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European Journal of Clinical Microbiology & Infectious Diseases

https://read.qxmd.com/read/38041722/deciphering-mechanisms-affecting-cefepime-taniborbactam-in-vitro-activity-in-carbapenemase-producing-enterobacterales-and-carbapenem-resistant-pseudomonas-spp-isolates-recovered-during-a-surveillance-study-in-spain
#1
JOURNAL ARTICLE
Marta Hernández-García, María García-Castillo, Marta Nieto-Torres, Germán Bou, Alain Ocampo-Sosa, Cristina Pitart, Irene Gracia-Ahufinger, Xavier Mulet, Álvaro Pascual, Nuria Tormo, Antonio Oliver, Patricia Ruiz-Garbajosa, Rafael Cantón
PURPOSE: To characterize the resistance mechanisms affecting the cefepime-taniborbactam combination in a collection of carbapenemase-producing Enterobacterales (CPE) and carbapenem-resistant Pseudomonas spp. (predominantly P. aeruginosa; CRPA) clinical isolates. METHODS: CPE (n = 247) and CRPA (n = 170) isolates were prospectively collected from patients admitted to 8 Spanish hospitals. Susceptibility to cefepime-taniborbactam and comparators was determined by broth microdilution...
December 2, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38041721/performance-evaluation-of-core-genome-multilocus-sequence-typing-for-genotyping-of-mycobacterium-tuberculosis-strains-in-china-based-on-multicenter-population-based-collection
#2
JOURNAL ARTICLE
Zhuo Quan, Meng Li, Yiwang Chen, Jialei Liang, Howard Takiff, Qian Gao
PURPOSE: To evaluate the performance of core genome multilocus sequence typing (cgMLST) for genotyping Mycobacterium tuberculosis (M.tuberculosis) Strains in regions where the lineage 2 strains predominate. METHODS: We compared clustering by whole-genome SNP typing with cgMLST clustering in the analysis of WGS data of 6240 strains from five regions of China. Using both the receiver operating characteristic (ROC) curve and epidemiological investigation to determine the optimal threshold for defining genomic clustering by cgMLST...
December 2, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38036711/clinical-and-molecular-characteristics-of-klebsiella-pneumoniae-infection-in-a-tertiary-general-hospital-of-wuhan-china
#3
JOURNAL ARTICLE
Yating Xiang, Hongpan Tian, Qingsong Chen, Jihong Gu, Hongmao Liu, Cuixiang Wang, Yirong Li
OBJECTIVES: The aim of this study was to investigate the clinical and molecular characteristics of Klebsiella pneumoniae infection from a tertiary general hospital in Wuhan, China. METHODS: From December 2019 to August 2022, 311 non-duplicate isolates of K. pneumoniae were collected from a tertiary hospital in Wuhan. These comprised 140 carbapenem-resistant K. pneumoniae (CRKP) isolates and 171 carbapenem-susceptible K. pneumoniae (CSKP) isolates. The clinical characteristics of patients with K...
December 1, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38032514/risk-exploration-and-prediction-model-construction-for-linezolid-resistant-enterococcus-faecalis-based-on-big-data-in-a-province-in-southern-china
#4
JOURNAL ARTICLE
Peijun Liu, Bangwei Zeng, Xiaoyan Wu, Feng Zheng, Yangmei Zhang, Xiaohua Liao
BACKGROUND: Enterococcus faecalis is a common cause of healthcare-associated infections. Its resistance to linezolid, the antibiotic of last resort for vancomycin-resistant enterococci, has become a growing threat in healthcare settings. METHODS: We analyzed the data of E. faecalis isolates from 26 medical institutions between 2018 and 2020 and performed univariate and multivariate logistic regression analyses to determine the independent predictors for linezolid-resistant E...
November 30, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38030860/performance-of-the-aspergillus-galactomannan-lateral-flow-assay-with-a-digital-reader-for-the-diagnosis-of-invasive-aspergillosis-a-multicenter-study
#5
JOURNAL ARTICLE
Jian Guo, Chenlu Xiao, Wenjie Tian, Li Lv, Liang Hu, Lijun Ni, Dongjiang Wang, Wei Li, Dan Qiao, Wenjuan Wu
PURPOSE: The objective of this multicenter study was to compare the diagnostic performance of lateral flow assay (LFA) and enzyme-linked immunosorbent assay (ELISA) to detect the Dynamiker Aspergillus Galactomannan levels in serum and bronchoalveolar lavage fluid (BALF) samples for I. METHODS: We registered 310 clinically suspected Aspergillus infection patients from December 2021 to February 2023 and classified them into subgroups as the "IA group" and "non-IA group" based on the latest EORTC/MSG guidelines...
November 29, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38017356/retraction-note-a-novel-approach-to-managing-covid-19-patients-results-of-lopinavir-plus-doxycycline-cohort
#6
Yasemin Cag, Sacit Icten, Burcu Isik-Goren, Naciye Betul Baysal, Begum Bektas, Ece Selvi, Pinar Ergen, Ozlem Aydin, Ayse Canan Ucisik, Fatma Yilmaz-Karadag, Hulya Caskurlu, Tulin Akarsu-Ayazoglu, Hasan Kocoglu, Sinan Uzman, Muge Nural-Pamukcu, Ferhat Arslan, Gurhan Bas, Mahmut Tayyar Kalcioglu, Haluk Vahaboglu
No abstract text is available yet for this article.
November 28, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38012351/can-daily-bathing-with-4-chlorhexidine%C3%A2-%C3%A2-daily-chlorhexidine-wipe-for-1%C3%A2-week-be-effective-in-decolonizing-candida-auris-colonization
#7
JOURNAL ARTICLE
Umran Elbahr, Amira Khairy, Farouq Dayyab, Clark Steven Delos Reyes, Jennie Pastrana, Chithra Vineeth, Suha Hejres, Shruti Prem Sudha, Ozge Keskin, Shiv Singh Rana, Elias Fadel, Hakan Erdem, Oguz Resat Sipahi
BACKGROUND: Herein, it is aimed to present the decolonizing rates of Candida auris colonized cases after daily bathing with 4% chlorhexidine plus daily cleaning with 4% chlorhexidine wipe for 1 week (will be mentioned as DCHX). METHODS: The study period was from October, 2021, to November, 2022. Inclusion criteria were (i) age > 18, (ii) receiving DCHX, (iii) proven C. auris carrier on auricular, or axillar or inguinal swab surveillance cultures up to 5-day period before DCHX...
November 28, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38010594/epidemiology-and-emm-types-among-group-a-streptococcal-pharyngitis-in-finland-a-prospective-laboratory-based-study
#8
JOURNAL ARTICLE
Mirva Virolainen, Kirsi Gröndahl-Yli-Hannuksela, Kaisu Rantakokko-Jalava, Tapio Seiskari, Emilia Lönnqvist, Terhi Kolari, Tiia Rissanen, Hanne-Leena Hyyryläinen, Jaana Vuopio
PURPOSE: Streptococcus pyogenes (mostly termed group A Streptococcus - GAS) is the most important bacterial causative of pharyngitis. However, epidemiology of GAS pharyngitis is not widely established. This study describes GAS pharyngitis cases and emm-type distribution in a prospective study covering over 2 years in two Hospital Districts in Finland. METHODS: A prospective, systematic collection of GAS pharyngitis isolates was conducted between March 2018 and December 2020 in two large Hospital Districts in Finland...
November 27, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37999783/assessing-the-colony-morphotypes-and-antibiotic-susceptibility-profile-of-malaysian-clinical-burkholderia-pseudomallei-to-support-the-use-of-eucast-disk-diffusion-breakpoints-to-determine-antibiotic-resistance
#9
JOURNAL ARTICLE
Shirley Yi Fen Hii, Nurul Naziha Zaiful Bahrina, Maswani Nabilah Mohd Zaidi, Rohaidah Hashim, Norazah Ahmad
Burkholderia pseudomallei is intrinsically resistant to many antibiotics. This study aimed to assess bacterial colony morphotypes and the validity of using disk diffusion method (DD) to determine antibiotic resistance in Malaysian clinical B. pseudomallei isolates for ceftazidime (CAZ), meropenem (MEM), amoxicillin-clavulanate (AMC) and doxycycline (DOX). DD produced good categorical agreements exhibiting concordance of 100% with reference method, broth microdilution for CAZ and DOX, 98.6% for MEM and 97.2% for AMC...
November 24, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37996728/two-episodes-of-bacteremia-of-zoonotic-origin-caused-by-different-streptococcus-canis-isolates-in-the-same-patient-within-a-time-span-of-1%C3%A2-year
#10
JOURNAL ARTICLE
Domingo Fernández Vecilla, Jorge Rodríguez Grande, Nuria Fraile Valcárcel, María Carmen Nieto Toboso, Mikel Joseba Urrutikoetxea Gutiérrez, Felicitas Elena Calvo Muro, Alain Ocampo-Sosa, José Luis Díaz de Tuesta Del Arco
Two episodes of bacteremia of cutaneous origin in a female patient were caused by two unrelated Streptococcus canis isolates within 1-year interval between the two infection episodes. The most likelihood transmission route in both episodes was a dog pet that habitually licked patient´s legs. Isolates were characterised by antimicrobial susceptibility test and whole genome sequencing. They belonged to sequence type (ST) 40 and 43, respectively. The ST40 isolate harboured antimicrobial resistance genes aadE, ermB and tetO, displaying resistance to erythromycin, clindamycin and tetracyclines, while ST43 isolate did not presented any known antimicrobial resistance determinant and was susceptible to all antibiotics tested...
November 24, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37996727/idiopathic-intracranial-hypertension-secondary-to-fluoroquinolone-therapy-french-pharmacovigilance-data-review
#11
JOURNAL ARTICLE
A Hureaux, M Bermejo, P M Suret, M Bonnet, Y N'Guyen, M Hentzien, Z Djerada, B Azzouz, Firouzé Bani-Sadr
We investigate spontaneous reports of IIH related to fluoroquinolones recorded in the French national pharmacovigilance database in order to detect a possible pharmacovigilance signal. The association between IIH risk and fluoroquinolone exposure was assessed using a case/non-case study. Between 1985 and July 2023, 17 reports of IIH after fluoroquinolone exposure were recorded. No specific fluoroquinolone was predominant. IIH led to death in one case and blindness in one case. The Reporting Odds Ratio was 2...
November 24, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37993680/cefepime-versus-carbapenems-for-treatment-of-ampc-beta-lactamase-producing-enterobacterales-bloodstream-infections
#12
JOURNAL ARTICLE
Julia Herrmann, Anne-Valérie Burgener-Gasser, Daniel Goldenberger, Jan Roth, Maja Weisser, Pranita D Tamma, Sarah Tschudin-Sutter
PURPOSE: Cefepime is recommended for treating infections caused by AmpC beta-lactamase-producing Enterobacterales (AmpC-PE), though supporting evidence is limited. Therefore, this study compared outcomes associated with cefepime versus carbapenem therapy for bloodstream infections (BSIs) caused by AmpC-PE after phenotypic exclusion of ESBL-co-producing isolates. METHODS: This retrospective cohort study compared definite cefepime versus carbapenem treatment for AmpC-PE BSI in hospitalized patients of the University Hospital Basel, Switzerland, between 01/2015 and 07/2020...
November 23, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37993679/comparing-ethanol-lock-therapy-versus-vancomycin-lock-in-a-salvation-strategy-for-totally-implantable-vascular-access-device-infections-due-to-coagulase-negative-staphylococci-the-ethalock-study-a-prospective-double-blind-randomized-clinical-trial
#13
JOURNAL ARTICLE
Olivier Lesens, Emmanuel Forestier, Elisabeth Botelho-Nevers, Patricia Pavese, Gary David, Bertrand Nougarede, Violaine Corbin, Bruno Pereira, Claire Aumeran, Léo Sauvat
OBJECTIVES: Little is known about efficacy and safety of ethanol lock therapy (ELT) to treat totally implantable venous access device (TIVAD) infections. The objective of this trial was to evaluate the effectiveness and safety profile of a local treatment with ELT without removal for TIVAD infection due to coagulase-negative staphylococci. METHODS: We performed a prospective, multicenter, double-blind, randomized clinical trial comparing the efficacy of 40% ELT versus vancomycin lock therapy (VLT) in TIVAD infections due to coagulase-negative staphylococci, complicated or not by bloodstream infection...
November 23, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37985552/prevalence-and-mortality-of-ceftazidime-avibactam-resistant-kpc-producing-klebsiella-pneumoniae-bloodstream-infections-2018-2022
#14
JOURNAL ARTICLE
Matteo Boattini, Gabriele Bianco, Paulo Bastos, Sara Comini, Silvia Corcione, André Almeida, Cristina Costa, Francesco Giuseppe De Rosa, Rossana Cavallo
INTRODUCTION: Ceftazidime/avibactam-resistance in Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) is a topic of great interest for epidemiological, diagnostic, and therapeutical reasons. However, data on its prevalence and burden on mortality in patients with bloodstream infection (BSI) are lacking. This study was aimed at identifying risk factors for mortality in patients suffering from ceftazidime/avibactam-resistant KPC-Kp BSI. METHODS: An observational retrospective study (January 2018-December 2022) was conducted at a tertiary hospital including all consecutive hospitalized adult patients with a ceftazidime/avibactam-resistant KPC-Kp BSI...
November 21, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37985551/comparative-proteomic-analysis-of-vancomycin-sensitive-and-vancomycin-intermediate-resistant-staphylococcus-aureus
#15
JOURNAL ARTICLE
Jian Hu, Xinjun Han, Xiaoxue Ma, Xutao Chen, Zhenping Zhou, Peilan Peng, Zhao Yu, Yongzhi Hou, Peiru Han, Long Pang, Yali Yang, Jia Xu, Wenhui Wu
PURPOSE: The extensive use of vancomycin has led to the development of Staphylococcus aureus strains with varying degrees of resistance to vancomycin. The present study aimed to explore the molecular causes of vancomycin resistance by conducting a proteomics analysis of subcellular fractions isolated from vancomycin-intermediate resistant S. aureus (VISA) and vancomycin-sensitive S. aureus (VSSA) strains. METHODS: We conducted proteomics analysis of subcellular fractions isolated from 2 isogenic S...
November 21, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37985550/molecular-characterization-and-whole-genome-sequencing-of-corynebacterium-diphtheriae-causing-skin-lesion
#16
JOURNAL ARTICLE
Juliana Nunes Ramos, Max Roberto Batista Araújo, Lincoln Oliveira Sant'Anna, Sérgio Bokermann, Carlos Henrique Camargo, Fernanda Diniz Prates, Cláudio Tavares Sacchi, Verônica Viana Vieira, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Marcus Vinícius Canário Viana, Vasco Azevedo, Flávia Figueira Aburjaile, Ana Luiza de Mattos-Guaraldi, Louisy Sanches Dos Santos
We present a case of skin lesion caused by nontoxigenic Corynebacterium diphtheriae. Genomic taxonomy analyses corroborated the preliminary identification provided by mass spectrometry. The strain showed a susceptible phenotype with increased exposure to penicillin, the first drug of choice for the treatment. An empty type 1 class integron carrying only the sul1 gene, which encodes sulfonamide resistance, was found flanked by transposases. Virulence factors involved in adherence and iron uptake, as well as the CRISPR-Cas system, were predicted...
November 21, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37981633/usefulness-of-intraoperative-bile-culture-in-patients-with-acute-calculous-cholecystitis-with-previous-biliary-events-does-the-postoperative-management-change
#17
JOURNAL ARTICLE
Melissa Arias-Avilés, Jaume Tur-Martínez, Judith Camps-Lasa, Èric Herrero-Fonollosa, María Isabel García-Domingo, Esteban Cugat-Andorrà
PURPOSE: The aim of our study was to determine the usefulness of intraoperative gallbladder cultures in the postoperative course in surgically treated patients with acute calculous cholecystitis and previous biliary events (ACC-PBE). METHODS: Retrospective unicenter study on surgically treated ACC-patients between January 2014 and December 2018. Clinical benefit was defined as a > 20% change in postoperative antibiotic treatment. Secondary endpoints: postoperative morbidity and length-of-stay (LOS) in ACC-PBE patients with positive intraoperative biliary culture (IBC)...
November 20, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37981632/rapid-detection-of-s-pyogenes-and-s-pneumoniae-in-pleural-fluid-for-diagnosis-of-parapneumonic-empyema
#18
JOURNAL ARTICLE
Kelly De Schuyter, Jerina Boelens, Anne-Sophie Messiaen, Petra Schelstraete, Bruno Verhasselt, Diana Huis In't Veld, Steven Callens, Erica Sermijn, Yannick Vande Weygaerde, Stien Vandendriesche
The aim of this study was to assess the reliability of rapid antigen detection tests (RADT) for Streptococcus pyogenes (GAS) and Streptococcus pneumoniae on pleural fluid samples for diagnosis of parapneumonic effusion/empyema (PPE) and their potential for improving pathogen identification rates. Sixty-three pleural samples were included from 54 patients on which GAS and S. pneumoniae RADT (BinaxNOW), culture, 16S rRNA PCR, and S. pneumoniae-specific PCR were performed. GAS RADT showed a sensitivity of 95.2% and a specificity of 100%...
November 20, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37980302/the-epidemiology-of-multidrug-resistant-organisms-in-persons-diagnosed-with-cancer-in-norway-2008-2018-expanding-surveillance-using-existing-laboratory-and-register-data
#19
JOURNAL ARTICLE
Anders Skyrud Danielsen, Petter Elstrøm, Hanne-Merete Eriksen-Volle, Solveig Hofvind, David W Eyre, Oliver Kacelnik, Jørgen Vildershøj Bjørnholt
Surveillance has revealed an increase of multidrug-resistant organisms (MDROs), even in low-prevalent settings such as Norway. MDROs pose a particular threat to at-risk populations, including persons with cancer. It is necessary to include such populations in future infection surveillance. By combining existing data sources, we aimed to describe the epidemiology of MDROs in persons diagnosed with cancer in Norway from 2008 to 2018. A cohort was established using data from the Cancer Registry of Norway, which was then linked to notifications of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin- and/or linezolid-resistant enterococci (V/LRE), and carbapenemase-producing Gram-negative bacilli (CP-GNB) from the Norwegian Surveillance System for Communicable Diseases, and laboratory data on third-generation cephalosporin-resistant Enterobacterales (3GCR-E) from Oslo University Hospital (OUH)...
November 18, 2023: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/37980301/diagnostic-efficacy-of-an-optimized-nucleotide-maldi-tof-ms-assay-for-anti-tuberculosis-drug-resistance-detection
#20
JOURNAL ARTICLE
Xichao Ou, Zexuan Song, Bing Zhao, Shaojun Pei, Chong Teng, Huiwen Zheng, Wencong He, Ruida Xing, Yiting Wang, Shengfen Wang, Hui Xia, Yang Zhou, Ping He, Yanlin Zhao
PURPOSE: We aimed at evaluating the diagnostic efficacy of a nucleotide matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) assay to detect drug resistance of Mycobacterium tuberculosis. METHODS: Overall, 263 M. tuberculosis clinical isolates were selected to evaluate the performance of nucleic MALDI-TOF-MS for rifampin (RIF), isoniazid (INH), ethambutol (EMB), moxifloxacin (MXF), streptomycin (SM), and pyrazinamide (PZA) resistance detection...
November 18, 2023: European Journal of Clinical Microbiology & Infectious Diseases
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