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Breast Disease

Hamidreza Khorshidi, Iman Azari, Vahid Kholghi Oskooei, Mohammad Taheri, Soudeh Ghafouri-Fard
BACKGROUND: The long non-coding RNA (lncRNA) DSCAM-AS1 has been demonstrated to participate in the pathogenesis of breast cancer and tamoxifen resistance. OBJECTIVE: To evaluate expression profile of DSCAM-AS1 in invasive ductal carcinoma of breast and its suitability as a biomarker for diagnosis of breast cancer. METHODS: We evaluated expression of DSCAM-AS1 in 108 breast tissues including tumoral and adjacent non-cancerous tissues (ANCTs) by means of quantitative real time PCR...
December 28, 2018: Breast Disease
Simona Barberi, Giacomo Montagna, Lorenzo Rossi
OBJECTIVE: to show that the expression of urokinase plasminogen activator (uPA) in the leucocytes of patients with benign and malignant breast lesions correlates with its expression in the lesions, and to explore the role of uPA as a tumour marker in breast cancer. METHODS: using real time reverse transcriptase - polymerase chain reaction (RT-PCR), we examined the expression of uPA in leukocytes and tissues of three groups of women: a) with breast cancer (BC), b) with benign breast lesions and c) a control group of healthy women...
December 13, 2018: Breast Disease
S Lambat Emery, A Kalovidouri, E David-Montefiore
Mondor's disease can be a challenging diagnosis. The case we present is of a 29 year-old Brazilian woman, under combined hormonal contraception, who consulted for a painful lump on her right breast. She presented a complete resolution after a local treatment of heparinoid cream and a non-steroidal anti-inflammatory oral treatment, but relapsed 18 months later. Oral combined hormonal contraception was the only "risk factor" found, in this case, and the modification of the latter helped resolve the relapse clinical symptoms...
September 19, 2018: Breast Disease
Zackariah Clement, William McLeay, Clive Hoffmann, Peter Shin, Munir Chowdhry, Michael Eaton
BACKGROUND: Positive margins after Breast conserving surgery (BCS) for breast cancer can result in local recurrence (LR) requiring further surgery. This can lead to unnecessary patient anxiety, poor prognosis and impose additional economic burden to our health system. The aim of this study is to assess the rate of re-excision for positive margins after BCS using the sector resection technique. METHODS: This single centre retrospective cohort study included all women who underwent BCS using sector resection between the years of 2012 and 2016...
August 31, 2018: Breast Disease
Hadi Ghaffari, Nahid Nafissi, Mohammad Hashemi-Bahremani, Mahmoud Reza Alebouyeh, Ahmad Tavakoli, Davod Javanmard, Farah Bokharaei-Salim, Helya Sadat Mortazavi, Seyed Hamidreza Monavari
BACKGROUND: The etiology and molecular mechanisms involved in the development of breast cancer still remain poorly understood. Some epidemiological studies have shown an association between human papillomavirus (HPV) and breast cancer. However, the findings are controversial. OBJECTIVE: Our study was aimed to investigate the presence of HPV DNA in breast carcinomas of Iranian women. METHODS: In total, 72 samples of formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer collected between December 2014 and April 2016 were examined...
July 30, 2018: Breast Disease
S Denariyakoon, C Watcharakul, P Techanitisawat, A Chulakadabba, P Sampatanukul, D Boonjunwetwat, K Chatamra
Recurrent hemorrhagic cyst is an uncommon presentation of breast disease. The ordinary imaging could not demonstrate the malignant features of the cyst. However, the non-contrast dedicated breast computerized tomography could support the malignancy concern. Although tissue diagnosis cannot show the malignant cell, Surgical excision could be offered without uncompromising. Eventually, ductal carcinoma in-situ was diagnosed and further adjuvant treatment could be given. We reported the first case report of ductal carcinoma in-situ, hypersecretory type, presented by a hemorrhagic cyst...
July 25, 2018: Breast Disease
A Alikhassi, Sh F Hamidpour, M Firouzmand, M Navid, M Eghbal
BACKGROUND: The limitations of mammography as a screening and diagnostic tool, especially for younger women with dense breasts, makes it necessary to use an adjunctive modality to cover its shortcomings. Ultrasound and thermography both have potential role in this era. OBJECTIVES: We will compare the accuracy of thermography with ultrasound in breast cancer diagnosis in a clinical setting. PATIENTS AND METHODS: This study consisted of 78 women who underwent ultrasound and thermography on the same day, since evaluations were performed for both breasts in all patients separately, each breast was considered a distinct case...
April 9, 2018: Breast Disease
Haruko Takuwa, Wakako Tsuji, Fumiaki Yotsumoto
BACKGROUND: As the aging population grows, the number of elderly breast cancer patients has rapidly increased especially in Japan; a suitable treatment for elderly patients, considering chronic comorbidities and treatment tolerance, is urgently needed. METHODS: In this retrospective study, 286 elderly breast cancer patients were investigated. Tumor characteristics and survival outcome were compared between 70-79-year-old and ≥ 80-year-old groups. Disease-free survival, overall survival, and breast cancer-specific survival were compared, and the effect of variables was analyzed statistically...
April 5, 2018: Breast Disease
Haruko Takuwa, Shigehira Saji, Masahiro Takada, Sachiko Takahara, Akira Yamauchi
BACKGROUND: Among estrogens, estradiol (E2) has the strongest physiological activity as a stimulator in estrogen receptor (ER)-positive breast cancer. The aim of this study is to investigate E2 dynamics during endocrine therapy and to explore the optimal environment in which tamoxifen (TAM) exhibits better efficacy for ER-positive premenopausal early breast cancer patients. METHODS: This is a retrospective study enrolled 194 patients with premenopausal ER-positive early-stage breast cancer who aging ≤45 years at onset and receiving luteinizing hormone-releasing hormone-agonist (LHRH-a) and TAM-therapy...
March 19, 2018: Breast Disease
Nikolaos S Salemis
Intracystic breast carcinoma is a rare clinical entity accounting for 0.5-2% of all breast cancers. It represents a distinctive clinical form rather a histological subtype of breast cancer and can either be in situ or invasive tumor. We herein describe a rare case of intracystic breast carcinoma arising from the wall of a cyst in a postmenopausal patient, who presented with a rapidly growing complex breast cyst. Diagnostic evaluation and management of the patient are discussed along with a review of the literature...
March 16, 2018: Breast Disease
Bunzo Nakata, Kenji Kuroda, Yasuhiko Yoshida, Nozomi Iimori, Go Masuda, Tomihiro Lee, Masashige Tendo, Takeshi Hori, Hiroshi Sato, Tetsuro Ishikawa
Here we report the case of a 77-year-old woman with a huge cancer of the right breast for which size was measured on computed tomography in our hospital preoperatively and in other hospital 3 years earlier. During the 3-year untreated interval, the tumor grew from 4 cm to 13 cm in maximum diameter, and the tumor-volume doubling time (TVDT) was calculated as 209 days. The patient underwent mastectomy with axillary lymph node dissection, with the large skin defect covered by autologous skin graft. The pathological diagnosis was pure mucinous carcinoma (MC) of the breast with a low MIB-1 index, no vessel invasion, and no lymph node metastasis...
March 16, 2018: Breast Disease
Zackariah Clement, William McLeay, Clive Hoffmann, Peter Shin, Andrew Kiu, Michael Eaton
BACKGROUND/OBJECTIVE: This study aimed to analyse the local recurrence (LR) and breast cancer related mortality (BCRM) in older women who underwent breast-conserving surgery (BCS) with and without adjuvant radiotherapy (XRT). METHODS: This retrospective study included a total of 299 women who underwent BCS for early breast carcinoma, between the years of 2007 and 2011. Predictive risk factors, local recurrence (LR) and breast cancer related mortality (BCRM) were assessed with a mean follow-up period of 84 months...
2018: Breast Disease
Syrine Abdeljaoued, Lhem Bettaieb, Meher Nasri, Olfa Adouni, Aida Goucha, Hatem Bouzaiene, Hamouda Boussen, Khaled Rahal, Amor Gamoudi
BACKGROUND: Male breast cancer (MBC) is a rare and neglected disease. Prognostic and predictive factors in MBC are extrapoled from trials conducted on its female counterpart. OBJECTIVE: Since the relationship between the transcription factor Forkhead box M1 (FOXM1) expression and the clinical response to chemotherapy and hormonotherapy in MBC remains unknown, we sought to investigate the predictive value of FOXM1 in MBC. METHODS: FOXM1 expression was assessed in 130 MBC cases...
2018: Breast Disease
Nikolaos S Salemis
Metaplastic carcinoma of the breast with mesenchymal differentiation (MCMD), previously known as carcinosarcoma, is a very rare and aggressive tumor that has been recently classified as a subtype of metaplastic breast carcinoma. It accounts for 0.08%-0.2% of all breast cancers, with only a few cases reported in the literature. Histologically, MCMD is characterized by a biphasic pattern of malignant epithelial and sarcomatous components without evidence of a transition zone between the two elements. We herein describe a unique case of metaplastic carcinoma of the breast with chondrosarcomatous differentiation in a postmenopausal woman who presented with a large, rapidly growing, ulcerated, bleeding mass and signs of impending sepsis...
2018: Breast Disease
Z Nahleh, G Botrus, A Dwivedi, N Badri, S Otoukesh, N Diab, S Biswas, M Jennings, S Elzamly
BACKGROUND: Breast cancer is the leading cause of cancer death in Hispanic/Latina women nationwide. Limited cancer research has been conducted in this population. El Paso, Texas is a large border city with a population of around 900,000, of which 85% are Latinos and would provide a suitable setting for this study. The aim of this study is to evaluate ethnic differences and cancer characteristics in Hispanic/latina women with breast cancer. METHODS: After IRB approval, we retrospectively analyzed the variables of patients with breast cancer treated consecutively at a large tertiary medical center in El Paso, TX between 2005-2015...
2018: Breast Disease
Megha Tandon, Pankaj Panwar, R M Kirby, Sankaran Narayanan, Soni Soumian, Mark Stephens
Metastases to the breast are very uncommon as compared to primary tumours. Breast is an unusual site for metastasis from renal cell carcinoma. Only occasional cases are reported in the literature. These metastases must be clearly diagnosed as the treatment of primary breast cancer and metastases differs markedly. Treatment of isolated metastases from renal cell carcinoma is usually surgical resection. We report two cases of isolated metachronous metastases to breast from renal cell carcinoma.
2018: Breast Disease
Boubacar Efared, Gabrielle Atsame Ebang, Layla Tahiri, Ibrahim S Sidibé, Fatimazahra Erregad, Nawal Hammas, Moulay Abdelilah Melhouf, Abdelaziz Banani, Laila Chbani, Hinde El Fatemi
BACKGROUND: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. The aim of our study was to analyse histolopathological, radiological and clinical features of PT from an experience of a single center. METHODS: It was a retrospective study including 106 patients diagnosed with phyllodes tumors on surgical specimens at the department of pathology, of Hassan II university hospital (Fez, Morocco), from 2009 to 2016...
2018: Breast Disease
Mohammad Jaseem Hassan, Monika Sharma, Shaan Khetrapal, Sabina Khan, Sujata Jetley
Crystallizing galactocele is a very rare entity which yields a viscous, chalky material on Fine Needle Aspiration Cytology (FNAC). FNAC is used both for diagnosis as well as treatment of this condition. We present here a case of 26 years old lactating female who presented with swelling in the right breast for 8 months. The swelling was firm, discrete, non-tender and mobile involving the upper inner quadrant of right breast. A diagnosis of benign breast disease, possibly fibroadenoma was made clinically. FNAC of the lesion yielded thick, milky and chalky material...
2018: Breast Disease
D Lokanatha, Abhishek Anand, K C Lakshmaiah, K Govind Babu, Linu Abraham Jacob, M C Suresh Babu, K N Lokesh, A H Rudresha, L K Rajeev, Smitha C Saldanha, G V Giri, Deepak Koppaka, Rekha V Kumar
INTRODUCTION: Primary angiosarcoma of the breast is a rare entity with incidence of less than 0.05% of all malignant breast neoplasms. It occurs in young females without any associated risk factors. The tumor behaves aggressively and has a poor prognosis compared to invasive ductal carcinoma. METHOD: It was a retrospective observational study done at a tertiary cancer center from January 2012 to December 2016. The medical records of patients diagnosed with primary breast angiosarcoma were reviewed for the study...
2018: Breast Disease
Nesrine Mejri, Mehdi Benna, Houda El Benna, Labidi Soumaya, Mehdi Afrit, Bechir Zouari, Hamouda Boussen
PURPOSE: We evaluated the relation between first site of recurrence of early breast cancer and disease profile at presentation and reported survival results, suggesting a personalized diagnostic imaging guidance during follow up. METHODS: Among 1400 early breast cancer treated from 2000 to 2010, 324 relapses were divided into 4 groups according to first site: A-locoregional, B-bone, C-Brain and D-visceral. We analyzed redictive factors of each group compared to a control group of 100 non relapsing patients and the remaining groups matched...
2018: Breast Disease
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