Lucia Sideli, Monica Aas, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Luis Alameda, Eva Velthorst, Giulia Trotta, Giada Tripoli, Adriano Schimmenti, Andrea Fontana, Charlotte Gayer-Anderson, Simona Stilo, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Domenico Berardi, Giuseppe D'Andrea, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Julio Sanjuán, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E Jongsma, Peter B Jones, James B Kirkbride, Pierre-Michel Llorca, Andrea Tortelli, Baptiste Pignon, Lieuwe de Haan, Jean-Paul Selten, Jim Van Os, Bart P Rutten, Richard Bentall, Marta Di Forti, Robin M Murray, Craig Morgan, Helen L Fisher
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls...
June 19, 2023: Social Psychiatry and Psychiatric Epidemiology