Juan Novoa, Gil Hardy, William Manzanares
Sepsis is a life-threatening condition characterized by multiorgan dysfunction due to an exaggerated host response to infection associated with a homeostatic failure. In sepsis, different interventions, aimed at improving clinical outcomes, have been tested over the past decades. Among these most recent strategies, intravenous high-dose micronutrients (vitamins and/or trace elements) have been investigated. According to current knowledge, sepsis is characterized by low thiamine levels, which are associated with illness severity, hyperlactatemia, and poor clinical outcomes...
February 23, 2023: Nutrition
Chun-Ta Huang, Po-Heng Chen, Seu-Hwa Chen, June-Horng Lue, Yi-Ju Tsai
OBJECTIVES: Glia (i.e., astrocyte and microglia) activation in the central nervous system plays a critical role in developing neuropathic pain. Microglia can be activated into proinflammatory (M1) and anti-inflammatory (M2) phenotypes. Switching microglial polarization from M1 to M2 phenotypes represents a novel therapeutic strategy for neuropathic pain. Curcumin has been widely used for its anti-inflammatory and immunomodulatory effects. This study investigated effects of curcumin on astrocyte activation and microglia polarization in the cuneate nucleus (CN) and development of neuropathic pain behavior after chronic constriction injury (CCI) of the median nerve...
February 14, 2023: Nutrition
Asumi Hayashi, Yusuke Taki, Kazumori Arai, Shinsuke Sato, Kazuya Higashizono, Erina Nagai, Masato Nishida, Masaya Watanabe, Ko Ohata, Hideyuki Kanemoto, Makoto Suzuki, Noriyuki Oba
A 76-y-old Japanese man who had undergone gastrectomy 4.5 y earlier experienced 2 wk of sore throat, heartburn, and difficulty swallowing. Endoscopy showed deep, craterlike, longitudinal ulcers in the lower and middle esophagus. Immunohistochemistry and blood tests were negative for herpes simplex virus and cytomegalovirus infections. The patient reported no other symptoms affecting the gastrointestinal tract. Although his symptoms ameliorated after initial hospitalization and treatment, they re-emerged a few days after being discharged...
February 10, 2023: Nutrition
Felipe Silva Neves, Carla Adriano Martins, Vanessa Sequeira Fontes, Aline Priscila Batista, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, Ana Paula Carlos Cândido
OBJECTIVE: The aim of this study was to investigate the involvement of Brazilian adolescents in home cooking, estimating its associations with sex and socioeconomic status. METHODS: This cross-sectional study involved a probabilistic sample of 14- to 19-y-olds enrolled in 29 public schools in the municipality of Juiz de Fora, MG, Southeast Brazil (n = 835). To assess involvement in home cooking, a 12-question questionnaire was used. The content was based on the Brazilian Food Guide, which encourages the acquisition, development, and sharing of culinary skills...
February 10, 2023: Nutrition
Michele Barone, Alfredo Di Leo, Marian A E de van der Schueren
Malnutrition can play an important prognostic role in terms of survival in patients with amyotrophic lateral sclerosis (ALS). In this clinical context, applying criteria defining malnutrition requires particular attention, especially in the initial stage of the disease. This article discusses the application of the most recent criteria used for the definition of malnutrition when applied to patients with ALS. Currently, the Global Leadership Initiative on Malnutrition (GLIM) criteria, which have received a worldwide consensus, are based on parameters such as unintentional weight loss, low body mass index (BMI), and reduced muscle mass (phenotypic criteria) in combination with reduced food intake and assimilation or inflammation and disease (etiologic criteria)...
February 10, 2023: Nutrition
Jun-Hong Chen, Minchao Jin
OBJECTIVES: Although egg-based interventions are effective in alleviating undernutrition for infants and toddlers, little is known regarding their effectiveness for children in remote and poor areas of China. For policy and intervention implications, the aim of this study was to examine the effects of offering one hard-boiled egg per school day to school-age children in less-developed areas of China. METHODS: This analytical sample included 346 school-age children...
February 8, 2023: Nutrition
Eazaz Lbban, Ammar Ashor, Oliver M Shannon, Iskandar Idris, Mario Siervo
Endothelial dysfunction (ED) is an early marker of vascular damage linked to the loss of integrity of the endothelial lining and represents a key step in the pathogenesis of atherosclerosis and cardiovascular diseases (CVDs). ED may be reversible, hence the development and testing of effective early interventions could be beneficial for the prevention and treatment of CVDs. Recent studies have demonstrated that the consumption of dietary nitrate (NO3 - ), an inorganic anion that serves as a substrate for the gas transmitter nitric oxide (NO), can lower blood pressure, improve endothelial function and, in observational studies, reduce the risk for CVD...
February 7, 2023: Nutrition
Paulina Bielska, Ewa Skotarczak, Dorota Cais-Sokolińska, Joanna Teichert
OBJECTIVE: A study was carried out to identify characteristics of consumers of dairy products. METHODS: Based on a questionnaire with 127 participants, aged 22 to 52, a simulation model was developed, taking into account factors influencing the development of health-seeking behavior. RESULTS: A relationship was found between consumer proinnovative attitude, actual prohealth behavior, and characteristics of the consumer influencing the consumption of calcium...
February 7, 2023: Nutrition
Qiuyun Yang, Manrui Li, Jinyuan Liu, Lingxuan Zhang, Ruixuan Yuan, Yang Xu, Jingwen Zheng, Shuqiang Cao, Hao Dai, Miao Liao, Meili Lv, Xiaogang Chen, Yadong Guo, Xiaoqi Xie, Lin Zhang, Xiameng Chen, Weibo Liang
Ferroptosis, a newly characterized form of programmed cell death that results from lipid peroxidation and mitochondrial dysfunction, has been demonstrated to be involved in the pathogenesis of traumatic brain injury (TBI). Scientific evidence has shown that intermittent fasting (IF) reduces both the lipid peroxidation and the mitochondrial dysfunction, raising the question of whether IF affects the ferroptosis induced by TBI. Here, based on an established TBI animal model, we examine the effects of IF on the activation of ferroptosis pathway as well as related outcomes...
February 4, 2023: Nutrition
Juliana Farias de Novaes, Mariana De Santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Fernanda Martins de Albuquerque, Érica Priulli, Leandro Licursi de Oliveira, Maria do Carmo Gouveia Peluzio
OBJECTIVE: The aim of this study was to evaluate the association of body fat, anti- and inflammatory adipokines with anti- and oxidative markers. METHODS: We conducted a cross-sectional study with 378 schoolchildren ages 8 to 9 y in Viçosa, Minas Gerais, Brazil. We obtained information on sociodemographic and lifestyle characteristics via questionnaires, measured height and weight, and estimated body fat by dual energy x-ray absorptiometry. Blood sample was collected to analyze the adipokines (adiponectin, leptin, chemerin, and retinol-binding protein 4) by enzyme-linked immunosorbent assay based on the sandwich principle; and anti- and oxidant markers (plasma ferric reducing antioxidant power [FRAP], superoxide dismutase [SOD], and malondialdehyde [MDA]) by enzymatic methods...
February 3, 2023: Nutrition
Francesca Coppi, Alberto Farinetti, Claudio Stefanelli, Anna Vittoria Mattioli
No abstract text is available yet for this article.
January 28, 2023: Nutrition
Analie Nunes Couto, Hildegard Hedwig Pohl, Moisés Evandro Bauer, Carla Helena Augustin Schwanke
OBJECTIVES: This study aimed to verify the performance of the triglyceride-glucose (TyG) index in predicting metabolic syndrome (MetS) using three different criteria in healthy individuals living in rural areas. In addition, it aimed to estimate the TyG index cutoff point in the prediction of MetS. METHODS: The study was a cross-sectional study of healthy individuals (aged ≥18 y) living in rural areas of southern Brazil. Individuals with diabetes mellitus were excluded...
January 21, 2023: Nutrition
Talia Masino, Patricia Eustachio Colombo, Kia Reis, Inge Tetens, Alexandr Parlesak
OBJECTIVES: A frequently suggested approach to reduce greenhouse gas emissions (GHGEs) caused by food production is to reduce the intake of animal products, which can create nutritional deficiencies. This study aimed to identify culturally acceptable nutritional solutions for German adults that are both climate friendly and health promoting. METHODS: Linear programming was applied to optimize the food supply for omnivores, pescatarians, vegetarians, and vegans considering nutritional adequacy, health promotion, GHGEs, affordability, and cultural acceptability by approaching German national food consumption...
January 21, 2023: Nutrition
Yuye Wang, Xiaoqian Niu, Dantao Peng
Alzheimer's disease is a worldwide public health problem. However, the treatment method and treatment effects are limited. The stages of preclinical Alzheimer's disease are thought to be a better intervention period. Thus, in this review, food is given focus and the intervention stage put forward. We summarized the role of diet, nutrient supplementation, and microbioecologics in cognitive decline and found that interventions such as modified Mediterranean-ketogenic diet, nuts, vitamin B, and Bifidobacterium breve A1 are beneficial to cognition protection...
January 11, 2023: Nutrition
Júlia Paulino Teixeira Oliveira, Simone Gonzaga do Carmo, Bruna de Almeida Aragão, Juliana Cunha, Patrícia Borges Botelho
OBJECTIVES: This study aimed to evaluate the effect of different meditation practices on eating behavior, changes in body weight, and mental health. METHODS: A virtual questionnaire was used to evaluate meditation practices and current and prepandemic weights. The questionnaire comprised specific and validated instruments to evaluate body image (silhouette scale), eating behavior (21-item three-factor eating questionnaire), current sleep quality (Pittsburgh Sleep Quality Index), and anxiety (Beck Anxiety Inventory)...
January 8, 2023: Nutrition
Jacek Polański, Krzysztof Dudek, Grzegorz Mazur, Mariusz Chabowski
OBJECTIVES: Lung cancer is the most common cancer. In patients with lung cancer, malnutrition may result in shorter overall survival, poorer treatment response, increased risk for complications and impaired physical and mental function. The aim of this study was to assess the effects of nutritional status on the psychological functioning and coping in patients with lung cancer. METHODS: The present study included 310 patients treated for lung cancer at the Lung Center between 2019 and 2020...
January 7, 2023: Nutrition
Inmaculada Aguilera-Buenosvinos, Miguel Ángel Martínez-González, Itziar Zazpe, Andrea Romanos-Nanclares, Rodrigo Sánchez-Bayona, Estefanía Toledo
OBJECTIVES: Dietary patterns may have a greater influence on human health than individual foods or nutrients, and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance of macronutrients, evidence indicates that the quality of macronutrient sources may play an important role in health outcomes. We sought to examine the relationship between healthful and unhealthful low-fat dietary patterns in relation to breast cancer. METHODS: We used observational data from a Mediterranean cohort study (the Seguimiento Universidad de Navarra project)...
January 7, 2023: Nutrition
Masahiro Aichi, Sho Hasegawa, Yusuke Kurita, Satoru Shinoda, Shingo Kato, Taichi Mizushima, Naho Ruiz Yokota, Etsuko Miyagi
OBJECTIVES: The aim of this study was to evaluate whether low skeletal muscle mass before initial treatment is an independent prognostic factor defining overall survival (OS) and progression-free survival (PFS) in patients diagnosed with stage III cervical cancer. METHODS: Body composition and clinicopathologic data were collected retrospectively. Information was extracted and analyzed from the medical records of 92 patients with stage III cervical cancer and undergoing concurrent chemoradiotherapy...
January 7, 2023: Nutrition
Maytinee Srifuengfung, Somporn Srifuengfung, Chalermsri Pummangura, Keerati Pattanaseri, Awirut Oon-Arom, Manit Srisurapanont
OBJECTIVES: This systematic review and meta-analysis synthesized the evidence from randomized controlled trials comparing vitamin D and placebo in reducing depressive symptoms and contributing to all-cause dropout rates. METHODS: Inclusion criteria were randomized controlled trials comparing reduced depression between depressed patients receiving vitamin D and those receiving placebo. We searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials through January 2022...
January 7, 2023: Nutrition
Masafumi Nozoe, Tatsuro Inoue, Mitsuru Ishida, Kenta Yamamoto, Masashi Kanai
OBJECTIVES: The aim of this study was to determine the effects of malnutrition on trunk function and lower leg muscle strength in patients with acute stroke upon hospitalization. METHODS: This prospective cohort study included hospitalized patients with acute stroke. Nutritional status was assessed using the Global Leadership Initiative on Malnutrition criteria. Trunk function and lower leg muscle strength were assessed using the trunk control test (TCT) and Motricity Index (MI), respectively, on admission and at discharge...
January 6, 2023: Nutrition
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