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Lung Cancer: Journal of the International Association for the Study of Lung Cancer

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https://read.qxmd.com/read/31405531/response-to-comment-on-low-dose-computed-tomography-screening-for-lung-cancer-in-people-with-workplace-exposure-to-asbestos
#1
LETTER
Patrick Maisonneuve, Sergio Iavicoli, Giulia Veronesi
No abstract text is available yet for this article.
August 4, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31377004/erratum-to-characteristics-of-252-patients-with-bronchopulmonary-neuroendocrine-tumours-treated-at-the-copenhagen-net-centre-of-excellence-lung-cancer-132-june-2019-141-149
#2
V Grøndahl, T Binderup, S W Langer, R H Petersen, K Nielsen, A Kjaer, B Federspiel, U Knigge
No abstract text is available yet for this article.
July 31, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31377003/correspondence-regarding-low-dose-computed-tomography-screening-for-lung-cancer-in-people-with-workplace-exposure-to-asbestos
#3
LETTER
Fabio Barbone, Fabiano Barbiero, Gianpiero Fasola
No abstract text is available yet for this article.
July 27, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31353097/erratum-to-vasculature-surrounding-a-nodule-a-novel-lung-cancer-biomarker-lung-cancer-114-december-2017-38-43
#4
Xiaohua Wang, Joseph K Leader, Renwei Wang, David Wilson, James Herman, Jian-Min Yuan, Jiantao Pu
No abstract text is available yet for this article.
July 26, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31400821/i-love-my-dog
#5
EDITORIAL
M Muller, P Baas
No abstract text is available yet for this article.
July 25, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31345567/corrigendum-to-treatment-and-outcome-of-432-patients-with-extensive-stage-small-cell-lung-cancer-in-first-second-and-third-line-results-from-the-prospective-german-tlk-cohort-study-lung-cancer-130-2019-april-216-225
#6
Claus-Christoph Steffens, Corinna Elender, Ulrich Hutzschenreuter, Stephanie Dille, Adrian Binninger, Lisa Spring, Martina Jänicke, Norbert Marschner
No abstract text is available yet for this article.
July 22, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31279497/corrigendum-to-low-dose-computed-tomography-screening-for-lung-cancer-in-people-with-workplace-exposure-to-asbestos-lung-cancer-131-may-2019-23-30
#7
Patrick Maisonneuve, Cristiano Rampinelli, Raffaella Bertolotti, Alessandro Misotti, Filippo Lococo, Monica Casiraghi, Lorenzo Spaggiari, Massimo Bellomi, Pierluigi Novellis, Michela Solinas, Elisa Dieci, Marco Alloisio, Luca Fontana, Benedetta Persechino, Sergio Iavicoli, Giulia Veronesi
No abstract text is available yet for this article.
July 3, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31235317/small-cell-lung-cancer-elevates-procalcitonin-levels-in-the-absence-of-infection
#8
LETTER
Alfredo Jose Pardo-Cabello, Victoria Manzano-Gamero
No abstract text is available yet for this article.
June 17, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31235316/trained-dogs-can-identify-malignant-solitary-pulmonary-nodules-in-exhaled-gas
#9
A Guirao, L Molins, I Ramón, G Sunyer, N Viñolas, R Marrades, D Sánchez, J J Fibla, M Boada, J Hernández, R Guzmán, A Libreros, A Gómez-Caro, C Guerrero, A Agustí
OBJECTIVES: To investigate the capacity of a trained dog to identify LC in patients with malignant SPN. METHODS: We collected 90 exhaled gas samples from 30 patients with SPN (3 samples/patient). As controls we used 61 healthy volunteers and 18 COPD patients without SNP or LC, in each of whom we collected 5 exhaled gas samples (n = 395). The dog (Blat, a 4-year-old crossbreed between a Labrador Retriever and a Pitbull) and the methodology used were the same as previously reported by our group (see: https://drive...
June 15, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31182249/nivolumab-for-advanced-non-small-cell-lung-cancer-patients-with-mild-idiopathic-interstitial-pneumonia-a-multicenter-open-label-single-arm-phase-ii-trial
#10
Daichi Fujimoto, Makiko Yomota, Akimasa Sekine, Mitsunori Morita, Takeshi Morimoto, Yukio Hosomi, Takashi Ogura, Hiromi Tomioka, Keisuke Tomii
OBJECTIVES: The efficacy of nivolumab against metastatic non-small cell lung cancer (NSCLC) has been demonstrated; however, pneumonitis is relatively common and is a potentially life-threatening immune-related adverse event. Patients with idiopathic interstitial pneumonia (IIP) have a higher risk of pneumonitis and are generally excluded from clinical trials. Additionally, to date, a multicenter prospective trial for previously-treated NSCLC patients with IIP has not been performed. To fulfill this unmet medical need, we conducted a multicenter, open-label single-arm phase II trial to evaluate the efficacy and safety of nivolumab in NSCLC patients with mild IIP...
June 3, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31320002/sensitivity-of-next-generation-sequencing-assays-detecting-oncogenic-fusions-in-plasma-cell-free-dna
#11
Julianna G Supplee, Marina S D Milan, Lee P Lim, Kristy T Potts, Lynette M Sholl, Geoffrey R Oxnard, Cloud P Paweletz
OBJECTIVES: Plasma genotyping represents an opportunity for convenient detection of clinically actionable mutations in advanced cancer patients, such has been well-documented in non-small cell lung cancer (NSCLC). Oncogenic gene fusions are complex variants that may be more challenging to detect by next-generation sequencing (NGS) of plasma cell-free DNA (cfDNA). Rigorous evaluation of plasma NGS assays in the detection of fusions is needed to maximize clinical utility. MATERIALS AND METHODS: Additional plasma was collected from patients with advanced NSCLC and ALK, ROS1, or RET gene fusions in tissue who had undergone clinical plasma NGS using Guardant360™ (G360, Guardant Health)...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31320001/endobronchial-and-surgical-treatment-of-pulmonary-carcinoid-tumors-a-systematic-literature-review
#12
REVIEW
E M B P Reuling, C Dickhoff, P W Plaisier, H J Bonjer, J M A Daniels
The treatment of pulmonary carcinoid has changed over the last decades. Although surgical resection is still the gold standard, minimally invasive endobronchial procedures have emerged as a parenchyma sparing alternative for tumors located in the central airways. This review was performed to identify the optimal treatment strategy for pulmonary carcinoid, with a particular focus on the feasibility and outcome of parenchyma sparing techniques versus surgical resection. A systematic review of the literature was carried out using MEDLINE, Embase and the Cochrane databases, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31320000/heterogeneity-of-pd-l1-expression-in-non-small-cell-lung-cancer-implications-for-specimen-sampling-in-predicting-treatment-response
#13
Alexander Haragan, John K Field, Michael P A Davies, Carles Escriu, Aaron Gruver, John R Gosney
OBJECTIVES: PD-L1 expression on tumour cells can guide the use of anti-PD-1/PD-L1 immune modulators to treat patients with non-small cell lung cancer (NSCLC). Heterogeneity of PD-L1 expression both within and between tumour sites is a well-documented phenomenon that compromises its predictive power. Our aim was to better characterise the pattern and extent of PD-L1 heterogeneity with a view to optimising tumour sampling and improve its accuracy as a biomarker. MATERIALS AND METHODS: Expression of PD-L1 was assessed by immunochemistry using the SP263 clone in 107 resected primary NSCLCs and their nodal metastases...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319999/clinical-utility-of-plasma-based-digital-next-generation-sequencing-in-oncogene-driven-non-small-cell-lung-cancer-patients-with-tyrosine-kinase-inhibitor-resistance
#14
Jon Zugazagoitia, Ana Gómez-Rueda, Eloisa Jantus-Lewintre, Dolores Isla, Carlos Camps, Inmaculada Ramos, Jose Manuel Trigo, Reyes Bernabé, Oscar Juan-Vidal, Jose Miguel Sanchez-Torres, Rosario García-Campelo, Mariano Provencio, Enriqueta Felip, Javier de Castro, Iris Faull, Richard B Lanman, Santiago Ponce-Aix, Luis Paz-Ares, Pilar Garrido
OBJECTIVES: Resistance to tyrosine-kinase inhibitors (TKIs) is a clinical challenge in patients with oncogene-driven non-small-cell lung cancers (NSCLC). We have analyzed the utility of next-generation sequencing (NGS) of cell-free circulating tumor DNA (ctDNA) to impact the clinical care of patients with TKI resistance. MATERIALS AND METHODS: We conducted a multi-institutional prospective study including consecutive EGFR, ALK, or ROS1-altered NSCLC patients with TKI resistance from 12 Spanish institutions...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319998/paired-genomic-analysis-of-squamous-cell-carcinoma-transformed-from-egfr-mutated-lung-adenocarcinoma
#15
Sehhoon Park, Joon Ho Shim, Boram Lee, Inju Cho, Woong-Yang Park, Youjin Kim, Se-Hoon Lee, Yoon La Choi, Joungho Han, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
OBJECTIVES: Adenocarcinoma (ADC) to squamous cell carcinoma (SCC) transformation (AST) is reported in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer after tyrosine kinase inhibitor (TKI) failure. However, little is known about the underlying genomic changes during the AST process. MATERIALS AND METHODS: We retrospectively reviewed our tissue database collected after first- or second- generation EGFR TKI resistance (n = 263) and identified 3 cases of AST...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319997/evaluation-of-a-health-service-adopting-proactive-approach-to-reduce-high-risk-of-lung-cancer-the-liverpool-healthy-lung-programme
#16
Bhagabati Ghimire, Roberta Maroni, Daniel Vulkan, Zoheb Shah, Edward Gaynor, Michelle Timoney, Lisa Jones, Rachel Arvanitis, Martin Ledson, Linda Lukehirst, Paul Rutherford, Faye Clarke, Katy Gardner, Michael W Marcus, Sarah Hill, Darcy Fideo, Sabrina Mason, Samuel G Smith, Samantha L Quaife, Karen Fitzgerald, Veronique Poirier, Stephen W Duffy, John K Field
OBJECTIVES: This Liverpool Healthy Lung Programme is a response to high rates of lung cancer and respiratory diseases locally and aims to diagnose lung cancer at an earlier stage by proactive approach to those at high risk of lung cancer. The objective of this study is to evaluate the programme in terms of its likely effect on mortality from lung cancer and its delivery to deprived populations. METHODS: Persons aged 58-75 years, with a history of smoking or a diagnosis of chronic obstructive pulmonary disease (COPD)2 according to general practice records were invited for lung health check in a community health hub setting...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319996/early-serum-tumor-marker-dynamics-predict-progression-free-and-overall-survival-in-single-pd-1-pd-l1-inhibitor-treated-advanced-nsclc-a-retrospective-cohort-study
#17
David Lang, Andreas Horner, Elmar Brehm, Kaveh Akbari, Benedikt Hergan, Klaus Langer, Christian Asel, Mario Scala, Bernhard Kaiser, Bernd Lamprecht
OBJECTIVES: To evaluate serum tumor markers (STM) as biomarkers for treatment monitoring and prognosis in advanced non-small cell lung cancer (NSCLC) treated with single-agent PD-1/PD-L1-directed immune checkpoint inhibitor (ICI) therapy. MATERIALS AND METHODS: Carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), cytokeratin-19 fragments (CYFRA 21-1) and neuron specific enolase (NSE) were routinely measured at NSCLC diagnosis, initially elevated markers were used for follow-up...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319995/guideline-adherence-of-mediastinal-staging-of-non-small-cell-lung-cancer-a-multicentre-retrospective-analysis
#18
Jelle E Bousema, Martijn van Dorp, Fieke Hoeijmakers, Ilse A Huijbregts, Nicole P Barlo, Gerben P Bootsma, WimJan P van Boven, Niels J M Claessens, Anne-Marie C Dingemans, Wessel E Hanselaar, Robert Th J Kortekaas, Jan-Willem H P Lardenoije, Jos G Maessen, W Hermien Schreurs, Yvonne Vissers, Maggy Youssef-El Soud, Marcel G W Dijkgraaf, JoukeT Annema, Frank J C van den Broek
OBJECTIVES: Mediastinal lymph node staging of NSCLC by initial endosonography and confirmatory mediastinoscopy is recommended by the European guideline. We assessed guideline adherence on mediastinal staging, whether staging procedures were performed systematically and unforeseen N2 rates following staging by endosonography with or without confirmatory mediastinoscopy. MATERIAL AND METHODS: We performed a multicentre (n = 6) retrospective analysis of NSCLC patients without distant metastases, who were surgical candidates and had an indication for mediastinal staging in the year 2015...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319994/a-phase-ib-study-of-the-combination-of-afatinib-and-ruxolitinib-in-egfr-mutant-nsclc-with-progression-on-egfr-tkis
#19
Ji Soo Park, Min Hee Hong, You Jin Chun, Hye Ryun Kim, Byoung Chul Cho
OBJECTIVES: We evaluated the safety and efficacy of the combination therapy of afatinib, an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), and ruxolitinib, a JAK1/2 selective inhibitor, in patients with EGFR mutant NSCLC progressing on at least one kind of EGFR-TKI. MATERIALS AND METHODS: In this phase Ib open-label study, we used a 3 + 3 dose-escalation design. Patients with histologically diagnosed EGFR-mutant stage IV NSCLC and documented disease progression on EGFR-TKI therapies were enrolled...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/31319993/impact-of-keap1-nfe2l2-cul3-mutations-on-duration-of-response-to-egfr-tyrosine-kinase-inhibitors-in-egfr-mutated-non-small-cell-lung-cancer
#20
Jessica A Hellyer, Henning Stehr, Millie Das, Sukhmani K Padda, Kavitha Ramchandran, Joel W Neal, Maximilian Diehn, Heather A Wakelee
OBJECTIVES: For patients with Epidermal Growth Factor Receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), frontline EGFR-tyrosine kinase inhibitor (TKI) therapy compared to chemotherapy improves outcomes. However, resistance to these agents uniformly develops. Recently, mutations in the KEAP1-NFE2L2 pathway have been implicated as a potential mechanism of acquired EGFR TKI resistance. MATERIALS AND METHODS: We examined all patients with metastatic NSCLC with mutations in both EGFR and KEAP1/NFE2L2/CUL3 identified on next generation sequencing from 2015 - 2018...
August 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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