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European Journal of Clinical Microbiology & Infectious Diseases

https://read.qxmd.com/read/38609699/symptoms-predictive-of-fusobacterium-necrophorum-pharyngotonsillitis-an-observational-study-of-cases-presenting-to-hospitals-in-southern-sweden
#1
JOURNAL ARTICLE
Josefina Pagels, Gustav Torisson, Lisa Wasserstrom, Katarina Hedin, Karin Holm, David Nygren
OBJECTIVES: Fusobacterium necrophorum is a common cause of pharyngotonsillitis. However, no guidelines exist on when to diagnose or treat it. We aimed to investigate associations between clinical criteria and F. necrophorum-positivity in pharyngotonsillitis and assess the predictive potential of a simple scoring system. METHODS: Pharyngotonsillitis patients who were tested for F. necrophorum (PCR) and presented to hospitals in the Skåne Region, Sweden, between 2013-2020 were eligible...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38607579/derivation-and-validation-of-a-predictive-mortality-model-of-in-hospital-patients-with-acinetobacter-baumannii-nosocomial-infection-or-colonization
#2
JOURNAL ARTICLE
Carola Maria Gagliardo, Davide Noto, Antonina Giammanco, Andrea Catanzaro, Maria Concetta Cimino, Rosalia Lo Presti, Antonino Tuttolomondo, Maurizio Averna, Angelo Baldassare Cefalù
PURPOSE: Acinetobacter baumannii (Ab) is a Gram-negative opportunistic bacterium responsible for nosocomial infections or colonizations. It is considered one of the most alarming pathogens due to its multi-drug resistance and due to its mortality rate, ranging from 34 to 44,5% of hospitalized patients. The aim of the work is to create a predictive mortality model for hospitalized patient with Ab infection or colonization. METHODS: A cohort of 140 sequentially hospitalized patients were randomized into a training cohort (TC) (100 patients) and a validation cohort (VC) (40 patients)...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38607578/retrospective-and-prospective-evaluation-of-the-fluorotype%C3%A2-mycobacteria-ver-1-0-assay-for-the-identification-of-mycobacteria-from-cultures-in-a-french-center
#3
JOURNAL ARTICLE
Lisa Piasecki, Charlotte Genestet, Yvonne Benito, Jean-Philippe Rasigade, Gérard Lina, Oana Dumitrescu, Elisabeth Hodille
PURPOSE: Rapid, reliable identification of mycobacteria from positive cultures is essential for patient management, particularly for the differential diagnosis of Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM) species. The aim of the present study was to evaluate a new "In-Vitro-Diagnostic"-certified PCR kit, FluoroType®-Mycobacteria VER 1.0 (Hain Lifescience GmbH) for NTM and MTBC identification from cultures. METHODS: Mycobacteria identification isolated from positive cultures during routine practice at the Lyon university hospital mycobacteria laboratory obtained by hsp65 amplification/sequencing were compared retrospectively and prospectively to those obtained by and the FluoroType®-Mycobacteria VER 1...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38607577/lincosamide-monotherapy-treatment-of-methicillin-resistant-staphylococcus-aureus-pneumonia-in-tropical-australia-a-case-series
#4
JOURNAL ARTICLE
Stuart Campbell, Simon Smith, Josh Hanson
Existing recommended first-line antibiotic agents for MRSA pneumonia have several shortcomings. We reviewed 29 cases of community- and hospital-acquired MRSA pneumonia managed at our hospital. Lincosamide monotherapy was administered to 21/29 (72%) and was the predominant antibiotic regimen (> 50% course duration) in 19/29 (66%). Patients receiving lincosamide-predominant monotherapy were no more likely to die or require intensive care unit admission than patients receiving vancomycin-predominant monotherapy (5/19 (26%) versus 4/7 (57%), p = 0...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38607576/analysis-of-mild-and-severe-neonatal-enterovirus-infections-in-a-chinese-neonatal-tertiary-center-a-retrospective-case-control-study
#5
JOURNAL ARTICLE
Junshuai Li, Jingjing Xie, Min Zhang, Zhuojun Xiao, Fan Zhang, Weiqing Huang, Yong Zhou, Weiqun Yan, Rong Zhang, Xiaoming Peng
PURPOSE: To compare the clinical characteristics, virus serotype, and outcome in cases of mild and severe enteroviral infection at a tertiary neonatal intensive care unit in China. METHODS: A retrospective analysis of cases hospitalized between June and August 2019. Samples (stool or throat swabs) were examined using reverse transcription polymerase chain reaction. Positive cases were divided into two groups: mild infection and severe infection. RESULTS: A total of 149 cases were assigned to one of two groups: mild infection (n = 104) and severe infection (n = 45)...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38573394/emerging-and-re-emerging-infectious-diseases-in-pregnant-women-in-an-amazonian-region-a-large-retrospective-study-from-french-guiana
#6
JOURNAL ARTICLE
Najeh Hcini, Véronique Lambert, Jean-François Carod, Meredith Mathieu, Gabriel Carles, Olivier Picone, Jeanne Sibiude, Leo Pomar, Mathieu Nacher
PURPOSE: Over the past decade, the Amazon basin has faced numerous infectious epidemics. Our comprehension of the actual extent of these infections during pregnancy remains limited. This study aimed to clarify the clinical and epidemiological features of emerging and re-emerging infectious diseases during pregnancy in western French Guiana and along the Maroni River over the previous nine years. METHODS: This retrospective cohort study enrolled pregnant women living in west French Guiana territory and giving birth in the only local referral center after 22 weeks of gestation between 2013 and 2021...
April 4, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38557925/molecular-and-serological-evidence-of-chikungunya-virus-infection-with-high-case-fatality-among-pediatric-population-with-acute-encephalitis-syndrome-first-report-from-eastern-uttar-pradesh-india
#7
JOURNAL ARTICLE
Pooja Bhardwaj, Kamlesh Sah, Vishal Yadav, Shahzadi Gulafshan, Preeti Dhangur, Utkarsh Srivastava, Gaurav Raj Dwivedi, Manoj Murhekar, Bhupendra Sharma, Rajeev Singh
Acute encephalitis syndrome (AES) outbreaks in children of Eastern Uttar Pradesh (E-UP) region of India have been a longstanding public health issue, with a significant case fatality rate of 20-25%. Since past decade, a rise in chikungunya (CHIK) cases has been occurring, which is a reported etiology of AES. However, the burden of chikungunya virus (CHIKV) among pediatric AES (pAES) is unknown from E-UP. We included 238 hospitalized pAES cases. The presence of IgM antibodies for CHIKV, and Dengue virus (DENV) was tested, and RT-PCR was performed for CHIKV and DENV in serologically confirmed CHIKV and DENV pAES cases...
April 1, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38557924/an-observational-prospective-study-based-on-a-large-cohort-of-hiv-negative-neurosyphilis-patients-with-particular-reference-to-the-jarisch-herxheimer-reaction
#8
JOURNAL ARTICLE
Rui-Rui Peng, Juan Wu, Wei Zhao, Lin Zhu, Zhifang Guan, Xin Gu, Mei Shi, Junjun Yu, Yanchun Cheng, Pingyu Zhou
PURPOSE: The purpose of this study is to outline a complete picture of Jarisch-Herxheimer reaction (JHR) in the central nervous system among HIV-negative neurosyphilis patients. METHODS: A prospective study cohort of 772 cases with almost all stages of neurosyphilis depicted the features of JHR including occurrence rate, risk profiles, clinical manifestations, medical management and prognosis. RESULTS: The total occurrence rate of JHR was 9...
April 1, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536525/correction-to-added-diagnostic-value-of-16s-rrna-gene-pan-mycobacterial-pcr-for-nontuberculous-mycobacterial-infections-a-10-year-retrospective-study
#9
Simon Andenmatten, Onya Opota, Jessica Mazza-Stalder, Laurent Nicod, Gilbert Greub, Katia Jaton
No abstract text is available yet for this article.
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536524/clinical-impact-and-cost-consequence-analysis-of-eplex%C3%A2-blood-culture-identification-panels-for-the-rapid-diagnosis-of-bloodstream-infections-a-single-center-randomized-controlled-trial
#10
JOURNAL ARTICLE
Yvan Caspar, A Deves, C Richarme, M Le Marechal, L Ponderand, A-L Mounayar, S Lejeune, J Arata-Bardet, M Gallouche, C Recule, D Maubon, C Garnaud, M Cornet, M Veloso, B Chabani, M Maurin, S David-Tchouda, P Pavese
To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536523/suitability-of-reduced-dose-glucocorticoids-therapy-regimen-for-antibody-associated-vasculitis-patients-with-tb-a-retrospective-study
#11
JOURNAL ARTICLE
Rui Wen, Jingni Xiao, Ning Ding, Yong Zhong, Qiong Yuan, Jiali Li, Qi Wang, Hebin Xie, Jiao Qin
INTENTION: Immunosuppressive therapy is the major treatment approach for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Due to impaired cellular immunological function and the use of glucocorticoids and immunosuppressants, AAV patients are predisposed to opportunistic infections, including tuberculosis (TB). This retrospective study aims to analyze the clinical characteristics of patients with AAV and TB and explore suitable glucocorticoid regimens for them...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38530466/crp-under-130-mg-l-rules-out-the-diagnosis-of-legionella-pneumophila-serogroup-1-urinella-study
#12
JOURNAL ARTICLE
Timothée Klopfenstein, Souheil Zayet, Samantha Poloni, Vincent Gendrin, Damien Fournier, Jean-Baptiste Vuillemenot, Philippe Selles, Alain Dussaucy, Gaelle Coureau, Marta Avalos-Fernandez, Lynda Toko, Pierre-Yves Royer, Charles-Eric Lavoignet, Bouchra Amari, Marc Puyraveau, Catherine Chirouze
INTRODUCTION: In case of pneumonia, some biological findings are suggestive for Legionnaire's disease (LD) including C-reactive protein (CRP). A low level of CRP is predictive for negative Legionella Urinary-Antigen-Test (L-UAT). METHOD: Observational retrospective study in Nord-Franche-Comté Hospital with external validation in Besançon University Hospital, France which included all adults with L-UAT performed during January 2018 to December 2022. The objective was to determine CRP optimal threshold to predict a L-UAT negative result...
March 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38530465/multidrug-resistant-organism-bloodstream-infection-and-hospital-acquisition-among-inpatients-in-three-tertiary-greek-hospitals-during-the-covid-19-era
#13
JOURNAL ARTICLE
Polyxeni Karakosta, Sophia Vourli, Elisavet Kousouli, Georgios Meletis, Areti Tychala, Christina Louka, Alexandra Vasilakopoulou, Efthymia Protonotariou, Vasiliki Mamali, Olympia Zarkotou, Lemonia Skoura, Spyros Pournaras
From 2019 (pre-COVID-19) to 2022 (COVID-19 years), three tertiary Greek hospitals monitored MDRO bloodstream infection (BSI) and hospital acquisition relying on laboratory data. Surveillance covered carbapenem-resistant Enterobacterales (CRE), Acinetobacter baumannii (CRAB), Pseudomonas aeruginosa (CRPA), vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA), in intensive care units (ICUs) and non-ICUs. Non-ICUs experienced significant increases in CRE, CRAB and VRE during the pandemic...
March 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517573/a-decade-of-neonatal-sepsis-in-stockholm-sweden-gram-positive-pathogens-were-four-times-as-common-as-gram-negatives
#14
JOURNAL ARTICLE
Frida Oldendorff, Viveka Nordberg, Christian G Giske, Lars Navér
PURPOSE: To assess Gram-positive bacterial (GPB) bloodstream infection (BSI) in neonates, covering incidence, morbidity, mortality, antimicrobial resistance patterns and biomarkers in Region Stockholm, Sweden between 2006 and 2016. METHODS: A population-based retrospective epidemiological study including infants with GPB-BSI, admitted to the neonatal units at Karolinska University Hospital (KUH). Data were collected from patient records, the Swedish Neonatal Quality Register, the microbiological laboratory at KUH and the Swedish Public Health Agency...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517572/whole-genome-sequencing-and-molecular-epidemiology-of-methicillin-resistant-staphylococcus-aureus-isolated-from-patients-with-bacteraemia-in-slovenia
#15
JOURNAL ARTICLE
Urška Dermota, Andraž Celar Šturm, Tina Triglav, Katja Strašek Smrdel, Ivana Velimirović
PURPOSE: Data on the molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates from patients with bacteraemia in Slovenia are lacking. The aim of this study was to phenotypically and genotypically investigate 82 MRSA strains isolated from patients with bloodstream infections in central Slovenia between 2019 and 2022. METHODS: Whole-genome sequencing of selected strains was performed to characterize the strains based on sequence typing, antimicrobial resistance, toxin, and virulence factors genes...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517571/molecular-monitoring-of-viral-infections-in-immunocompromised-patients-in-a-large-university-hospital-in-italy-reflections-after-thirteen-years-of-real-life-activity
#16
JOURNAL ARTICLE
Lilia Cinti, Piergiorgio Roberto, Matteo Rossi, Anna Napoli, Gianluca Russo, Anna Paola Iori, Giuseppe Gentile, Maria Augurusa, Corrado Girmenia, Guido Antonelli, Aurelia Gaeta
PURPOSE: This study aimed to investigate the prevalence and viral reactivations of clinical interest in the immunocompromised patient with particular focus on hematologic and solid organ transplant recipients. METHODS: Molecular screening data of CMV, EBV, JCV and BKV from 2011 to 2023 were analyzed. This extensive time span allowed the access to more than 100,000 samples from over 20,000 patients treated at Policlinico Umberto I. It was possible to temporally investigate patient attendance patterns, average age distribution, seasonality of infections, and positivity rates of the analyzed viruses...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38512514/salmonella-infections-in-denmark-from-2013-2022-with-focus-on-serotype-distribution-invasiveness-age-sex-and-travel-exposition
#17
JOURNAL ARTICLE
Nicholas Slinning Aarø, Mia Torpdahl, Torben Rasmussen, Martin Jensen, Hans Linde Nielsen
PURPOSE: To analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022. METHODS: Confirmed cases of Salmonella enterica subsp. enterica were examined using the National Register of Enteric Pathogens during 2013-2022. Proportions, incidence rates (IR), relative risk (RR), and 95% confidence intervals (CI) were calculated to assess differences in serotypes, invasiveness, age, sex, and travel exposure. RESULTS: We identified 9,944 Danish Salmonella enterica subsp...
March 21, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38492058/evaluation-and-1-year-follow-up-of-patients-presenting-at-a-lyme-borreliosis-expertise-centre-a-prospective-cohort-study-with-validated-questionnaires
#18
JOURNAL ARTICLE
F R van de Schoor, M E Baarsma, S A Gauw, J Ursinus, H D Vrijmoeth, H J M Ter Hofstede, A D Tulen, M G Harms, A Wong, C C van den Wijngaard, L A B Joosten, J W Hovius, B J Kullberg
OBJECTIVES: To describe the course of symptoms reported by patients with symptoms attributed to Lyme borreliosis (LB) without being subsequently diagnosed with LB. METHODS: We performed a prospective cohort study with patients presenting at the outpatient clinic of two clinical LB centres. The primary outcome was the prevalence of persistent symptoms, which were defined as clinically relevant fatigue (CIS, subscale fatigue), pain (SF-36, subscale bodily pain), and cognitive impairment (CFQ) for ≥ 6 months and onset < 6 months over the first year of follow-up...
March 16, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38483681/pulmonary-surfactant-impacts-in-vitro-activity-of-selected-antifungal-drugs-against-candida-krusei-and-candida-albicans
#19
JOURNAL ARTICLE
Alina Nussbaumer-Pröll, Peter Matzneller, Sabine Eberl, Markus Zeitlinger
PURPOSE: This study investigates how surfactants affect the in-vitro anti-infective efficacy of micafungin, caspofungin, anidulafungin, and amphotericin B in treating pulmonary mycoses. METHODS: MIC values for antifungal agents were determined against Candida krusei (now Pichia kudriavzevii) ATCC 6258, Candida albicans ATCC 90028, and 18 clinical isolates using the broth microdilution method in RPMI medium, following EUCAST recommendations. MIC assays included testing with and without Curosurf® surfactant at 1 mg/mL for C...
March 14, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472522/human-campylobacter-spp-infections-in-italy
#20
JOURNAL ARTICLE
Verena Zerbato, Stefano Di Bella, Riccardo Pol, Roberto Luzzati, Gianfranco Sanson, Simone Ambretti, Stefano Andreoni, Richard Aschbacher, Mariano Bernardo, Alessandra Bielli, Gioconda Brigante, Marina Busetti, Giulio Camarlinghi, Davide Carcione, Antonella Carducci, Nicola Clementi, Edoardo Carretto, Chiara Chilleri, Giulia Codda, Alessandra Consonni, Venera Costantino, Venere Cortazzo, Manuela Di Santolo, Saveria Dodaro, Barbara Fiori, Aurora García-Fernández, Claudio Foschi, Elisa Gobbato, Francesca Greco, Roberto Marcello La Ragione, Nicasio Mancini, Alberto Enrico Maraolo, Anna Marchese, Daniela Marcuccio, Roberta Marrollo, Carola Mauri, Annarita Mazzariol, Gianluca Morroni, Adriana Mosca, Giacomo Nigrisoli, Elisabetta Pagani, Eva Maria Parisio, Simona Pollini, Mario Sarti, Annarita Sorrentino, Domenico Trotta, Laura Villa, Chiara Vismara, Luigi Principe
PURPOSE: Campylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017-2021. METHODS: Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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