Qiuyun Yang, Manrui Li, Jinyuan Liu, Lingxuan Zhang, Ruixuan Yuan, Yang Xu, Jingwen Zheng, Shuqiang Cao, Hao Dai, Miao Liao, Meili Lv, Xiaogang Chen, Yadong Guo, Xiaoqi Xie, Lin Zhang, Xiameng Chen, Weibo Liang
Ferroptosis, a newly characterized form of programmed cell death that results from lipid peroxidation and mitochondrial dysfunction, has been demonstrated to be involved in the pathogenesis of traumatic brain injury (TBI). Scientific evidence has shown that intermittent fasting (IF) reduces both the lipid peroxidation and the mitochondrial dysfunction, raising the question of whether IF affects the ferroptosis induced by TBI. Here, based on an established TBI animal model, we examine the effects of IF on the activation of ferroptosis pathway as well as related outcomes...
February 4, 2023: Nutrition