journal
https://read.qxmd.com/read/38885569/associations-between-residential-environments-and-late-onset-schizophrenia-in-uk-biobank-interaction-with-genetic-risk-factor
#1
JOURNAL ARTICLE
Chen Shen, Xinning Tong, Jinjun Ran, Shengzhi Sun, Qian Yang, Huiyong Shen, Xiaoxin I Yao
BACKGROUND: Environment and genes both contribute to schizophrenia. However, the impact of different natural environments surrounding residential addresses on schizophrenia in urban settings remains unknown. This study aimed to investigate the association of urbanisation, measured by residential environments, with late-onset schizophrenia and explore whether genetic risk for schizophrenia modified the associations. METHODS: We examined the associations between residential environments and late-onset schizophrenia and its interaction with genetic risk factors in UK Biobank, followed from 2006 to 2010 (baseline) to Dec 2021...
June 16, 2024: Schizophrenia Research
https://read.qxmd.com/read/38870719/the-impact-of-daily-social-support-on-the-associations-between-daily-negative-events-and-daily-suspiciousness-across-different-clinical-stages-of-psychosis
#2
JOURNAL ARTICLE
L Morosan, E Raposo de Almeida, S van der Tuin, D van den Berg, S H Booij, J T W Wigman
No abstract text is available yet for this article.
June 12, 2024: Schizophrenia Research
https://read.qxmd.com/read/38870718/childhood-trauma-associated-with-psychotic-like-experiences-among-people-living-with-hiv-the-chain-mediation-effect-of-stigma-and-resilience
#3
JOURNAL ARTICLE
Jiaping Yang, Shuyi Zhai, Dongfang Wang
BACKGROUND: Previous research established the associations between childhood trauma and psychosis, but the effects of childhood trauma on psychotic-like experiences (PLEs) among people living with HIV (PLWH) and the potential mediation mechanisms in these associations remain unclear. OBJECTIVE: This study aimed to investigate the effects of childhood trauma on PLEs, as well as the chain mediation roles of stigma and resilience in this relationship. Furthermore, we explored whether the aforementioned associations differed when hallucinatory experiences (HEs) and delusional experiences (DEs) were separately modeled...
June 12, 2024: Schizophrenia Research
https://read.qxmd.com/read/38865807/social-network-structure-as-a-biopsychosocial-suicide-prevention-target-for-young-people-at-clinical-high-risk-for-psychosis
#4
REVIEW
Annamarie B Defayette, Steven M Silverstein, Anthony R Pisani
Young people who are at clinical high-risk for psychosis experience suicidal thoughts and behaviors at a greater rate than young people in the general population. However, no suicide prevention interventions have been specifically designed for or tested with this group of young people. To address this gap, we need to identify and leverage malleable potential intervention targets that can be measured at multiple levels of analysis. Here, we argue that social network structure, or the pattern of relationships in which a person is embedded, offers one potential target for intervention...
June 11, 2024: Schizophrenia Research
https://read.qxmd.com/read/38865806/altered-cardiac-autonomic-functioning-associates-with-self-disorders-in-schizophrenia
#5
JOURNAL ARTICLE
Karl Erik Sandsten, Magnus T Jensen, Ditte Saebye, Kaylee Null, Georg Northoff, Josef Parnas
Elevated resting heart rate (RHR) and reduced heart rate variability (HRV) are signs of autonomic nervous system dysfunction identified in schizophrenia (SCZ). This dysfunction has been found to manifest prior to the onset of the clinical diagnosis. Yet whether such autonomic dysfunction is associated with vulnerability to schizophrenia remains unknown. This case-control study included recent onset SCZ patients (n = 35) and healthy controls (HC) (n = 33). Patients were scored for self-disorders (SD's) using the EASE manual and all participants underwent a 5-minute resting state electrocardiogram (ECG) recording...
June 11, 2024: Schizophrenia Research
https://read.qxmd.com/read/38851167/the-importance-of-oxidative-biomarkers-in-diagnosis-treatment-and-monitoring-schizophrenia-patients
#6
JOURNAL ARTICLE
Elżbieta Cecerska-Heryć, Aleksandra Polikowska, Natalia Serwin, Anna Michalczyk, Patrycja Stodolak, Małgorzata Goszka, Martyn Zoń, Marta Budkowska, Ernest Tyburski, Piotr Podwalski, Katarzyna Waszczuk, Krzysztof Rudkowski, Jolanta Kucharska-Mazur, Monika Mak, Agnieszka Samochowiec, Błażej Misiak, Leszek Sagan, Jerzy Samochowiec, Barbara Dołęgowska
INTRODUCTION: The etiology of schizophrenia (SCZ), an incredibly complex disorder, remains multifaceted. Literature suggests the involvement of oxidative stress (OS) in the pathophysiology of SCZ. OBJECTIVES: Determination of selected OS markers and brain-derived neurotrophic factor (BDNF) in patients with chronic SCZ and those in states predisposing to SCZ-first episode psychosis (FP) and ultra-high risk (UHR). MATERIALS AND METHODS: Determination of OS markers and BDNF levels by spectrophotometric methods and ELISA in 150 individuals (116 patients diagnosed with SCZ or in a predisposed state, divided into four subgroups according to the type of disorder: deficit schizophrenia, non-deficit schizophrenia, FP, UHR)...
June 7, 2024: Schizophrenia Research
https://read.qxmd.com/read/38851166/effects-of-pde10a-inhibitor-mk-8189-in-people-with-an-acute-episode-of-schizophrenia-a-randomized-proof-of-concept-clinical-trial
#7
JOURNAL ARTICLE
Yuki Mukai, Robert Lupinacci, Stephen Marder, Linda Snow-Adami, Tiffini Voss, Sean M Smith, Michael F Egan
BACKGROUND: PDE10A inhibition represents a potential mechanism for treating schizophrenia. PDE10A inhibitors increase cyclic nucleotides in striatal neurons, thereby mimicking the effects of dopamine receptor D2 antagonists and D1 agonists. We evaluated the PDE10A inhibitor MK-8189 for treating schizophrenia. METHODS: Randomized, double-blind, placebo and active-controlled, phase 2a, multicenter, inpatient trial in adults experiencing an acute episode of schizophrenia...
June 7, 2024: Schizophrenia Research
https://read.qxmd.com/read/38843584/the-effect-of-second-generation-antipsychotics-on-anxiety-depression-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#8
REVIEW
Ali Abdolizadeh, Maryam Hosseini Kupaei, Yasaman Kambari, Aron Amaev, Vittal Korann, Edgardo Torres-Carmona, Jianmeng Song, Fumihiko Ueno, Michel-Teruki Koizumi, Shinichiro Nakajima, Sri Mahavir Agarwal, Philip Gerretsen, Ariel Graff-Guerrero
OBJECTIVE: Despite the high prevalence of anxiety in schizophrenia, no established guideline exists for the management of these symptoms. We aimed to synthesize evidence on the effect of second-generation antipsychotics (SGAs) on anxiety in patients with schizophrenia. METHODS: We systematically searched Medline, Embase, PsycInfo, Web of Science, PubMed, and Cochrane library to identify randomized controlled trials of SGAs that reporting anxiety measures in schizophrenia...
June 5, 2024: Schizophrenia Research
https://read.qxmd.com/read/38823319/predicting-treatment-resistance-in-schizophrenia-patients-machine-learning-highlights-the-role-of-early-pathophysiologic-features
#9
REVIEW
David Barruel, Jacques Hilbey, Jean Charlet, Boris Chaumette, Marie-Odile Krebs, Valérie Dauriac-Le Masson
Detecting patients with a high-risk profile for treatment-resistant schizophrenia (TRS) can be beneficial for implementing individually adapted therapeutic strategies and better understanding the TRS etiology. The aim of this study was to explore, with machine learning methods, the impact of demographic and clinical patient characteristics on TRS prediction, for already established risk factors and unexplored ones. This was a retrospective study of 500 patients admitted during 2020 to the University Hospital Group for Paris Psychiatry...
May 31, 2024: Schizophrenia Research
https://read.qxmd.com/read/38820980/global-neural-self-disturbance-in-schizophrenia-a-systematic-fmri-review
#10
REVIEW
Sami George Sabbah, Georg Northoff
There is a general consensus that schizophrenia (SZ) is characterized by major changes in the sense of self. Phenomenological studies suggest that these changes in the sense of self stem from a basic disturbance, hence the term 'basic self-disturbance'. While imaging studies demonstrate changes in various regions during self-focused tasks, the exact neural correlates of such basic self-disturbances remain unclear. If the self-disturbance is indeed basic and thereby underlies all other symptoms, one would expect it to be related to more global rather than local changes in the brain...
May 30, 2024: Schizophrenia Research
https://read.qxmd.com/read/38815468/schizophrenia-and-the-bodily-self
#11
REVIEW
Vittorio Gallese, Martina Ardizzi, Francesca Ferroni
Despite the historically consolidated psychopathological perspective, on the one hand, contemporary organicistic psychiatry often highlights abnormalities in neurotransmitter systems like dysregulation of dopamine transmission, neural circuitry, and genetic factors as key contributors to schizophrenia. Neuroscience, on the other, has so far almost entirely neglected the first-person experiential dimension of this syndrome, mainly focusing on high-order cognitive functions, such as executive function, working memory, theory of mind, and the like...
May 29, 2024: Schizophrenia Research
https://read.qxmd.com/read/38795661/clinical-effects-of-a-yoga-based-intervention-for-patients-with-schizophrenia-a-six-month-randomized-controlled-trial
#12
JOURNAL ARTICLE
Shivarama Varambally, Bharath Holla, Ganesan Venkatasubramanian, Thrinath Mullapudi, Praveen Raj, Venkataram Shivakumar, Rita Christopher, Monojit Debnath, Mariamma Philip, Rose Dawn Bharath, B N Gangadhar
BACKGROUND: Yoga has shown promise as an add-on therapy for patients with schizophrenia. However, most studies have been short-term, with methodological limitations. METHODS: We conducted a six-month parallel-group randomized-controlled trial (with rater blinding) to evaluate the effectiveness of a yoga-based intervention in improving symptoms and quality of life in patients with schizophrenia. We recruited 110 patients from an urban tertiary hospital and a semi-urban community centre who met DSM 5 criteria for schizophrenia and were on stable medication for at least six weeks...
May 24, 2024: Schizophrenia Research
https://read.qxmd.com/read/38788432/overview-on-cognitive-impairment-in-psychotic-disorders-from-impaired-microcircuits-to-dysconnectivity
#13
JOURNAL ARTICLE
L Mana, M Schwartz-Pallejà, M Vila-Vidal, G Deco
Schizophrenia's cognitive deficits, often overshadowed by positive symptoms, significantly contribute to the disorder's morbidity. Increasing attention highlights these deficits as reflections of neural circuit dysfunction across various cortical regions. Numerous connectivity alterations linked to cognitive symptoms in psychotic disorders have been reported, both at the macroscopic and microscopic level, emphasizing the potential role of plasticity and microcircuits impairment during development and later stages...
May 23, 2024: Schizophrenia Research
https://read.qxmd.com/read/38776722/role-of-electroconvulsive-therapy-in-patients-with-clozapine-refractory-schizophrenia
#14
LETTER
Matej Markota, Paul E Croarkin, Melanie T Gentry, Jonathan G Leung
No abstract text is available yet for this article.
May 21, 2024: Schizophrenia Research
https://read.qxmd.com/read/38772324/grey-matter-volume-reduction-in-the-frontotemporal-cortex-associated-with-persistent-verbal-auditory-hallucinations-in-chinese-patients-with-chronic-schizophrenia-insights-from-a-3%C3%A2-t-magnetic-resonance-imaging-study
#15
JOURNAL ARTICLE
Honghong Ren, Jinguang Li, Jun Zhou, Xiaogang Chen, Jinsong Tang, Zongchang Li, Qianjin Wang
BACKGROUND: Persistent auditory verbal hallucinations (pAVHs) are a fundamental manifestation of schizophrenia (SCZ), yet the exact connection between pAVHs and brain structure remains contentious. This study aims to explore the potential correlation between pAVHs and alterations in grey matter volume (GMV) within specific brain regions among individuals diagnosed with SCZ. METHODS: 76 SCZ patients with pAVHs (pAVH group), 57 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group) were investigated using 3 T magnetic resonance imaging...
May 20, 2024: Schizophrenia Research
https://read.qxmd.com/read/38763092/the-danger-of-averages-in-the-context-of-heterogeneity-response-to-the-letter-to-the-editor-of-scz-res-role-of-ect-in-patients-with-crs-markota-et-al-2024
#16
LETTER
Helio Elkis, Debora Luciana Melzer-Ribeiro, Isabel Cristina Napolitano, Christoph U Correll
No abstract text is available yet for this article.
May 18, 2024: Schizophrenia Research
https://read.qxmd.com/read/38763091/the-contributions-of-risk-taking-and-impulsivity-to-jumping-to-conclusions-in-the-psychosis-spectrum
#17
JOURNAL ARTICLE
Tana Gabbert, Jakob Scheunemann, Ryan P Balzan, Niels Doehring, Julia Elmers, Steffen Moritz
The jumping to conclusions (JTC) bias has been linked to the formation and maintenance of delusions across the psychosis spectrum. However, it remains unclear whether this bias reflects a primary cognitive deviation or is secondary to other cognitive processes. To this end, we investigated the relationship between JTC, risk-taking, impulsivity, and sensation seeking in individuals with psychotic-like experiences (PLEs) and controls. A large online community sample (N = 1151) completed the Fish Task as a measure for the JTC bias, as well as the Balloon Analogue Risk Task (BART) and the Brief Risk-Taking Propensity Scale (R-1) as measures of the propensity to take risks...
May 18, 2024: Schizophrenia Research
https://read.qxmd.com/read/38761436/associations-between-fearlessness-about-death-and-suicidal-ideation-in-individuals-with-psychosis
#18
JOURNAL ARTICLE
Jennifer Villa, Duncan G Campbell, Emma M Parrish, Min Eun Jeon, Morgan Robison, Thomas Joiner, Amy E Pinkham, Philip D Harvey, Colin A Depp
BACKGROUND: Despite high rates of suicide among people with psychosis, relatively little is known about the mechanisms underlying the transition from suicidal ideation to behavior in this population. The Interpersonal Psychological Theory of Suicide (IPTS) proposes that fearlessness about death (FAD) may play a role in this relationship. The present study tested whether constructs of the IPTS [thwarted belongingness (TB), perceived burdensomeness (PB), and FAD] were associated with the severity of suicidal ideation in a sample of adults with histories of psychosis...
May 17, 2024: Schizophrenia Research
https://read.qxmd.com/read/38761435/efficacy-of-sodium-nitroprusside-in-the-treatment-of-drug-naive-subjects-in-first-episode-psychosis-an-open-label-study
#19
LETTER
Marcelo P M Adelino, Marcel V Nunes, Mariele F Q Nunes, Lucas C Quarantini, Jaime E C Hallak, Acioly L T Lacerda
No abstract text is available yet for this article.
May 17, 2024: Schizophrenia Research
https://read.qxmd.com/read/38761434/elevated-intrinsic-cortical-curvature-in-treatment-resistant-schizophrenia-evidence-of-structural-deformation-in-functional-connectivity-areas-and-comparison-with-alternate-indices-of-structure
#20
JOURNAL ARTICLE
Edgardo Torres-Carmona, Fumihiko Ueno, Yusuke Iwata, Shinichiro Nakajima, Jianmeng Song, Wanna Mar, Ali Abdolizadeh, Sri Mahavir Agarwal, Vincenzo de Luca, Gary Remington, Philip Gerretsen, Ariel Graff-Guerrero
BACKGROUND: Research suggests structural and connectivity abnormalities in patients with treatment-resistant schizophrenia (TRS) compared to first-line responders and healthy-controls. However, measures of these abnormalities are often influenced by external factors like nicotine and antipsychotics, limiting their clinical utility. Intrinsic-cortical-curvature (ICC) presents a millimetre-scale measure of brain gyrification, highly sensitive to schizophrenia differences, and associated with TRS-like traits in early stages of the disorder...
May 17, 2024: Schizophrenia Research
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