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Journal of Clinical Epidemiology

Benjamin Djulbegovic, Tea Reljic, Shira Elqayam, Adam Cuker, Iztok Hozo, Qi Zhou, Shelly-Anne Li, Paul Alexander, Robby Nieuwlaat, Wojtek Wiercioch, Holger Schünemann, Gordon Guyatt
BACKGROUND: The determinants of practice guideline panels' recommendations remain uncertain. OBJECTIVE: To investigate factors considered by members of 8 panels convened by the American Society of Hematology to develop guidelines when using the GRADE system. METHODS: Two level hierarchical, random-effect, multivariable logistic regression analysis to explore the relation between GRADE and non-GRADE factors and strength of recommendations (SOR)...
February 16, 2019: Journal of Clinical Epidemiology
Van Thu Nguyen, Mehdi Benchoufi, BridgetYoung, Lina Ghosn, Philippe Ravaud, Isabelle Boutron
OBJECTIVE: New forms of research involving collective intelligence (CI) of diverse individuals mobilized through crowdsourcing is successfully emerging in various fields. This scoping review aimed to describe these methods across different fields and propose a framework for implementation. STUDY DESIGN AND SETTING: We searched seven electronic databases for reports describing projects that had mobilized CI with crowdsourcing. We used content analysis to develop themes and categories of the methods...
February 14, 2019: Journal of Clinical Epidemiology
Clovis Mariano Faggion
No abstract text is available yet for this article.
February 14, 2019: Journal of Clinical Epidemiology
Paulo Schiavom Duarte
No abstract text is available yet for this article.
February 14, 2019: Journal of Clinical Epidemiology
Charlene Soobiah, Gayle Manley, Sharon Marr, Ainsley Moore, Elliot PausJenssen, Sylvia Teare, Jemila Hamid, Andrea C Tricco, Sharon Straus
OBJECTIVE: To identify relevant outcomes and measures to inform a systematic review (SR) on the comparative effectiveness of geriatrician-led care models. STUDY DESIGN AND SETTING: In the modified Delphi to select outcomes for inclusion in the SR, knowledge users (KU) from Ontario, Alberta and Saskatchewan rated outcome importance using a Likert scale. A survey was then completed by geriatricians to determine optimal measures for selected outcomes. Findings were analyzed using frequencies, means, and standard deviations (SD)...
February 13, 2019: Journal of Clinical Epidemiology
Christodoulou Evangelia, M A Jie, Gary S Collins, Ewout W Steyerberg, Jan Y Verbakel, Ben van Calster
OBJECTIVE: To compare performance of logistic regression (LR) with machine learning (ML) for clinical prediction modeling. STUDY DESIGN AND SETTING: We conducted a Medline literature search (1/2016 to 8/2017), and extracted comparisons between LR and ML models for binary outcomes. RESULTS: We included 71 out of 927 studies. The median sample size was 1250 (range 72-3,994,872), with 19 predictors considered (range 5-563) and 8 events per predictor (range 0...
February 11, 2019: Journal of Clinical Epidemiology
Livia Puljak
No abstract text is available yet for this article.
February 8, 2019: Journal of Clinical Epidemiology
Chris Del Mar
No abstract text is available yet for this article.
February 8, 2019: Journal of Clinical Epidemiology
Holger J Schünemann, Reem A Mustafa, Jan Brozek, Nancy Santesso, Patrick M Bossuyt, Karen R Steingart, Mariska Leeflang, Stefan Lange, Tommaso Trenti, Miranda Langendam, Rob Scholten, Lotty Hooft, Mohammad Hassan Murad, Roman Jaeschke, Anne Rutjes, Jasvinder Singh, Mark Helfand, Paul Glasziou, Ingrid Arévalo Rodriguez, Elie A Akl, Jonathan J Deeks, Gordon H Guyatt
OBJECTIVES: This article describes GRADE's framework of moving from test accuracy to patient or population important outcomes. We focus on the common scenario when studies directly evaluating the effect of diagnostic and other tests or strategies on health outcomes are not available or are not providing the best available evidence. STUDY DESIGN AND SETTING: Using practical examples, we explored how guideline developers and other decision makers can use information from test accuracy to develop a recommendation by linking evidence that addresses downstream consequences...
February 7, 2019: Journal of Clinical Epidemiology
Mirko Gabelica, Jakica Cavar, Livia Puljak
OBJECTIVE: To analyze data sharing practices among authors of randomized controlled trials (RCT) published in seven high-ranking anesthesiology journals from 2014 to 2016. STUDY DESIGN AND SETTING: We analyzed data sharing statements in 619 included RCTs and contacted their corresponding authors, asking them to share de-identified raw data from trial. RESULTS: Of the 86 (14%) authors who responded to our query for data sharing, only 24 (4%) provided the requested data...
February 6, 2019: Journal of Clinical Epidemiology
R Brian Haynes, Dalton Budhram, John Cherian, Emma Iserman, Alfonso Iorio, Cynthia Lokker
OBJECTIVES: To determine reliability and validity of McMaster PLUS measures of scientific merit and clinical importance of articles in medical journals. STUDY DESIGN AND SETTING: Analytic survey of peer-reviewed medical journals. Articles qualified for inclusion by meeting: 1) scientific criteria and 2) a clinical importance rating threshold. Included articles were sent as e-mail alerts to physicians according to their clinical interests. Internal measures included the number of high-quality, clinically important studies published in source journals and response to alerts...
February 4, 2019: Journal of Clinical Epidemiology
Tesfa Dejenie Habtewold, Sisay Mulugeta Alemu, Shimels Hussien Mohammed, Aklilu Endalamaw, Mohammed Akibu Mohammed, Andreas A Teferra, Abera Kenay Tura, Nigus Gebremedhin Asefa, Balewgizie Sileshi Tegegne
OBJECTIVES: The aims of this overview are to assess the trend of narrative and systematic reviews in Ethiopia, examine their methodological quality and suggest future directions for improvement. STUDY DESIGN AND SETTING: All narrative reviews and systematic reviews with or without a meta-analysis on topics associated with Ethiopia irrespective of place of publication and authors affiliation were included. The International Narrative Systematic assessment (INSA) for narrative reviews and A MeaSurement Tool to Assess Systematic Reviews (AMSTAR-2) for systematic reviews with or without a meta-analysis were used for quality appraisal...
February 2, 2019: Journal of Clinical Epidemiology
Ewan Gray, Joachim Marti, David H Brewster, Jeremy C Wyatt, Romain Piaget-Rossel, Peter S Hall
OBJECTIVE: Evidence-based guidelines recommend adjuvant chemotherapy in early stage breast cancer whenever treatment benefit is considered sufficient to outweigh the associated risks. However, many groups of patients were either excluded from or underrepresented in the clinical trials that form the evidence base for this recommendation. This study aims to determine whether using administrative healthcare data - Real World Data (RWD) - and econometric methods for causal analysis to provide 'Real World Evidence' (RWE) are feasible methods for addressing this gap...
January 31, 2019: Journal of Clinical Epidemiology
Linda Nyanchoka, Catrin Tudur-Smith, Van Nguyen Thu, Valentia Iversen, Andrea C Tricco, Raphaël Porcher
BACKGROUND/OBJECTIVES: Different methods to examine research gaps have been described, but there are still no standard methods for identifying, prioritizing or reporting research gaps. This study aimed to describe the methods used to identify, prioritize and display gaps in health research. METHODS: A scoping review using the Arksey and O'Malley methodological framework was carried out. We included all study types describing or reporting on methods to identify, prioritize and display gaps or priorities in health research...
January 30, 2019: Journal of Clinical Epidemiology
Daniel Kotz, Wolfgang Viechtbauer, Mark Spigt, Rik Crutzen
No abstract text is available yet for this article.
January 29, 2019: Journal of Clinical Epidemiology
Adam G Dunn, Liat Orenstein, Enrico Coiera, Kenneth D Mandl, Florence T Bourgeois
OBJECTIVE: To determine whether certain trial characteristics are associated with faster or more frequent inclusion in systematic reviews for drug interventions in type 2 diabetes. STUDY DESIGN AND SETTING: We examined trials included in systematic reviews published between 1 January 2007 and 1 January 2017. Primary outcomes were time between trial publication and first inclusion in a systematic review, and frequency of inclusion in systematic reviews over the study period...
January 29, 2019: Journal of Clinical Epidemiology
Antonino Cartabellotta, Julie K Tilson
Evidence-based medicine (EBM) has experienced numerous advances since its inception over two decades ago. Yet a persistent gulf remains between how medicine is actually practiced and the goal of providing care based on best available research evidence integrated with patient perspective and clinical expertise. A primary source of challenge for EBM is induced by inefficiencies in the generation, synthesis, and translation of evidence. During the 8th International Conference for Evidence-based Healthcare Teachers and Developers, GIMBE Foundation presented an innovative approach by defining an ecosystem of evidence...
January 29, 2019: Journal of Clinical Epidemiology
Clovis Mariano Faggion, Karla Diaz Cavero
OBJECTIVES: To report systematic review definitions that are published in overviews of reviews and to propose a new classification of systematic reviews. STUDY DESIGN AND SETTING: In this review of overviews, we searched PubMed for systematic review definitions that were reported in overviews of reviews that were published in the medical literature between November 2017 and May 2018. Two independent authors extracted and descriptively reported the systematic review definitions from the overviews...
January 23, 2019: Journal of Clinical Epidemiology
Anja Zgodic, Christopher H Schmid, Ingram Olkin, Thomas A Trikalinos
OBJECTIVE: To evaluate diagnostic tests, analysts use meta-analyses to provide inputs to parameters in decision models. Choosing parameter estimands from meta-analyses requires understanding the meta-analytic and decision-making contexts. STUDY DESIGN AND SETTING: We expand on an analysis comparing positron emission tomography (PET), PET with computed tomography (PET/CT), and conventional workup (CW) in women with suspected recurrent breast cancer. We discuss Bayesian meta-analytic summaries (posterior mean over a set of existing studies, posterior estimate in an existing study, posterior predictive mean in a new study) used to estimate diagnostic test parameters (prevalence, sensitivity, specificity) needed to calculate quality-adjusted life years in a decision model contextualizing PET, PET/CT, and CW...
January 14, 2019: Journal of Clinical Epidemiology
Jan A Roth, Thomas Sakoparnig, Simon Neubauer, Eleonore Kuenzel-Pawlik, Martin Gerber, Andreas F Widmer, Balthasar L Hug, Christian Abshagen, Geoffrey Fucile, Martin Gerber, Balthasar L Hug, Bernd Jaegle, Eleonore Kuenzel-Pawlik, Simon Neubauer, Rakesh Padiyath, Jan A Roth, Thomas Sakoparnig, Thierry Sengstag, Damian Spyra, Andreas F Widmer
OBJECTIVES: We aimed to quantify the shared information between medical diagnoses of an adult inpatient population in order to explore both multimorbidity patterns and vice versa the unrelatedness of medical diagnoses. STUDY DESIGN AND SETTING: This was a cross-sectional study, performed at a tertiary care center in Switzerland. Diagnoses were routinely coded using the International Classification of Diseases, 10th revision. RESULTS: Among 190,837 inpatient cases, 7,994 unique diagnoses were coded...
January 11, 2019: Journal of Clinical Epidemiology
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