journal
Journals APMIS : Acta Pathologica, Micr...

APMIS : Acta Pathologica, Microbiologica, et Immunologica Scandinavica

https://read.qxmd.com/read/38873951/dynamics-of-endemic-human-coronavirus-and-sars-cov-2-in-a-hospital-of-madrid-spain-retrospective-study-from-june-2020-to-july-2023
#1
JOURNAL ARTICLE
Rojo-Marcos Gerardo, Hernández-García Guiomar, González-Sarria Ander, Guerrero-Cañar Carlos Andrés, Arévalo-Cañas Coral
An observational and retrospective study was carried out to analyse HCoV positivity from a multiplex PCR respiratory panel and RT-PCR for SARS-CoV-2 in respiratory samples from 1 June 2020 to 31 July 2023 at the Príncipe de Asturias University Hospital (HUPA) in Alcalá de Henares, Madrid, Spain. Out of 2802 respiratory panels, 1258 (44.8%) turned out positive. HCoV was detected in 114 (4%) cases (range 0-23; median 1.5; IQR 0-3.75) with positivity rates ranging from 0% to 14%. All four variants of HCoV circulated, and OC-43 was the most common in 62...
June 14, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38873945/unraveling-the-intricacies-of-cancer-associated-fibroblasts-a-comprehensive-review-on-metabolic-reprogramming-and-tumor-microenvironment-crosstalk
#2
REVIEW
Sana Ahuja, Niti Sureka, Sufian Zaheer
Cancer-associated fibroblasts (CAFs) are crucial component of tumor microenvironment (TME) which undergo significant phenotypic changes and metabolic reprogramming, profoundly impacting tumor growth. This review delves into CAF plasticity, diverse origins, and the molecular mechanisms driving their continuous activation. Emphasis is placed on the intricate bidirectional crosstalk between CAFs and tumor cells, promoting cancer cell survival, proliferation, invasion, and immune evasion. Metabolic reprogramming, a cancer hallmark, extends beyond cancer cells to CAFs, contributing to the complex metabolic interplay within the TME...
June 14, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38873700/routine-use-of-msi-testing-in-colorectal-cancer-using-a-proposed-algorithm
#3
JOURNAL ARTICLE
Marie Ley Ringgaard, Torben Steiniche, Søren Palmelund Krag
Fifteen percent of all colorectal cancers have detectable defects in the mismatch repair system (dMMR). MMR status is used to identify possible Lynch Syndrome (LS) and to determine prognosis and choice of treatment. Two standard techniques for determining MMR status are immunohistochemistry (IHC) and analysis for microsatellite instability (MSI) by PCR. Recently, our department introduced Idylla™ MSI assay as an alternative option to IHC, and as part of this, we introduced a decision algorithm. The purpose of this study was to review the use of the new method and our algorithm and to assess possible false-positive results...
June 14, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38860355/changes-in-t-cell-subsets-occur-in-interstitial-lung-disease-and-may-contribute-to-pathology-via-complicated-immune-cascade
#4
JOURNAL ARTICLE
Mehmet Ali Karaselek, Tugce Duran, Serkan Kuccukturk, Hulya Vatansev, Pembe Oltulu
The study aimed to investigate the expression profiles of transcription factors, cytokines, and co-stimulatory molecules in helper T (Th)-cell subsets within bronchoalveolar lavage (BAL) samples of patients with interstitial lung diseases (ILDs). Twenty ILDs patients were included in the study, comprising those with idiopathic pulmonary fibrosis (IPF) (n:8), autoimmune-related ILDs (auto-ILD) (n:4), and orphan diseases (O-ILD) (n:8), alongside five control subjects. Flow cytometry was employed to evaluate the Th to cytotoxic T cell (CTL) ratio in BAL fluid, while cytopathological examination assessed macrophages, lymphocytes, and neutrophils...
June 11, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38837462/aetiological-profile-of-acute-encephalitis-syndrome-in-assam-india-during-a-4-year-period-from-2019-to-2022
#5
JOURNAL ARTICLE
Dharitree Sonowal, Ajanta Sharma, Kimmi Sarmah, Deepak Upadhaya, Sachin Kumar, Harpreet Kaur
Acute encephalitis syndrome (AES) is a major public health concern in India as the aetiology remains unknown in the majority of cases with the current testing algorithm. We aimed to study the incidence of Japanese encephalitis (JE) and determine the aetiology of non-JE AES cases to develop an evidence-based testing algorithm. Cerebrospinal fluid (CSF) samples were tested for Japanese encephalitis virus by ELISA and polymerase chain reaction (PCR). Multiplex real-time PCR was done for Dengue, Chikungunya, West Nile, Zika, Enterovirus, Epstein Barr Virus, Herpes Simplex Virus, Adenovirus, Cytomegalovirus, Herpesvirus 6, Parechovirus, Parvovirus B19, Varicella Zoster Virus, Scrub typhus, Rickettsia species, Leptospira, Salmonella species, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Plasmodium species and by ELISA for Mumps and Measles virus...
June 5, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38837446/outer-membrane-vesicles-from-x-ray-irradiated-pseudomonas-aeruginosa-alleviate-lung-injury-caused-by-p-%C3%A2-aeruginosa-infection-mediated-sepsis
#6
JOURNAL ARTICLE
Hongxia Bi, Jiayuan Qin, Jiaqi Huang, Cejun Zhong, Yanbin Liu
Pseudomonas aeruginosa infection causes pneumonia and sepsis. Previous research found that X-ray radiation can induce P. aeruginosa to release outer membrane vesicles (OMVs) of relatively consistent sizes. This study found that OMVs derived from X-ray-irradiated P. aeruginosa can significantly inhibit lung leakage, inflammatory cell infiltrating into lung, and the production of pro-inflammatory cytokines, IL-1β and TNFα caused by P. aeruginosa infection under preventive and therapeutic administration conditions...
June 5, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38798084/clinical-characteristics-and-risk-factors-of-connective-tissue-disease-complicated-with-bronchiectasis-and-pulmonary-infection
#7
JOURNAL ARTICLE
Xuan Qi, Jiaying Yang, Hongtao Jin, Yuran Xiao, Ying Wang, Yiqing Zhang
The clinical data from 118 CTD patients with bronchiectasis were collected and categorized into two groups: pulmonary infection present (n = 67) and absent (n = 51), for comparative analysis of characteristics and risk factors. Then, we analyzed and compared their demographics, disease characteristics, and risk factors for infection. Among the whole cohort (n = 118), the incidence of pulmonary infections was 56.78%. The occurrence of rheumatoid arthritis, systemic lupus erythematosus, and vasculitis was found to be associated with an increased risk of pulmonary infection...
May 26, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38798081/beta-cell-activity-and-development-of-type-1-diabetes
#8
REVIEW
Rikke Thea, Karsten Buschard
Type 1 diabetes (T1D) is an autoimmune disease, resulting in diminished islet integrity and destruction of the insulin-secreting beta cells. In this review, we investigate the intrinsic relationship between the development of T1D and the activity of the beta cells. The idea was initially hypothesized in 1982 that an increased beta-cell activity would enhance the surface antigen expression and thereby attract the immune system. Later, other findings support this idea, including increased risk of T1D development during third trimester of pregnancy, and the difference in T1D incidence in Russian and Finnish Karelia due to different lifestyles...
May 26, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38775301/fumarate-hydratase-deficient-renal-cell-carcinoma-an-oncology-care-institutional-experience
#9
JOURNAL ARTICLE
Meenakshi Kamboj, Gurudutt Gupta, Sunil Pasricha, Anurag Mehta, Sudhir Rawal, Amitabh Singh, Anila Sharma, Garima Durga, Divya Bansal, Himanshi Diwan
Renal cell carcinoma (RCC) accounts for 2% of all cancer cases worldwide, and majority are sporadic. The latest World Health Organization (WHO) classification of renal cell tumors (fifth edition, 2022) has molecularly defined renal tumor entities, which includes fumarate hydratase (FH)-deficient RCC. FH-deficient RCC is an aggressive carcinoma caused by pathogenic alterations in FH gene, seen in 15% of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) syndrome. These tumors occur more frequently at a younger age and present at an advanced stage, carrying a dismal prognosis...
May 22, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38775107/enhanced-angiogenesis-of-human-umbilical-vein-endothelial-cells-via-thp-1-derived-m2c-like-macrophages-and-treatment-with-proteasome-inhibitors-bortezomib-and-ixazomib
#10
JOURNAL ARTICLE
Selin Engür-Öztürk, Elif Kaya-Tİlkİ, Zerrin Cantürk, Miriş Dİkmen
The leading cause of cancer-related death is lung cancer, with metastasis being the most common cause of death. To elucidate the role of macrophages in lung cancer and angiogenesis processes, we established an in vitro co-culture model of A549 or HUVEC with THP-1 cells that polarized to M2c macrophages with hydrocortisone. The proteasome inhibitors bortezomib and ixazomib were investigated for their effects on proliferation, invasion, migration, metastasis, and angiogenesis pathways. The effects of bortezomib and ixazomib on gene expression in gene panels, including crucial genes related to angiogenesis and proteasomes, were investigated after the co-culture model to determine these effects at the molecular level...
May 22, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38773823/the-criteria-for-chronic-rhinosinusitis-in-children-with-cystic-fibrosis-are-rarely-fulfilled-after-initiation-of-cftr-modulator-treatment
#11
JOURNAL ARTICLE
Magne Bech, Marianne Skov, Ida S B Andersen, Christian von Buchwald, Kasper Aanæs
The vast majority of people with cystic fibrosis (pwCF) have untreated secondary chronic rhinosinusitis (CRS). Whereas the introduction of the cystic fibrosis transmembrane conductance regulator modulator (CFTRm) treatment regime has improved the lung function of pwCF, few studies have been published examining the effect on sinonasal symptoms in children. Our aim was to explore the effect of double CFTRm treatment on CRS and olfaction in children with CF. pwCF were included in this non-randomized cross-sectional study, where an otolaryngologist performed a complete ENT examination before initiating treatment with elaxacaftor/tezacaftor/ivacaftor (ETI)...
May 21, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38757248/staining-pattern-of-specific-and-cross-reacting-melan-a-antibodies-a-comparative-study-on-15-840-samples-from-133-human-tumor-types
#12
JOURNAL ARTICLE
Shiva Boroojerdi, Sören Weidemann, Anne Menz, Maximilian Lennartz, Sebastian Dwertmann Rico, Ria Schlichter, Simon Kind, Viktor Reiswich, Florian Viehweger, Ahmed Abdulwahab Bawahab, Doris Höflmeyer, Christoph Fraune, Natalia Gorbokon, Andreas M Luebke, Claudia Hube-Magg, Franziska Büscheck, Till Krech, Andrea Hinsch, Frank Jacobsen, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Stefan Steurer, Sarah Minner, Andreas H Marx, Christian Bernreuther, Till S Clauditz, David Dum, Patrick Lebok
The Melan-A (melanocyte antigen) protein, also termed 'melanoma antigen recognized by T cells 1' (MART-1) is a protein with unknown function whose expression is specific for the melanocyte lineage. Antibodies against Melan-A are thus used for identifying melanocytic tumors, but some Melan-A antibodies show an additional - diagnostically useful - cross-reactivity against an unspecified protein involved in corticosteroid hormone synthesis. To comprehensively compare the staining patterns of a specific and a cross-reactive Melan-A antibody in normal and neoplastic tissues, tissue microarrays containing 15,840 samples from 133 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types were analyzed by immunohistochemistry...
May 16, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38757239/activity-of-propyl-propane-thiosulfinate-and-propyl-propane-thiosulfonate-against-carbapenem-resistant-gram-negative-bacteria
#13
JOURNAL ARTICLE
Antonio Sorlózano-Puerto, Laura Cerezo-Collado, Elvira Roca-Lagrilliere, Alberto Baños-Arjona, José Gutiérrez-Fernández
Organosulfur compounds derived from plants of the Allium genus, such as propyl-propane-thiosulfinate (PTS) and propyl-propane-thiosulfonate (PTSO), have been proposed as an alternative in antibiotic resistance. The aim of this study was to compare the activity of these substances with other antibiotics against clinical isolates of carbapenem-resistant (CAR-R) and carbapenem-susceptible (CAR-S) Gram-negative bacteria. A total of 126 clinical isolates of CAR-R and 155 CAR-S bacteria were selected, including Enterobacterales, A...
May 16, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38757234/stage-related-increase-in-pim2-expression-in-mycosis%C3%A2-fungoides
#14
JOURNAL ARTICLE
Mie Holm Nielsen, Pia Rude Nielsen, Michael Bzorek, Jens Ole Eriksen, Ulrike Wehkamp, Lise Maria Lindahl, Anders Woetmann, Niels Ødum, Thomas Litman, Lise Mette Rahbek Gjerdrum
The oncogene PIM2 is upregulated in several malignancies but has never been investigated in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). PIM2 is a well-known oncogene and is regulated by cell signaling pathways like the JAK/STAT- and NF-kB-pathway, key regulators in the pathogenesis of CTCL. The aim of this study was to examine the role of PIM2 in MF. PIM2 gene expression was measured in 81 formalin-fixed paraffin-embedded skin biopsies from patients with MF and 46 control biopsies from healthy skin (HS) and benign inflammatory skin disease (BID)...
May 16, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38741286/myositis-ossificans-mimicking-bone-surface-osteosarcoma-case-report-with-literature-review
#15
REVIEW
Joseph O Werenski, Yin P Hung, Connie Y Chang, G Petur Nielsen, Santiago A Lozano-Calderón
Myositis ossificans, a benign tumor composed of spindle cells and osteoblasts, can clinically and radiologically mimic osteosarcoma. While recognition and accurate diagnosis of myositis ossificans can be a challenge, this is critical as it may allow a conservative surgical approach to maximize functional outcomes. Herein, we present a patient with surface myositis ossificans confirmed genetically by the presence of COL1A1::USP6 gene fusion, along with a literature review. Due to the enhanced visualization of the bone matrix, computed tomography (CT) imaging may be a superior imaging modality to magnetic resonance (MR) imaging...
May 13, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38741279/fourier-transform-infrared-spectroscopy-imaging-is-a-useful-adjunct-to-routine-histopathology-to-identify-failure-of-polyethylene-inlays-in-revision-total-hip%C3%A2-arthroplasty
#16
JOURNAL ARTICLE
Songyun Liu, Deborah J Hall, Corina Dommann-Scherrer, Robin Pourzal, Peter Wahl
The use of highly crosslinked ultra-high molecular weight polyethylene (XLPE) has significantly reduced the volumetric wear of acetabular liners, thereby reducing the incidence of osteolysis. However, contemporary components tend to generate smaller wear particles, which can no longer be identified using conventional histology. This technical limitation can result in imprecise diagnosis. Here, we report on two uncemented total hip arthroplasty cases (~7 years in situ) revised for periprosthetic fracture of the femur and femoral loosening, respectively...
May 13, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38659394/development-of-a-reverse-transcription-loop-mediated-isothermal-amplification-assay-with-novel-quantitative-ph-biosensor-readout-method-for-sars-cov-2-detection
#17
JOURNAL ARTICLE
Dian Ekayanti Astari, Muhammad Nasrum Massi, Rina Masadah, Marhaen Hardjo, Rosdiana Natzir, Michael Erlichster, Gursharan Chana, Efstratios Skafidas, Zeba Islam Seraj, Sabrina M Elias, Gita Vita Soraya
Reverse transcription loop-mediated isothermal amplification (RT-LAMP) is a molecular amplification method that can detect SARS-CoV-2 in a shorter time than the current gold-standard molecular diagnostic reverse transcription-polymerase chain reaction (RT-PCR). However, previously developed RT-LAMP assays have mostly relied on highly subjective visual colorimetric interpretation. In this study, an RT-LAMP assay was developed with quantitative measurement of reaction pH using a novel portable pH biosensor compared to qualitative colorimetric interpretation and gel electrophoresis, with 57 clinical COVID-19 samples used for validation of the test...
April 25, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38659357/cefepime-distribution-by-microdialysis-in-peritoneal-fluid-of-rats-with-or-without-experimental-peritonitis
#18
JOURNAL ARTICLE
Michele Vaz Dos Anjos, Eduarda Possa, Gisele da Silva Fonseca, Larissa Bergoza, Leandro Tasso
The aim of this study was to investigate the penetration of cefepime into rat peritoneal fluid by microdialysis and to determine the relationship between unbound drug plasma and tissue concentration in healthy animals and in a sepsis model established through cecal ligation and puncture-induced peritonitis. Probe recovery was performed by dialysis and retrodialysis. Cefepime was administered at a dose of 110 mg/kg intravenously. Samples were collected for about 4 h, and concentrations were determined by liquid chromatography-electrospray ionization-QTOF MS...
April 24, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38658316/in-vitro-determination-of-the-susceptibility-of-malassezia-furfur-biofilm-to-different-commercially-used-antimicrobials
#19
JOURNAL ARTICLE
Fábio Cassola, Nedy Ramírez, Camila Delarmelina, Marta Cristina Teixeira Duarte
Malassezia furfur is a yeast known as the etiological agent of seborrheic dermatitis. We evaluated the action of five different antimicrobials (amphotericin B, chloramphenicol, ketoconazole, fluconazole, and nystatin) on inhibiting biofilm formation and removing biofilm already formed by M. furfur. The assays were carried out using the microdilution method, and scanning electron microscopy images were used to analyze the biofilm structure. According to the results obtained, the percentage of inhibition was higher for chloramphenicol, followed by ketoconazole, nystatin, and amphotericin B...
April 24, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38644557/lncrna-snhg1-serves-as-a-biomarker-for-systemic-lupus-erythematosus-and-participates-in-the-disease-progression
#20
JOURNAL ARTICLE
Linsen Jiang, Anning Qi, Hongyu Yang, Shuping Wang, Fei Wang, Xuemei Bai, Juan Ren
LncRNAs play an important role in autoimmune diseases. The purpose of this study was to explore the role of lncRNA SNHG1 in systemic lupus erythematosus (SLE), and laid a theoretical foundation for the study of SLE. The basic clinical information of all subjects was first collected for statistical analysis, and SNHG1 expression in the serum of all subjects was detected by RT-qPCR. The value of SNHG1 in the diagnosis of SLE was assessed by ROC. The correlation between SNHG1 and each blood sample index was analyzed by Pearson correlation analysis...
April 21, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
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