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Journals European Journal of Clinical M...

European Journal of Clinical Microbiology & Infectious Diseases

https://read.qxmd.com/read/38472519/unmasking-bartonella-henselae-infection-in-the-shadows-of-long-covid-thanks-to-clinical-metagenomics
#61
JOURNAL ARTICLE
Aurélien Aubry, Emilie Corvilain, Théo Ghelfenstein-Ferreira, François Camelena, Véronique Meignin, Béatrice Berçot, Jérôme Le Goff, Maud Salmona
The diagnosis of long COVID often relies on symptoms post-COVID-19, occasionally lacking biological evidence. This case study illustrates how investigating long COVID uncovered an underlying bartonellosis through clinical metagenomics. Following mild COVID-19, a 26-year-old woman experienced persistent symptoms during 5 months, including axillary adenopathy. Pathological examination, 16 S rRNA PCR, and clinical metagenomic analysis were done on an adenopathy biopsy. The latter revealed Bartonella henselae DNA and RNA...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472518/association-of-scrub-typhus-with-the-risk-of-venous-thromboembolism-and-long-term-mortality-a-population-based-cohort-study
#62
JOURNAL ARTICLE
En-Shao Liu, Yi-Ting Wu, Wen-Miin Liang, Feng-Yu Kuo
BACKGROUND: The existing literature lacks studies examining the epidemiological link between scrub typhus and deep vein thrombosis (DVT) or pulmonary embolism (PE), and the long-term outcomes. The objective of this study is to explore the potential association between scrub typhus and the subsequent risk of venous thromboembolism, and long-term mortality. METHOD: This nationwide cohort study identified 10,121 patients who were newly diagnosed with scrub typhus. Patients with a prior DVT or PE diagnosis before the scrub typhus infection were excluded...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38460030/does-selective-digestive-decontamination-sdd-increase-antibiotic-resistance-long-term-comparison-of-two-intensive-care-units-with-and-without-sdd-of-the-same-tertiary-hospital
#63
JOURNAL ARTICLE
Alicia Rodríguez-Gascón, Yanire Lloréns-Villar, María Ángeles Solinís, Helena Barrasa, Andrés Canut-Blasco
PURPOSE: The aim of this study was to to compare the antimicrobial resistance rate and its relationship with the antibiotic consumption in two separate Intensive Care Units (ICUs) of the same hospital, one with and other without selective decontamination of the digestive tract (SDD). METHODS: We performed a retrospective study in the two ICUs of the Araba University Hospital. Trauma and neurosurgical patients are admitted to the SDD-ICU, and general digestive surgery patients go to the no SDD-ICU...
March 9, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38457097/carbapenem-or-new-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-an-italian-survey-supported-by-sita-simit-and-siaarti-to-identify-the-factors-affecting-empiric-antimicrobial-therapy-choice-in-real-life-clinical-practice
#64
JOURNAL ARTICLE
Marta Colaneri, Camilla Genovese, Andrea Lombardi, Darcy Holmes, Alessandra Bandera, Andrea Gori
While a tailored antibiotic treatment plan is often straightforward, what we often observe in daily clinical practice is a highly variable approach when defining empirical therapy. Specifically, a debate exists on preference to spare the new β-lactams and β-lactamase inhibitors (BL-BLIs) or to apply a carbapenem-sparing strategy first. To investigate, we designed a web survey aimed at investigating the variables considered relevant to empirically choosing one antibiotic over the other. Submitted to Italian infectious diseases and intensive care physicians through the support of Società Italiana di Malattie Infettive e Tropicali (SIMIT), Società Italiana di Terapia Antinfettiva (SITA) and Società Italiana Anestesia, Analgesia, Rianimazione e Terapia Intensiva (SIAARTI)...
March 8, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38443737/intraventricular-or-intrathecal-polymyxin-b-for-treatment-of-post-neurosurgical-intracranial-infection-caused-by-carbapenem-resistant-gram-negative-bacteria-a-8-year-retrospective-study
#65
JOURNAL ARTICLE
Yangmin Hu, Danyang Li, Gensheng Zhang, Yunjian Dai, Meng Chen, Huifang Jiang, Wei Cui
PURPOSE: Post-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria (CRGNB) is a life-threatening complication. This study aimed to assess the current practices and clinical outcomes of intravenous (IV) combined with intraventricular (IVT)/intrathecal (ITH) polymyxin B in treating CRGNB intracranial infection. METHODS: A retrospective study was conducted on patients with post-neurosurgical intracranial infection due to CRGNB from January 2013 to December 2020...
March 5, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38438704/hybrid-capture-shotgun-sequencing-detected-unexpected-viruses-in-the-cerebrospinal-fluid-of-children-with-acute-meningitis-and-encephalitis
#66
JOURNAL ARTICLE
Cristian Launes, Juan Camacho, Marina Pons-Espinal, F Xavier López-Labrador, Cristina Esteva, María Cabrerizo, María Dolores Fernández-García, Marta Fogeda, Josefa Masa-Calles, Noemí López-Perea, Juan Emilio Echevarría, Carmen Muñoz-Almagro, David Tarragó
PURPOSE: Investigation of undiagnosed cases of infectious neurological diseases, especially in the paediatric population, remains a challenge. This study aimed to enhance understanding of viruses in CSF from children with clinically diagnosed meningitis and/or encephalitis (M/ME) of unknown aetiology using shotgun sequencing enhanced by hybrid capture (HCSS). METHODS: A single-centre prospective study was conducted at Sant Joan de Déu University Hospital, Barcelona, involving 40 M/ME episodes of unknown aetiology, recruited from May 2021 to July 2022...
March 4, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38421466/evaluation-of-clinitest%C3%A2-rapid-covid-19%C3%A2-%C3%A2-influenza-antigen-test-in-a-cohort-of-symptomatic-patients-in-an-emergency-department
#67
JOURNAL ARTICLE
Alfredo Maldonado-Barrueco, Almudena Gutiérrez-Arroyo, Iván Bloise, María de Ceano-Vivas, Angélica Rivera-Nuñez, Rosario Torres Santos-Olmos, Dolores Montero Vega, Julio García-Rodríguez
OBJECTIVES: Rapid management of patients with respiratory tract infections in hospital emergency departments is one of the main objectives since the concurrent circulation of respiratory viruses following the SARS-CoV-2 pandemic. The use of new combined point-of-care antigen tests for detecting influenza A/B and SARS-CoV-2 represents an advantage in response time over the molecular tests. The objective was to evaluate the suitability of the CLINITEST® Rapid Covid-19 + Influenza Antigen test (Siemens Healthineers, Germany) (RCIA test) by measuring the sensitivity, specificity, Cohen's kappa, and cut-off values...
February 29, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38206519/a-multicenter-evaluation-of-the-qiastat-dx-meningitis-encephalitis-syndromic-test-kit-as-compared-to-the-conventional-diagnostic-microbiology-workflow
#68
MULTICENTER STUDY
Stefan A Boers, Robin van Houdt, Nina M van Sorge, Jelle Groot, Yvette van Aarle, Mario J A W M van Bussel, Louise F E Smit, Els Wessels, Eric C J Claas
PURPOSE: Rapid diagnosis and treatment of infectious meningitis and encephalitis (ME) is critical to minimize morbidity and mortality. Recently, Qiagen introduced the CE-IVD QIAstat-Dx ME panel (QS-ME) for syndromic diagnostic testing of meningitis and encephalitis. Some data on the performance of the QS-ME in comparison to the BioFire FilmArray ME panel are available. In this study, the performance of the QS-ME is compared to the current diagnostic workflow in two academic medical centers in the Netherlands...
March 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38416290/successful-treatment-of-sino-pulmonary-infection-skull-base-osteomyelitis-caused-by-new-delhi-metallo-%C3%AE-lactamase-producing-pseudomonas-aeruginosa-in-a-renal-transplant-recipient-by-using-an-investigational-antibiotic-cefepime-zidebactam-wck-5222
#69
JOURNAL ARTICLE
Rajeev Soman, Rasika Sirsat, Ayesha Sunavala, Neha Punatar, Jugal Mehta, Camilla Rodrigues, Balaji Veeraraghavan
A case of sino-pulmonary infection with skull base osteomyelitis due to XDR-Pseudomonas aeruginosa in renal transplant recipient was successfully treated with investigational antibiotic, cefepime/zidebactam (WCK 5222). This case highlights challenges in managing XDR-pseudomonal infection where source control was infeasible, antibiotic options were extremely limited and individualized dose adjustments were needed.
February 28, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38416289/invasive-disease-caused-simultaneously-by-two-different-serotypes-of-streptococcus-pneumoniae-a-microbiological-appreciation
#70
JOURNAL ARTICLE
Emilia Cercenado, Belén Ramos, Marta Pérez-Abeledo, Julio Sempere, Jose Yuste, Juan Carlos Sanz
We report a clinical case of a child with an invasive pneumococcal disease caused by two different pneumococcal serotypes that belonged to different sequence types. She was a 15-month-old girl with pneumonia and pleural effusion in which S. pneumoniae colonies with different morphologies grew, one from the blood culture (characteristic greyish appearance) and the other from the pleural fluid (mucoid appearance). The isolate from blood was serotype 22 F (ST698/CC698/GPSC61), while the isolate from the pleural fluid was serotype 3 (ST180/CC180/GPSC12)...
February 28, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38411778/validation-of-a-new-risk-stratification-system-based-management-for-methicillin-resistant-staphylococcus-aureus-bacteraemia-analysis-of-a-multicentre-prospective-study
#71
JOURNAL ARTICLE
Taeeun Kim, Sang-Rok Lee, Seong Yeon Park, Song Mi Moon, Jiwon Jung, Min Jae Kim, Heungsup Sung, Mi-Na Kim, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim, Eun Hee Song, Yong Pil Chong
PURPOSE: Distinguishing between complicated and uncomplicated Staphylococcus aureus bacteraemia (SAB) is therapeutically essential. However, this distinction has limitations in reflecting the heterogeneity of SAB and encouraging targeted diagnostics. Recently, a new risk stratification system for SAB metastatic infection, involving stepwise approaches to diagnosis and treatment, has been suggested. We assessed its applicability in methicillin-resistant SAB (MRSAB) patients. METHODS: We retrospectively analysed data of a 3-year multicentre, prospective cohort of hospitalised patients with MRSAB...
February 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38407691/comparison-of-gradient-diffusion-and-molecular-methods-using-allplex%C3%A2-ng-dr-assay-seegene%C3%A2-for-macrolide-and-fluoroquinolone-screening-resistance-in-neisseria-gonorrhoeae
#72
JOURNAL ARTICLE
Alfredo Maldonado-Barrueco, Claudia Sanz-González, Iker Falces-Romero, Paloma García-Clemente, Juana Cacho-Calvo, Inmaculada Quiles-Melero
Antimicrobial resistance in Neisseria gonorrhoeae (NG) is increasing worldwide. Second-line treatments with macrolides or fluoroquinolones are an option for NG infections in some cases following the STI guideline recommendations. In our study, we compared the gradient diffusion test using EUCAST 2024 breakpoints with a new molecular method using the Allplex™ NG&DR assay (Seegene® ) including A2059G/C2611 mutations (23S rRNA) associated with high/moderate-level macrolide resistance and S91F mutation (gyrA) relationship with fluoroquinolone resistance in NG isolates (n = 100)...
February 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38388739/in-vitro-susceptibility-of-neisseria-gonorrhoeae-to-netilmicin-and-etimicin-in-comparison-to-gentamicin-and-other-aminoglycosides
#73
JOURNAL ARTICLE
Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich, Sven N Hobbie
PURPOSE: Single doses of gentamicin have demonstrated clinical efficacy in the treatment of urogenital gonorrhea, but lower cure rates for oropharyngeal and anorectal gonorrhea. Formulations selectively enriched in specific gentamicin C congeners have been proposed as a less toxic alternative to gentamicin, potentially permitting higher dosing to result in increased plasma exposures at the extragenital sites of infection. The purpose of the present study was to compare the antibacterial activity of individual gentamicin C congeners against Neisseria gonorrhoeae to that of other aminoglycoside antibiotics...
February 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38388738/emergence-of-a-clinical-salmonella-enterica-serovar-1-4-5-12-i-isolate-st3606-in-china-with-susceptibility-decrease-to-ceftazidime-avibactam-carrying-a-novel-bla-ctx-m-261-variant-and-a-bla-ndm-5
#74
JOURNAL ARTICLE
Jie Wei, Shimei Shen, Qinghuan Zhang, Jinping Lu, Shenglan Mao, Chunhong Zou, Hua Zhou, YeLin Wei, Xingyi Ou, Jinyu Huang, Deqiang Wang, Xiaobin Li, Qun Wan, Baoju Shan, Zhenlin Zhang
PURPOSE: The detection rate of Salmonella enterica serovar 1,4,[5], 12: i: - (S. 1,4,[5], 12: i: -) has increased as the most common serotype globally. A S. 1,4,[5], 12: i: - strain named ST3606 (sequence type 34), isolated from a fecal specimen of a child with acute diarrhea hospitalized in a tertiary hospital in China, was firstly reported to be resistant to carbapenem and ceftazidime-avibactam. The aim of this study was to characterize the whole-genome sequence of S. 1,4,[5], 12: i: - isolate, ST3606, and explore its antibiotic resistance genes and their genetic environments...
February 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38383889/cost-effectiveness-of-latent-tuberculosis-infection-testing-and-treatment-with-6-week-regimen-among-key-population-in-rural-communities-in-china-a-decision-analysis-study
#75
JOURNAL ARTICLE
Xuefang Cao, Tonglei Guo, Henan Xin, Jiang Du, Chenlu Yang, Boxuan Feng, Yijun He, Lingyu Shen, Yuanzhi Di, Zihan Li, Yanxiao Chen, Jianguo Liang, Qi Jin, Li Wang, Lei Gao
PURPOSE: Several model studies suggested the implementation of latent tuberculosis infection (LTBI) testing and treatment could greatly reduce the incidence of tuberculosis (TB) and achieve the 2035 target of the "End TB" Strategy in China. The present study aimed to evaluate the cost-effectiveness of LTBI testing and TB preventive treatment among key population (≥ 50 years old) susceptible to TB at community level in China. METHODS: A Markov model was developed to investigate the cost-effectiveness of LTBI testing using interferon gamma release assay (IGRA) and subsequent treatment with 6-month daily isoniazid regimen (6H) (as a standard regimen for comparison) or 6-week twice-weekly rifapentine and isoniazid regimen (6-week H2 P2 ) in a cohort of 10,000 adults with an average initial age of 50 years...
February 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38379053/evaluating-fourier-transform-infrared-spectroscopy-with-ir-biotyper-as-a-faster-and-simpler-method-for-investigating-the-sources-of-an-outbreak-of-legionellosis
#76
JOURNAL ARTICLE
Naoki Nakajima, Michio Jinnai, Shinji Izumiyama, Toshiro Kuroki
Fourier-transform infrared (FTIR) spectroscopy using the IR Biotyper and core genome single nucleotide polymorphism (cgSNP) analysis were performed on 12 Legionella isolates associated with an outbreak at a spa house in Kanagawa Prefecture, Japan, and 3 non-outbreak isolates. The discriminative power of FTIR spectroscopy for 48-h incubation conditions of L. pneumophila in this outbreak was lower than cgSNP-based typing but higher than serogroup typing. FTIR spectroscopy could screen outbreak isolates from a group of genetically related isolates and may be useful as an initial typing method in Legionella outbreak investigations...
February 20, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38379052/disseminated-nocardiosis-and-anti-gm-csf-antibodies
#77
JOURNAL ARTICLE
Barbara Brugnoli, Lorenzo Salvati, Nicoletta Di Lauria, Annarita Botta, Camilla Tozzetti, Alessandro Biscarini, Manuela Capone, Filomena Ferrentino, Chiara Naldi, Giovanni Ascione, Alessio Mazzoni, Laura Maggi, Ilaria Campo, Brenna Carey, Bruce Trapnell, Francesco Liotta, Lorenzo Cosmi, Alessandro Bartoloni, Francesco Annunziato, Paola Parronchi, Boaz Palterer
Infections that are unusually severe or caused by opportunistic pathogens are a hallmark of primary immunodeficiency (PID). Anti-cytokine autoantibodies (ACA) are an emerging cause of acquired immunodeficiency mimicking PID. Nocardia spp. are Gram-positive bacteria generally inducing disseminated infections in immunocompromised patients, but seldom also occurring in apparently immunocompetent hosts. Anti-GM-CSF autoantibodies are associated with autoimmune pulmonary alveolar proteinosis (PAP). In those patients, an increased incidence of disseminated nocardiosis and cryptococcosis has been observed...
February 20, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38376634/real-world-experience-with-meropenem-vaborbactam-for-the-treatment-of-infections-caused-by-esbl-producing-enterobacterales-and-carbapenem-resistant-klebsiella-pneumoniae
#78
JOURNAL ARTICLE
Giusy Tiseo, Valentina Galfo, Niccolò Riccardi, Lorenzo Roberto Suardi, Manuela Pogliaghi, Cesira Giordano, Alessandro Leonildi, Simona Barnini, Marco Falcone
PURPOSE: Real-world experience with meropenem/vaborbactam (M/V) is limited. Our aim is to report a clinical experience of M/V in the treatment of resistant Gram-negative bacilli. METHODS: This is a prospective observational study including patients hospitalized in the University Hospital of Pisa (March 2021-Jan 2023) with infections by both extended-spectrum β-lactamases (ESBL)-producing Enterobacterales and carbapenem-resistant Klebsiella pneumoniae (Kp) treated with M/V...
February 20, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38376633/recurrent-bacteremia-and-endocarditis-due-to-staphylococcus-capitis-in-a-patient-with-bowen-s-disease-a-case-report
#79
JOURNAL ARTICLE
Alejandro Díez-Vidal, María Elena González-García, Irene Marco-Clement, Javier Azores-Moreno, Patricia Roces-Álvarez, Cristina Marcelo-Calvo, Patricia Martínez-Martín, Borja González-Muñoz, Fernando Fernández-Hinojal, Belén Loeches
This case report details the management of a 79-year-old male with recurrent methicillin-resistant Staphylococcus capitis bacteremia and endocarditis. The patient's clinical journey encompassed multiple hospital admissions, with challenges in managing endocarditis, pacemaker replacements, and potential cutaneous sources of infection. The treatment regimen included intravenous antibiotic therapy during hospitalization and suppressive antibiotic treatment upon discharge, alongside a decolonization strategy for his scalp lesions...
February 20, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38372832/risk-factors-and-outcome-associated-with-the-acquisition-of-mdr-linezolid-resistant-enterococcus-faecium-a-report-from-tertiary-care-centre
#80
JOURNAL ARTICLE
Vandana Rani, N Kitoi Aye, Rushika Saksena, Kailash Chandra Dabi, Mohammad Amin-Ul Mannan, Rajni Gaind
OBJECTIVE: The aim of the study was to determine the resistance profile of linezolid-resistant Enterococcus faecium (LREfm) and to investigate risk factors and outcomes associated with LREfm infections. MATERIAL AND METHODS: A prospective case-control study was undertaken (2019 to 2022) and included 202 patients with LREfm infections (cases) and 200 controls with LSEfm infections. Clinical data was prospectively collected and analysed for risk factors and outcomes...
February 19, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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