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European Journal of Clinical Microbiology & Infectious Diseases

https://read.qxmd.com/read/38329634/usutu-virus-avian-and-human-infection-after-more-than-25%C3%A2-years-of-circulation
#21
LETTER
Giuseppe Giglia, Agliani Gianfilippo, Maria Teresa Mandara, Erwin de Bruin, Andrea Gröne, Judith M A van den Brand
No abstract text is available yet for this article.
February 8, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38326546/impact-of-an-interventional-bundle-on-complications-associated-with-peripheral-venous-catheters-in-elderly-patients
#22
JOURNAL ARTICLE
María Jesús Pérez-Granda, Álvaro Irigoyen-von-Sierakowski, Neera Toledo, Eva Rodríguez, María Luisa Cruz, Giovanna Hernanz, José Antonio Serra, Martha Kestler, Patricia Muñoz, María Guembe
PURPOSE: Elderly patients admitted to geriatrics departments often require peripheral venous catheters (PVC), which should be inserted and maintained following a series of preventive recommendations. Our objective was to evaluate the impact of a training bundle comprising measures aimed at reducing complications associated with the use of PVC in elderly patients admitted to a tertiary teaching hospital. METHODS: We performed a prospective study of patients who received a PVC within 24 h of admission to a geriatrics department...
February 8, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38326545/comparison-of-influenza-and-covid-19-associated-pulmonary-aspergillosis-in-china
#23
JOURNAL ARTICLE
Jiankang Zhao, Xianxia Zhuo, Danni Pu, Guohui Fan, Binghuai Lu, Bin Cao
PURPOSE: We conducted a monocentric retrospective study using the latest definitions to compare the demographic, clinical, and biological characteristics of influenza-associated pulmonary aspergillosis (IAPA) and COVID-19-associated pulmonary aspergillosis (CAPA). METHODS: The study retrospectively enrolled 180 patients, including 70 influenza/IPA patients (with positive influenza A/B and Aspergillus) and 110 COVID-19/IPA patients (with positive SARS-CoV-2 and Aspergillus)...
February 7, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38326544/neonatal-sars-cov-2-immunoglobulin-g-antibodies-at-delivery-and-their-impact-on-covid-19
#24
JOURNAL ARTICLE
Susanne Vetter-Laracy, Victoria Jimenez, Marina Roldán, Marta Bernardino, Pere Balliu-Badia, Paula Lara, Ricardo Manuel Arcay, Pablo Fraile-Ribot, Maria Vila, Francisco Fanjul
OBJECTIVE: To assess neonatal SARS-CoV-2 anti-spike IgG antibody levels after maternal mRNA COVID-19 vaccination and/or infection during pregnancy and evaluate their protective effect. METHODS: Prospective observational study, conducted from January 2021 to December 2022. Infants were tested for anti-spike IgG antibodies at birth and then every 3 months until disappearance of titer. A follow-up was done for SARS-CoV-2 infection up to 12 months. RESULTS: In total, 147 newborns were enrolled with a median (IQR) gestational age of 39...
February 7, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38319508/reduced-susceptibility-to-aztreonam-avibactam-conferred-by-acquired-ampc-type-%C3%AE-lactamases-in-pbp3-modified-escherichia-coli
#25
JOURNAL ARTICLE
Nicolas Helsens, Mustafa Sadek, Christophe Le Terrier, Laurent Poirel, Patrice Nordmann
PURPOSE: Carbapenemase-producing Enterobacterales are a growing threat, and very few therapeutic options remain active against those multidrug resistant bacteria. Aztreonam is the molecule of choice against metallo-beta-lactamases (MBL) producers since it is not hydrolyzed by those enzymes, but the co-production of acquired plasmidic cephalosporinases or extended-spectrum β-lactamases leading to aztreonam resistance may reduce the efficacy of this molecule. Hence, the development of the aztreonam-avibactam (AZA) combination provides an interesting therapeutic alternative since avibactam inhibits the activity of both cephalosporinases and extended-spectrum β-lactamases...
February 6, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38296911/genetic-analysis-of-vancomycin-variable-enterococcus-faecium-clinical-isolates-in-italy
#26
JOURNAL ARTICLE
Sonia Nina Coccitto, Marzia Cinthi, Serena Simoni, Antonella Pocognoli, Guido Zeni, Annarita Mazzariol, Gianluca Morroni, Marina Mingoia, Eleonora Giovanetti, Andrea Brenciani, Carla Vignaroli
PURPOSE: To investigate the occurrence of vancomycin-variable enterococci (VVE) in a hospital in central Italy. METHODS: vanA positive but vancomycin-susceptible Enterococcus faecium isolates (VVE-S) were characterized by antibiotic susceptibility tests, molecular typing (PFGE and MLST), and WGS approach. The reversion of VVE-S to a resistant phenotype was assessed by exposure to increasing vancomycin concentrations, and the revertant isolates were used in filter mating experiments...
January 31, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38278986/inhibitors-against-new-delhi-metallo-betalactamase-1-ndm-1-and-its-variants-endemic-in-indian-settings-along-with-the-laboratory-functional-gain-mutant-of-ndm-1
#27
JOURNAL ARTICLE
Nabeela Farhat, Asad U Khan
PURPOSE: The emergence of NDM-1 producing bacteria has become common in both hospital and community settings, but no inhibitor has yet been available for clinical treatment. Hence, demanding the urgent need of NDM-1 inhibitors, we initiated to screen broad spectrum inhibitors against NDM natural variants and laboratory mutant. METHODS: We used docking and molecular dynamics simulations, in silico pharmacokinetic investigations, and density functional theory calculation to characterize molecules...
January 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38277033/evaluation-of-the-mts%C3%A2-aztreonam-avibactam-strip-liofilchem-on-new-delhi-metallo-%C3%AE-lactamase-producing-enterobacterales
#28
JOURNAL ARTICLE
Cardot Martin Emilie, Colombier Marie Alice, Gougeon Marine, Eric Farfour, Annabelle Pourbaix, Laurent Dortet, Limousin Lucie, Vasse Marc
The combination of ceftazidime-avibactam (CAZ-AVI) and aztreonam (ATM) is used to treat MBL-producing Enterobacterales-related infections. The new combination aztreonam-avibactam (AZA) is currently in development. We compared results obtained with the new MIC test strip (MTS) AZA (Liofilchem) with broth microdilution method (BMD) on 41 MBL-producing Enterobacterales from 41 clinical samples. The MTS AZA was also compared to combination testing method using CAZ-AVI and ATM strips. Compared to BMD, categorical agreement (CA) was 100%...
January 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38277032/a-14-year-review-2007-2020-of-helminthiasis-epidemiology-in-a-hospital-in-southern-madrid-spain
#29
JOURNAL ARTICLE
Jorge Ligero-López, María Dolores Corbacho-Loarte, Víctor Antón-Berenguer, Francisco Jesús Merino-Fernández, José Miguel Rubio-Muñoz, Beatriz Valle-Borrego
PURPOSE: Vast majority of helminth diseases remain neglected tropical diseases (NTDs), causing significant morbidity. The widespread and periodic distribution of antiparasitic drugs, remains the cornerstone for controlling these diseases. In Spain, most helminthiasis cases are imported, and suspicion and diagnosis have become increasingly important. Our primary objective is to present the epidemiological landscape of helminthiasis diagnoses within our facility, while also detailing the demographic characteristics of the affected population...
January 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38273191/predicting-the-primary-infection-source-of-escherichia-coli-bacteremia-using-virulence-associated-genes
#30
JOURNAL ARTICLE
Christian Schaadt Ilsby, Frederik Boetius Hertz, Henrik Westh, Jonathan Monk, Peder Worning, Helle Krogh Johansen, Katrine Hartung Hansen, Mette Pinholt
PURPOSE: To investigate the role of E. coli virulence-associated genes (VAGs) in predicting urinary tract infection (UTI) as the source of bacteremia in two distinct hospital populations, one with a large general catchment area and one dominated by referrals. METHODS: E. coli bacteremias identified at Department of Clinical Microbiology (DCM), Hvidovre Hospital and DCM, Rigshospitalet in the Capital Region of Denmark from October to December 2018. Using whole genome sequencing (WGS), we identified 358 VAGs from 224 E...
January 25, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38270806/a-molecular-toolbox-for-fast-and-convenient-diagnosis-of-emerging-and-reemerging-bacterial-pathogens-causing-fever-of-intermediate-duration
#31
JOURNAL ARTICLE
Elva Vega-García, Génesis Palacios, José A Pérez, Mónica Vélez-Tobarias, Ana María Torres-Vega, Carlos Ascaso-Terrén, Emma Carmelo
PURPOSE: Fever of intermediate duration (FID) is defined as a fever in the community without a specific origin or focus, with a duration between 7 and 28 days. FID is often caused by pathogens associated with animal contact or their arthropods parasites, such as ticks, fleas, or lice. The purpose of this work is to design a collection of molecular tools to promptly and accurately detect common bacterial pathogens causing FID, including bacteria belonging to genera Rickettsia, Bartonella, Anaplasma, and Ehrlichia, as well as Coxiella burnetii...
January 25, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38265603/genomic-epidemiology-and-molecular-characteristics-of-bla-ndm-1-positive-carbapenem-resistant-pseudomonas-aeruginosa-belonging-to-international-high-risk-clone-st773-in-the-gauteng-region-south-africa
#32
JOURNAL ARTICLE
Hyunsul Jung, Johann D D Pitout, Yasufumi Matsumura, Kathy-Anne Strydom, Chanel Kingsburgh, Marthie M Ehlers, Marleen M Kock
PURPOSE: The emergence of carbapenem-resistant P. aeruginosa (CRPA) harbouring acquired carbapenemase genes (blaVIM , blaIMP and blaNDM ) has become a global public health threat. Three CRPA isolates included in the study had an extensively drug-resistant phenotype with susceptibility to colistin only and were positive for the blaNDM-1 gene. The current study aimed to investigate the genomic epidemiology and molecular characteristics of the blaNDM-1 -positive CRPA isolates collected from the Gauteng region, South Africa...
January 24, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38261158/migratory-pattern-of-zoonotic-toxocara-cati-and-t-canis-in-experimentally-infected-pigs
#33
JOURNAL ARTICLE
Casper Sahl Poulsen, Ayako Yoshida, Tinna Thordardottir Wellbrant, Pall Skuli Leifsson, Per Skallerup, Stig Milan Thamsborg, Peter Nejsum
BACKGROUND: Over a billion people are infected with Toxocara canis or T. cati, the roundworms of dogs and cats. Historically, T. canis has been considered the main species responsible for human toxocarosis, but as serodiagnosis cannot discriminate between the two species, this remains unresolved. We used pigs as a relevant large animal model for human infection to assess the migratory pattern of T. cati and T. canis. METHODS: Pigs were inoculated with T. cati or T...
January 23, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38246947/risk-factors-outcomes-and-epidemiological-and-etiological-study-of-hospitalized-covid-19-patients-with-bacterial-co-infection-and-secondary-infections
#34
JOURNAL ARTICLE
Yishan Duan, Jing Wang, Suyan Wang, Rui Zhang, Jinrui Hu, Weimin Li, Bojiang Chen
BACKGROUND: As a common complication of viral respiratory tract infection, bacterial infection was associated with higher mortality and morbidity. Determining the prevalence, culprit pathogens, outcomes, and risk factors of co-infection and secondary infection occurring in hospitalized patients with coronavirus disease 2019 (COVID-19) will be beneficial for better antibiotic management. METHODS: In this retrospective cohort research, we assessed clinical characteristics, laboratory parameters, microbiologic results, and outcomes of laboratory-confirmed COVID-19 patients with bacterial co-infection and secondary infection in West China Hospital from 2022 December 2nd to 2023 March 15th...
January 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38240989/analysis-of-clinical-characteristics-and-risk-factors-for-death-due-to-severe-influenza-in-children
#35
JOURNAL ARTICLE
Ruiyang Sun, Xue Zhang, Wanyu Jia, Peng Li, Chunlan Song
OBJECTIVE: The study analyzed the clinical features of children who had severe influenza and discussed on the risk factors associated with death in this population. METHODS: A total of 167 children with severe influenza admitted to the intensive care unit of our hospital from January 2018 to August 2023 were selected and divided into the death group (27 cases) and the survival group (140 cases). Demographic characteristics and clinical data were collected and compared between the two groups...
January 19, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38240988/performance-evaluation-of-bruker-umic-%C3%A2-microdilution-panel-and-disc-diffusion-to-determine-cefiderocol-susceptibility-in-enterobacterales-acinetobacter-baumannii-pseudomonas-aeruginosa-stenotrophomonas-maltophilia-achromobacter-xylosoxidans-and-burkolderia
#36
JOURNAL ARTICLE
Gabriele Bianco, Matteo Boattini, Sara Comini, Paolo Gaibani, Rossana Cavallo, Cristina Costa
PURPOSE: Cefiderocol susceptibility testing (AST) represents an open challenge for clinical microbiology. Herein, we evaluated the performance of the UMIC® Cefiderocol broth microdilution (BMD) test and disc diffusion on Gram-negative species. METHODS: UMIC® Cefiderocol BMD test, disc diffusion and reference BMD were in parallel performed on a collection of 256 clinical isolates. Categorical agreement (CA), essential agreement (EA), bias, major errors (MEs) and very major errors (VMEs) were calculated for both AST methods...
January 19, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38236366/bezlotoxumab-during-the-first-episode-of-clostridioides-difficile-infection-in-patients-at-high-risk-of-recurrence
#37
JOURNAL ARTICLE
Rosa Escudero-Sanchez, Antonio Ramos-Martínez, Antonio F Caballero-Bermejo, Beatriz Díaz-Pollán, Guillermo Ruiz-Carrascoso, María Olmedo Samperio, Patricia Muñoz García, Paloma Merino Amador, Fernando González Romo, Oriol Martín Segarra, Gema Navarro Jiménez, Laura Del Campo Albendea, Alfonso Muriel García, Javier Cobo
PURPOSE: To describe a cohort with a high risk of recurrence who received bezlotoxumab during the first episode of Clostridioides difficile infection (CDI) and to compare this cohort with patients with similar characteristics who did not receive the monoclonal antibody. METHODS: A prospective and multicentre study of patients with a high risk of recurrence (expected recurrence rate>35%) who were treated with bezlotoxumab during their first episode of CDI was conducted...
January 18, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38236365/feasibility-of-tracking-invasive-escherichia-coli-disease-among-older-adults-in-a-community-setting-a-prospective-observational-study
#38
JOURNAL ARTICLE
Joachim Doua, Miquel Ekkelenkamp, Theo Verheij, Oscar Go, Stephen Ruhmel, Kimberly Leathers, Bart Spiessens, Sanne van Rooij, Vance G Fowler, Jeroen Geurtsen, Rowena Dolor, Michal Sarnecki, Ranee Chatterjee, Jan Poolman, Marc Bonten
PURPOSE: Invasive Escherichia coli disease (IED) encompasses a diverse range of sterile site infections. This study evaluated the feasibility of capturing IED among community-dwelling older adults to inform the implementation of a phase 3 efficacy trial of a novel vaccine against IED (NCT04899336). METHODS: EXPECT-1 (NCT04087681) was a prospective, multinational, observational study conducted in medically stable participants aged ≥ 60 years...
January 18, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38233610/molecular-analysis-of-metallo-beta-lactamase-producing-pseudomonas-aeruginosa-in-switzerland-2022-2023
#39
JOURNAL ARTICLE
Jacqueline Findlay, Otavio Hallal Ferreira Raro, Laurent Poirel, Patrice Nordmann
OBJECTIVES: The occurrence of metallo-beta-lactamase-producing Pseudomonas aeruginosa (MBL-PA) isolates is increasing globally, including in Switzerland. The aim of this study was to characterise, phenotypically and genotypically, the MBL-PA isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) reference laboratory over a 12-month period from July 2022 to July 2023. METHODS: Thirty-nine non-duplicate MBL-PA Isolates were submitted to NARA over the study period from across Switzerland...
January 18, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38231308/an-unusual-case-of-endotipsitis-persistent-infection-and-migration-to-the-right-atrium-of-a-transjugular-intrahepatic-portosystemic-shunt-tips
#40
JOURNAL ARTICLE
Silvia Calpena-Martínez, Nerea Carrasco-Antón, Catalina Cleary-Martín, Rafael Hernández-Estefanía, Jaime Esteban, Alfonso Cabello-Úbeda, Elizabet Petkova-Saiz
Endotipsitis is an underdiagnosed entity mainly because it requires a high initial level of suspicion. It should be considered in the differential diagnosis of persistent bacteremia in the cirrhotic patient with TIPS. Most cases are treated conservatively with a long-term antibiotherapy, due to the impossibility of surgical removal of the TIPS, except in a liver transplant or autopsy. The patient we present had endotipsitis that manifested as persistent bacteremia with thrombosis of the TIPS. Initially, conservative management with intravenous antibiotherapy was performed; however, due to mechanical complications caused by migration of the original endoprosthesis, it was decided to perform surgery...
January 17, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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