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American Journal of Hypertension

Panagiota Anyfanti, Eugenia Gkaliagkousi, Areti Triantafyllou, Konstantina Dipla, Hippocrates Zarifis, Polyvios Arseniou, Antonios Lazaridis, Stella Douma
BACKGROUND: We investigated for the first time whether patients with recent-onset, uncomplicated hypertension and different hypertension phenotypes exhibit altered values of SEVR, a surrogate measure of myocardial perfusion that correlates with the ratio of subendocardial to subepicardial blood flow. We additionally explored whether SEVR correlates with arterial stiffness in a population free from the long-term effects of essential hypertension. METHODS: Non-treated individuals free from any known health problems were classified as true hypertensives (TH), white-coat hypertensives (WCH), masked hypertensives (MH) and normotensives...
March 16, 2019: American Journal of Hypertension
Renata M Lataro, Marcondes A B Silva, Fabiola L Mestriner, Stefany B A Cau, Rita C A Tostes, Helio C Salgado
BACKGROUND: Acetylcholinesterase inhibition prevents autonomic imbalance, reduces inflammation and attenuates the development of hypertension. Considering that vascular dysfunction is a crucial feature of arterial hypertension, we investigated the effects of chronic administration of acetylcholinesterase inhibitors - pyridostigmine or donepezil - on vascular reactivity of spontaneously hypertensive rats (SHR). METHODS: Endothelium-dependent relaxant responses to acetylcholine and contractile responses induced by electric field stimulation (EFS) and alpha-adrenergic agonist were studied in mesenteric resistance arteries from SHR and Wistar Kyoto rats...
March 15, 2019: American Journal of Hypertension
Ojas H Mehta, James D Cameron, Sam Mirzaee
Familial hypercholesterolemia (FH) is a common hereditary lipid disorder associated with substantial risk of premature atherosclerotic cardiovascular disease (ASCVD). We report an interesting newly diagnosed index case of FH in a 31 year old man who presented to the hospital with a ST-elevated myocardial infarction (STEMI). He had a background of inadequately treated hypertension and hypercholesterolemia. Further investigations raised the possibility of secondary hypertension after the identification of renal artery stenosis, in addition to other areas of mesenteric arterial stenoses...
March 14, 2019: American Journal of Hypertension
J M Bock, W E Hughes, D P Casey
BACKGROUND: Age-associated arterial stiffening may be the result of greater tonic sympathetic nerve activity. However, age-associated changes in central artery responsiveness to sympathoexcitatory stimuli are understudied. Therefore, we examined changes in central-artery stiffness and wave reflection in response to sympathoexcitatory stimuli in young and older adults. METHODS: Fourteen young (25±4yrs) and 15 older (68±4yrs) subjects completed 3min of the cold pressor test (CPT) and lower-body negative pressure (LBNP) separated by 15min...
March 11, 2019: American Journal of Hypertension
Muti Goloba, Rajendra Raghuraman, Nansi Botros, Uzma Khan, Monique Klein, Amelia Brown, Donovan Duffy, Nick Anim-Nyame, Duolao Wang, Isaac Manyonda, Tarek F Antonios
BACKGROUND: Capillary rarefaction (CR) is an established hallmark of essential hypertension (EH). The aim of this study was to examine early changes in capillary density (CD) and blood pressure (BP) in low birth weight (LBW) infants who are at risk of developing EH in later life. METHODS: We studied 77 LBW infants and 284 normal birth weight (NBW) infants, all born to normotensive mothers in a longitudinal multi-centre study. Intravital capillaroscopy was used to measure functional (BCD) and maximal capillary density (MCD) at birth, 3 months, 6 months and 12 months...
March 1, 2019: American Journal of Hypertension
Eugenia Gkaliagkousi, Panagiota Anyfanti, Stella Douma
No abstract text is available yet for this article.
March 1, 2019: American Journal of Hypertension
Kazushi Tsuda
No abstract text is available yet for this article.
February 28, 2019: American Journal of Hypertension
E Victor Adlin
No abstract text is available yet for this article.
February 26, 2019: American Journal of Hypertension
Gabriel Coll-de-Tuero, Marc Comas-Cufí, Antonio Rodríguez-Poncelas, Joan Barrot-de-la Puente, Jordi Blanch, Josep Figa-Vaello, Maria A Barceló, Marc Saez
BACKGROUND: Our objective of this study was to determine if rate of eGFR decline and its intensity was associated with cardiovascular risk and death in hypertensive patients whose baseline estimated glomerular filtration rate (eGFR) was higher than 60 mL/min/1.73m2. METHODS: This study comprised 2,516 hypertensive patients who had had at least two serum creatinine measurements over a four-year period. An eGFR reduction of ≥10% per year has been deemed as high-eGFR and a reduction in eGFR of less than 10% per year as a low decline...
February 22, 2019: American Journal of Hypertension
Atsushi Nakagomi, Taishi Tsuji, Masamichi Hanazato, Yoshio Kobayashi, Katsunori Kondo
BACKGROUND: Many factors are associated with hypertension development. We focused on social participation as an aspect of social capital and investigated the contextual relationship between community-level social participation and hypertension using multilevel regression analyses. METHODS: We used cross-sectional data from the 2016 Japan Gerontological Evaluation Study-a population-based study of functionally independent adults aged 65 years or older. The sample comprised 116,013 participants nested in 818 communities...
February 22, 2019: American Journal of Hypertension
Bonita Falkner
No abstract text is available yet for this article.
February 16, 2019: American Journal of Hypertension
Qi Liu, Shuna Jin, Xiaojie Sun, Xia Sheng, Zhenxing Mao, Yangqian Jiang, Hongxiu Liu, Chen Hu, Wei Xia, Yuanyuan Li, Shunqing Xu
BACKGROUND: Pregnancy hypertensive disorders have impaired neurodevelopment in offspring. We aimed to explore the association of normal range maternal blood pressure (BP) with child neurodevelopment, as well as the possible role of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) therein. METHODS: Among 1,008 mother-child pairs recruited in Wuhan, China, in 2013-2015, we measured maternal third-trimester BP (systolic and diastolic BP, SBP and DBP) and cord glucocorticoids (cortisol and cortisone), a marker reflecting placental 11β-HSD2 activity...
February 16, 2019: American Journal of Hypertension
Alastair J Sandilands, Kevin M O'Shaughnessy, Y Yasmin
Background: Activation of beta-1 adrenoreceptors (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in the β1-AR could therefore alter the physiological and clinical effects of this hormone. We tested this hypothesis in patients from a primary care cohort being screened for primary hyperaldosteronism, PHA (n=465). Methods: Demographic and haemodynamic data were measured and plasma renin determined by a standard immunoassay...
February 11, 2019: American Journal of Hypertension
Andrea Vecchiola, Cristóbal Andrés Fuentes, Eric Raúl Barros, Alejandro Martínez-Aguayo, Hernán García, Fidel Allende, Sandra Solari, Roberto Olmos, Cristian Carvajal, Alejandra Tapia-Castillo, Carmen Campino, Alexis Mikes Kalergis, Rene Baudrand, Carlos Enrique Fardella
Background: Aldosterone has been linked with obesity, metabolic syndrome (MetS), pro-inflammatory and pro-thrombotic states; however, most studies relate these indicators with primary aldosteronism (PA), excluding non-PA patients. Objective: To determine whether aldosterone, renin or the plasma aldosterone/renin ratio (ARR) are associated with metabolic disorders and inflammatory/vascular biomarkers in a non-PA population. Methods: We studied 275 patients including adolescents and adults of both genders and measured plasma and urinary aldosterone and determined the plasma renin activity (PRA)...
February 9, 2019: American Journal of Hypertension
Mai Mehanna, Zhiying Wang, Yan Gong, Caitrin W McDonough, Amber L Beitelshees, John G Gums, Arlene B Chapman, Gary L Schwartz, Kent R Bailey, Julie A Johnson, Stephen T Turner, Rhonda M Cooper-DeHoff
Background: Inter-individual variability in blood pressure (BP) response to antihypertensives has been reported. Although plasma renin activity (PRA) is a potential biomarker for personalizing antihypertensive therapy in European-American (EA) and African-American (AA) hypertensives, clinical utility of PRA-guided prescribing is incompletely understood. Methods: sing systematic-phased-approach, PRA's clinical utility was assessed. After categorizing by baseline-PRA, clinic systolic-BP (SBP) responses to metoprolol and chlorthalidone were compared in 134 EAs and 102 AAs enrolled in the Pharmacogenomics Evaluation of Antihypertensive Responses-2 (PEAR-2) trial...
February 9, 2019: American Journal of Hypertension
Marilucy Lopez-Sublet, Nicolas Girerd, Erwan Bozec, Jean-Loup Machu, João Pedro Ferreira, Faiez Zannad, Jean-Jacques Mourad, Patrick Rossignol
Objective: The attenuation of physiological nocturnal decline of blood pressure (BP) - called nondipper pattern - has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. The present study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study. Methods: The STANISLAS Cohort is a single-center, familial longitudinal cohort comprised of 1006 families (4295 subjects) recruited in 1993-1995 for a 5-year periodic health examination...
February 7, 2019: American Journal of Hypertension
Swati Sakhuja, John N Booth Iii, Donald M Lloyd-Jones, Cora E Lewis, Stephen J Thomas, Joseph E Schwartz, Daichi Shimbo, James M Shikany, Mario Sims, Yuichiro Yano, Paul Muntner
Background: Several health behaviors have been associated with hypertension based on clinic blood pressure (BP). Data on the association of health behaviors with nocturnal hypertension and non-dipping systolic BP (SBP) are limited. Methods: We analyzed data for participants with ambulatory BP monitoring (ABPM) at the Year 30 Coronary Artery Risk Development in Young Adults (CARDIA) study exam in 2015-2016 (n=781) and the baseline Jackson Heart Study (JHS) exam in 2000-2004 (n=1,046)...
February 2, 2019: American Journal of Hypertension
Dandan Xie, Jingping Zhu, Qianqian Liu, Jun Li, Mengjiu Song, Kai Wang, Qian Zhou, Yuanhui Jia, Ting Li
Background and objective: Preeclampsia (PE) is a common disease during pregnancy. It is generally accepted that PE is closely associated with shallow placenta implantation caused by the dysfunction of trophoblast cells. Trophoblasts have been recognized to share histological and behavioral characteristics with cancer cells, and many lines of evidence have emphasized that histone deacetylases (HDACs) are therapeutic targets for cancer treatment with the most promising. However, the roles of HDACs have not been well established in preeclampsia...
February 2, 2019: American Journal of Hypertension
Chen Liu, Renna Luo, Wei Wang, Zhangzhe Peng, Gail V W Johnson, Rodney E Kellems, Yang Xia
Background: Although numerous recent studies have shown a strong link between inflammation and hypertension, the underlying mechanisms by which inflammatory cytokines induce hypertension remain to be fully elucidated. Hypertensive disorders are also associated with elevated pressor sensitivity. Tissue transglutaminase (TG2), a potent crosslinking enzyme, is known to be transcriptionally activated by inflammatory cytokines and stabilize angiotensin II (Ang II) receptor AT1 (AT1R) via ubiquitination-preventing posttranslational modification...
February 2, 2019: American Journal of Hypertension
Stephen P Juraschek, Lewis A Lipsitz, Jennifer L Beach, Kenneth J Mukamal
Objective: To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, CVD, and mortality. Methods: We analyzed OH measurements from the ACCORD BP trial, which evaluated two BP goals (systolic BP [SBP]<120mmHg versus SBP<140mmHg) and incident cardiovascular disease (CVD) among adults with diabetes and hypertension. Seated BP was measured after 5 minutes of rest at baseline and follow-up visits (12-month, 48-month, and exit)...
January 31, 2019: American Journal of Hypertension
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