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Journals European Journal of Clinical M...

European Journal of Clinical Microbiology & Infectious Diseases

https://read.qxmd.com/read/38536525/correction-to-added-diagnostic-value-of-16s-rrna-gene-pan-mycobacterial-pcr-for-nontuberculous-mycobacterial-infections-a-10-year-retrospective-study
#1
Simon Andenmatten, Onya Opota, Jessica Mazza-Stalder, Laurent Nicod, Gilbert Greub, Katia Jaton
No abstract text is available yet for this article.
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536524/clinical-impact-and-cost-consequence-analysis-of-eplex%C3%A2-blood-culture-identification-panels-for-the-rapid-diagnosis-of-bloodstream-infections-a-single-center-randomized-controlled-trial
#2
JOURNAL ARTICLE
Yvan Caspar, A Deves, C Richarme, M Le Marechal, L Ponderand, A-L Mounayar, S Lejeune, J Arata-Bardet, M Gallouche, C Recule, D Maubon, C Garnaud, M Cornet, M Veloso, B Chabani, M Maurin, S David-Tchouda, P Pavese
To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536523/suitability-of-reduced-dose-glucocorticoids-therapy-regimen-for-antibody-associated-vasculitis-patients-with-tb-a-retrospective-study
#3
JOURNAL ARTICLE
Rui Wen, Jingni Xiao, Ning Ding, Yong Zhong, Qiong Yuan, Jiali Li, Qi Wang, Hebin Xie, Jiao Qin
INTENTION: Immunosuppressive therapy is the major treatment approach for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Due to impaired cellular immunological function and the use of glucocorticoids and immunosuppressants, AAV patients are predisposed to opportunistic infections, including tuberculosis (TB). This retrospective study aims to analyze the clinical characteristics of patients with AAV and TB and explore suitable glucocorticoid regimens for them...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38530466/crp-under-130-mg-l-rules-out-the-diagnosis-of-legionella-pneumophila-serogroup-1-urinella-study
#4
JOURNAL ARTICLE
Timothée Klopfenstein, Souheil Zayet, Samantha Poloni, Vincent Gendrin, Damien Fournier, Jean-Baptiste Vuillemenot, Philippe Selles, Alain Dussaucy, Gaelle Coureau, Marta Avalos-Fernandez, Lynda Toko, Pierre-Yves Royer, Charles-Eric Lavoignet, Bouchra Amari, Marc Puyraveau, Catherine Chirouze
INTRODUCTION: In case of pneumonia, some biological findings are suggestive for Legionnaire's disease (LD) including C-reactive protein (CRP). A low level of CRP is predictive for negative Legionella Urinary-Antigen-Test (L-UAT). METHOD: Observational retrospective study in Nord-Franche-Comté Hospital with external validation in Besançon University Hospital, France which included all adults with L-UAT performed during January 2018 to December 2022. The objective was to determine CRP optimal threshold to predict a L-UAT negative result...
March 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38530465/multidrug-resistant-organism-bloodstream-infection-and-hospital-acquisition-among-inpatients-in-three-tertiary-greek-hospitals-during-the-covid-19-era
#5
JOURNAL ARTICLE
Polyxeni Karakosta, Sophia Vourli, Elisavet Kousouli, Georgios Meletis, Areti Tychala, Christina Louka, Alexandra Vasilakopoulou, Efthymia Protonotariou, Vasiliki Mamali, Olympia Zarkotou, Lemonia Skoura, Spyros Pournaras
From 2019 (pre-COVID-19) to 2022 (COVID-19 years), three tertiary Greek hospitals monitored MDRO bloodstream infection (BSI) and hospital acquisition relying on laboratory data. Surveillance covered carbapenem-resistant Enterobacterales (CRE), Acinetobacter baumannii (CRAB), Pseudomonas aeruginosa (CRPA), vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA), in intensive care units (ICUs) and non-ICUs. Non-ICUs experienced significant increases in CRE, CRAB and VRE during the pandemic...
March 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517573/a-decade-of-neonatal-sepsis-in-stockholm-sweden-gram-positive-pathogens-were-four-times-as-common-as-gram-negatives
#6
JOURNAL ARTICLE
Frida Oldendorff, Viveka Nordberg, Christian G Giske, Lars Navér
PURPOSE: To assess Gram-positive bacterial (GPB) bloodstream infection (BSI) in neonates, covering incidence, morbidity, mortality, antimicrobial resistance patterns and biomarkers in Region Stockholm, Sweden between 2006 and 2016. METHODS: A population-based retrospective epidemiological study including infants with GPB-BSI, admitted to the neonatal units at Karolinska University Hospital (KUH). Data were collected from patient records, the Swedish Neonatal Quality Register, the microbiological laboratory at KUH and the Swedish Public Health Agency...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517572/whole-genome-sequencing-and-molecular-epidemiology-of-methicillin-resistant-staphylococcus-aureus-isolated-from-patients-with-bacteraemia-in-slovenia
#7
JOURNAL ARTICLE
Urška Dermota, Andraž Celar Šturm, Tina Triglav, Katja Strašek Smrdel, Ivana Velimirović
PURPOSE: Data on the molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates from patients with bacteraemia in Slovenia are lacking. The aim of this study was to phenotypically and genotypically investigate 82 MRSA strains isolated from patients with bloodstream infections in central Slovenia between 2019 and 2022. METHODS: Whole-genome sequencing of selected strains was performed to characterize the strains based on sequence typing, antimicrobial resistance, toxin, and virulence factors genes...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38517571/molecular-monitoring-of-viral-infections-in-immunocompromised-patients-in-a-large-university-hospital-in-italy-reflections-after-thirteen-years-of-real-life-activity
#8
JOURNAL ARTICLE
Lilia Cinti, Piergiorgio Roberto, Matteo Rossi, Anna Napoli, Gianluca Russo, Anna Paola Iori, Giuseppe Gentile, Maria Augurusa, Corrado Girmenia, Guido Antonelli, Aurelia Gaeta
PURPOSE: This study aimed to investigate the prevalence and viral reactivations of clinical interest in the immunocompromised patient with particular focus on hematologic and solid organ transplant recipients. METHODS: Molecular screening data of CMV, EBV, JCV and BKV from 2011 to 2023 were analyzed. This extensive time span allowed the access to more than 100,000 samples from over 20,000 patients treated at Policlinico Umberto I. It was possible to temporally investigate patient attendance patterns, average age distribution, seasonality of infections, and positivity rates of the analyzed viruses...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38512514/salmonella-infections-in-denmark-from-2013-2022-with-focus-on-serotype-distribution-invasiveness-age-sex-and-travel-exposition
#9
JOURNAL ARTICLE
Nicholas Slinning Aarø, Mia Torpdahl, Torben Rasmussen, Martin Jensen, Hans Linde Nielsen
PURPOSE: To analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022. METHODS: Confirmed cases of Salmonella enterica subsp. enterica were examined using the National Register of Enteric Pathogens during 2013-2022. Proportions, incidence rates (IR), relative risk (RR), and 95% confidence intervals (CI) were calculated to assess differences in serotypes, invasiveness, age, sex, and travel exposure. RESULTS: We identified 9,944 Danish Salmonella enterica subsp...
March 21, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38492058/evaluation-and-1-year-follow-up-of-patients-presenting-at-a-lyme-borreliosis-expertise-centre-a-prospective-cohort-study-with-validated-questionnaires
#10
JOURNAL ARTICLE
F R van de Schoor, M E Baarsma, S A Gauw, J Ursinus, H D Vrijmoeth, H J M Ter Hofstede, A D Tulen, M G Harms, A Wong, C C van den Wijngaard, L A B Joosten, J W Hovius, B J Kullberg
OBJECTIVES: To describe the course of symptoms reported by patients with symptoms attributed to Lyme borreliosis (LB) without being subsequently diagnosed with LB. METHODS: We performed a prospective cohort study with patients presenting at the outpatient clinic of two clinical LB centres. The primary outcome was the prevalence of persistent symptoms, which were defined as clinically relevant fatigue (CIS, subscale fatigue), pain (SF-36, subscale bodily pain), and cognitive impairment (CFQ) for ≥ 6 months and onset < 6 months over the first year of follow-up...
March 16, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38483681/pulmonary-surfactant-impacts-in-vitro-activity-of-selected-antifungal-drugs-against-candida-krusei-and-candida-albicans
#11
JOURNAL ARTICLE
Alina Nussbaumer-Pröll, Peter Matzneller, Sabine Eberl, Markus Zeitlinger
PURPOSE: This study investigates how surfactants affect the in-vitro anti-infective efficacy of micafungin, caspofungin, anidulafungin, and amphotericin B in treating pulmonary mycoses. METHODS: MIC values for antifungal agents were determined against Candida krusei (now Pichia kudriavzevii) ATCC 6258, Candida albicans ATCC 90028, and 18 clinical isolates using the broth microdilution method in RPMI medium, following EUCAST recommendations. MIC assays included testing with and without Curosurf® surfactant at 1 mg/mL for C...
March 14, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472522/human-campylobacter-spp-infections-in-italy
#12
JOURNAL ARTICLE
Verena Zerbato, Stefano Di Bella, Riccardo Pol, Roberto Luzzati, Gianfranco Sanson, Simone Ambretti, Stefano Andreoni, Richard Aschbacher, Mariano Bernardo, Alessandra Bielli, Gioconda Brigante, Marina Busetti, Giulio Camarlinghi, Davide Carcione, Antonella Carducci, Nicola Clementi, Edoardo Carretto, Chiara Chilleri, Giulia Codda, Alessandra Consonni, Venera Costantino, Venere Cortazzo, Manuela Di Santolo, Saveria Dodaro, Barbara Fiori, Aurora García-Fernández, Claudio Foschi, Elisa Gobbato, Francesca Greco, Roberto Marcello La Ragione, Nicasio Mancini, Alberto Enrico Maraolo, Anna Marchese, Daniela Marcuccio, Roberta Marrollo, Carola Mauri, Annarita Mazzariol, Gianluca Morroni, Adriana Mosca, Giacomo Nigrisoli, Elisabetta Pagani, Eva Maria Parisio, Simona Pollini, Mario Sarti, Annarita Sorrentino, Domenico Trotta, Laura Villa, Chiara Vismara, Luigi Principe
PURPOSE: Campylobacter is a frequent cause of enteric infections with common antimicrobial resistance issues. The most recent reports of campylobacteriosis in Italy include data from 2013 to 2016. We aimed to provide national epidemiological and microbiological data on human Campylobacter infections in Italy during the period 2017-2021. METHODS: Data was collected from 19 Hospitals in 13 Italian Regions. Bacterial identification was performed by mass spectrometry...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472521/increase-in-the-incidence-of-invasive-fungal-infections-due-to-volvariella-volvacea
#13
JOURNAL ARTICLE
Feng-Zeng Li, Meng Jia, Ai-Jun Chen, Sheng Fang
PURPOSE: We aimed to show the increasing incidence of invasive fungal infections due to Volvariella Volvacea in patients with immunosuppression. METHODS: We present a case of an invasive fungal infection caused by Volvariella volvacea, and summarize the clinical and pathological features based on this case and a review of the literature. RESULTS: A total of seven patients with IFIs due to Volvariella Volvacea have been reported in the literature...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472520/host-parasite-interaction-in-severe-and-uncomplicated-malaria-infection-in-ghanaian-children
#14
JOURNAL ARTICLE
Richard H Asmah, Daniel Sai Squire, Selorme Adupko, David Adedia, Eric Kyei-Baafour, Ebenezer K Aidoo, Patrick F Ayeh-Kumi
PURPOSE: During malarial infection, both parasites and host red blood cells (RBCs) come under severe oxidative stress due to the production of free radicals. The host system responds in protecting the RBCs against the oxidative damage caused by these free radicals by producing antioxidants. In this study, we investigated the antioxidant enzyme; superoxide dismutase (SOD) activity and cytokine interactions with parasitaemia in Ghanaian children with severe and uncomplicated malaria. METHODOLOGY: One hundred and fifty participants aged 0-12 years were administered with structured questionnaires...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472519/unmasking-bartonella-henselae-infection-in-the-shadows-of-long-covid-thanks-to-clinical-metagenomics
#15
JOURNAL ARTICLE
Aurélien Aubry, Emilie Corvilain, Théo Ghelfenstein-Ferreira, François Camelena, Véronique Meignin, Béatrice Berçot, Jérôme Le Goff, Maud Salmona
The diagnosis of long COVID often relies on symptoms post-COVID-19, occasionally lacking biological evidence. This case study illustrates how investigating long COVID uncovered an underlying bartonellosis through clinical metagenomics. Following mild COVID-19, a 26-year-old woman experienced persistent symptoms during 5 months, including axillary adenopathy. Pathological examination, 16 S rRNA PCR, and clinical metagenomic analysis were done on an adenopathy biopsy. The latter revealed Bartonella henselae DNA and RNA...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38472518/association-of-scrub-typhus-with-the-risk-of-venous-thromboembolism-and-long-term-mortality-a-population-based-cohort-study
#16
JOURNAL ARTICLE
En-Shao Liu, Yi-Ting Wu, Wen-Miin Liang, Feng-Yu Kuo
BACKGROUND: The existing literature lacks studies examining the epidemiological link between scrub typhus and deep vein thrombosis (DVT) or pulmonary embolism (PE), and the long-term outcomes. The objective of this study is to explore the potential association between scrub typhus and the subsequent risk of venous thromboembolism, and long-term mortality. METHOD: This nationwide cohort study identified 10,121 patients who were newly diagnosed with scrub typhus. Patients with a prior DVT or PE diagnosis before the scrub typhus infection were excluded...
March 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38460030/does-selective-digestive-decontamination-sdd-increase-antibiotic-resistance-long-term-comparison-of-two-intensive-care-units-with-and-without-sdd-of-the-same-tertiary-hospital
#17
JOURNAL ARTICLE
Alicia Rodríguez-Gascón, Yanire Lloréns-Villar, María Ángeles Solinís, Helena Barrasa, Andrés Canut-Blasco
PURPOSE: The aim of this study was to to compare the antimicrobial resistance rate and its relationship with the antibiotic consumption in two separate Intensive Care Units (ICUs) of the same hospital, one with and other without selective decontamination of the digestive tract (SDD). METHODS: We performed a retrospective study in the two ICUs of the Araba University Hospital. Trauma and neurosurgical patients are admitted to the SDD-ICU, and general digestive surgery patients go to the no SDD-ICU...
March 9, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38457097/carbapenem-or-new-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-an-italian-survey-supported-by-sita-simit-and-siaarti-to-identify-the-factors-affecting-empiric-antimicrobial-therapy-choice-in-real-life-clinical-practice
#18
JOURNAL ARTICLE
Marta Colaneri, Camilla Genovese, Andrea Lombardi, Darcy Holmes, Alessandra Bandera, Andrea Gori
While a tailored antibiotic treatment plan is often straightforward, what we often observe in daily clinical practice is a highly variable approach when defining empirical therapy. Specifically, a debate exists on preference to spare the new β-lactams and β-lactamase inhibitors (BL-BLIs) or to apply a carbapenem-sparing strategy first. To investigate, we designed a web survey aimed at investigating the variables considered relevant to empirically choosing one antibiotic over the other. Submitted to Italian infectious diseases and intensive care physicians through the support of Società Italiana di Malattie Infettive e Tropicali (SIMIT), Società Italiana di Terapia Antinfettiva (SITA) and Società Italiana Anestesia, Analgesia, Rianimazione e Terapia Intensiva (SIAARTI)...
March 8, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38443737/intraventricular-or-intrathecal-polymyxin-b-for-treatment-of-post-neurosurgical-intracranial-infection-caused-by-carbapenem-resistant-gram-negative-bacteria-a-8-year-retrospective-study
#19
JOURNAL ARTICLE
Yangmin Hu, Danyang Li, Gensheng Zhang, Yunjian Dai, Meng Chen, Huifang Jiang, Wei Cui
PURPOSE: Post-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria (CRGNB) is a life-threatening complication. This study aimed to assess the current practices and clinical outcomes of intravenous (IV) combined with intraventricular (IVT)/intrathecal (ITH) polymyxin B in treating CRGNB intracranial infection. METHODS: A retrospective study was conducted on patients with post-neurosurgical intracranial infection due to CRGNB from January 2013 to December 2020...
March 5, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38438704/hybrid-capture-shotgun-sequencing-detected-unexpected-viruses-in-the-cerebrospinal-fluid-of-children-with-acute-meningitis-and-encephalitis
#20
JOURNAL ARTICLE
Cristian Launes, Juan Camacho, Marina Pons-Espinal, F Xavier López-Labrador, Cristina Esteva, María Cabrerizo, María Dolores Fernández-García, Marta Fogeda, Josefa Masa-Calles, Noemí López-Perea, Juan Emilio Echevarría, Carmen Muñoz-Almagro, David Tarragó
PURPOSE: Investigation of undiagnosed cases of infectious neurological diseases, especially in the paediatric population, remains a challenge. This study aimed to enhance understanding of viruses in CSF from children with clinically diagnosed meningitis and/or encephalitis (M/ME) of unknown aetiology using shotgun sequencing enhanced by hybrid capture (HCSS). METHODS: A single-centre prospective study was conducted at Sant Joan de Déu University Hospital, Barcelona, involving 40 M/ME episodes of unknown aetiology, recruited from May 2021 to July 2022...
March 4, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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