuohao Liu, Bingrong Dang, Zhen Li, Xingsheng Wang, Yuhan Liu, Fen Wu, Xinhui Cao, Chunming Wang, Changjun Lin
As the outermost layer of the human body, the skin suffers from various external factors especially light damage, among which ultraviolet B (UVB) irradiation is common and possesses a relatively high biological damage capacity. Pyroptosis is a newly discovered type of programmed cell death, which can induce cell rupture and induce local inflammatory response. However, the molecular mechanisms of pyroptosis in photodamaged skin is poorly understood. Baicalin, a flavonoid extracted from the desiccated root of Scutellaria baicalensis Georgi (Huang Qin)...
May 9, 2024: Journal of Photochemistry and Photobiology. B, Biology
Andrew Buzza, Kalista Tapas, Juanita Anders, Michael Jenkins, Michael Moffitt
INTRODUCTION: Photobiomodulation (PBM) has been studied since the 1960s as a clinical tool. More recently, PBM has been observed to reduce compound action potential components and hypersensitivities associated with neuropathic pains. However, no definitive description of efficacious light parameters has been determined. Some reasons may be that previous meta-analyses and reviews have focused on emitter output rather than the light at the target tissue and have included data sets that are large but with notable variability (e...
May 7, 2024: Journal of Photochemistry and Photobiology. B, Biology
Klaudia Szymczak, Agata Woźniak-Pawlikowska, Natalia Burzyńska, Magdalena Król, Lei Zhang, Joanna Nakonieczna, Mariusz Grinholc
INTRODUCTION: Emerging antibiotic resistance among bacterial pathogens has forced an urgent need for alternative non-antibiotic strategies development that could combat drug resistant-associated infections. Suppression of virulence of ESKAPE pathogens' by targeting multiple virulence traits provides a promising approach. OBJECTIVES: Here we propose an iron-blocking antibacterial therapy based on a cationic heme-mimetic gallium porphyrin (GaCHP), which antibacterial efficacy could be further enhanced by photodynamic inactivation...
May 5, 2024: Journal of Photochemistry and Photobiology. B, Biology
Ekin Daplan, Luca Turin
Visible light triggers free radical production in alive and intact Drosophila melanogaster. We exposed fruit flies to red (613-631 nm), green (515-535 nm), and blue (455-475 nm) light while we monitored changes in unpaired electron content with an electron spin resonance spectrometer (ESR/EPR). The immediate response to light is a rapid increase in spin content lasting approximately 10 s followed by a slower, linear increase for approximately 170 s. When the light is turned off, the spin population promptly decays with a similar time course, though never fully returning to baseline...
April 30, 2024: Journal of Photochemistry and Photobiology. B, Biology
Chao Wang, Takayuki Nambu, Hiroki Takigawa, Hugo Maruyama, Chiho Mashimo, Toshinori Okinaga
Periodontitis, a chronic infectious disease leading to gingival atrophy and potential tooth loss through alveolar bone resorption, is closely linked to the oral microbiome. Fusobacterium nucleatum, known to facilitate late-stage bacterial colonization in the oral microbiome, plays a crucial role in the onset of periodontitis. Controlling F. nucleatum abundance is vital for preventing and treating periodontal disease. Photodynamic therapy combined with 5-aminolevulinic acid (ALA-PDT) has been reported to be bactericidal against Pseudomonas aeruginosa and Staphylococcus aureus...
April 26, 2024: Journal of Photochemistry and Photobiology. B, Biology
Yuxin Chen, Laura Forster, Kehong Wang, Himadri S Gupta, Xiaopeng Li, Jun Huang, Yunfeng Rui
Since the mechanism underlying real-time acquisition of mechanical strength during laser-induced skin wound fusion remains unclear, and collagen is the primary constituent of skin tissue, this study investigates the structural and mechanical alterations in collagen at temperatures ranging from 40 °C to 60 °C using various spectroscopic techniques and molecular dynamics calculations. The COMSOL Multiphysics coupling is employed to simulate the three-dimensional temperature field, stress-strain relationship, and light intensity distribution in the laser thermal affected zone of skin wounds during dual-beam laser welding process...
April 26, 2024: Journal of Photochemistry and Photobiology. B, Biology
Shaogang Guo, Yanyou Wu, Mohamed Aboueldahab
Whether rapid oxygen isotopic exchange between bicarbonate and water occurs in photosynthesis is the key to determine the source of oxygen by classic 18 O-labeled photosynthetic oxygen evolution experiments. Here we show that both Microcystis aeruginosa and Chlamydomonas reinhardtii utilize a significant proportion (>16%) of added bicarbonate as a carbon source for photosynthesis. However, oxygen isotopic signal in added bicarbonate cannot be traced in the oxygen in organic matter synthesized by these photosynthetic organisms...
April 25, 2024: Journal of Photochemistry and Photobiology. B, Biology
Tainá Caroline Dos Santos Malavazzi, Lucas Andreo, Andreia Martinelli, Maria Fernanda Setúbal Destro Rodrigues, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes, Fabio Daumas Nunes, Raquel Agnelli Mesquita-Ferrari
Photobiomodulation therapy (PBM) has shown positive effects when applied locally to modulate the inflammatory process and facilitate muscle repair. However, the available literature on the mechanisms of action of vascular photobiomodulation (VPBM), a non-invasive method of vascular irradiation, specifically in the context of local muscle repair, is limited. Thus, this study aimed to assess the impact of vascular photobiomodulation (VPBM) using a low-level laser (LLL) on the inflammatory response and the process of skeletal muscle repair whether administered prior to or following cryoinjury-induced acute muscle damage in the tibialis anterior (TA) muscles...
April 24, 2024: Journal of Photochemistry and Photobiology. B, Biology
Qiuhao Ye, Jiao Wang, Ruotao Guo, Guizhi Chen, Yating Shen, Yijin Wu, Jingtang Wang, Zeyu Lin, Kun Wang, Jianling Chen, Yiru Peng
Accurately visualizing the intracellular trafficking of upconversion nanoparticles (UCNPs) loaded with phthalocyanines and achieving precise photodynamic therapy (PDT) using near-infrared (NIR) laser irradiation still present challenges. In this study, a novel NIR laser-triggered upconversion luminescence (UCL) imaging-guided nanoparticle called FA@TPA-NH-ZnPc@UCNPs (FTU) was developed for PDT. FTU consisted of UCNPs, folic acid (FA), and triphenylamino-phenylaniline zinc phthalocyanine (TPA-NH-ZnPc). Notably, TPA-NH-ZnPc showcases aggregation-induced emission (AIE) characteristic and NIR absorption properties at 741 nm, synthesized initially via molybdenum-catalyzed condensation reaction...
April 24, 2024: Journal of Photochemistry and Photobiology. B, Biology
Amanda Koberstain Surur, Analú Barros de Oliveira, Sarah Raquel De Annunzio, Túlio Morandin Ferrisse, Carla Raquel Fontana
Bacterial antibiotic resistance is one of the most significant challenges for public health. The increase in bacterial resistance, mainly due to microorganisms harmful to health, and the need to search for alternative treatments to contain infections that cannot be treated by conventional antibiotic therapy has been aroused. An alternative widely studied in recent decades is antimicrobial photodynamic therapy (aPDT), a treatment that can eliminate microorganisms through oxidative stress. Although this therapy has shown satisfactory results in infection control, it is still controversial in the scientific community whether bacteria manage to develop resistance after successive applications of aPDT...
April 23, 2024: Journal of Photochemistry and Photobiology. B, Biology
Joseph W Jackson, Pravin R Kaldhone, Leonid A Parunov, Caitlin F Stewart, John G Anderson, Scott J MacGregor, Michelle Maclean, Chintamani D Atreya
Chemical and UV light-based pathogen reduction technologies are currently in use for human platelet concentrates (PCs) to enhance safety from transfusion-transmitted infections. Relative to UV light, 405 nm violet-blue light in the visible spectrum is known to be less harmful. Hence, in this report for the first time, we have assessed the global hemostasis activity of PCs stored in plasma and the activities of six plasma coagulation factors (CFs) as a measure of in vitro hemostatic activity following exposure to the microbicidal 405 nm light...
April 23, 2024: Journal of Photochemistry and Photobiology. B, Biology
Magdalena de Arriba, Nicole Borel, Salomé LeibundGut-Landmann
Many common skin diseases are associated with changes in the microbiota. This applies for the commensal yeast Malassezia, which is linked to a wide range of skin disorders ranging from mild dandruff to severe seborrheic and atopic dermatitis, all of which have a detrimental impact on the individuals' quality of life. While antifungal medications offer relief in many cases, the challenges of disease recurrence and the emergence of resistance to the limited range of available antifungal drugs poses a pressing need for innovative therapeutic options...
April 23, 2024: Journal of Photochemistry and Photobiology. B, Biology
Jia Xu, Bing-Bing Huang, Chun-Mei Lai, Yu-Sheng Lu, Jing-Wei Shao
As a sort of fluorescent carbon nanomaterial with a particle size of less than 10 nm, carbon dots (CDs) have their own merits of good dispersibility in water, stable optical properties, strong chemical inertness, stable optical properties, and good biosecurity. These excellent peculiarities facilitated them like sensing, imaging, medicine, catalysis, and optoelectronics, making them a new star in the field of nanotechnology. In particular, the development of CDs in the fields of chemical probes, imaging, cancer therapy, antibacterial and drug delivery has become a hot topic in current research...
April 21, 2024: Journal of Photochemistry and Photobiology. B, Biology
Angela Paola Yaya-Candela, Felipe Gustavo Ravagnani, Natasha Dietrich, Rafaela Sousa, Maurício S Baptista
Endolysosomes perform a wide range of cellular functions, including nutrient sensing, macromolecule digestion and recycling, as well as plasma membrane repair. Because of their high activity in cancerous cells, endolysosomes are attractive targets for the development of novel cancer treatments. Light-activated compounds termed photosensitizers (PS) can catalyze the oxidation of specific biomolecules and intracellular organelles. To selectively damage endosomes and lysosomes, HT-29 colorectal cancer cells were incubated with nanomolar concentrations of meso-tetraphenylporphine disulfonate (TPPS2a ), an amphiphilic PS taken up via endocytosis and activated by green light (522 nm, 2...
April 19, 2024: Journal of Photochemistry and Photobiology. B, Biology
Shazia Bano, Jose Quilez Alburquerque, Harrison James Roberts, Sumiao Pang, Huang-Chiao Huang, Tayyaba Hasan
The prognosis for patients with advanced-stage pancreatic ductal adenocarcinoma (PDAC) remains dismal. It is generally accepted that combination cancer therapies offer the most promise, such as Folforinox, despite their associated high toxicity. This study addresses the issue of chemoresistance by introducing a complementary dual priming approach to attenuate the DNA repair mechanism and to improve the efficacy of a type 1 topoisomerase (Top1) inhibitor. The result is a regimen that integrates drug-repurposing and nanotechnology using 3 clinically relevant FDA-approved agents (1) Top1 inhibitor (irinotecan) at subcytotoxic doses (2) benzoporphyrin derivative (BPD) as a photoactive molecule for photodynamic priming (PDP) to improve the delivery of irinotecan within the cancer cell and (3) minocycline priming (MNP) to modulate DNA repair enzyme Tdp1 (tyrosyl-DNA phosphodiesterase) activity...
April 16, 2024: Journal of Photochemistry and Photobiology. B, Biology
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