Yuwen Chu, Shuo Zhang, Wei Wan, Jialiang Yang, Yumeng Zhang, Chuanqi Nie, Weipeng Xing, Shanhe Tong, Jinyang Liu, Geng Tian, Bing Wang, Lei Ji
Histology slide, tissue microbes, and the host gene expression can be independent prognostic factors of colorectal cancer (CRC), but the underlying associations and biological significance of these multimodal omics remain unknown. Here, we comprehensively profiled the matched pathological images, intratumoral microbes, and host gene expression characteristics in 527 patients with CRC. By clustering these patients based on histology slide features, we classified the patients into two histology slide subtypes (HSS)...
February 25, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica