Mia Øgaard Mønsted, Mesut Bilgin, Marek Kuzma, Helena Pelantová, Kristina Pedersen, Petra Tomášová, Anastasiia Nazmutdinova, Blanka Šedivá, David Funda, Josué L Castro-Mejía, Laurits Juulskov Holm, Dennis Sandris Nielsen, Martin Haupt-Jorgensen
Type 1 diabetes (T1D) is an autoimmune disease with rising incidence. Pre- and manifest T1D is associated with intestinal barrier dysfunction, skewed microbiota composition, and serum dyslipidemia. The intestinal mucus layer protects against pathogens and its structure and phosphatidylcholine (PC) lipid composition may be compromised in T1D, potentially contributing to barrier dysfunction. This study compared pre-diabetic Non-Obese Diabetic (NOD) mice to healthy C57BL/6 mice by analyzing the intestinal mucus PC profile by shotgun lipidomics, plasma metabolomics by mass spectrometry and nuclear magnetic resonance, intestinal mucus production by histology, and cecal microbiota composition by 16S rRNA sequencing...
February 21, 2023: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica