Jianshen Zhu, Shuyun Liu, Haoran Zhang, Wenjing Zhao, Jinmei Ding, Ronghua Dai, Ke Xu, Chuan He, Jiajia Liu, Lingyu Yang, He Meng
Alzheimer's disease (AD) is an irreversible neurodegenerative disease that affects more than 44 million people worldwide. The pathogenic mechanisms of AD still remain unclear. Currently, there are numerous studies investigating the microbiota-gut-brain axis in humans and rodents indicated that gut microbiota played a role in neurodegenerative diseases, including AD. However, the underlying relationship between the progress of AD disease and the dynamic distribution of gut microbiota is not well understood. In the present study, APPswe /PS1ΔE9 transgenic mice of different ages and sex were employed...
June 26, 2023: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica