Esther F Davis, Daniela R Crousillat, Jesus Peteiro, Jose Lopez-Sendon, Roxy Senior, Michael D Shapiro, Patricia A Pellikka, Radmila Lyubarova, Khaled Alfakih, Khaled Abdul-Nour, Rebecca Anthopolos, Yifan Xu, Dennis M Kunichoff, Jerome L Fleg, John A Spertus, Judith Hochman, David Maron, Michael H Picard, Harmony R Reynolds
BACKGROUND: Global longitudinal strain (GLS) is a sensitive marker for identifying subclinical myocardial dysfunction in obstructive coronary artery disease (CAD). Little is known about the relationship between GLS and ischemia in patients with myocardial ischemia and no obstructive CAD (INOCA). OBJECTIVES: To investigate the relationship between resting GLS and ischemia on stress echocardiography (SE) in patients with INOCA. METHODS: Left ventricular GLS was calculated offline on resting SE images at enrollment (n=144) and 1-year follow-up (n=120) in the CIAO-ISCHEMIA study, which enrolled participants with moderate or severe ischemia by local SE interpretation (>3 segments with new or worsening wall motion abnormality and no obstructive (<50% stenosis) CAD on coronary CT angiography...
September 16, 2023: Journal of the American Society of Echocardiography