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European Journal of Clinical Microbiology & Infectious Diseases

https://read.qxmd.com/read/36964885/carriage-of-multidrug-resistant-gram-negative-bacilli-duration-and-risk-factors
#1
JOURNAL ARTICLE
S Herrera, B Torralbo, S Herranz, J Bernal-Maurandi, E Rubio, C Pitart, I Fortes, S Valls, L Rodríguez, G Santana, M Bodro, C Garcia-Vidal, M Hernández-Meneses, P Puerta, L Morata, A Villella, M J Bertran, M Brey, A Soriano, A Del Río, J A Martinez
Identification of risk factors influencing the duration of carriage of multidrug-resistant Gram-negative bacilli (MDR-GNB) may be useful for infection control. The aim of this study is to estimate the impact of several factors collected for routine hospital surveillance on the duration of carriage of selected MDR-GNB. From January 2015 to July 2021, patients with at least two clinical/surveillance samples positive for MDR-GNB different from ESBL-producing E. coli or AmpC - exclusively producing Enterobacterales were assessed...
March 25, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36964269/staphylococcus-aureus-nasal-colonization-level-and-intracellular-reservoir-a-prospective-cohort-study
#2
JOURNAL ARTICLE
Josselin Rigaill, Marie Gavid, Martin Fayolle, Mohamed Fedy Morgene, Yann Lelonge, Florence Grattard, Bruno Pozzetto, Adeline Crépin, Jean-Michel Prades, Frédéric Laurent, Elisabeth Botelho-Nevers, Philippe Berthelot, Paul O Verhoeven
Staphylococcus aureus is a major pathogen in humans. The nasal vestibule is considered as the main reservoir of S. aureus. However, even though the nasal cavity may also be colonized by S. aureus, the relationships between the two sites are still unclear. We conducted a prospective study in humans to assess the S. aureus colonization profiles in the vestibule and nasal cavity, and to investigate the presence of intracellular S. aureus in the two sites. Patients undergoing ear, nose, and throat surgery were swabbed during endoscopy to determine S...
March 24, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36959358/streptococcus-gallolyticus-meningitis-and-strongyloides-stercoralis-hyperinfection-in-a-patient-with-systemic-lupus-erythematosus
#3
LETTER
Sonya Natasha Hutabarat, Ana Domazetovska, Helen Ziochos, Geraldine Hassett, Hong Foo
No abstract text is available yet for this article.
March 23, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36940050/genomic-epidemiology-and-transmission-dynamics-of-recurrent-clostridioides-difficile-infection-in-western-australia
#4
JOURNAL ARTICLE
Daniel R Knight, Korakrit Imwattana, Deirdre A Collins, Su-Chen Lim, Stacey Hong, Papanin Putsathit, Thomas V Riley
Recurrent cases of Clostridioides difficile infection (rCDI) remain one of the most common and serious challenges faced in the management of CDI. The accurate distinction between a relapse (caused by infection with the same strain) and reinfection (caused by a new strain) has implications for infection control and prevention, and patient therapy. Here, we used whole-genome sequencing to investigate the epidemiology of 94 C. difficile isolates from 38 patients with rCDI in Western Australia. The C. difficile strain population comprised 13 sequence types (STs) led by ST2 (PCR ribotype (RT) 014, 36...
March 20, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36940049/outbreak-of-oxa-48-producing-enterobacteriaceae-in-a-neonatal-intensive-care-unit-in-western-sweden
#5
JOURNAL ARTICLE
Erika Tång Hallbäck, Anna Johnning, Sofia Myhrman, Marie Studahl, Elisabet Hentz, Anders Elfvin, Ingegerd Adlerberth
In 2015, an outbreak caused by OXA-48-producing Enterobacteriaceae affected a neonatal intensive care unit at a Swedish University Hospital. The aim was to explore the transmission of OXA-48-producing strains between infants and the transfer of resistance plasmids between strains during the outbreak. Twenty-four outbreak isolates from ten suspected cases were whole-genome sequenced. A complete assembly was created for the index isolate (Enterobacter cloacae) and used as a mapping reference to detect its plasmids in the remaining isolates (17 Klebsiella pneumoniae, 4 Klebsiella aerogenes, and 2 Escherichia coli)...
March 20, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36932278/epidemiology-and-clinical-presentation-of-community-acquired-staphylococcus-aureus-bacteraemia-in-children-under-5%C3%A2-years-of-age-admitted-to-the-manhi%C3%A3-a-district-hospital-mozambique-2001-2019
#6
JOURNAL ARTICLE
Marcelino Garrine, Llorenç Quintó, Sofia Santos Costa, Augusto Messa, Arsénia J Massinga, Delfino Vubil, Tacilta Nhampossa, Sérgio Massora, Sozinho Ácacio, Anélsio Cossa, Betuel Sigaúque, Quique Bassat, Isabel Couto, Inácio Mandomando
Staphylococcus aureus bacteraemia (SAB) is one of the most common bloodstream infections globally. Data on the burden and epidemiology of community-acquired SAB in low-income countries are scarce but needed to define preventive and management strategies. Blood samples were collected from children < 5 years of age with fever or severe disease admitted to the Manhiça District Hospital for bacterial isolation, including S. aureus. Between 2001 and 2019, 7.6% (3,197/41,891) of children had bacteraemia, of which 12...
March 18, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36930391/a-fatal-case-of-strongyloides-hyperinfection-with-obscure-risk-factors
#7
LETTER
Abhishek Mewara, Rajendra Gudisa, Nikita Sharma, Rimjhim Kanaujia
No abstract text is available yet for this article.
March 17, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36929324/rida%C3%A2-gene-helicobacter-pylori-pcr-on-the-elite-ingenius-system
#8
JOURNAL ARTICLE
Lucie Bénéjat, Astrid Ducournau, Chloé Domingues Martins, Emilie Bessède, Philippe Lehours
PCR detection of Helicobacter pylori infection in gastric biopsies allows the detection of this bacterium and the mutations associated with macrolide resistance. The aim of this study was to evaluate the performance of RIDA®GENE H. pylori PCR (r-Biopharm) on the ELITe InGenius System (Elitech). Two hundred gastric biopsies were obtained. These biopsies were ground in nutrient broth. Two hundred microliters of this suspension was treated with proteinase K, and then, 200 µL was transferred to an ELITe InGenius sample tube and tested using RIDA®GENE H...
March 16, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36920628/staphylococcus-aureus-bacteraemia-cardiac-implantable-electronic-device-and-the-risk-of-endocarditis-a-retrospective-population-based-cohort-study
#9
JOURNAL ARTICLE
Andreas Berge, Casper Carlsén, Alexandros Petropoulos, Fredrik Gadler, Magnus Rasmussen
Patients with cardiac implantable electronic device (CIED) and Staphylococcus aureus bacteraemia (SAB) are at risk of having infective endocarditis (IE). The objectives were to describe a Swedish population-based cohort of patients with CIED and SAB, to identify risk factors, and to construct a predictive score for IE. Patients over 18 years old in the Stockholm Region identified to have SAB in the Karolinska Laboratory database from January 2015 through December 2019 were matched to the Swedish Pacemaker and Implantable Cardioverter-Defibrillator ICD Registry to identify the study cohort...
March 15, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36905566/enhanced-bacterial-killing-with-a-combination-of-sulbactam-minocycline-against-dual-carbapenemase-producing-acinetobacter-baumannii
#10
JOURNAL ARTICLE
Suriya Chandran, Yuvasri Manokaran, Saranya Vijayakumar, Baby Abirami Shankar, Yamuna Devi Bakthavatchalam, Hariharan Triplicane Dwarakanathan, Binesh Lal Yesudason, Balaji Veeraraghavan
Carbapenem-resistant Acinetobacter baumannii (CRAB) is often difficult to treat. Considering the current circumstances, there is an unquestionable need for new therapeutic options to treat CRAB infections. In the present study, the synergistic activity of sulbactam-based combination was determined against genetically characterized CRAB isolates. Non-duplicate CRAB isolates (n = 150) recovered from blood culture and endotracheal aspirates were included in this study. The minimum inhibitory concentrations (MICs) of tetracyclines (minocycline, tigecycline, eravacycline) and their comparators (meropenem, sulbactam, cefoperazone/sulbactam, ceftazidime/avibactam, and colistin) were determined using the microbroth dilution method...
March 11, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36890281/nasotracheal-enterococcal-carriage-and-resistomes-detection-of-optra-poxta-and-cfrd-carrying-strains-in-migratory-birds-livestock-pets-and-in-contact-humans-in-spain
#11
JOURNAL ARTICLE
Idris Nasir Abdullahi, Carmen Lozano, Guillermo Juárez-Fernández, Ursula Höfle, Carmen Simón, Silvia Rueda, Angela Martínez, Sandra Álvarez-Martínez, Paula Eguizábal, Beatriz Martínez-Cámara, Myriam Zarazaga, Carmen Torres
This study determined the carriage rates and antimicrobial resistance (AMR) genes of enterococci from nasotracheal samples of three healthy animal species and in-contact humans. Nasal samples were collected from 27 dog-owning households (34 dogs, 41 humans) and 4 pig-farms (40 pigs, 10 pig-farmers), and they were processed for enterococci recovery (MALDI-TOF-MS identification). Also, a collection of 144 enterococci previously recovered of tracheal/nasal samples from 87 white stork nestlings were characterized...
March 9, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36881216/incidence-and-clinical-and-microbiological-features-of-invasive-and-probable-invasive-streptococcal-group-a-infections-in-children-and-adults-in-the-brussels-capital-region-2005-2020
#12
JOURNAL ARTICLE
Lisa Zangarini, Delphine Martiny, Véronique Yvette Miendje Deyi, Maya Hites, Evelyne Maillart, Marc Hainaut, Marc Delforge, Anne Botteaux, Veerle Matheeussen, Herman Goossens, Marie Hallin, Pierre Smeesters, Nicolas Dauby
Assess the incidence, risk factors, clinical and microbiological features, and outcome of both probable invasive and invasive group A Streptococcus (GAS) infections in children and adults in the BrusselsCapital Region between 2005 and 2020. A retrospective, multicentric study was performed in three university hospitals in Brussels. Patients were identified through the centralized laboratory information system. Epidemiological and clinical data were collected from patients' hospital records. A total of 467 cases were identified...
March 7, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36877262/resistance-to-ceftazidime-avibactam-in-a-kpc-2-producing-klebsiella-pneumoniae-caused-by-the-extended-spectrum-beta-lactamase-veb-25
#13
JOURNAL ARTICLE
Jacqueline Findlay, Laurent Poirel, Maxime Bouvier, Valeria Gaia, Patrice Nordmann
Carbapenem-resistant Enterobacterales, including KPC-producing Klebsiella pneumoniae, represent a major threat to public health due to their rapid spread. The beta-lactam/beta-lactamase inhibitor (BL/BLI) combination ceftazidime-avibactam (CAZ-AVI) has recently been introduced and shown to exhibit excellent activity toward multidrug-resistant KPC-producing Enterobacterales strains. However, CAZ-AVI-resistant K. pneumoniae isolates are being increasingly reported, mostly corresponding to producers of KPC variants that confer resistance to CAZ-AVI but at a cost of carbapenem resistance...
March 6, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36877261/staphylococcus-aureus-hitchhiking-from-colonization-to-bacteremia-via-candida-within-icu-infection-prevention-studies-a-proof-of-concept-modelling
#14
JOURNAL ARTICLE
James C Hurley
Whether Candida within the patient microbiome drives the pathogenesis of Staphylococcus aureus bacteremia, described as microbial hitchhiking, cannot be directly studied. Group-level observations from studies of various decontamination and non-decontamination-based ICU infection prevention interventions and studies without study interventions (observational groups) collectively enable tests of this interaction within causal models. Candidate models of the propensity for Staphylococcus aureus bacteremia to arise with versus without various antibiotic, anti-septic, and antifungal exposures, each identified as singleton exposures, were tested using generalized structural equation modelling (GSEM) techniques with Candida and Staphylococcus aureus colonization appearing as latent variables within the models...
March 6, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36856898/analysis-of-risk-factors-associated-with-healthcare-associated-carbapenem-resistant-klebsiella-pneumoniae-infection-in-a-large-general-hospital-a-case-case-control-study
#15
JOURNAL ARTICLE
Wenzhi Huang, Fu Qiao, Yuhua Deng, Shichao Zhu, Jingwen Li, Zhiyong Zong, Wei Zhang
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection is a major public health threat in the world. To inform the prevention and control of CRKP infection in hospitals, this study analyzed the factors associated with CRKP infection and resistance to carbapenems in K. pneumoniae. This case-case-control study was carried out in a large general hospital in China from January 2016 to December 2018, comprising 494 hospitalized patients infected with CRKP (case group 1) and 2429 hospitalized patients infected with carbapenem-susceptible K...
March 1, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36849838/the-safety-and-immunogenicity-of-inactivated-covid-19-vaccine-in-old-pulmonary-tuberculosis-patients
#16
JOURNAL ARTICLE
Lei Yang, Feng Xiang, Dian Wang, Qiao Guo, Bing Deng, DePeng Jiang, Hong Ren
The immunogenicity and safety of vaccines against coronavirus disease 2019 (COVID-19) remain unknown in patients with a history of pulmonary tuberculosis (OPTB). Therefore, the safety and effectiveness of inactivated vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were assessed in patients with a history of PTB. The study cohort included 106 healthy controls and 93 adult patients with OPTB who received a two-dose vaccination. The study period was 21 to 105 days. Concentrations of antibodies (Abs) against receptor-binding domain (RBD) IgG and SARS-CoV-2 neutralizing Abs (NAbs) were measured, in addition to the frequencies of SARS-CoV-2-specific B and a portion T cells...
February 28, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36847927/antibiotic-resistance-and-resistance-mechanism-of-corynebacterium-kroppenstedtii-isolated-from-patients-with-mastadenitis
#17
JOURNAL ARTICLE
Qin Zhang, Shi Wu, Peipei Song, Yi Liu, Li Ding, Qingyu Shi, Xuan Zhu, Liyuan Zhang, Jun Zhang, Qin Wang, Jian Xu, Fupin Hu
To investigate the antibiotic resistance and resistance mechanism of Corynebacterium kroppenstedtii (C. kroppenstedtii) isolated from patients with mastadenitis. Ninety C. kroppenstedtii clinical isolates were obtained from clinical specimens in 2018-2019. Species identification was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Antimicrobial susceptibility testing was performed by the broth microdilution method. The resistance genes were detected using PCR and DNA sequencing...
February 27, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36826718/massive-secretions-in-paragonimiasis-pleural-effusion-a-new-finding-concerning-clinical-recognition-and-treatment
#18
JOURNAL ARTICLE
Yunxuan Zhang, Yimin Xie, Yarui Luo, Shuang Xiang, Wen Zhong, Na Wu, Meng Chen, Xiaojiao Zhou, Shulei Peng, Qiang Chen
Some paragonimiasis patients in Chongqing, southwest China, have recently exhibited pleural effusions (PEs) with massive viscous secretions. This study aimed to investigate their clinical characteristics, thereby promoting effective treatments. A 3-year retrospective review of paragonimiasis patients who were admitted for nonhomogeneous PEs at Chongqing University Three Gorges Hospital was conducted. Epidemiological data, symptoms, laboratory and imaging findings, treatments, and outcomes were analyzed. Twenty-eight patients were identified, of which 22 (78...
February 24, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36820931/norfloxacin-prophylaxis-effect-on-multidrug-resistance-in-patients-with-cirrhosis-and-bacterial-infections
#19
JOURNAL ARTICLE
Sebastián Marciano, Maria N Gutierrez-Acevedo, Sabrina Barbero, Lorena Del C Notari, Marina Agozino, Jose L Fernandez, Maria M Anders, Nadia Grigera, Florencia Antinucci, Orlando F Orozco Ganem, Maria D Murga, Daniela Perez, Ana Palazzo, Liria Martinez Rejtman, Ivonne G Duarte, Julio Vorobioff, Victoria Trevizan, Sofía Bulaty, Fernando Bessone, Marcelo Valverde, Martín Elizondo, José D Bosia, Silvia M Borzi, Teodoro E Stieben, Adriano Masola, Sebastian E Ferretti, Diego Arufe, Ezequiel Demirdjian, Maria P Raffa, Mirta Peralta, Hugo A Fainboim, Cintia E Vazquez, Pablo Ruiz, José E Martínez, Leandro A Heffner, Andrea Odzak, Melisa Dirchwolf, Astrid Smud, Manuel Mendizabal, Carla Bellizzi, Ana Martinez, Jesica Tomatis, Andres Bruno, Agñel Ramos, Josefina Pages, Silvina Tevez, Adrian C Gadano, Diego H Giunta
It is unclear whether norfloxacin predisposes to infections by multidrug-resistant organisms (MDROs). We aimed to evaluate if patients with cirrhosis receiving norfloxacin prophylaxis at the time of the diagnosis of bacterial infections were more likely to present a multidrug-resistant isolate than those without prophylaxis. This is a cross-sectional study of hospitalized patients with cirrhosis and bacterial infections from Argentina and Uruguay (NCT03919032) from September 2018 to December 2020. The outcome variable was a multidrug-resistant bacterial infection...
February 23, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36811709/investigation-of-the-presence-of-capnophilic-bacteria-in-routine-urine-cultures
#20
JOURNAL ARTICLE
Zeynep Ceren Karahan, İrem Altinsoy, Bilge Nur Çalişkan, Sıla Dede, Görkem Kayiş, Hasan Can Türkoğlu, Ebru Evren, Beyza Doğanay Erdoğan, Selin Gamze Kiliç, İştar Dolapçi, Alper Tekeli
Capnophilic Escherichia coli (CEC) strains are rarely isolated from urinary tract infections (UTIs). The purpose of this research was to look into the incidence and traits of the CEC strains that cause UTIs. Nine (0.11%) epidemiologically unrelated CEC isolates with varying antibiotic susceptibility patterns were identified from patients with various co-morbidities after the evaluation of 8500 urine samples. Three of these strains belonged to the O25b-ST131 clone, and none of them possessed the yadF gene. Due to adverse incubation conditions, CEC isolation is difficult...
February 22, 2023: European Journal of Clinical Microbiology & Infectious Diseases
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